Activation of central opioid receptors induces cardioprotection against ischemia-reperfusion injury

Anesthesia and Analgesia

Volumn 111, Issue 1, 2010, Pages 24-28

  Wong, Gordon T C ^a   Ling, Jiang Ling ^a,b   Irwin, Michael G ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

17 METHYLNALOXONE; MORPHINE; OPIATE RECEPTOR; SODIUM CHLORIDE; TRIPHENYLTETRAZOLIUM; CARDIOTONIC AGENT; DRUG DERIVATIVE; N-METHYLNALOXONE; NALOXONE; NARCOTIC ANALGESIC AGENT; NARCOTIC ANTAGONIST; QUATERNARY AMMONIUM DERIVATIVE;

ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; CATHETER; CONTROL GROUP; DRUG EFFECT; DRUG INFUSION; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; ISCHEMIC PRECONDITIONING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; STAINING; ANIMAL; BLOOD PRESSURE; CORONARY BLOOD VESSEL; DRUG POTENTIATION; HEART INFARCTION PREVENTION; HEART MUSCLE; HEART RATE; INTRASPINAL DRUG ADMINISTRATION; METHODOLOGY; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANALGESICS, OPIOID; ANIMALS; BLOOD PRESSURE; CARDIOTONIC AGENTS; CORONARY VESSELS; HEART RATE; INJECTIONS, SPINAL; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALE; MORPHINE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NALOXONE; NARCOTIC ANTAGONISTS; QUATERNARY AMMONIUM COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID;

EID: 77954680385     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e3181b8b77e     Document Type: Article

References (20)

1. Gross GJ. Role of opioids in acute and delayed preconditioning. J Mol Cell Cardiol 2003;35:709-18
2. Schultz JE, Hsu AK, Gross GJ. Morphine mimics the cardio-protective effect of ischemic preconditioning via a glibenclamide-sensitive mechanism in the rat heart. Circ Res 1996;78:1100-4
3. Lessa MA, Tibirica E, Lessa MA, Tibirica E. Pharmacologic evidence for the involvement of central and peripheral opioid receptors in the cardioprotective effects of fentanyl. Anesth Analg 2006;103:815-21
4. Zhang Y, Irwin MG, Wong TM. Remifentanil preconditioning protects against ischemic injury in the intact rat heart. Anes-thesiology 2004;101:918-23
5. Groban L, Vernon JC, Butterworth J. Intrathecal morphine reduces infarct size in a rat model of ischemia-reperfusion injury. Anesth Analg 2004;98:903-9
6. Li R, Wong GT, Wong TM, Zhang Y, Xia Z, Irwin MG. Intrathecal morphine preconditioning induces cardioprotec-tion via activation of delta, kappa, and mu opioid receptors in rats. Anesth Analg 2009;108:23-9
7. Yaksh TL, Rudy TA. Chronic catheterization of the spinal subarachnoid space. Physiol Behav 1976;17:1031-6
8. Lewanowitsch T, Irvine RJ. Naloxone methiodide reverses opioid-induced respiratory depression and analgesia without withdrawal. Eur J Pharmacol 2002;445:61-7
9. Milanes MV, Martinez MD, Gonzalez-Cuello A, Laorden ML. Evidence for a peripheral mechanism in cardiac opioid withdrawal. Naunyn Schmiedebergs Arch Pharmacol 2001;364:193-8
10. Lewanowitsch T, Irvine RJ. Naloxone and its quaternary derivative, naloxone methiodide, have differing affinities for mu, delta, and kappa opioid receptors in mouse brain homog-enates. Brain Res 2003;964:302-5
11. Chien GL, Mohtadi K, Wolff RA, Van Winkle DM. Naloxone blockade of myocardial ischemic preconditioning does not require central nervous system participation. Basic Res Cardiol 1999;94:136-43
12. Schultz JJ, Hsu AK, Gross GJ. Ischemic preconditioning is mediated by a peripheral opioid receptor mechanism in the intact rat heart. J Mol Cell Cardiol 1997;29:1355-62
13. Liang BT, Gross GJ. Direct preconditioning of cardiac myo-cytes via opioid receptors and KATP channels. Circ Res 1999;84:1396-400
14. Eliasson T, Mannheimer C, Waagstein F, Andersson B, Bergh CH, Augustinsson LE, Hedner T, Larson G. Myocardial turnover of endogenous opioids and calcitonin-gene-related pep-tide in the human heart and the effects of spinal cord stimulation on pacing-induced angina pectoris. Cardiology 1998;89:170-7
15. Wang L, Oka N, Tropak M, Callahan J, Lee J, Wilson G, Redington A, Caldarone CA. Remote ischemic preconditioning elaborates a transferable blood-borne effector that protects mitochondrial structure and function and preserves myocar-dial performance after neonatal cardioplegic arrest. J Thorac Cardiovasc Surg 2008;136:335-42
16. Wang TL, Chang H, Hung CR, Tseng YZ. Attenuation of neutrophil and endothelial activation by intravenous morphine in patients with acute myocardial infarction. Am J Cardiol 1997;80:1532-5
17. Wang TL, Chang H, Hung CR, Tseng YZ. Morphine preconditioning attenuates neutrophil activation in rat models of myocardial infarction. Cardiovasc Res 1998;40:557-63
18. Ang KK, McRitchie RJ, Minson JB, Llewellyn-Smith IJ, Pilowsky PM, Chalmers JP, Arnolda LF. Activation of spinal opioid receptors contributes to hypotension after hemorrhage in conscious rats. Am J Physiol 1999;276: H1552-8
19. Frithiof R, Rundgren M. Activation of central opioid receptors determines the timing of hypotension during acute hemorrhage-induced hypovolemia in conscious sheep. Am J Physiol Regul Integr Comp Physiol 2006;291: R987-96
20. Meylan N, Elia N, Lysakowski C, Tramer MR. Benefit and risk of intrathecal morphine without local anaesthetic in patients undergoing major surgery: meta-analysis of randomized trials. Br J Anaesth 2009;102:156-67