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Volumn 4, Issue 5, 2010, Pages 561-567

Defining primary bile acid diarrhea: Making the diagnosis and recognizing the disorder

Author keywords

bile salts; chronic diarrhea; enterohepatic circulation; FGF19; IBS; ileum; malabsorption; SeHCAT

Indexed keywords

BILE ACID; FIBROBLAST GROWTH FACTOR 19; TAUROSELCHOLIC ACID SE 75;

EID: 77958027847     PISSN: 17474124     EISSN: None     Source Type: Journal    
DOI: 10.1586/egh.10.54     Document Type: Review
Times cited : (45)

References (51)
  • 1
    • 0014071178 scopus 로고
    • The syndrome of ileal disease and the broken enterohepatic circulation: Cholerheic enteropathy
    • Key description of bile acid-induced diarrhea
    • Hofmann AF. The syndrome of ileal disease and the broken enterohepatic circulation: Cholerheic enteropathy. Gastroenterology 52(4), 752-757 (1967). Key description of bile acid-induced diarrhea.
    • (1967) Gastroenterology , vol.52 , Issue.4 , pp. 752-757
    • Hofmann, A.F.1
  • 2
    • 66149115985 scopus 로고    scopus 로고
    • Bile acids: Trying to understand their chemistry and biology with the hope of helping patients
    • Hofmann AF. Bile acids: Trying to understand their chemistry and biology with the hope of helping patients. Hepatology 49(5), 1403-1418 (2009).
    • (2009) Hepatology , vol.49 , Issue.5 , pp. 1403-1418
    • Hofmann, A.F.1
  • 4
    • 0015231376 scopus 로고
    • Breath test for altered bile-acid metabolism
    • Fromm H, Hofmann AF. Breath test for altered bile-acid metabolism. Lancet 2(7725), 621-625 (1971).
    • (1971) Lancet , vol.2 , Issue.7725 , pp. 621-625
    • Fromm, H.1    Hofmann, A.F.2
  • 5
    • 0019404471 scopus 로고
    • Se-75-labeled bile acid analogs, new radiopharmaceuticals for investigating the enterohepatic circulation
    • Boyd GS, Merrick MV, Monks R, Thomas IL. Se-75-labeled bile acid analogs, new radiopharmaceuticals for investigating the enterohepatic circulation. J. Nucl. Med. 22(8), 720-725 (1981).
    • (1981) J. Nucl. Med. , vol.22 , Issue.8 , pp. 720-725
    • Boyd, G.S.1    Merrick, M.V.2    Monks, R.3    Thomas, I.L.4
  • 6
    • 0021920402 scopus 로고
    • Is bile acid malabsorption underdiagnosed? An evaluation of accuracy of diagnosis by measurement of SeHCAT retention
    • Merrick MV, Eastwood MA, Ford MJ. Is bile acid malabsorption underdiagnosed? An evaluation of accuracy of diagnosis by measurement of SeHCAT retention. Br. Med. J. (Clin. Res. Ed.) 290(6469), 665-668 (1985).
    • (1985) Br. Med. J. (Clin. Res. Ed.) , vol.290 , Issue.6469 , pp. 665-668
    • Merrick, M.V.1    Eastwood, M.A.2    Ford, M.J.3
  • 7
    • 0023228639 scopus 로고
    • 75SeHCAT test in the detection of bile acid malabsorption in functional diarrhoea and its correlation with small bowel transit
    • Sciarretta G, Fagioli G, Furno A et al. 75SeHCAT test in the detection of bile acid malabsorption in functional diarrhoea and its correlation with small bowel transit. Gut 28(8), 970-975 (1987).
    • (1987) Gut , vol.28 , Issue.8 , pp. 970-975
    • Sciarretta, G.1    Fagioli, G.2    Furno, A.3
  • 9
    • 0025824484 scopus 로고
    • Idiopathic bile acid malabsorption - A review of clinical presentation, diagnosis, and response to treatment
    • Williams AJK, Merrick MV, Eastwood MA. Idiopathic bile acid malabsorption - a review of clinical presentation, diagnosis, and response to treatment. Gut 32, 1004-1006 (1991).
