메뉴 건너뛰기




Volumn 4, Issue 5, 2010, Pages 637-651

The enteric nervous system as a regulator of intestinal epithelial barrier function in health and disease

Author keywords

barrier function; enteric nervous system; enterocyte; inflammatory bowel disease; irritable bowel syndrome; neurotransmitters

Indexed keywords

INTERLEUKIN 6; JUNCTIONAL ADHESION MOLECULE A; MYOSIN LIGHT CHAIN KINASE; PROTEIN ZO1; PROTEIN ZO2; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR;

EID: 77958026197     PISSN: 17474124     EISSN: None     Source Type: Journal    
DOI: 10.1586/egh.10.51     Document Type: Review
Times cited : (49)

References (120)
  • 1
    • 67649216750 scopus 로고    scopus 로고
    • Intestinal barrier function: Molecular regulation and disease pathogenesis
    • Groschwitz KR, Hogan SP. Intestinal barrier function: Molecular regulation and disease pathogenesis. J. Allergy Clin. Immunol. 124, 3-20 (2009).
    • (2009) J. Allergy Clin. Immunol. , vol.124 , pp. 3-20
    • Groschwitz, K.R.1    Hogan, S.P.2
  • 2
    • 0032491391 scopus 로고    scopus 로고
    • The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton
    • Fanning AS, Jameson BJ, Jesaitis LA et al. The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton. J. Biol. Chem. 273, 29745-29753 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 29745-29753
    • Fanning, A.S.1    Jameson, B.J.2    Jesaitis, L.A.3
  • 3
    • 0033552629 scopus 로고    scopus 로고
    • Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins
    • Itoh M, Furuse M, Morita K et al. Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J. Cell. Biol. 147, 1351-1363 (1999).
    • (1999) J. Cell. Biol. , vol.147 , pp. 1351-1363
    • Itoh, M.1    Furuse, M.2    Morita, K.3
  • 4
    • 67249084776 scopus 로고    scopus 로고
    • Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions
    • Fanning AS, Anderson JM. Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions. Ann. N.Y. Acad. Sci. 1165, 113-120 (2009).
    • (2009) Ann. N.Y. Acad. Sci. , vol.1165 , pp. 113-120
    • Fanning, A.S.1    Anderson, J.M.2
  • 5
    • 77949903147 scopus 로고    scopus 로고
    • Epithelial barriers in homeostasis and disease
    • Overview of the role of tight junctions and role of barrier dysfunction in health and disease
    • Marchiando AM, Graham WV, Turner JR. Epithelial barriers in homeostasis and disease. Annu. Rev. Pathol. 5, 119-144 (2010). Overview of the role of tight junctions and role of barrier dysfunction in health and disease.
    • (2010) Annu. Rev. Pathol. , vol.5 , pp. 119-144
    • Marchiando, A.M.1    Graham, W.V.2    Turner, J.R.3
  • 6
    • 0033521140 scopus 로고    scopus 로고
    • Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3
    • Wittchen ES, Haskins J, Stevenson BR. Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3. J. Biol. Chem. 274, 35179-35185 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 35179-35185
    • Wittchen, E.S.1    Haskins, J.2    Stevenson, B.R.3
  • 7
    • 77951468091 scopus 로고    scopus 로고
    • Multiple facets of intestinal permeability and epithelial handling of dietary antigens
    • Menard S, Cerf-Bensussan N, Heyman M. Multiple facets of intestinal permeability and epithelial handling of dietary antigens. Mucosal Immunol. 3, 247-259 (2010).
    • (2010) Mucosal Immunol. , vol.3 , pp. 247-259
    • Menard, S.1    Cerf-Bensussan, N.2    Heyman, M.3
  • 9
    • 0027744129 scopus 로고
    • Occludin: A novel integral membrane protein localizing at tight junctions
    • Describes the discovery of occludin, an important breakthrough in identification of structure and function of the tight junction (TJs
    • Furuse M, Hirase T, Itoh M et al. Occludin: A novel integral membrane protein localizing at tight junctions. J. Cell. Biol. 123, 1777-1788 (1993). Describes the discovery of occludin, an important breakthrough in identification of structure and function of the tight junction (TJs).
