메뉴 건너뛰기




Volumn 86, Issue 5, 2010, Pages 345-352

Impact of aciclovir on ulcer healing, lesional, genital and plasma HIV-1 RNA among patients with genital ulcer disease in Malawi

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; PLACEBO; VIRUS RNA;

EID: 77958077166     PISSN: 13684973     EISSN: 14723263     Source Type: Journal    
DOI: 10.1136/sti.2009.041814     Document Type: Article
Times cited : (18)

References (49)
  • 1
    • 0033017798 scopus 로고    scopus 로고
    • From epidemiological synergy to public health policy and practice: The contribution of other sexually transmitted diseases to sexual transmission of HIV infection
    • Fleming DT, Wasserheit JN. From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection. Sex Transm Infect 1999;75:3-17.
    • (1999) Sex Transm Infect , vol.75 , pp. 3-17
    • Fleming, D.T.1    Wasserheit, J.N.2
  • 2
    • 0036137322 scopus 로고    scopus 로고
    • Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: A meta-analysis
    • Wald A, Link K. Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis. J Infect Dis 2002;185:45-52.
    • (2002) J Infect Dis , vol.185 , pp. 45-52
    • Wald, A.1    Link, K.2
  • 3
    • 29144444035 scopus 로고    scopus 로고
    • Herpes simplex virus 2 infection increases HIV acquisition in men and women: Systematic review and meta-analysis of longitudinal studies
    • Freeman EE, Weiss HA, Glynn JR, et al. Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies. Aids 2006;20:73-83.
    • (2006) Aids , vol.20 , pp. 73-83
    • Freeman, E.E.1    Weiss, H.A.2    Glynn, J.R.3
  • 4
    • 0035857959 scopus 로고    scopus 로고
    • Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda
    • Gray RH, Wawer MJ, Brookmeyer R, et al. Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda. Lancet 2001;357:1149-53.
    • (2001) Lancet , vol.357 , pp. 1149-1153
    • Gray, R.H.1    Wawer, M.J.2    Brookmeyer, R.3
  • 5
    • 0033805754 scopus 로고    scopus 로고
    • Interactions between herpes simplex virus type 2 and human immunodeficiency virus type 1 infection in African women: Opportunities for intervention
    • Mbopi-Keou FX, Gresenguet G, Mayaud P, et al. Interactions between herpes simplex virus type 2 and human immunodeficiency virus type 1 infection in African women: opportunities for intervention. J Infect Dis 2000;182:1090-6.
    • (2000) J Infect Dis , vol.182 , pp. 1090-1096
    • Mbopi-Keou, F.X.1    Gresenguet, G.2    Mayaud, P.3
  • 6
    • 0037032950 scopus 로고    scopus 로고
    • Association between cervical shedding of herpes simplex virus and HIV-1
    • McClelland RS, Wang CC, Overbaugh J, et al. Association between cervical shedding of herpes simplex virus and HIV-1. Aids 2002;16:2425-30.
    • (2002) Aids , vol.16 , pp. 2425-2430
    • McClelland, R.S.1    Wang, C.C.2    Overbaugh, J.3
  • 7
    • 34447552364 scopus 로고    scopus 로고
    • Cervicovaginal HIV-1 and herpes simplex virus type 2 shedding during genital ulcer disease episodes
    • Legoff J, Weiss HA, Gresenguet G, et al. Cervicovaginal HIV-1 and herpes simplex virus type 2 shedding during genital ulcer disease episodes. Aids 2007;21:1569-78.
    • (2007) Aids , vol.21 , pp. 1569-1578
    • Legoff, J.1    Weiss, H.A.2    Gresenguet, G.3
  • 8
    • 1842615043 scopus 로고    scopus 로고
    • The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: A review of two overlapping epidemics
    • Corey L, Wald A, Celum CL, et al. The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: a review of two overlapping epidemics. J Acquir Immune Defic Syndr 2004;35:435-45.
    • (2004) J Acquir Immune Defic Syndr , vol.35 , pp. 435-445
    • Corey, L.1    Wald, A.2    Celum, C.L.3
  • 10
    • 1942531336 scopus 로고    scopus 로고
    • Epidemiology of herpes simplex virus type 2 infection in the developing world
    • Weiss H. Epidemiology of herpes simplex virus type 2 infection in the developing world. Herpes 2004;11(Suppl 1):24A-35A.
    • (2004) Herpes , vol.11 , Issue.SUPPL. 1
    • Weiss, H.1
  • 11
    • 1942435283 scopus 로고    scopus 로고
    • Epidemiology of genital herpes simplex virus infection in developed countries
    • Malkin JE. Epidemiology of genital herpes simplex virus infection in developed countries. Herpes 2004;11(Suppl 1):2A-23A.
