Common carotid intima-media thickness in growth hormone (GH)-deficient adolescents: A prospective study after GH withdrawal and restarting GH replacement

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 5, 2005, Pages 2659-2665

  Colao, Annamaria ^a   Di Somma, Carolina ^a   Rota, Francesca ^a   Di Maio, Salvatore ^b   Salerno, Mariacarolina ^a   Klain, Antonella ^b   Spiezia, Stefano ^c   Lombardi, Gaetano ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b SANTOBONO PAUSILIPON CHILDREN S HOSPITAL   (Italy)

^c S Maria degli Incurabili Hospital of Naples   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; FIBRINOGEN; GLUCOSE; GROWTH HORMONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN; SOMATOMEDIN;

ADOLESCENT; ADULT; ARTERY INTIMA PROLIFERATION; ARTICLE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; COMMON CAROTID ARTERY; CONTROLLED STUDY; FEMALE; FIBRINOGEN BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; HOMEOSTASIS; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR;

ADOLESCENT; ADULT; CAROTID ARTERY, COMMON; FEMALE; HORMONE REPLACEMENT THERAPY; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; NITRIC OXIDE; PROSPECTIVE STUDIES; TUNICA INTIMA;

EID: 18844459887     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-1844     Document Type: Article

References (47)

1. Rosen T, Bengtsson BA 1990 Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 336:285-288
2. Bates AS, Vant'Hoff W, Jones PJ, Clayton RN 1996 The effect of hypopituitarism on life expectancy. J Clin Endocrinol Metab 81:1169-1172
3. Bulöw B, Hagmar L, Mikoczy Z, Nordström CH, Erfurth EM 1997 Increased cerebrovascular mortality in patients with hypopituitarism. Clin Endocrinol 46:75-81
4. Bulöw B, Hagmar L, Eskilsson J, Erfurth EM 2000 Hypopituitary females have a high incidence of cardiovascular morbidity and an increased prevalence of cardiovascular risk factors. J Clin Endocrinol Metab 85:574-584
5. Tomlinson JW, Holden N, Hills RK, Wheatley K, Clayton RN, Bates AS, Sheppard MC, Stewart PM 2001 Association between premature mortality and hypopituitarism. West Midlands prospective study Hypopituitary Study Group. Lancet 357:425-431
6. Beshyah SA, Johnston DG 1999 Cardiovascular disease and risk factors in adults with hypopituitarism. Clin Endocrinol 50:1-15
7. Colao A, Di Somma C, Marzullo P, Lombardi G 2001 Growth hormone and the heart. Clin Endocrinol 54:137-154
8. Vance ML, Mauras N 1999 Growth hormone therapy in adults and children. N Engl J Med 341:1206-1216
9. Carroll PV, Christ ER, Sonksen PH 2000 Growth hormone replacement in adults with growth hormone deficiency: assessment of current knowledge. Trends Endocrinol Metab 11:231-238
10. Bengtsson BA, Johannsson G, Shalet SM, Simpson H, Sonken PH 2000 Treatment of growth hormone deficiency in adults. J Clin Endocrinol Metab 85:933-942
11. Markussis V, Beshyah SA, Fisher C, Sharp P, Nicholaides AN, Johnston D 1992 Detection of premature atherosclerosis by high resolution ultrasonography in symptom free hypopituitary adults. Lancet 340:1188-1192
12. Capaldo B, Patti L, Oliviero U, Longobardi S, Pardo F, Vitale F, Fazio S, Di Rella F, Biondi B, Lombardi G, Saccà L 1997 Increased arterial intima-media thickness in childhood-onset growth hormone deficiency. J Clin Endocrinol Metab 82:1378-1381
13. Borson-Chazot F, Serusclat A, Kalfallah Y, Ducottet X, Sassolas G, Bernard S, Labrousse F, Pastene J, Sassolas A, Roux Y, Berthezéne F 1999 Decrease in carotid intima-media thickness after one year growth hormone (GH) treatment in adults with GH deficiency. J Clin Endocrinol Metab 84:1329-1333