    • (1991) Gut , vol.32 , pp. 1004-1006
    • Williams, A.J.K.1    Merrick, M.V.2    Eastwood, M.A.3
  • 10
    • 0027977042 scopus 로고
    • Bile acid malabsorption in Crohn's disease and indications for its assessment using SeHCAT
    • Nyhlin H, Merrick MV, Eastwood MA. Bile acid malabsorption in Crohn's disease and indications for its assessment using SeHCAT. Gut 35, 90-93 (1994).
    • (1994) Gut , vol.35 , pp. 90-93
    • Nyhlin, H.1    Merrick, M.V.2    Eastwood, M.A.3
  • 11
    • 0034278062 scopus 로고    scopus 로고
    • Bile acid malabsorption in persistent diarrhoea
    • One of several papers studying the frequency of abnormal 75Se-homocholyltaurine (SeHCAT) tests in patients with various conditions producing chronic diarrhea
    • Smith MJ, Cherian P, Raju GS, Dawson BF, Mahon S, Bardhan KD. Bile acid malabsorption in persistent diarrhoea. J. R. Coll. Physicians (Lond.) 34, 448-451 (2000). One of several papers studying the frequency of abnormal 75Se-homocholyltaurine (SeHCAT) tests in patients with various conditions producing chronic diarrhea.
    • (2000) J. R. Coll. Physicians (Lond.) , vol.34 , pp. 448-451
    • Smith, M.J.1    Cherian, P.2    Raju, G.S.3    Dawson, B.F.4    Mahon, S.5    Bardhan, K.D.6
  • 12
    • 0042929633 scopus 로고    scopus 로고
    • Bile acid malabsorption in patients with chronic diarrhoea: Clinical value of SeHCAT test
    • Wildt S, Rasmussen SN, Madsen JL, Rumessen JJ. Bile acid malabsorption in patients with chronic diarrhoea: Clinical value of SeHCAT test. Scand. J. Gastroenterol. 38, 826-830 (2003).
    • (2003) Scand. J. Gastroenterol. , vol.38 , pp. 826-830
    • Wildt, S.1    Rasmussen, S.N.2    Madsen, J.L.3    Rumessen, J.J.4
  • 13
    • 0015767212 scopus 로고
    • Diarrhoea associated with idiopathic bile acid malabsorption. Fact or fantasy?
    • Thaysen EH, Pedersen L. Diarrhoea associated with idiopathic bile acid malabsorption. Fact or fantasy? Dan. Med. Bull. 20(6), 174-177 (1973).
    • (1973) Dan. Med. Bull. , vol.20 , Issue.6 , pp. 174-177
    • Thaysen, E.H.1    Pedersen, L.2
  • 14
    • 0017036391 scopus 로고
    • Idiopathic bile acid catharsis
    • Descriptions of patients with primary bile acid diarrhea
    • Thaysen EH, Pedersen L. Idiopathic bile acid catharsis. Gut 17(12), 965-970 (1976). Descriptions of patients with primary bile acid diarrhea.
    • (1976) Gut , vol.17 , Issue.12 , pp. 965-970
    • Thaysen, E.H.1    Pedersen, L.2
  • 16
    • 69949136438 scopus 로고    scopus 로고
    • Systematic review: The prevalence of idiopathic bile acid malabsorption (I-BAM) as diagnosed by SeHCAT scanning in patients with diarrhoea-predominant irritable bowel syndrome (IBS)
    • Review summarizing the prevalence of primary bile acid diarrhea, as shown in 18 studies and over 1000 patients
    • Wedlake L, A'Hern R, Thomas K, Walters JRF, Andreyev HJN. Systematic review: The prevalence of idiopathic bile acid malabsorption (I-BAM) as diagnosed by SeHCAT scanning in patients with diarrhoea-predominant irritable bowel syndrome (IBS). Aliment Pharmacol. Ther. 30, 707-717 (2009). Review summarizing the prevalence of primary bile acid diarrhea, as shown in 18 studies and over 1000 patients.
    • (2009) Aliment Pharmacol. Ther. , vol.30 , pp. 707-717
    • Wedlake, L.1    A'Hern, R.2    Thomas, K.3    Walters, J.R.F.4    Andreyev, H.J.N.5
  • 17
    • 71449120930 scopus 로고    scopus 로고
    • Applicability of the reported prevalence of bile salt malabsorption in irritable bowel
    • Ford AC. Applicability of the reported prevalence of bile salt malabsorption in irritable bowel. Aliment Pharmacol. Ther. 31(1), 161-162 (2010).