    • (2004) Herpes , vol.11 , Issue.SUPPL. 1
    • Malkin, J.E.1
  • 12
    • 0028878701 scopus 로고
    • Sexually transmitted diseases and human immunodeficiency virus control in Malawi: A field study of genital ulcer disease
    • Behets FM, Liomba G, Lule G, et al. Sexually transmitted diseases and human immunodeficiency virus control in Malawi: a field study of genital ulcer disease. J Infect Dis 1995;171:451-5.
    • (1995) J Infect Dis , vol.171 , pp. 451-455
    • Behets, F.M.1    Liomba, G.2    Lule, G.3
  • 13
    • 15744405302 scopus 로고    scopus 로고
    • Improving the accuracy of syndromic diagnosis of genital ulcer disease in Malawi
    • Hoyo C, Hoffman I, Moser BK, et al. Improving the accuracy of syndromic diagnosis of genital ulcer disease in Malawi. Sex Transm Dis 2005;32:231-7.
    • (2005) Sex Transm Dis , vol.32 , pp. 231-237
    • Hoyo, C.1    Hoffman, I.2    Moser, B.K.3
  • 14
    • 27444433828 scopus 로고    scopus 로고
    • Changes in the etiology of sexually transmitted diseases in Botswana between 1993 and 2002: Implications for the clinical management of genital ulcer disease
    • Paz-Bailey G, Rahman M, Chen C, et al. Changes in the etiology of sexually transmitted diseases in Botswana between 1993 and 2002: implications for the clinical management of genital ulcer disease. Clin Infect Dis 2005;41:1304-12.
    • (2005) Clin Infect Dis , vol.41 , pp. 1304-1312
    • Paz-Bailey, G.1    Rahman, M.2    Chen, C.3
  • 15
    • 16944366643 scopus 로고    scopus 로고
    • Comparison of clinical diagnosis and standard laboratory and molecular methods for the diagnosis of genital ulcer disease in Lesotho: Association with human immunodeficiency virus infection
    • Morse SA, Trees DL, Htun Y, et al. Comparison of clinical diagnosis and standard laboratory and molecular methods for the diagnosis of genital ulcer disease in Lesotho: association with human immunodeficiency virus infection. J Infect Dis 1997;175:583-9.
    • (1997) J Infect Dis , vol.175 , pp. 583-589
    • Morse, S.A.1    Trees, D.L.2    Htun, Y.3
  • 16
    • 0033977354 scopus 로고    scopus 로고
    • Human immunodeficiency virus infection and genital ulcer disease in South Africa: The herpetic connection
    • Chen CY, Ballard RC, Beck-Sague CM, et al. Human immunodeficiency virus infection and genital ulcer disease in South Africa: the herpetic connection. Sex Transm Dis 2000;27:21-9.
    • (2000) Sex Transm Dis , vol.27 , pp. 21-29
    • Chen, C.Y.1    Ballard, R.C.2    Beck-Sague, C.M.3
  • 18
    • 34250892469 scopus 로고    scopus 로고
    • The molecular diagnosis of lymphogranuloma venereum: Evaluation of a real-time multiplex polymerase chain reaction test using rectal and urethral specimens
    • Chen CY, Chi KH, Alexander S, et al. The molecular diagnosis of lymphogranuloma venereum: evaluation of a real-time multiplex polymerase chain reaction test using rectal and urethral specimens. Sex Transm Dis 2007;34:451-5.
    • (2007) Sex Transm Dis , vol.34 , pp. 451-455
    • Chen, C.Y.1    Chi, K.H.2    Alexander, S.3
  • 19
    • 3142676477 scopus 로고    scopus 로고
    • Performance of commercially available enzyme immunoassays for detection of antibodies against herpes simplex virus type 2 in African populations
    • van Dyck E, Buve A, Weiss HA, et al. Performance of commercially available enzyme immunoassays for detection of antibodies against herpes simplex virus type 2 in African populations. J Clin Microbiol 2004;42:2961-5.
    • (2004) J Clin Microbiol , vol.42 , pp. 2961-2965
    • Van Dyck, E.1    Buve, A.2    Weiss, H.A.3
  • 20
    • 45149111658 scopus 로고    scopus 로고
    • Performance of HerpeSelect and Kalon assays in detection of antibodies to herpes simplex virus type 2
    • LeGoff J, Mayaud P, Gresenguet G, et al. Performance of HerpeSelect and Kalon assays in detection of antibodies to herpes simplex virus type 2. J Clin Microbiol 2008;46:1914-18.
