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Volumn 96, Issue 11, 2010, Pages 824-830

Modification of myocardial substrate utilisation: A new therapeutic paradigm in cardiovascular disease

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINO ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARDIOVASCULAR AGENT; CARVEDILOL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ETOMOXIR; FATTY ACID; GLUCOSE; GLUCOSE INSULIN POTASSIUM; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; LACTIC ACID; OXYGEN; PERHEXILINE MALEATE; PROPRANOLOL; RANOLAZINE; TRIMETAZIDINE; UNCLASSIFIED DRUG;

EID: 77953717010     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/hrt.2009.190256     Document Type: Review
Times cited : (58)

References (79)
  • 1
    • 0037046203 scopus 로고    scopus 로고
    • Adaptation and maladaptation of the heart in diabetes: Part I: General concepts
    • Taegtmeyer H, McNulty P, Young ME. Adaptation and maladaptation of the heart in diabetes: part I: general concepts. Circulation 2002;105:1727-33.
    • (2002) Circulation , vol.105 , pp. 1727-1733
    • Taegtmeyer, H.1    McNulty, P.2    Young, M.E.3
  • 2
    • 0037117651 scopus 로고    scopus 로고
    • Adaptation and maladaptation of the heart in diabetes: Part II: Potential mechanisms
    • Young ME, McNulty P, Taegtmeyer H. Adaptation and maladaptation of the heart in diabetes: part II: potential mechanisms. Circulation 2002;105:1861-70.
    • (2002) Circulation , vol.105 , pp. 1861-1870
    • Young, M.E.1    McNulty, P.2    Taegtmeyer, H.3
  • 3
    • 33947239659 scopus 로고    scopus 로고
    • The failing heartean engine out of fuel
    • Neubauer S. The failing heartean engine out of fuel. N Engl J Med 2007;356:1140-51.
    • (2007) N Engl J Med , vol.356 , pp. 1140-1151
    • Neubauer, S.1
  • 4
    • 50549202600 scopus 로고
    • The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • Randle PJ, Garland PB, Hales CN, et al. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963;1:785-9.
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3
  • 5
    • 0001463166 scopus 로고
    • Metabolic studies on the human heart in vivo. I. Studies on carbohydrate metabolism of the human heart
    • Bing RJ, Siegel A, Vitale A, et al. Metabolic studies on the human heart in vivo. I. Studies on carbohydrate metabolism of the human heart. Am J Med 1953;15:284-96.
    • (1953) Am J Med , vol.15 , pp. 284-296
    • Bing, R.J.1    Siegel, A.2    Vitale, A.3
  • 7
    • 0028154042 scopus 로고
    • Ischemia induces translocation of the insulin-responsive glucose transporter GLUT4 to the plasma membrane of cardiac myocytes
    • Sun D, Nguyen N, DeGrado TR, et al. Ischemia induces translocation of the insulinresponsive glucose transporter GLUT4 to the plasma membrane of cardiac myocytes. Circulation 1994;89:793-8. (Pubitemid 24056208)
    • (1994) Circulation , vol.89 , Issue.2 , pp. 793-798
    • Sun, D.1    Nguyen, N.2    DeGrado, T.R.3    Schwaiger, M.4    Brosius III, F.C.5
  • 8
    • 0029075281 scopus 로고
    • Regulation of glucose metabolism in cardiac muscle
    • Hue L, Depre C, Lefebvre V, et al. Regulation of glucose metabolism in cardiac muscle. Biochem Soc Trans 1995;23:311-14.
    • (1995) Biochem Soc Trans , vol.23 , pp. 311-314
    • Hue, L.1    Depre, C.2    Lefebvre, V.3
  • 9
    • 0026587014 scopus 로고
    • Relation between glycolysis and calcium homeostasis in postischemic myocardium
    • Jeremy RW, Koretsune Y, Marban E, et al. Relation between glycolysis and calcium homeostasis in postischemic myocardium. Circ Res 1992;70:1180-90.