    • (2010) Aliment Pharmacol. Ther. , vol.31 , Issue.1 , pp. 161-162
    • Ford, A.C.1
  • 19
    • 0029969524 scopus 로고    scopus 로고
    • Serum 7 α-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea
    • Validation of C4 and SeHCAT in bile acid-induced diarrhea
    • Brydon WG, Nyhlin H, Eastwood MA, Merrick MV. Serum 7 α-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea. Eur. J. Gastroenterol. Hepatol. 8(2), 117-123 (1996). Validation of C4 and SeHCAT in bile acid-induced diarrhea.
    • (1996) Eur. J. Gastroenterol. Hepatol. , vol.8 , Issue.2 , pp. 117-123
    • Brydon, W.G.1    Nyhlin, H.2    Eastwood, M.A.3    Merrick, M.V.4
  • 20
    • 0032917843 scopus 로고    scopus 로고
    • Bile acid malabsorption as a cause of chronic diarrhea: Diagnostic value of 7α-hydroxy-4-cholesten-3-one in serum
    • Sauter GH, Munzing W, von Rilter C, Paumgartner G. Bile acid malabsorption as a cause of chronic diarrhea: Diagnostic value of 7α-hydroxy-4-cholesten-3-one in serum. Dig. Dis. Sci. 44(1), 14-19 (1999).
    • (1999) Dig. Dis. Sci. , vol.44 , Issue.1 , pp. 14-19
    • Sauter, G.H.1    Munzing, W.2    Von Rilter, C.3    Paumgartner, G.4
  • 21
    • 67650480494 scopus 로고    scopus 로고
    • Measurement of serum 7 α-hydroxy-4-cholesten-3-one (or 7 αC4), a surrogate test for bile acid malabsorption in health, ileal disease and irritable bowel syndrome using liquid chromatography-tandem mass spectrometry
    • Camilleri M, Nadeau A, Tremaine WJ et al. Measurement of serum 7 α-hydroxy-4-cholesten-3-one (or 7 αC4), a surrogate test for bile acid malabsorption in health, ileal disease and irritable bowel syndrome using liquid chromatography-tandem mass spectrometry. Neurogastroenterol. Motil. 21(7), 734-e43 (2009).
    • (2009) Neurogastroenterol. Motil. , vol.21 , Issue.7
    • Camilleri, M.1    Nadeau, A.2    Tremaine, W.J.3
  • 22
    • 35448957983 scopus 로고    scopus 로고
    • Systematic evaluation of the causes of chronic watery diarrhea with functional characteristics
    • Bile acid diarrhea was found to be the most common cause of functional diarrhea
    • Fernandez-Banares F, Esteve M, Salas A et al. Systematic evaluation of the causes of chronic watery diarrhea with functional characteristics. Am. J. Gastroenterol. 102(11), 2520-2528 (2007). Bile acid diarrhea was found to be the most common cause of functional diarrhea.
    • (2007) Am. J. Gastroenterol. , vol.102 , Issue.11 , pp. 2520-2528
    • Fernandez-Banares, F.1    Esteve, M.2    Salas, A.3
  • 23
    • 64849089859 scopus 로고    scopus 로고
    • Small intestinal bacterial overgrowth, bile acid malabsorption and gluten intolerance as possible causes of chronic watery diarrhoea
    • Fan X, Sellin JH. Small intestinal bacterial overgrowth, bile acid malabsorption and gluten intolerance as possible causes of chronic watery diarrhoea. Aliment. Pharmacol. Ther. 29(10), 1069-1077 (2009).
    • (2009) Aliment. Pharmacol. Ther. , vol.29 , Issue.10 , pp. 1069-1077
    • Fan, X.1    Sellin, J.H.2
  • 25
    • 17044458998 scopus 로고    scopus 로고
    • Guidelines for the investigation of chronic diarrhoea
    • 2nd edition
    • Thomas PD, Forbes A, Green J et al. Guidelines for the investigation of chronic diarrhoea, 2nd edition. Gut 52(Suppl. 5), v1-v15 (2003).