    • (2008) J Clin Microbiol , vol.46 , pp. 1914-1918
    • LeGoff, J.1    Mayaud, P.2    Gresenguet, G.3
  • 21
    • 1642420994 scopus 로고    scopus 로고
    • A modified poisson regression approach to prospective studies with binary data
    • Zou G. A modified poisson regression approach to prospective studies with binary data. Am J Epidemiol 2004;159:702-6.
    • (2004) Am J Epidemiol , vol.159 , pp. 702-706
    • Zou, G.1
  • 23
    • 33746774864 scopus 로고    scopus 로고
    • Sexually transmitted diseases treatment guidelines, 2006
    • Workowski KA, Berman SM. Sexually transmitted diseases treatment guidelines, 2006. MMWR Recomm Rep 2006;55:1-94.
    • (2006) MMWR Recomm Rep , vol.55 , pp. 1-94
    • Workowski, K.A.1    Berman, S.M.2
  • 24
    • 67650649763 scopus 로고    scopus 로고
    • Impact of acyclovir on genital and plasma HIV-1 RNA, genital herpes simplex virus type 2 DNA, and ulcer healing among HIV-1-infected African women with herpes ulcers: A randomized placebo-controlled trial
    • Mayaud P, Legoff J, Weiss HA, et al. Impact of acyclovir on genital and plasma HIV-1 RNA, genital herpes simplex virus type 2 DNA, and ulcer healing among HIV-1-infected African women with herpes ulcers: a randomized placebo-controlled trial. J Infect Dis 2009;200:216-26.
    • (2009) J Infect Dis , vol.200 , pp. 216-226
    • Mayaud, P.1    Legoff, J.2    Weiss, H.A.3
  • 25
    • 70349337700 scopus 로고    scopus 로고
    • Improvement in healing and reduction in HIV shedding with episodic acyclovir therapy as part of syndromic management among men: A randomized, controlled trial
    • Paz-Bailey G, Sternberg M, Puren AJ, et al. Improvement in healing and reduction in HIV shedding with episodic acyclovir therapy as part of syndromic management among men: A randomized, controlled trial. J Infect Dis 2009;200:1039-49.
    • (2009) J Infect Dis , vol.200 , pp. 1039-1049
    • Paz-Bailey, G.1    Sternberg, M.2    Puren, A.J.3
  • 26
    • 34547776391 scopus 로고    scopus 로고
    • An update on short-course episodic and prevention therapies for herpes genitalis
    • Corey L, Bodsworth N, Mindel A, et al. An update on short-course episodic and prevention therapies for herpes genitalis. Herpes 2007;14(Suppl 1):5A-11A.
    • (2007) Herpes , vol.14 , Issue.SUPPL. 1
    • Corey, L.1    Bodsworth, N.2    Mindel, A.3
  • 28
    • 0032122348 scopus 로고    scopus 로고
    • Frequent recovery of HIV-1 from genital herpes simplex virus lesions in HIV-1-infected men
    • Schacker T, Ryncarz AJ, Goddard J, et al. Frequent recovery of HIV-1 from genital herpes simplex virus lesions in HIV-1-infected men. JAMA 1998;280:61-6.
    • (1998) JAMA , vol.280 , pp. 61-66
    • Schacker, T.1    Ryncarz, A.J.2    Goddard, J.3
  • 29
    • 0035970644 scopus 로고    scopus 로고
    • Viral burden in genital secretions determines male-to-female sexual transmission of HIV-1: A probabilistic empiric model
    • Chakraborty H, Sen PK, Helms RW, et al. Viral burden in genital secretions determines male-to-female sexual transmission of HIV-1: a probabilistic empiric model. Aids 2001;15:621-7.
    • (2001) Aids , vol.15 , pp. 621-627
    • Chakraborty, H.1    Sen, P.K.2    Helms, R.W.3
  • 30
    • 17344371256 scopus 로고    scopus 로고
    • High levels of human immunodeficiency virus type 1 in blood and semen of seropositive men in sub-Saharan Africa
    • Dyer JR, Kazembe P, Vernazza PL, et al. High levels of human immunodeficiency virus type 1 in blood and semen of seropositive men in sub-Saharan Africa. J Infect Dis 1998;177:1742-6.