14. Pfeifer M, Verhovec R, Zizek B, Prezelj J, Poredos P, Clayton RN 1999 Growth hormone treatment (GH) reverses early atherosclerotic changes in GH-deficient adults. J Clin Endocrinol Metab 84:453-457
15. Murata M, Kaji H, Mizuno I, Sakurai T, Iida K, Okimura Y, Chihara K 2003 A study of carotid intima-media thickness in GH-deficient Japanese adults during onset among adults and children. Eur J Endocrinol 148:333-338
16. Leonsson M, Hulthe J, Oscarsson J, Johannsson G, Wendelhag I, Wikstrand J, Bengtsson BA 2002 Intima-media thickness in cardiovascularly asymptomatic hypopituitary adults with growth hormone deficiency: relation to body mass index, gender, and other cardiovascular risk factors. Clin Endocrinol (Oxf) 57:751-759
17. Bonithon-Kopp C, Touboul P-J, Berr C, Berr C, Leroux C, Mainard F, Bourbon D, Ducimetiere P 1996 Relation of intima-media thickness to atherosclerotic plaques in carotid arteries. The vascular aging (EVA) study. Arterioscler Thromb Vasc Biol 16:310-316
18. Vasan RS, Sullivan LM, D'Agostino RB, Roubenoff R, Harris T, Sawyer DB, Levy D, Wilson PW 2003 Serum insulin-like growth factor 1 and risk for heart failure in elderly individuals without a previous myocardial infarction: the Framingham Heart Study. Ann Intern Med 139:642-648
19. Laughlin GA, Barrett-Connor E, Criqui MH, Kritz-Silverstein D 2004 The prospective association of serum insulin-like growth factor 1 (1GF-1) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho-Bernardo study. J Clin Endocrinol Metab 8:114-120
20. Colao A, Di Somma C, Filippella M, Rota F, Pivonello R, Orio Jr F, Vitale G, Lombardi G 2004 Insulin-like growth factor-1 deficiency determines increased intima-media thickness at common carotid arteries in adult patients with growth hormone deficiency. Clin Endocrinol (Oxf) 61:360-366
21. Shalet SM, Rosenfeld RG 1998 Growth hormone replacement therapy during transition of patients with childhood-onset growth hormone deficiency into adulthood: what are the issues? Growth Horm IGF Res 8(Suppl B):177-184
22. Longobardi S, Merola B, Pivonello R, Di Rella F, Di Somma C, Colao A, Ghigo E, Camanni F, Lombardi G 1996 Reevaluation of GH secretion in sixty-nine adults diagnosed as GH deficient patients during childhood. J Clin Endocrinol Metab 81:1244-1247
23. Aimaretti G, Baffoni C, Bellone S, Di Vito L, Corneli G, Arvat E, Benso L, Camanni F, Ghigo E 2000 Retesting young adults with childhood-onset growth hormone (GH) deficiency with GH-releasing-hormone-plus-arginine test. J Clin Endocrinol Metab 85:3693-3699
24. Johannsson G, Albertsson-Wikland K Bengtsson BA 1999 Discontinuation of growth hormone (GH) treatment: metabolic effects in GH-deficient and GH-sufficient adolescent patients compared with control subjects. J Clin Endocrinol Metab 84:4516-4524
25. Davis PH, Dawson JD, Riley WA, Lauer RM 2001 Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle-age. The Muscatine Study. Circulation 104:2815-2819
26. Colao A, Di Somma C, Salerno M, Spinelli L, Orio F, Lombardi G 2002 The cardiovascular risk of GH-deficient adolescents. J Clin Endocrinol Metab 87:3650-3655
27. Lanes R, Gunczler P, Lopez E, Esaa S, Villaroel O, Revel-Chion R 2001 Cardiac mass and function, carotid artery intima-media thickness, and lipoprotein levels in growth hormone-deficient adolescents. J Clin Endocrinol Metab 86:1061-1065
28. 1998 Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency. J Clin Endocrinol Metab 83:379-381
29. Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G 2001 Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients with GH deficiency. J Clin Endocrinol Metab 86:1874-1881
