Identification of non-furan containing A2A antagonists using database mining and molecular similarity approaches

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 23, 2006, Pages 5993-5997

  Richardson, Christine M ^a   Gillespie, Roger J ^a   Williamson, Douglas S ^a   Jordan, Allan M ^a   Fink, Alexandra ^a   Knight, Antony R ^a   Sellwood, Daniel M ^a   Misra, Anil ^a  

^a Vernalis PLC   (United Kingdom)

Author keywords

A2A; Database mining; Molecular similarity; Non furan; Pharmacophore

Indexed keywords

ADENOSINE A2 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT;

ARTICLE; DATA BASE; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINATION; FLUORINE; FURANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PYRIMIDINES; RECEPTOR, ADENOSINE A2A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33751064572     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.116     Document Type: Article

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