    • (1998) J Infect Dis , vol.177 , pp. 1742-1746
    • Dyer, J.R.1    Kazembe, P.2    Vernazza, P.L.3
  • 31
    • 47849108168 scopus 로고    scopus 로고
    • Roles of clinical and subclinical reactivated herpes simplex virus type 2 infection and human immunodeficiency virus type 1 (HIV-1)-induced immunosuppression on genital and plasma HIV-1 levels
    • Nagot N, Ouedraogo A, Konate I, et al. Roles of clinical and subclinical reactivated herpes simplex virus type 2 infection and human immunodeficiency virus type 1 (HIV-1)-induced immunosuppression on genital and plasma HIV-1 levels. J Infect Dis 2008;198:241-9.
    • (2008) J Infect Dis , vol.198 , pp. 241-249
    • Nagot, N.1    Ouedraogo, A.2    Konate, I.3
  • 32
    • 33847219957 scopus 로고    scopus 로고
    • Negative mucosal synergy between herpes simplex type 2 and HIV in the female genital tract
    • Rebbapragada A, Wachihi C, Pettengell C, et al. Negative mucosal synergy between herpes simplex type 2 and HIV in the female genital tract. Aids 2007;21:589-98.
    • (2007) Aids , vol.21 , pp. 589-598
    • Rebbapragada, A.1    Wachihi, C.2    Pettengell, C.3
  • 33
    • 38149074165 scopus 로고    scopus 로고
    • The genital tract immune milieu: An important determinant of HIV susceptibility and secondary transmission
    • Kaul R, Pettengell C, Sheth PM, et al. The genital tract immune milieu: an important determinant of HIV susceptibility and secondary transmission. J Reprod Immunol 2008;77:32-40.
    • (2008) J Reprod Immunol , vol.77 , pp. 32-40
    • Kaul, R.1    Pettengell, C.2    Sheth, P.M.3
  • 34
    • 47549091972 scopus 로고    scopus 로고
    • Herpes simplex virus and HIV-1: Deciphering viral synergy
    • Van de Perre P, Segondy M, Foulongne V, et al. Herpes simplex virus and HIV-1: deciphering viral synergy. Lancet Infect Dis 2008;8:490-7.
    • (2008) Lancet Infect Dis , vol.8 , pp. 490-497
    • Van De Perre, P.1    Segondy, M.2    Foulongne, V.3
  • 35
    • 45249108765 scopus 로고    scopus 로고
    • Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: A randomised, double-blind, placebo-controlled trial
    • Celum C, Wald A, Hughes J, et al. Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial. Lancet 2008;371:2109-19.
    • (2008) Lancet , vol.371 , pp. 2109-2119
    • Celum, C.1    Wald, A.2    Hughes, J.3
  • 36
    • 33847130152 scopus 로고    scopus 로고
    • Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus
    • Nagot N, Ouedraogo A, Foulongne V, et al. Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus. N Engl J Med 2007;356:790-9.
    • (2007) N Engl J Med , vol.356 , pp. 790-799
    • Nagot, N.1    Ouedraogo, A.2    Foulongne, V.3
  • 37
    • 33751241122 scopus 로고    scopus 로고
    • Impact of suppressive herpes therapy on genital HIV-1 RNA among women taking antiretroviral therapy: A randomized controlled trial
    • Ouedraogo A, Nagot N, Vergne L, et al. Impact of suppressive herpes therapy on genital HIV-1 RNA among women taking antiretroviral therapy: a randomized controlled trial. Aids 2006;20:2305-13.
    • (2006) Aids , vol.20 , pp. 2305-2313
    • Ouedraogo, A.1    Nagot, N.2    Vergne, L.3
  • 38
    • 62349083377 scopus 로고    scopus 로고
    • Impact of aciclovir on genital and plasma HIV-1 RNA in HSV-2/HIV-1 co-infected women: A randomized placebo-controlled trial in South Africa
    • Delany S, Mlaba N, Clayton T, et al. Impact of aciclovir on genital and plasma HIV-1 RNA in HSV-2/HIV-1 co-infected women: a randomized placebo-controlled trial in South Africa. Aids 2009;23:461-9.
    • (2009) Aids , vol.23 , pp. 461-469
    • Delany, S.1    Mlaba, N.2    Clayton, T.3
  • 39
    • 50849123514 scopus 로고    scopus 로고
    • Suppressive acyclovir therapy reduces HIV cervicovaginal shedding in HIV- and HSV-2-infected women, Chiang Rai, Thailand
    • Dunne EF, Whitehead S, Sternberg M, et al. Suppressive acyclovir therapy reduces HIV cervicovaginal shedding in HIV- and HSV-2-infected women, Chiang Rai, Thailand. J Acquir Immune Defic Syndr 2008;49:77-83.