    • (1992) Circ Res , vol.70 , pp. 1180-1190
    • Jeremy, R.W.1    Koretsune, Y.2    Marban, E.3
  • 10
    • 0037376604 scopus 로고    scopus 로고
    • Cardiac ischemia causes inhibition of the Na/K ATPase by a labile cytosolic compound whose production is linked to oxidant stress
    • Fuller W, Parmar V, Eaton P, et al. Cardiac ischemia causes inhibition of the Na/K ATPase by a labile cytosolic compound whose production is linked to oxidant stress. Cardiovasc Res 2003;57:1044-51.
    • (2003) Cardiovasc Res , vol.57 , pp. 1044-1051
    • Fuller, W.1    Parmar, V.2    Eaton, P.3
  • 11
    • 0025721058 scopus 로고
    • Myocardial lactate metabolism during exercise
    • Stanley WC. Myocardial lactate metabolism during exercise. Med Sci Sports Exerc 1991;23:920-4.
    • (1991) Med Sci Sports Exerc , vol.23 , pp. 920-924
    • Stanley, W.C.1
  • 12
    • 0019434531 scopus 로고
    • Myocardial lactate metabolism: Evidence of lactate release during net chemical extraction in man
    • Gertz EW, Wisneski JA, Neese R, et al. Myocardial lactate metabolism: evidence of lactate release during net chemical extraction in man. Circulation 1981;63:1273-9. (Pubitemid 11120662)
    • (1981) Circulation , vol.63 , Issue.6 I , pp. 1273-1279
    • Gertz, E.W.1    Wisneski, J.A.2    Neese, R.3
  • 13
    • 0022802645 scopus 로고
    • Fuel selection in animals
    • Randle PJ. Fuel selection in animals. Biochem Soc Trans 1986;14:799-806.
    • (1986) Biochem Soc Trans , vol.14 , pp. 799-806
    • Randle, P.J.1
  • 14
    • 18344394762 scopus 로고    scopus 로고
    • Glucose insulin potassium infusion improves systolic function in patients with chronic ischemic cardiomyopathy
    • Cottin Y, Lhuillier I, Gilson L, et al. Glucose insulin potassium infusion improves systolic function in patients with chronic ischemic cardiomyopathy. Eur J Heart Fail 2002;4:181-4.
    • (2002) Eur J Heart Fail , vol.4 , pp. 181-184
    • Cottin, Y.1    Lhuillier, I.2    Gilson, L.3
  • 15
    • 0008340411 scopus 로고    scopus 로고
    • Haemodynamic effects of intracoronary pyruvate in patients with congestive heart failure: An open study
    • Hermann HP, Pieske B, Schwarzmuller E, et al. Haemodynamic effects of intracoronary pyruvate in patients with congestive heart failure: an open study. Lancet 1999;353:1321-3.
    • (1999) Lancet , vol.353 , pp. 1321-1323
    • Hermann, H.P.1    Pieske, B.2    Schwarzmuller, E.3
  • 16
    • 0019543906 scopus 로고
    • Alterations of carbohydrate and lipid metabolism in the acutely ischemic heart
    • Liedtke AJ. Alterations of carbohydrate and lipid metabolism in the acutely ischemic heart. Prog Cardiovasc Dis 1981;23:321-36.
    • (1981) Prog Cardiovasc Dis , vol.23 , pp. 321-336
    • Liedtke, A.J.1
  • 17
    • 0842341728 scopus 로고
    • Effect of fatty acid oxidation on efficiency of energy production in rat heart
    • Hutter JF, Piper HM, Spieckerman PG. Effect of fatty acid oxidation on efficiency of energy production in rat heart. Am J Physiol 1985;249:H723-8.
    • (1985) Am J Physiol , vol.249
    • Hutter, J.F.1    Piper, H.M.2    Spieckerman, P.G.3
  • 18
    • 8444242276 scopus 로고    scopus 로고
    • Uncoupling proteins in human heart
    • Murray AJ, Anderson RE, Watson GC, et al. Uncoupling proteins in human heart. Lancet 2004;364:1786-8.
    • (2004) Lancet , vol.364 , pp. 1786-1788
    • Murray, A.J.1    Anderson, R.E.2    Watson, G.C.3
  • 19
    • 0036773047 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha (PPARalpha) signaling in the gene regulatory control of energy metabolism in the normal and diseased heart
    • Finck BN, Kelly DP. Peroxisome proliferator-activated receptor alpha (PPARalpha) signaling in the gene regulatory control of energy metabolism in the normal and diseased heart. J Mol Cell Cardiol 2002;34:1249-57.