    • (1993) J. Cell. Biol. , vol.123 , pp. 1777-1788
    • Furuse, M.1    Hirase, T.2    Itoh, M.3
  • 10
    • 0032577975 scopus 로고    scopus 로고
    • Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
    • Furuse M, Fujita K, Hiiragi T et al. Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J. Cell. Biol. 141, 1539-1550 (1998).
    • (1998) J. Cell. Biol. , vol.141 , pp. 1539-1550
    • Furuse, M.1    Fujita, K.2    Hiiragi, T.3
  • 11
    • 0035102580 scopus 로고    scopus 로고
    • The roles of claudin superfamily proteins in paracellular transport
    • Heiskala M, Peterson PA, Yang Y. The roles of claudin superfamily proteins in paracellular transport. Traffic 2, 93-98 (2001).
    • (2001) Traffic , vol.2 , pp. 93-98
    • Heiskala, M.1    Peterson, P.A.2    Yang, Y.3
  • 12
    • 2642614521 scopus 로고    scopus 로고
    • Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration
    • Martin-Padura I, Lostaglio S, Schneemann M et al. Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J. Cell. Biol. 142, 117-127 (1998).
    • (1998) J. Cell. Biol. , vol.142 , pp. 117-127
    • Martin-Padura, I.1    Lostaglio, S.2    Schneemann, M.3
  • 13
    • 0035914359 scopus 로고    scopus 로고
    • Protein kinase C regulates the phosphorylation and cellular localization of occludin
    • Andreeva AY, Krause E, Muller EC et al. Protein kinase C regulates the phosphorylation and cellular localization of occludin. J. Biol. Chem. 276, 38480-38486 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 38480-38486
    • Andreeva, A.Y.1    Krause, E.2    Muller, E.C.3
  • 14
    • 0033783241 scopus 로고    scopus 로고
    • Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets
    • Clarke H, Soler AP, Mullin JM. Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets. J. Cell. Sci. 113 (Pt 18), 3187-3196 (2000).
    • (2000) J. Cell. Sci. , vol.113 , Issue.PART 18 , pp. 3187-3196
    • Clarke, H.1    Soler, A.P.2    Mullin, J.M.3
  • 15
    • 0030982357 scopus 로고    scopus 로고
    • Possible involvement of phosphorylation of occludin in tight junction formation
    • DOI 10.1083/jcb.137.6.1393
    • Sakakibara A, Furuse M, Saitou M et al. Possible involvement of phosphorylation of occludin in tight junction formation. J. Cell. Biol. 137, 1393-1401 (1997). (Pubitemid 27265950)
    • (1997) Journal of Cell Biology , vol.137 , Issue.6 , pp. 1393-1401
    • Sakakibara, A.1    Furuse, M.2    Saitou, M.3    Ando-Akatsuka, Y.4    Tsukita, S.5
  • 16
    • 0032550221 scopus 로고    scopus 로고
    • Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions
    • Saitou M, Fujimoto K, Doi Y et al. Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions. J. Cell. Biol. 141, 397-408 (1998).
    • (1998) J. Cell. Biol. , vol.141 , pp. 397-408
    • Saitou, M.1    Fujimoto, K.2    Doi, Y.3
  • 17
    • 0033635344 scopus 로고    scopus 로고
    • Complex phenotype of mice lacking occludin, a component of tight junction strands
    • Saitou M, Furuse M, Sasaki H et al. Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol. Biol. Cell. 11, 4131-4142 (2000).
    • (2000) Mol. Biol. Cell. , vol.11 , pp. 4131-4142
    • Saitou, M.1    Furuse, M.2    Sasaki, H.3
  • 18
    • 20144372620 scopus 로고    scopus 로고
    • High-throughput mapping of a dynamic signaling network in mammalian cells
    • Barrios-Rodiles M, Brown KR, Ozdamar B et al. High-throughput mapping of a dynamic signaling network in mammalian cells. Science 307, 1621-1625 (2005).
    • (2005) Science , vol.307 , pp. 1621-1625
    • Barrios-Rodiles, M.1    Brown, K.R.2    Ozdamar, B.3
  • 19
    • 0033376599 scopus 로고    scopus 로고
    • Claudin-1 contributes to the epithelial barrier function in MDCK cells
    • Inai T, Kobayashi J, Shibata Y. Claudin-1 contributes to the epithelial barrier function in MDCK cells. Eur. J. Cell. Biol. 78, 849-855 (1999).
