Suppressive acyclovir therapy reduces HIV cervicovaginal shedding in HIV- and HSV-2-infected women, chiang rai, thailand

Journal of Acquired Immune Deficiency Syndromes

Volumn 49, Issue 1, 2008, Pages 77-83

  Dunne, Eileen F ^a   Whitehead, Sara ^a,b   Sternberg, Maya ^a   Thepamnuay, Sukhon ^c   Leelawiwat, Wanna ^b   McNicholl, Janet M ^a,b   Sumanapun, Surin ^c   Tappero, Jordan W ^a,b   Siriprapasiri, Taweesap ^a,b   Markowitz, Lauri ^a,b  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b MINISTRY OF PUBLIC HEALTH   (Thailand)

^c Chiang Rai Provincial Public Health Office   (Thailand)

Author keywords

HIV transmission; HIV 1; HSV 2; Suppressive acyclovir

Indexed keywords

ACICLOVIR; PLACEBO; VIRUS RNA; ANTIVIRUS AGENT;

ADULT; ANTIVIRAL THERAPY; ARTICLE; CD4 LYMPHOCYTE COUNT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG INDUCED HEADACHE; DRUG WITHDRAWAL; FEMALE; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MAJOR CLINICAL STUDY; MIXED INFECTION; NAUSEA; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; THAILAND; TREATMENT RESPONSE; VAGINAL LAVAGE; VIRUS INHIBITION; VIRUS LOAD; VIRUS SHEDDING; VIRUS TRANSMISSION; ADOLESCENT; DRUG EFFECT; GENITAL HERPES; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; ISOLATION AND PURIFICATION; MIDDLE AGED; UTERINE CERVIX; VAGINA; VIROLOGY;

ACYCLOVIR; ADOLESCENT; ADULT; ANTIVIRAL AGENTS; CERVIX UTERI; CROSS-OVER STUDIES; FEMALE; HERPES GENITALIS; HIV INFECTIONS; HIV-1; HUMANS; MIDDLE AGED; PLACEBOS; THAILAND; VAGINA; VIRAL LOAD; VIRUS SHEDDING;

EID: 50849123514     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3181831832     Document Type: Article

References (26)

1. Schacker T, Ryncarz AJ, Goddard J, et al. Frequent recovery of HIV-1 from genital herpes simplex virus lesions in HIV-1-infected men. JAMA. 1998;280:61-66.
2. Mbopi-Keou FX, Gresenguet G, Mayaud P, et al. Interactions between herpes simplex virus type 2 and human immunodeficiency virus type 1 infection in African women: opportunities for intervention. J Infect Dis. 2000;182:1090-1096.
3. McClelland RS, Wang CC, Overbaugh J, et al. Association between cervical shedding of herpes simplex virus and HIV-1. AIDS. 2002;16: 2425-2430.
4. Gray RH, Li X, Wawer MJ, et al. Determinants of HIV-1 load in subjects with early and later HIV infections, in a general-population cohort of Rakai, Uganda. J Infect Dis. 2004;189:1209-1215.
5. Cachay ER, Frost SD, Richman DD, et al. Herpes simplex virus type 2 infection does not influence viral dynamics during early HIV-1 infection. J Infect Dis. 2007;195:1270-1277.
6. Schacker T, Zeh J, Hu H, et al. Changes in plasma human immunodeficiency virus type 1 RNA associated with herpes simplex virus reactivation and suppression. J Infect Dis. 2002;186:1718-1725.
7. Ouedraogo A, Nagot N, Vergne L, et al. Impact of suppressive herpes therapy on genital HIV-1 RNA among women taking antiretroviral therapy: a randomized controlled trial. AIDS. 2006;20:2305-2313.
8. Nagot N, Ouedraogo A, Foulongne V, et al. Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus. N Engl J Med. 2007; 356:790-799.
9. Zuckerman RA, Lucchetti A, Whittington WL, et al. Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-l/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial. J Infect Dis. 2007;196:1500-1508.
10. Celum CL, Robinson NJ, Cohen MS. Potential effect of HIV type 1 antiretroviral and herpes simplex virus type 2 antiviral therapy on transmission and acquisition of HIV type 1 infection. J Infect Dis. 2005; 191(Suppl 1):S107-S114.
11. Celum C, Wald A, Hughes J, et al. HPTN 039 Protocol Team. Effect of acyclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: A randomized, double-blind, placebo-controlled trial. Lancet. 2008;371:2109-2119.
12. FDA. Acyclovir Product Information. Available at: http://www.fda.gov/ cder/foi/anda/98/74-976-Acyclovir.htm. Accessed June 2008.
13. Villanueva JM, Ellerbrock TV, Lennox JL, et al. The menstrual cycle does not affect human immunodeficiency virus type 1 levels in vaginal secretions. J Infect Dis. 2002;185:170-177.
14. Ministry of Public Health Thailand Bureau of AIDS, TB, and STD, Department of Disease Control, Ministry of Public Health. Guideline for Comprehensive and Continuum Care for PLHA, 2004. In. Nonthaburi, Thailand; 2004.
15. CDC. 1997 Revised guidelines for performing CD4+ T-cell determinations in persons infected with human immunodeficiency virus (HIV). MMWR Recomm Rep. 1997;46:1-29.
16. Nugent RP, Krohn MA, Hillier SL. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol. 1991;29:297-301.
17. Mbopi Keou FX, Gresenguet G, Mayaud P, et al. Genital herpes simplex virus type 2 shedding is increased in HIV-infected women in Africa. AIDS. 1999;13:536-537.
18. Helsel DR. Insider Censoring: Distortion of data with Nondetects. Human and Ecological Risk Assessment. 2005;11:1127-1137.
19. Helsel DR. More than obvious: better methods for interpreting nondetect data. Environ Sci Technol. 2005;39:419A-423A.
20. Helsel DR, Cohn TA. Estimation of descriptive statistics for multiply censored water quality data. Water Resour Res. 1988:24:1997-2004.
21. Helsel DR. Nondetects and Data Analysis: Statistics for Censored Environmental Data. Wiley:New York, 2005.
22. Efron B, Tibshirani RJ. Introduction to the Bootstrap. Chapman and Hall: New York, London; 1993.
23. Feingold M, Gillespie BW Cross-over trials with censored data. Stat Med. 1996;15:953-967.
24. Woolson RF, O'Gorman TW A comparison of several tests for censored paired data. Stat Med. 1992;11:193-208.
25. Zou G. A modified poisson regression approach to prospective studies with binary data. Am J Epidemiol. 2004;159:702-706.
26. Verbeke G, Molenberghs G. Linear Mixed Models for Longitudinal Data. New York; 2000.