Solid-phase synthesis of N-9-substituted 2,8-diaminopurines

Tetrahedron Letters

Volumn 47, Issue 50, 2006, Pages 8897-8900

  Cole, Andrew G ^a   Metzger, Axel ^a   Ahmed, Gulzar ^a   Brescia, Marc Raleigh ^a   Chan, Ray J ^a   Wen, James ^a   O'Brien, Linda ^a   Qin, Lan Ying ^a   Henderson, Ian ^a  

^a PHARMACOPEIA INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 NITROURACIL; PURINE DERIVATIVE; THIOUREA; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ARTICLE; CYCLIZATION; DRUG SYNTHESIS; MICROWAVE RADIATION; SOLID;

EID: 33750610161     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.10.050     Document Type: Article

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23. Microwave reactions were performed using a LAVIS-1000 multiQUANT irradiating at 500 W for 5 × 1 min with 15 min intervals between each irradiation.
24. Analytical HPLC analysis was conducted using a PDA linked Waters Millenium 2290 and Phenomenex Luna 3u 50 × 3 mm C8 column.