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 1249-1257
    • Finck, B.N.1    Kelly, D.P.2
  • 20
    • 26444485985 scopus 로고    scopus 로고
    • Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle
    • Koonen DP, Glatz JF, Bonen A, et al. Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle. Biochim Biophys Acta 2005;1736:163-80.
    • (2005) Biochim Biophys Acta , vol.1736 , pp. 163-180
    • Koonen, D.P.1    Glatz, J.F.2    Bonen, A.3
  • 21
    • 0033578604 scopus 로고    scopus 로고
    • Muscle-specific overexpression of FAT/CD36 enhances fatty acid oxidation by contracting muscle, reduces plasma triglycerides and fatty acids, and increases plasma glucose and insulin
    • Ibrahimi A, Bonen A, Blinn WD, et al. Muscle-specific overexpression of FAT/CD36 enhances fatty acid oxidation by contracting muscle, reduces plasma triglycerides and fatty acids, and increases plasma glucose and insulin. J Biol Chem 1999;274:26761-6.
    • (1999) J Biol Chem , vol.274 , pp. 26761-26766
    • Ibrahimi, A.1    Bonen, A.2    Blinn, W.D.3
  • 23
    • 0032729717 scopus 로고    scopus 로고
    • Arrhythmias and conduction defects as presenting symptoms of fatty acid oxidation disorders in children
    • Bonnet D, Martin D, Pascale DL, et al. Arrhythmias and conduction defects as presenting symptoms of fatty acid oxidation disorders in children. Circulation 1999;100:2248-53.
    • (1999) Circulation , vol.100 , pp. 2248-2253
    • Bonnet, D.1    Martin, D.2    Pascale, D.L.3
  • 24
    • 0033574265 scopus 로고    scopus 로고
    • Molecular heterogeneity in very-long-chain acyl-CoA dehydrogenase deficiency causing pediatric cardiomyopathy and sudden death
    • Mathur A, Sims HF, Gopalakrishnan D, et al. Molecular heterogeneity in very-longchain acyl-CoA dehydrogenase deficiency causing pediatric cardiomyopathy and sudden death. Circulation 1999;99:1337-43. (Pubitemid 29129919)
    • (1999) Circulation , vol.99 , Issue.10 , pp. 1337-1343
    • Mathur, A.1    Sims, H.F.2    Gopalakrishnan, D.3    Gibson, B.4    Rinaldo, P.5    Vockley, J.6    Hug, G.7    Strauss, A.W.8
  • 25
    • 0028817917 scopus 로고
    • Molecular basis of human mitochondrial very-long-chain acyl-CoA dehydrogenase deficiency causing cardiomyopathy and sudden death in childhood
    • Strauss AW, Powell CK, Hale DE, et al. Molecular basis of human mitochondrial very-long-chain acyl-CoA dehydrogenase deficiency causing cardiomyopathy and sudden death in childhood. Proc Natl Acad Sci USA 1995;92:10496-500.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10496-10500
    • Strauss, A.W.1    Powell, C.K.2    Hale, D.E.3
  • 26
    • 0031028222 scopus 로고    scopus 로고
    • Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo
    • Young LH, Renfu Y, Russell R, et al. Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo. Circulation 1997;95:415-22. (Pubitemid 27056209)
    • (1997) Circulation , vol.95 , Issue.2 , pp. 415-422
    • Young, L.H.1    Renfu, Y.2    Russell, R.3    Hu, X.4    Caplan, M.5    Ren, J.6    Shulman, G.I.7    Sinusas, A.J.8
  • 27
    • 0029913165 scopus 로고    scopus 로고
    • Metabolic fate of glucose in reversible low-flow ischemia of the isolated working rat heart
    • Bolukoglu H, Goodwin GW, Guthrie PH, et al. Metabolic fate of glucose in reversible low-flow ischemia of the isolated working rat heart. Am J Physiol 1996;270:H817-26.
    • (1996) Am J Physiol , vol.270
    • Bolukoglu, H.1    Goodwin, G.W.2    Guthrie, P.H.3
  • 28
    • 0035080301 scopus 로고    scopus 로고
    • Cardiac energetics during ischaemia and the rationale for metabolic interventions
    • Feb
    • Stanley WC. Cardiac energetics during ischaemia and the rationale for metabolic interventions. Coron Artery Dis 2001 Feb;12 (Suppl. 1):S3-7.
