1,3-disubstituted-2-carboxyl quinolones: Highly potent and selective endothelin A receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 13, 2000, Pages 1487-1490

  Haesslein, Jean Luc ^a   Baholet, Isabelle ^a   Fortin, Michel ^b   Iltis, Alain ^a   Khider, Jean ^a   Periers, Anne Marie ^a   Pierre, Christine ^a   Vevert, Jean Paul ^a  

^a Medicinal Chemistry   (France)

^b Central Research   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; QUINOLONE DERIVATIVE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN VENTRICLE; CEREBELLUM; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; RAT; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOLOGICAL ASSAY; CYCLIZATION; DRUG DESIGN; FEMALE; HUMANS; MALE; MICE; MOLECULAR STRUCTURE; QUINOLONES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0034601261     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00264-X     Document Type: Article

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