30. Colao A, di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G 2002 The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: a 12-month prospective study. J Clin Endocrinol Metab 87:1088-1093
31. Castelli WP 1996 Lipids, risk factors and ischaemic heart disease. Atherosclerosis 124(Suppl):S1-S9
32. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC 1985 Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
33. Colao A, Cerbone G, Pivonello R, Aimaretti G, Loche S, Di Somma C, Faggiano A, Corneli G, Ghigo E, Lombardi G 1999 The growth hormone (GH) response to arginine plus GH releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH deficiency. J Clin Endocrinol Metab 84:1277-1282
34. Colao A, Di Somma C, Pivonello R, Loche S, Aimaretti G, Cerbone G, Faggiano A Corneli G, Ghigo E, Lombardi G 1999 Bone loss is correlated to the severity of growth hormone deficiency in adult patients with hypopituitarism. J Clin Endocrinol Metab 84:1919-1924
35. Simon A, Gariepy J, Chironi G, Megnien JL, Levenson J 2002 Intima-media thickness: a new tool for diagnosis and treatment of cardiovascular risk. J Hypertens 20:159-169
36. Belcaro G, Laurora G, Cesarone MR 1993 Noninvasive ultrasonic biopsy: evaluation of early arteriosclerotic lesions progression in normal asymptomatic, hyperlipidemic and diabetic subjects. Angiology 44:93-99
37. Abdu TA, Neary R, Elhadd TA, Akber M, Clayton RN 2001 Coronary risk in growth hormone deficient hypopituitary adults: increased predicted risk is due largely to lipid profile abnormalities. Clin Endocrinol 55:209-216
38. Delafontaine P, Lou, H, Alexander RW 1991 Regulation of insulin-like growth factor 1 messenger RNA levels in vascular smooth muscle cells. Hypertension 18:742-747
39. Tsukahara H, Gordienko DV, Tonshoff B, Gelato MC, Goligorsky MS 1994 Direct demonstration of insulin-like growth factor 1 induced nitric oxide production by endothelial cells. Kidney Int 45:598-604
40. Walsh F, Barazi M, Pete G, Muniyappa R, Dunbar JC, Sowers JR 1996 Insulin-like growth factor-1 diminishes in vivo and in vitro vascular contractility: role of vascular nitric oxide. Endocrinology 137:1798-1803
41. Bayes-Genis A, Conover CA, Schwartz RS 2000 The insulin-like growth factor axis: a review of atherosclerosis and restenosis. Circ Res 86:125-130.
42. Böger RH, Skamira C, Bode-Böger SM, Brabant C, Von Zur Muhlen A, Frolich JC 1996 Nitric oxide mediates the hemodynamic effects of recombinant growth hormone in patients with acquired growth hormone deficiency. J Clin Invest 98:2706-2713
43. Colao A, Spiezia S, Cerbone G, Pivonello R, Marzullo P, Ferone D, Di Somma C, Assanti AP, Lombardi G 2001 Increased arterial intima-media thickness by B-M mode echodoppler ultrasonography in acromegaly. Clin Endocrinol (Oxf) 54:515-524
44. Colao A, Spinelli L, Cuocolo A, Spiezia S, Bonaduce D, Salvatore M, Lombardi G 2002 Cardiovascular consequences of early-onset growth hormone excess. J Clin Endocrinol Metab 87:3097-3104
45. Chanson P, Megnien JL, del Pino M, Coirault C, Merli I, Houdouin L, Harris AG, Levenson J, Lecarpentier Y, Simon A, Chemla D 1998 Decreased regional blood flow in patients with acromegaly. Clin Endocrinol (Oxf) 49:725-731
46. Brevetti G, Marzullo P, Silvestro A, Pivonello R, Oliva G, Di Somma C, Lombardi G, Colao A 2002 Early vascular alterations in acromegaly. J Clin Endocrinol Metab 87:3174-3179
47. Kasayama S, Otsuki M, Takagi M, Saito H, Sumitani S, Kouhara H, Koga M, Saitoh Y, Ohnishi T, Arita N 2001 Characterization of premature atherosclerosis of carotid arteries in acromegalic patients. Clin Endocrinol (Oxf) 54:791-796