    • (2001) Coron Artery Dis , vol.12 , Issue.SUPPL. 1
    • Stanley, W.C.1
  • 29
    • 34247231646 scopus 로고    scopus 로고
    • Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts
    • Sorokina N, O'Donnell JM, McKinney RD, et al. Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts. Circulation 2007;115:2033-41.
    • (2007) Circulation , vol.115 , pp. 2033-2041
    • Sorokina, N.1    O'Donnell, J.M.2    McKinney, R.D.3
  • 30
    • 21244492310 scopus 로고    scopus 로고
    • Myocardial substrate metabolism in the normal and failing heart
    • Stanley WC, Recchia FA, Lopaschuk GD. Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 2005;85:1093-129.
    • (2005) Physiol Rev , vol.85 , pp. 1093-1129
    • Stanley, W.C.1    Recchia, F.A.2    Lopaschuk, G.D.3
  • 34
    • 0030010439 scopus 로고    scopus 로고
    • Decreased energy reserve in an animal model of dilated cardiomyopathy. Relationship to contractile performance
    • Liao R, Nascimben L, Friedrich J, et al. Decreased energy reserve in an animal model of dilated cardiomyopathy. Relationship to contractile performance. Circ Res 1996;78:893-902.
    • (1996) Circ Res , vol.78 , pp. 893-902
    • Liao, R.1    Nascimben, L.2    Friedrich, J.3
  • 35
  • 36
    • 0018348929 scopus 로고
    • Perhexiline maleate and peripheral neuropathy
    • Bouche P, Bousser MG, Peytour MA, et al. Perhexiline maleate and peripheral neuropathy. Neurology 1979;29:739-43.
    • (1979) Neurology , vol.29 , pp. 739-743
    • Bouche, P.1    Bousser, M.G.2    Peytour, M.A.3
  • 38
    • 0022451358 scopus 로고
    • Perhexiline maleate treatment for severe angina pectoris-correlations with pharmacokinetics
    • Horowitz JD, Sia ST, Macdonald PS, et al. Perhexiline maleate treatment for severe angina pectoris-correlations with pharmacokinetics. Int J Cardiol 1986;13:219-29.
    • (1986) Int J Cardiol , vol.13 , pp. 219-229
    • Horowitz, J.D.1    Sia, S.T.2    Macdonald, P.S.3
  • 39
    • 0018600324 scopus 로고
    • Perhexiline maleate in the treatment of severe angina pectoris
    • Horowitz JD, Mashford ML. Perhexiline maleate in the treatment of severe angina pectoris. Med J Aust 1979;1:485-8.
    • (1979) Med J Aust , vol.1 , pp. 485-488
    • Horowitz, J.D.1    Mashford, M.L.2
  • 40
    • 0025343177 scopus 로고
    • Efficacy and safety of perhexiline maleate in refractory angina. A double-blind placebo-controlled clinical trial of a novel antianginal agent
    • Cole PL, Beamer AD, McGowan N, et al. Efficacy and safety of perhexiline maleate in refractory angina. A double-blind placebo-controlled clinical trial of a novel antianginal agent. Circulation 1990;81:1260-70.
    • (1990) Circulation , vol.81 , pp. 1260-1270
    • Cole, P.L.1    Beamer, A.D.2    McGowan, N.3
  • 41
    • 0033653158 scopus 로고    scopus 로고
    • Effect of perhexiline and oxfenicine on myocardial function and metabolism during low-flow ischemia/reperfusion in the isolated rat heart
    • Kennedy JA, Kiosoglous AJ, Murphy GA, et al. Effect of perhexiline and oxfenicine on myocardial function and metabolism during low-flow ischemia/reperfusion in the isolated rat heart. J Cardiovasc Pharmacol 2000;36:794-801.
    • (2000) J Cardiovasc Pharmacol , vol.36 , pp. 794-801
    • Kennedy, J.A.1    Kiosoglous, A.J.2    Murphy, G.A.3
  • 42
    • 0034678082 scopus 로고    scopus 로고
    • The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase
    • Kantor PF, Lucien A, Kozak R, et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res 2000;86:580-8.
