Editorial: Mitochondrial metabolism revisited: A route to cardioprotection

Cardiovascular Research

Volumn 88, Issue 2, 2010, Pages 209-210

  González Loyola, Alejandra ^a   Barba, Ignasi ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINOOXYACETIC ACID; ASPARTIC ACID; MALIC ACID; REACTIVE OXYGEN METABOLITE; CARDIOTONIC AGENT; GLUCOSE; MALIC ACID DERIVATIVE;

ANGINA PECTORIS; EDITORIAL; GLUCOSE OXIDATION; HEART FAILURE; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART PROTECTION; ISCHEMIC PRECONDITIONING; MITOCHONDRIAL RESPIRATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; CELL RESPIRATION; DRUG EFFECT; ENERGY METABOLISM; HEART INFARCTION PREVENTION; HEART LEFT VENTRICLE FUNCTION; HEART MITOCHONDRION; HEART MUSCLE; HEMODYNAMICS; HUMAN; METABOLISM; NOTE; OXIDATION REDUCTION REACTION; PATHOLOGY; PATHOPHYSIOLOGY; REPERFUSION INJURY;

AMINOOXYACETIC ACID; ANIMALS; ASPARTIC ACID; CARDIOTONIC AGENTS; CELL RESPIRATION; ENERGY METABOLISM; GLUCOSE; HEMODYNAMICS; HUMANS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALATES; MITOCHONDRIA, HEART; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; REACTIVE OXYGEN SPECIES; VENTRICULAR FUNCTION, LEFT;

EID: 77958096900     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvq258     Document Type: Editorial

References (15)

1. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 1986;74:1124-1136.
2. Yellon DM, Downey JM. Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev 2003;83:1113-1151.
3. Wong GT, Ling LingJ, Irwin MG. Activation of central opioid receptors induces car-dioprotection against ischemia-reperfusion injury. Anesth Analg 2010;111:24-28.
4. Mitchell MB, Meng X, Ao L, Brown JM, Harken AH, Banerjee A. Preconditioning of isolated rat heart is mediated by protein kinase C. Circ Res 1995;76:73-81.
5. Inagaki K, Chen L, Ikeno F, Lee FH, Imahashi K, Bouley DM et al. Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo. Circulation 2003;108:2304-2307.
6. Murphy E, Steenbergen C. Cardioprotection in females: a role for nitric oxide and altered gene expression. Heart Fail Rev2007;12:293-300.
7. Halestrap AP, ClarkeJS, Khauliulin I. The role of mitochondria in protection of the heart by preconditioning. Biochim Biophys Acta 2007;1767:1007-1031.
8. Miura T, Tanno M, Sato T. Mitochondrial kinase signalling pathways in myocardial protection from ischaemia/reperfusion-induced necrosis. Cardiovasc Res 2010;88: 7-15.
9. Garcia-Dorado D, Rodriguez-Sinovas A, Ruiz-Meana M, Inserte J, Agullo L, Cabestrero A. The end-effectors of preconditioning protection against myocardial cell death secondary to ischemia-reperfusion. Cardiovasc Res 2006;70:274-285.
10. Støttrup NB, Løfgren B, Birkler RD, Nielsen JM, Wang L, Caldarone CA et al. Inhi-bition of the malate-aspartate shuttle by pre-ischaemic aminooxyacetate loading of the heart induces cardioprotection. Cardiovasc Res 2010;88:257-266.
11. Safer B. The metabolic significance of the malate-aspartate shuttle cycle in the heart. Circ Res 1975;37:527-533.
12. Lee L, Campbell R, Scheuermann-Freestone M, Taylor R, Gunaruwan P, Williams L et al. Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment Circulation 2005;112: 3280-3288.
13. Beadle RM, Frenneaux M. Modification of myocardial substrate utilisation: a new therapeutic paradigm in cardiovascular disease. Heart 2010;96:824-830.
14. Kloner RA, Nesto RW. Glucose-insulin-potassium for acute myocardial infarction: continuing controversy over cardioprotection. Circulation 2008;117: 2523-2533.
15. InserteJ, Barba I, Hernando V, Garcia-Dorado D. Delayed recovery of intracellular acidosis during reperfusion prevents calpain activation and determines protection in postconditioned myocardium. Cardiovasc Res 2009;81:116-122.