    • (2008) J Acquir Immune Defic Syndr , vol.49 , pp. 77-83
    • Dunne, E.F.1    Whitehead, S.2    Sternberg, M.3
  • 40
    • 56749131188 scopus 로고    scopus 로고
    • Herpes simplex virus (HSV)-suppressive therapy decreases plasma and genital HIV-1 levels in HSV-2/HIV-1 coinfected women: A randomized, placebo-controlled, cross-over trial
    • Baeten JM, Strick LB, Lucchetti A, et al. Herpes simplex virus (HSV)-suppressive therapy decreases plasma and genital HIV-1 levels in HSV-2/HIV-1 coinfected women: a randomized, placebo-controlled, cross-over trial. J Infect Dis 2008; 198:1804-8.
    • (2008) J Infect Dis , vol.198 , pp. 1804-1808
    • Baeten, J.M.1    Strick, L.B.2    Lucchetti, A.3
  • 41
    • 38449119047 scopus 로고    scopus 로고
    • Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: A randomized, double-blind, placebo-controlled crossover trial
    • Zuckerman RA, Lucchetti A, Whittington WL, et al. Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial. J Infect Dis 2007;196:1500-8.
    • (2007) J Infect Dis , vol.196 , pp. 1500-1508
    • Zuckerman, R.A.1    Lucchetti, A.2    Whittington, W.L.3
  • 42
    • 62349128691 scopus 로고    scopus 로고
    • HSV suppression reduces seminal HIV-1 levels in HIV-1/HSV-2 co-infected men who have sex with men
    • Zuckerman RA, Lucchetti A, Whittington WL, et al. HSV suppression reduces seminal HIV-1 levels in HIV-1/HSV-2 co-infected men who have sex with men. Aids 2009;23:479-83.
    • (2009) Aids , vol.23 , pp. 479-483
    • Zuckerman, R.A.1    Lucchetti, A.2    Whittington, W.L.3
  • 44
    • 50849109191 scopus 로고    scopus 로고
    • Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues
    • Lisco A, Vanpouille C, Tchesnokov EP, et al. Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues. Cell Host Microbe 2008;4:260-70.
    • (2008) Cell Host Microbe , vol.4 , pp. 260-270
    • Lisco, A.1    Vanpouille, C.2    Tchesnokov, E.P.3
  • 45
    • 42049102191 scopus 로고    scopus 로고
    • Effect of herpes simplex suppression on incidence of HIV among women in Tanzania
    • Watson-Jones D, Weiss HA, Rusizoka M, et al. Effect of herpes simplex suppression on incidence of HIV among women in Tanzania. N Engl J Med 2008;358:1560-71.
    • (2008) N Engl J Med , vol.358 , pp. 1560-1571
    • Watson-Jones, D.1    Weiss, H.A.2    Rusizoka, M.3
  • 46
    • 83055197330 scopus 로고    scopus 로고
    • Twice-daily acyclovir to reduce HIV-1 transmission from HIV-1 / HSV-2 co-infected persons within HIV-1 serodiscordant couples: A randomized, double-blind, placebo-controlled trial
    • Abstract WELBC 101
    • Celum C, Wald A, Lingappa JR. Twice-daily acyclovir to reduce HIV-1 transmission from HIV-1 / HSV-2 co-infected persons within HIV-1 serodiscordant couples: a randomized, double-blind, placebo-controlled trial. (Abstract WELBC 101). 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention. Cape Town, South Africa 2009.
    • 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention. Cape Town, South Africa 2009
    • Celum, C.1    Wald, A.2    Lingappa, J.R.3
  • 47
    • 68349146396 scopus 로고    scopus 로고
    • Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition
    • Zhu J, Hladik F, Woodward A, et al. Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition. Nat Med 2009;15:886-92.
    • (2009) Nat Med , vol.15 , pp. 886-892
    • Zhu, J.1    Hladik, F.2    Woodward, A.3
  • 48
    • 33947424353 scopus 로고    scopus 로고
    • Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation
    • Zhu J, Koelle DM, Cao J, et al. Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation. J Exp Med 2007;204:595-603.
    • (2007) J Exp Med , vol.204 , pp. 595-603
    • Zhu, J.1    Koelle, D.M.2    Cao, J.3
  • 49
    • 48449099125 scopus 로고    scopus 로고
    • Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in Africa
    • Abu-Raddad LJ, Magaret AS, Celum C, et al. Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in Africa. PLoS One 2008;3:e2230.
    • (2008) PLoS One , vol.3
    • Abu-Raddad, L.J.1    Magaret, A.S.2    Celum, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.