    • (2000) Circ Res , vol.86 , pp. 580-588
    • Kantor, P.F.1    Lucien, A.2    Kozak, R.3
  • 43
    • 0028359703 scopus 로고
    • Trimetazidine: A new concept in the treatment of angina. Comparison with propranolol in patients with stable angina
    • Trimetazidine European multicenter study group
    • Detry JM, Sellier P, Pennaforte S, et al. Trimetazidine: a new concept in the treatment of angina. Comparison with propranolol in patients with stable angina. Trimetazidine European multicenter study group. Br J Clin Pharmacol 1994;37:279-88.
    • (1994) Br J Clin Pharmacol , vol.37 , pp. 279-288
    • Detry, J.M.1    Sellier, P.2    Pennaforte, S.3
  • 44
    • 0025110897 scopus 로고
    • Comparison of trimetazidine with nifedipine in effort angina: A double-blind, crossover study
    • la-Volta S, Maraglino G, la-Valentina P, et al. Comparison of trimetazidine with nifedipine in effort angina: a double-blind, crossover study. Cardiovasc Drugs Ther 1990;4 (Suppl 4):853-9.
    • (1990) Cardiovasc Drugs Ther , vol.4 , Issue.SUPPL. 4 , pp. 853-859
    • La-Volta, S.1    Maraglino, G.2    La-Valentina, P.3
  • 45
    • 11144356285 scopus 로고    scopus 로고
    • Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina
    • Chaitman BR, Skettino SL, Parker JO, et al. Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina. J Am Coll Cardiol 2004;43:1375-82.
    • (2004) J Am Coll Cardiol , vol.43 , pp. 1375-1382
    • Chaitman, B.R.1    Skettino, S.L.2    Parker, J.O.3
  • 46
    • 74949141109 scopus 로고    scopus 로고
    • A novel mechanism for the treatment of angina, arrhythmias, and diastolic dysfunction: Inhibition of late I(Na) using ranolazine
    • Maier LS. A novel mechanism for the treatment of angina, arrhythmias, and diastolic dysfunction: inhibition of late I(Na) using ranolazine. J Cardiovasc Pharmacol 2009;54:279-86.
    • (2009) J Cardiovasc Pharmacol , vol.54 , pp. 279-286
    • Maier, L.S.1
  • 47
    • 0033910352 scopus 로고    scopus 로고
    • First clinical trial with etomoxir in patients with chronic congestive heart failure
    • Schmidt-Schweda S, Holubarsch C. First clinical trial with etomoxir in patients with chronic congestive heart failure. Clin Sci (Lond) 2000;99:27-35. (Pubitemid 30479390)
    • (2000) Clinical Science , vol.99 , Issue.1 , pp. 27-35
    • Schmidt-Schweda, S.1    Holubarsch, C.2
  • 48
    • 34547800233 scopus 로고    scopus 로고
    • A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: The ERGO (etomoxir for the recovery of glucose oxidation) study
    • Holubarsch CJ, Rohrbach M, Karrasch M, et al. A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: the ERGO (etomoxir for the recovery of glucose oxidation) study. Clin Sci (Lond) 2007;113:205-12.
    • (2007) Clin Sci (Lond) , vol.113 , pp. 205-212
    • Holubarsch, C.J.1    Rohrbach, M.2    Karrasch, M.3
  • 49
    • 0034595294 scopus 로고    scopus 로고
    • ATP synthesis during low-flow ischemia: Influence of increased glycolytic substrate
    • Cave AC, Ingwall JS, Friedrich J, et al. ATP synthesis during low-flow ischemia: influence of increased glycolytic substrate. Circulation 2000;101:2090-6.
    • (2000) Circulation , vol.101 , pp. 2090-2096
    • Cave, A.C.1    Ingwall, J.S.2    Friedrich, J.3
  • 50
    • 0020682850 scopus 로고
    • Glucose, insulin, potassium protection during the course of hypothermic global ischemia and reperfusion: A new proposed mechanism by the scavenging of free radicals
    • Hess ML, Okabe E, Poland J, et al. Glucose, insulin, potassium protection during the course of hypothermic global ischemia and reperfusion: a new proposed mechanism by the scavenging of free radicals. J Cardiovasc Pharmacol 1983;5:35-43. (Pubitemid 13177948)
    • (1983) Journal of Cardiovascular Pharmacology , vol.5 , Issue.1 , pp. 35-43
    • Hess, M.L.1    Okabe, E.2    Poland, J.3
  • 51
    • 12544259347 scopus 로고    scopus 로고
    • Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: The CREATE-ECLA randomized controlled trial
    • Jan 26
    • Mehta SR, Yusuf S, Diaz R, et al. Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial. JAMA 2005 Jan 26;293:437-46.