    • (1999) Eur. J. Cell. Biol. , vol.78 , pp. 849-855
    • Inai, T.1    Kobayashi, J.2    Shibata, Y.3
  • 20
    • 0035013499 scopus 로고    scopus 로고
    • Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability
    • Van IC, Rahner C, Anderson JM. Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. J. Clin. Invest. 107, 1319-1327 (2001).
    • (2001) J. Clin. Invest. , vol.107 , pp. 1319-1327
    • Van, I.C.1    Rahner, C.2    Anderson, J.M.3
  • 21
    • 0345447585 scopus 로고    scopus 로고
    • Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms
    • Bruewer M, Luegering A, Kucharzik T et al. Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J. Immunol. 171, 6164-6172 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 6164-6172
    • Bruewer, M.1    Luegering, A.2    Kucharzik, T.3
  • 22
    • 0036305854 scopus 로고    scopus 로고
    • A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease
    • Zolotarevsky Y, Hecht G, Koutsouris A et al. A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology 123, 163-172 (2002).
    • (2002) Gastroenterology , vol.123 , pp. 163-172
    • Zolotarevsky, Y.1    Hecht, G.2    Koutsouris, A.3
  • 23
    • 45949086355 scopus 로고    scopus 로고
    • Mechanism of IL-1b-induced increase in intestinal epithelial tight junction permeability
    • Al-Sadi R, Ye D, Dokladny K et al. Mechanism of IL-1b-induced increase in intestinal epithelial tight junction permeability. J. Immunol. 180, 5653-5661 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 5653-5661
    • Al-Sadi, R.1    Ye, D.2    Dokladny, K.3
  • 24
    • 63849337600 scopus 로고    scopus 로고
    • Mechanism of cytokine modulation of epithelial tight junction barrier
    • Reviews the molecular effects of cytokines on TJ barrier and mechanisms that mediate modulation of TJ by cytokines
    • Al-Sadi R, Boivin M, Ma T. Mechanism of cytokine modulation of epithelial tight junction barrier. Front. Biosci. 14, 2765-2778 (2009). Reviews the molecular effects of cytokines on TJ barrier and mechanisms that mediate modulation of TJ by cytokines.
    • (2009) Front. Biosci. , vol.14 , pp. 2765-2778
    • Al-Sadi, R.1    Boivin, M.2    Ma, T.3
  • 25
    • 58149352586 scopus 로고    scopus 로고
    • Mechanism of interferon-g-induced increase in T84 intestinal epithelial tight junction
    • Boivin MA, Roy PK, Bradley A et al. Mechanism of interferon-g-induced increase in T84 intestinal epithelial tight junction. J. Interferon Cytokine Res. 29, 45-54 (2009).
    • (2009) J. Interferon Cytokine Res. , vol.29 , pp. 45-54
    • Boivin, M.A.1    Roy, P.K.2    Bradley, A.3
  • 26
    • 0028799226 scopus 로고
    • Tight junctions and the molecular basis for regulation of paracellular permeability
    • Anderson JM, van Itallie CM. Tight junctions and the molecular basis for regulation of paracellular permeability. Am. J. Physiol. 269, G467-G475 (1995).
    • (1995) Am. J. Physiol. , vol.269
    • Anderson, J.M.1    Van Itallie, C.M.2
  • 27
    • 0010617662 scopus 로고    scopus 로고
    • Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability
    • Hecht G, Pestic L, Nikcevic G et al. Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability. Am. J. Physiol. 271, C1678-C1684 (1996).
    • (1996) Am. J. Physiol. , vol.271
    • Hecht, G.1    Pestic, L.2    Nikcevic, G.3
  • 28
    • 70350509805 scopus 로고    scopus 로고
    • Intestinal mucosal barrier function in health and disease
    • Turner JR. Intestinal mucosal barrier function in health and disease. Nat. Rev. Immunol. 9, 799-809 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 799-809
    • Turner, J.R.1
  • 29
    • 77950588683 scopus 로고    scopus 로고
    • Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity
    • Weber CR, Raleigh DR, Su L et al. Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. J. Biol. Chem. 285, 12037-12046 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 12037-12046
    • Weber, C.R.1    Raleigh, D.R.2    Su, L.3
  • 30
    • 33947631511 scopus 로고    scopus 로고
    • IL-1b causes an increase in intestinal epithelial tight junction permeability
    • Al-Sadi RM, Ma TY. IL-1b causes an increase in intestinal epithelial tight junction permeability. J. Immunol. 178, 4641-4649 (2007).