    • (2003) Gut , vol.52 , Issue.SUPPL. 5
    • Thomas, P.D.1    Forbes, A.2    Green, J.3
  • 26
    • 38449100398 scopus 로고    scopus 로고
    • Gastroenterology services in the UK. The burden of disease, and the organisation and delivery of services for gastrointestinal and liver disorders: A review of the evidence
    • Williams JG, Roberts SE, Ali MF et al. Gastroenterology services in the UK. The burden of disease, and the organisation and delivery of services for gastrointestinal and liver disorders: A review of the evidence. Gut 56(Suppl. 1), 1-113 (2007).
    • (2007) Gut , vol.56 , Issue.SUPPL. 1 , pp. 1-113
    • Williams, J.G.1    Roberts, S.E.2    Ali, M.F.3
  • 28
    • 67650022807 scopus 로고    scopus 로고
    • Recognition and assessment of coeliac disease in children and adults: Summary of NICE guidance
    • Richey R, Howdle P, Shaw E, Stokes T. Recognition and assessment of coeliac disease in children and adults: Summary of NICE guidance. BMJ 338, b1684 (2009).
    • (2009) BMJ , vol.338
    • Richey, R.1    Howdle, P.2    Shaw, E.3    Stokes, T.4
  • 29
    • 0026515461 scopus 로고
    • Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue')
    • Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterology 102(1), 330-354 (1992).
    • (1992) Gastroenterology , vol.102 , Issue.1 , pp. 330-354
    • Marsh, M.N.1
  • 30
    • 0032937750 scopus 로고    scopus 로고
    • Discontinuation rates of cholesterol-lowering medications: Implications for primary care
    • Hiatt JG, Shamsie SG, Schectman G. Discontinuation rates of cholesterol-lowering medications: Implications for primary care. Am. J. Manag. Care 5(4), 437-444 (1999).
    • (1999) Am. J. Manag. Care , vol.5 , Issue.4 , pp. 437-444
    • Hiatt, J.G.1    Shamsie, S.G.2    Schectman, G.3
  • 32
    • 74549201833 scopus 로고    scopus 로고
    • Effectiveness and tolerability of colesevelam hydrochloride for bile-acid malabsorption in patients with cancer: A retrospective chart review and patient questionnaire
    • Wedlake L, Thomas K, Lalji A, Anagnostopoulos C, Andreyev HJN. Effectiveness and tolerability of colesevelam hydrochloride for bile-acid malabsorption in patients with cancer: A retrospective chart review and patient questionnaire. Clin. Therap. 31(11), 2549-2558 (2009).
    • (2009) Clin. Therap. , vol.31 , Issue.11 , pp. 2549-2558
    • Wedlake, L.1    Thomas, K.2    Lalji, A.3    Anagnostopoulos, C.4    Andreyev, H.J.N.5
  • 35
    • 33845490017 scopus 로고    scopus 로고
    • Budesonide treatment is associated with increased bile acid absorption in collagenous colitis
    • Bajor A, Kilander A, Galman C, Rudling M, Ung KA. Budesonide treatment is associated with increased bile acid absorption in collagenous colitis. Aliment. Pharmacol. Ther. 24(11-12), 1643-1649 (2006).
    • (2006) Aliment. Pharmacol. Ther. , vol.24 , Issue.11-12 , pp. 1643-1649
    • Bajor, A.1    Kilander, A.2    Galman, C.3    Rudling, M.4    Ung, K.A.5
  • 36
    • 0034070920 scopus 로고    scopus 로고
    • Role of bile acids and bile acid binding agents in patients with collagenous colitis
    • Ung KA, Gillberg R, Kilander A, Abrahamsson H. Role of bile acids and bile acid binding agents in patients with collagenous colitis. Gut 46(2), 170-175 (2000).
    • (2000) Gut , vol.46 , Issue.2 , pp. 170-175
    • Ung, K.A.1    Gillberg, R.2    Kilander, A.3    Abrahamsson, H.4
  • 37
    • 0026165709 scopus 로고
    • Primary bile acid diarrhoea without an ileal carrier defect: Quantification of active bile acid transport across the ileal brush border membrane
    • van Tilburg AJ, de Rooij FW, van den Berg JW, van Blankenstein M. Primary bile acid diarrhoea without an ileal carrier defect: Quantification of active bile acid transport across the ileal brush border membrane. Gut 32(5), 500-503 (1991).