    • (2005) JAMA , vol.293 , pp. 437-446
    • Mehta, S.R.1    Yusuf, S.2    Diaz, R.3
  • 52
    • 0029792760 scopus 로고    scopus 로고
    • Effects of insulin treatment on causespecific one-year mortality and morbidity in diabetic patients with acute myocardial infarction
    • DIGAMI study group. diabetes insulin-glucose in acute myocardial infarction
    • Malmberg K, Ryden L, Hamsten A, et al. Effects of insulin treatment on causespecific one-year mortality and morbidity in diabetic patients with acute myocardial infarction. DIGAMI study group. diabetes insulin-glucose in acute myocardial infarction. Eur Heart J 1996;17:1337-44.
    • (1996) Eur Heart J , vol.17 , pp. 1337-1344
    • Malmberg, K.1    Ryden, L.2    Hamsten, A.3
  • 53
    • 20244384563 scopus 로고    scopus 로고
    • Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): Effects on mortality and morbidity
    • Malmberg K, Ryden L, Wedel H, et al. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity. Eur Heart J 2005;26:650-61.
    • (2005) Eur Heart J , vol.26 , pp. 650-661
    • Malmberg, K.1    Ryden, L.2    Wedel, H.3
  • 54
    • 34249001974 scopus 로고    scopus 로고
    • Trimetazidine administration minimizes myocardial damage and improves left ventricular function after percutaneous coronary intervention
    • Labrou A, Giannoglou G, Zioutas D, et al. Trimetazidine administration minimizes myocardial damage and improves left ventricular function after percutaneous coronary intervention. Am J Cardiovasc Drugs 2007;7:143-50.
    • (2007) Am J Cardiovasc Drugs , vol.7 , pp. 143-150
    • Labrou, A.1    Giannoglou, G.2    Zioutas, D.3
  • 55
    • 0036899544 scopus 로고    scopus 로고
    • Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide
    • Willoughby SR, Stewart S, Chirkov YY, et al. Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide. Eur Heart J 2002;23:1946-54.
    • (2002) Eur Heart J , vol.23 , pp. 1946-1954
    • Willoughby, S.R.1    Stewart, S.2    Chirkov, Y.Y.3
  • 56
    • 34247173063 scopus 로고    scopus 로고
    • Metabolic modulation in heart failure: The coming of age
    • Ashrafian H, Frenneaux MP. Metabolic modulation in heart failure: the coming of age. Cardiovasc Drugs Ther 2007;21:5-7.
    • (2007) Cardiovasc Drugs Ther , vol.21 , pp. 5-7
    • Ashrafian, H.1    Frenneaux, M.P.2
  • 57
    • 4344697195 scopus 로고    scopus 로고
    • Cardiac metabolism as a target for the treatment of heart failure
    • Taegtmeyer H. Cardiac metabolism as a target for the treatment of heart failure. Circulation 2004;110:894-6.
    • (2004) Circulation , vol.110 , pp. 894-896
    • Taegtmeyer, H.1
  • 58
    • 0026615221 scopus 로고
    • 31P magnetic resonance spectroscopy in dilated cardiomyopathy and coronary artery disease. Altered cardiac high-energy phosphate metabolism in heart failure
    • Neubauer S, Krahe T, Schindler R, et al. 31P magnetic resonance spectroscopy in dilated cardiomyopathy and coronary artery disease. Altered cardiac high-energy phosphate metabolism in heart failure. Circulation 1992;86:1810-18.
    • (1992) Circulation , vol.86 , pp. 1810-1818
    • Neubauer, S.1    Krahe, T.2    Schindler, R.3
  • 60
    • 3242816108 scopus 로고    scopus 로고
    • Insulin resistance in idiopathic dilated cardiomyopathy: A possible etiologic link
    • Witteles RM, Tang WH, Jamali AH, et al. Insulin resistance in idiopathic dilated cardiomyopathy: a possible etiologic link. J Am Coll Cardiol 2004;44:78-81.