    • (2007) J. Immunol. , vol.178 , pp. 4641-4649
    • Al-Sadi, R.M.1    Ma, T.Y.2
  • 31
    • 13844308129 scopus 로고    scopus 로고
    • Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier: Role of myosin light-chain kinase protein expression
    • Ma TY, Boivin MA, Ye D et al. Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier: Role of myosin light-chain kinase protein expression. Am. J. Physiol. Gastrointest. Liver Physiol. 288, G422-G430 (2005).
    • (2005) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.288
    • Ma, T.Y.1    Boivin, M.A.2    Ye, D.3
  • 32
    • 33749026654 scopus 로고    scopus 로고
    • Disrupted barrier function through epithelial cell apoptosis
    • Schulzke JD, Bojarski C, Zeissig S et al. Disrupted barrier function through epithelial cell apoptosis. Ann. N.Y. Acad. Sci. 1072, 288-299 (2006).
    • (2006) Ann. N.Y. Acad. Sci. , vol.1072 , pp. 288-299
    • Schulzke, J.D.1    Bojarski, C.2    Zeissig, S.3
  • 33
    • 77149154988 scopus 로고    scopus 로고
    • Interleukin-6 is an important in vivo inhibitor of intestinal epithelial cell death in mice
    • Jin X, Zimmers TA, Zhang Z et al. Interleukin-6 is an important in vivo inhibitor of intestinal epithelial cell death in mice. Gut 59(2), 186-196 (2010).
    • (2010) Gut , vol.59 , Issue.2 , pp. 186-196
    • Jin, X.1    Zimmers, T.A.2    Zhang, Z.3
  • 34
    • 55749096587 scopus 로고    scopus 로고
    • Innate immune signalling at intestinal mucosal surfaces: A fine line between host protection and destruction
    • Cario E. Innate immune signalling at intestinal mucosal surfaces: A fine line between host protection and destruction. Curr. Opin. Gastroenterol. 24, 725-732 (2008).
    • (2008) Curr. Opin. Gastroenterol. , vol.24 , pp. 725-732
    • Cario, E.1
  • 35
    • 69249109191 scopus 로고    scopus 로고
    • TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury
    • Ey B, Eyking A, Gerken G et al. TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury. J. Biol. Chem. 284, 22332-22343 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 22332-22343
    • Ey, B.1    Eyking, A.2    Gerken, G.3
  • 36
    • 72149099326 scopus 로고    scopus 로고
    • Enteropathogenic Escherichia coli changes distribution of occludin and ZO-1 in tight junction membrane microdomains in vivo
    • Zhang Q, Li Q, Wang C et al. Enteropathogenic Escherichia coli changes distribution of occludin and ZO-1 in tight junction membrane microdomains in vivo. Microb. Pathog. 48(1), 28-34 (2010).
    • (2010) Microb. Pathog. , vol.48 , Issue.1 , pp. 28-34
    • Zhang, Q.1    Li, Q.2    Wang, C.3
  • 37
    • 70349150966 scopus 로고    scopus 로고
    • Adherent-invasive Escherichia coli, strain LF82 disrupts apical junctional complexes in polarized epithelia
    • Wine E, Ossa JC, Gray-Owen SD et al. Adherent-invasive Escherichia coli, strain LF82 disrupts apical junctional complexes in polarized epithelia. BMC Microbiol. 9, 180 (2009).
    • (2009) BMC Microbiol. , vol.9 , pp. 180
    • Wine, E.1    Ossa, J.C.2    Gray-Owen, S.D.3
  • 38
    • 34547116657 scopus 로고    scopus 로고
    • Salmonella enterica serovar Typhimurium regulates intercellular junction proteins and facilitates transepithelial neutrophil and bacterial passage
    • Kohler H, Sakaguchi T, Hurley BP et al. Salmonella enterica serovar Typhimurium regulates intercellular junction proteins and facilitates transepithelial neutrophil and bacterial passage. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G178-G187 (2007).