    • (1991) Gut , vol.32 , Issue.5 , pp. 500-503
    • Van Tilburg, A.J.1    De Rooij, F.W.2    Van Den Berg, J.W.3    Van Blankenstein, M.4
  • 38
    • 33645106624 scopus 로고    scopus 로고
    • Normal or increased bile acid uptake in isolated mucosa from patients with bile acid malabsorption
    • Bajor A, Kilander A, Fae A et al. Normal or increased bile acid uptake in isolated mucosa from patients with bile acid malabsorption. Eur. J. Gastroenterol. Hepatol. 18(4), 397-403 (2006).
    • (2006) Eur. J. Gastroenterol. Hepatol. , vol.18 , Issue.4 , pp. 397-403
    • Bajor, A.1    Kilander, A.2    Fae, A.3
  • 39
    • 0027097785 scopus 로고
    • Primary bile acid malabsorption: A pathophysiologic and clinical entity?
    • Key paper demonstrating increased bile acid pool size and questioning whether any malabsorption existed in primary bile acid diarrhea
    • van Tilburg AJ, de Rooij FW, van den Berg JW, van Blankenstein M. Primary bile acid malabsorption: A pathophysiologic and clinical entity? Scand. J. Gastroenterol. Suppl. 194, 66-70 (1992). Key paper demonstrating increased bile acid pool size and questioning whether any malabsorption existed in primary bile acid diarrhea.
    • (1992) Scand. J. Gastroenterol. Suppl. , vol.194 , pp. 66-70
    • Van Tilburg, A.J.1    De Rooij, F.W.2    Van Den Berg, J.W.3    Van Blankenstein, M.4
  • 40
    • 0030944084 scopus 로고    scopus 로고
    • Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2)
    • Oelkers P, Kirby LC, Heubi JE, Dawson PA. Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2). J. Clin. Invest. 99, 1880-1887 (1997).
    • (1997) J. Clin. Invest. , vol.99 , pp. 1880-1887
    • Oelkers, P.1    Kirby, L.C.2    Heubi, J.E.3    Dawson, P.A.4
  • 41
    • 0034878273 scopus 로고    scopus 로고
    • Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption
    • Montagnani M, Love MW, Rössel P, Dawson PA, Qvist P. Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption. Scand J. Gastroenterol. 36, 1077-1080 (2001).
    • (2001) Scand J. Gastroenterol. , vol.36 , pp. 1077-1080
    • Montagnani, M.1    Love, M.W.2    Rössel, P.3    Dawson, P.A.4    Qvist, P.5
  • 42
    • 33846002724 scopus 로고    scopus 로고
    • Analysis of ileal sodium/bile acid cotransporter and related nuclear receptor genes in a family with multiple cases of idiopathic bile acid malabsorption
    • Montagnani M, Abrahamsson A, Galman C et al. Analysis of ileal sodium/bile acid cotransporter and related nuclear receptor genes in a family with multiple cases of idiopathic bile acid malabsorption. World J. Gastroenterol. 12(47), 7710-7714 (2006).
    • (2006) World J. Gastroenterol. , vol.12 , Issue.47 , pp. 7710-7714
    • Montagnani, M.1    Abrahamsson, A.2    Galman, C.3
  • 43
    • 42149145538 scopus 로고    scopus 로고
    • Exploring possible mechanisms for primary bile acid malabsorption: Evidence for different regulation of ileal bile acid transporter transcripts in chronic diarrhoea
    • Balesaria S, Pell RJ, Abbott LJ et al. Exploring possible mechanisms for primary bile acid malabsorption: Evidence for different regulation of ileal bile acid transporter transcripts in chronic diarrhoea. Eur. J. Gastroenterol. Hepatol. 20(5), 413-422 (2008).
    • (2008) Eur. J. Gastroenterol. Hepatol. , vol.20 , Issue.5 , pp. 413-422
    • Balesaria, S.1    Pell, R.J.2    Abbott, L.J.3
  • 44
    • 69949133785 scopus 로고    scopus 로고
    • Indirect evidence for increased mechanosensitivity of jejunal secretomotor neurones in patients with idiopathic bile acid malabsorption
    • Bajor A, Ung KA, Ohman L et al. Indirect evidence for increased mechanosensitivity of jejunal secretomotor neurones in patients with idiopathic bile acid malabsorption. Acta Physiol. (Oxf.) 197, 129-137 (2009).