    • (2004) J Am Coll Cardiol , vol.44 , pp. 78-81
    • Witteles, R.M.1    Tang, W.H.2    Jamali, A.H.3
  • 61
    • 37849047917 scopus 로고    scopus 로고
    • Insulin-resistant cardiomyopathy clinical evidence mechanisms, and treatment options
    • Witteles RM, Fowler MB. Insulin-resistant cardiomyopathy clinical evidence, mechanisms, and treatment options. J Am Coll Cardiol 2008;51:93-102.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 93-102
    • Witteles, R.M.1    Fowler, M.B.2
  • 62
    • 33749321945 scopus 로고    scopus 로고
    • Role of changes in cardiac metabolism in development of diabetic cardiomyopathy
    • An D, Rodrigues B. Role of changes in cardiac metabolism in development of diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol 2006;291:H1489-506.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291
    • An, D.1    Rodrigues, B.2
  • 63
    • 0035936527 scopus 로고    scopus 로고
    • Pravastatin and the development of diabetes mellitus: Evidence for a protective treatment effect in the west of scotland coronary prevention study
    • Freeman DJ, Norrie J, Sattar N, et al. Pravastatin and the development of diabetes mellitus: evidence for a protective treatment effect in the west of scotland coronary prevention study. Circulation 2001;103:357-62.
    • (2001) Circulation , vol.103 , pp. 357-362
    • Freeman, D.J.1    Norrie, J.2    Sattar, N.3
  • 64
    • 0042410539 scopus 로고    scopus 로고
    • Effects of candesartan on mortality and morbidity in patients with chronic heart failure: The CHARM-Overall programme
    • Pfeffer MA, Swedberg K, Granger CB, et al. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet 2003;362:759-66.
    • (2003) Lancet , vol.362 , pp. 759-766
    • Pfeffer, M.A.1    Swedberg, K.2    Granger, C.B.3
  • 65
    • 0034688194 scopus 로고    scopus 로고
    • Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients
    • the heart outcomes prevention evaluation study investigators
    • Yusuf S, Sleight P, Pogue J, et al. Effects of an angiotensin-converting- enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. the heart outcomes prevention evaluation study investigators. N Engl J Med 2000;342:145-53.
    • (2000) N Engl J Med , vol.342 , pp. 145-153
    • Yusuf, S.1    Sleight, P.2    Pogue, J.3
  • 66
    • 34648832073 scopus 로고    scopus 로고
    • Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: A metaanalysis of randomised clinical trials
    • Lago RM, Singh PP, Nesto RW. Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a metaanalysis of randomised clinical trials. Lancet 2007;370:1129-36.
    • (2007) Lancet , vol.370 , pp. 1129-1136
    • Lago, R.M.1    Singh, P.P.2    Nesto, R.W.3
  • 67
    • 69249085657 scopus 로고    scopus 로고
    • Multi-centre experience on the use of perhexiline in chronic heart failure and refractory angina: Old drug, new hope
    • Phan TT, Shivu GN, Choudhury A, et al. Multi-centre experience on the use of perhexiline in chronic heart failure and refractory angina: old drug, new hope. Eur J Heart Fail 2009;11:881-6.
    • (2009) Eur J Heart Fail , vol.11 , pp. 881-886
    • Phan, T.T.1    Shivu, G.N.2    Choudhury, A.3
  • 68
    • 33644875657 scopus 로고    scopus 로고
    • Metabolic modulation with perhexiline in chronic heart failure: A randomized, controlled trial of short-term use of a novel treatment
    • Lee L, Campbell R, Scheuermann-Freestone M, et al. Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment. Circulation 2005;112:3280-8.
    • (2005) Circulation , vol.112 , pp. 3280-3288
    • Lee, L.1    Campbell, R.2    Scheuermann-Freestone, M.3
  • 69
    • 33645466318 scopus 로고    scopus 로고
    • Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure
    • Fragasso G, Perseghin G, De CF, et al. Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure. Eur Heart J 2006;27:942-8.
