Discovery of 2-aminoimidazopyridine adenosine A2A receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 22, 2010, Pages 6845-6849

  McGuinness, Brian F ^a   Cole, Andrew G ^a   Dong, Guizhen ^a   Brescia, Marc Raleigh ^a   Shao, Yuefei ^a   Henderson, Ian ^a   Rokosz, Laura L ^a   Stauffer, Tara M ^a   Mannava, Neelima ^a   Kimble, Earl F ^a   Hicks, Catherine ^a   White, Nicole ^a   Wines, Pamela G ^a   Quadros, Elizabeth ^a  

^a Ligand Pharmaceuticals Inc   (United States)

Author keywords

A2A receptor; Adenosine; Combinatorial chemistry; Imidazopyridine; Parkinson's disease

Indexed keywords

2 AMINOIMIDAZO[4,5 B]PYRIDINE; 2 CHLOROBENZOYL; 3 CHLOROBENZOYL; 3 CYANOBENZOYL; 3 FLUOROBENZOYL; 3 METHOXYBENZOYL; 3 TRIFLUOROMETHYLBENZOYL; 4 CYANOBENZOYL; 5 CARBOXAMIDO; ADENOSINE A2A RECEPTOR AGONIST; BENZIMIDAZOLE; N BUTYLAMINO; PIPERIDINYL; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG BINDING; DRUG BRAIN LEVEL; DRUG MECHANISM; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; IN VITRO STUDY; MOLECULAR WEIGHT; STRUCTURE ACTIVITY RELATION;

DRUG DISCOVERY; HUMANS; HYDROGEN BONDING; MICROSOMES; PYRIMIDINES; RECEPTOR, ADENOSINE A2A;

EID: 77958051128     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.064     Document Type: Article

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