    • (2009) Acta Physiol. (Oxf.) , vol.197 , pp. 129-137
    • Bajor, A.1    Ung, K.A.2    Ohman, L.3
  • 45
    • 70349496807 scopus 로고    scopus 로고
    • A new mechanism for bile acid diarrhea: Defective feedback inhibition of bile acid biosynthesis
    • Reduced levels of FGF19 suggest a new mechanism with increased bile acid synthesis
    • Walters JRF, Tasleem AM, Omer OS, Brydon WG, Dew T, Le Roux CW. A new mechanism for bile acid diarrhea: Defective feedback inhibition of bile acid biosynthesis. Clin. Gastro. Hepatol. 7, 1189-1194 (2009). Reduced levels of FGF19 suggest a new mechanism with increased bile acid synthesis.
    • (2009) Clin. Gastro. Hepatol. , vol.7 , pp. 1189-1194
    • Walters, J.R.F.1    Tasleem, A.M.2    Omer, O.S.3    Brydon, W.G.4    Dew, T.5    Le Roux, C.W.6
  • 46
    • 27844546989 scopus 로고    scopus 로고
    • Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
    • Detailed description of the effects of FGF15 on bile acid metabolism in the mouse
    • Inagaki T, Choi M, Moschetta A et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell. Metab. 2(4), 217-225 (2005). Detailed description of the effects of FGF15 on bile acid metabolism in the mouse.
    • (2005) Cell. Metab. , vol.2 , Issue.4 , pp. 217-225
    • Inagaki, T.1    Choi, M.2    Moschetta, A.3
  • 47
    • 33644867569 scopus 로고    scopus 로고
    • Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
    • Inagaki T, Moschetta A, Lee YK et al. Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc. Natl Acad. Sci. USA 103(10), 3920-3925 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.10 , pp. 3920-3925
    • Inagaki, T.1    Moschetta, A.2    Lee, Y.K.3
  • 48
    • 33751115468 scopus 로고    scopus 로고
    • Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man
    • Lundasen T, Galman C, Angelin B, Rudling M. Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man. J. Intern. Med. 260(6), 530-536 (2006).
    • (2006) J. Intern. Med. , vol.260 , Issue.6 , pp. 530-536
    • Lundasen, T.1    Galman, C.2    Angelin, B.3    Rudling, M.4
  • 49
    • 75349109261 scopus 로고    scopus 로고
    • Effects of chenodeoxycholate and a bile acid sequestrant, colesevelam, on intestinal transit and bowel function
    • Odunsi-Shiyanbade ST, Camilleri M, McKinzie S et al. Effects of chenodeoxycholate and a bile acid sequestrant, colesevelam, on intestinal transit and bowel function. Clin. Gastroenterol. Hepatol. 8(2), 159-165 (2010).
    • (2010) Clin. Gastroenterol. Hepatol. , vol.8 , Issue.2 , pp. 159-165
    • Odunsi-Shiyanbade, S.T.1    Camilleri, M.2    McKinzie, S.3
  • 50
    • 76549112800 scopus 로고    scopus 로고
    • Relevant use of Klotho in FGF19 subfamily signaling system in vivo
    • Tomiyama K, Maeda R, Urakawa I et al. Relevant use of Klotho in FGF19 subfamily signaling system in vivo. Proc. Natl Acad. Sci. USA 107(4), 1666-1671 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , Issue.4 , pp. 1666-1671
    • Tomiyama, K.1    Maeda, R.2    Urakawa, I.3
  • 51
    • 70449729508 scopus 로고    scopus 로고
    • Chronic diarrhea caused by idiopathic bile acid malabsorption: An explanation at last
    • Hofmann AF. Chronic diarrhea caused by idiopathic bile acid malabsorption: An explanation at last. Expert Rev.Gastroenterol. Hepatol. 3(5), 461-464 (2009).
    • (2009) Expert Rev.Gastroenterol. Hepatol. , vol.3 , Issue.5 , pp. 461-464
    • Hofmann, A.F.1


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