    • (2006) Eur Heart J , vol.27 , pp. 942-948
    • Fragasso, G.1    Perseghin, G.2    De, C.F.3
  • 70
    • 4944224833 scopus 로고    scopus 로고
    • Trimetazidine improves left ventricular function and quality of life in elderly patients with coronary artery disease
    • Vitale C, Wajngaten M, Sposato B, et al. Trimetazidine improves left ventricular function and quality of life in elderly patients with coronary artery disease. Eur Heart J 2004;25:1814-21.
    • (2004) Eur Heart J , vol.25 , pp. 1814-1821
    • Vitale, C.1    Wajngaten, M.2    Sposato, B.3
  • 71
    • 2942512039 scopus 로고    scopus 로고
    • Trimetazidine improves left ventricular function in diabetic patients with coronary artery disease: A double-blind placebocontrolled study
    • Rosano GM, Vitale C, Sposato B, et al. Trimetazidine improves left ventricular function in diabetic patients with coronary artery disease: a double-blind placebocontrolled study. Cardiovasc Diabetol 2003;2:16.
    • (2003) Cardiovasc Diabetol , vol.2 , pp. 16
    • Rosano, G.M.1    Vitale, C.2    Sposato, B.3
  • 72
    • 12744261465 scopus 로고    scopus 로고
    • Long term cardioprotective action of trimetazidine and potential effect on the inflammatory process in patients with ischaemic dilated cardiomyopathy
    • Di NP, Taccardi AA, Barsotti A. Long term cardioprotective action of trimetazidine and potential effect on the inflammatory process in patients with ischaemic dilated cardiomyopathy. Heart 2005;91:161-5.
    • (2005) Heart , vol.91 , pp. 161-165
    • Di, N.P.1    Taccardi, A.A.2    Barsotti, A.3
  • 73
    • 53449101397 scopus 로고    scopus 로고
    • Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy
    • Tuunanen H, Engblom E, Naum A, et al. Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy. Circulation 2008;118:1250-8.
    • (2008) Circulation , vol.118 , pp. 1250-1258
    • Tuunanen, H.1    Engblom, E.2    Naum, A.3
  • 74
    • 0036751370 scopus 로고    scopus 로고
    • Malonyl CoA control of fatty acid oxidation in the ischemic heart
    • Dyck JR, Lopaschuk GD. Malonyl CoA control of fatty acid oxidation in the ischemic heart. J Mol Cell Cardiol 2002;34:1099-109.
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 1099-1109
    • Dyck, J.R.1    Lopaschuk, G.D.2
  • 75
    • 28144459335 scopus 로고    scopus 로고
    • Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demandinduced ischemia
    • Stanley WC, Morgan EE, Huang H, et al. Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demandinduced ischemia. Am J Physiol Heart Circ Physiol 2005;289:H2304-9.
    • (2005) Am J Physiol Heart Circ Physiol , vol.289
    • Stanley, W.C.1    Morgan, E.E.2    Huang, H.3
  • 76
    • 33750211736 scopus 로고    scopus 로고
    • Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury
    • Dyck JR, Hopkins TA, Bonnet S, et al. Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury. Circulation 2006;114:1721-8.
    • (2006) Circulation , vol.114 , pp. 1721-1728
    • Dyck, J.R.1    Hopkins, T.A.2    Bonnet, S.3
  • 77
    • 0038497464 scopus 로고    scopus 로고
    • Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes
    • Kolterman OG, Buse JB, Fineman MS, et al. Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes. J Clin Endocrinol Metab 2003;88:3082-9.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3082-3089
    • Kolterman, O.G.1    Buse, J.B.2    Fineman, M.S.3
  • 78
    • 43249089631 scopus 로고    scopus 로고
    • Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways
    • Ban K, Noyan-Ashraf MH, Hoefer J, et al. Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation 2008;117:2340-50.
    • (2008) Circulation , vol.117 , pp. 2340-2350
    • Ban, K.1    Noyan-Ashraf, M.H.2    Hoefer, J.3
  • 79
    • 33845293219 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure
    • Sokos GG, Nikolaidis LA, Mankad S, et al. Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure. J Card Fail 2006;12:694-9.
    • (2006) J Card Fail , vol.12 , pp. 694-699
    • Sokos, G.G.1    Nikolaidis, L.A.2    Mankad, S.3


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