    • (2007) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.293
    • Kohler, H.1    Sakaguchi, T.2    Hurley, B.P.3
  • 39
    • 33845477453 scopus 로고    scopus 로고
    • Disruption of tight junctions and induction of proinflammatory cytokine responses in colonic epithelial cells by Campylobacter jejuni
    • Chen ML, Ge Z, Fox JG et al. Disruption of tight junctions and induction of proinflammatory cytokine responses in colonic epithelial cells by Campylobacter jejuni. Infect. Immun. 74, 6581-6589 (2006).
    • (2006) Infect. Immun. , vol.74 , pp. 6581-6589
    • Chen, M.L.1    Ge, Z.2    Fox, J.G.3
  • 40
    • 60149112512 scopus 로고    scopus 로고
    • Lactobacilli facilitate maintenance of intestinal membrane integrity during Shigella dysenteriae 1 infection in rats
    • Moorthy G, Murali MR, Devaraj SN. Lactobacilli facilitate maintenance of intestinal membrane integrity during Shigella dysenteriae 1 infection in rats. Nutrition 25, 350-358 (2009).
    • (2009) Nutrition , vol.25 , pp. 350-358
    • Moorthy, G.1    Murali, M.R.2    Devaraj, S.N.3
  • 41
    • 42149184871 scopus 로고    scopus 로고
    • Lactobacillus rhamnosus strain GG prevents enterohemorrhagic Escherichia coli O157:H7-induced changes in epithelial barrier function
    • Johnson-Henry KC, Donato KA, Shen-Tu G et al. Lactobacillus rhamnosus strain GG prevents enterohemorrhagic Escherichia coli O157:H7-induced changes in epithelial barrier function. Infect. Immun. 76, 1340-1348 (2008).
    • (2008) Infect. Immun. , vol.76 , pp. 1340-1348
    • Johnson-Henry, K.C.1    Donato, K.A.2    Shen-Tu, G.3
  • 42
    • 0030906468 scopus 로고    scopus 로고
    • Fecal β-D-galactosidase production and Bifidobacteria are decreased in Crohn's disease
    • Favier C, Neut C, Mizon C et al. Fecal β-D-galactosidase production and Bifidobacteria are decreased in Crohn's disease. Dig. Dis. Sci. 42, 817-822 (1997).
    • (1997) Dig. Dis. Sci. , vol.42 , pp. 817-822
    • Favier, C.1    Neut, C.2    Mizon, C.3
  • 44
    • 33845995125 scopus 로고    scopus 로고
    • Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
    • Zeissig S, Burgel N, Gunzel D et al. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 56, 61-72 (2007).
    • (2007) Gut , vol.56 , pp. 61-72
    • Zeissig, S.1    Burgel, N.2    Gunzel, D.3
  • 45
    • 0035185891 scopus 로고    scopus 로고
    • Neutrophil transmigration in inflammatory bowel disease is associated with differential expression of epithelial intercellular junction proteins
    • Kucharzik T, Walsh SV, Chen J et al. Neutrophil transmigration in inflammatory bowel disease is associated with differential expression of epithelial intercellular junction proteins. Am. J. Pathol. 159, 2001-2009 (2001).
    • (2001) Am. J. Pathol. , vol.159 , pp. 2001-2009
    • Kucharzik, T.1    Walsh, S.V.2    Chen, J.3
  • 46
    • 37549038994 scopus 로고    scopus 로고
    • JAM-A regulates permeability and inflammation in the intestine in vivo
    • Laukoetter MG, Nava P, Lee WY et al. JAM-A regulates permeability and inflammation in the intestine in vivo. J. Exp. Med. 204, 3067-3076 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 3067-3076
    • Laukoetter, M.G.1    Nava, P.2    Lee, W.Y.3
  • 47
    • 46049083963 scopus 로고    scopus 로고
    • Unique role of junctional adhesion molecule - A in maintaining mucosal homeostasis in inflammatory bowel disease
    • Vetrano S, Rescigno M, Cera MR et al. Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease. Gastroenterology 135, 173-184 (2008).
    • (2008) Gastroenterology , vol.135 , pp. 173-184
    • Vetrano, S.1    Rescigno, M.2    Cera, M.R.3
  • 48
    • 5044238408 scopus 로고    scopus 로고
    • Mast-cell responses to pathogens
    • Marshall JS. Mast-cell responses to pathogens. Nat. Rev. Immunol. 4, 787-799 (2004).
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 787-799
    • Marshall, J.S.1
  • 49
    • 0032966506 scopus 로고    scopus 로고
    • Mast cells are an important cellular source of tumour necrosis factor a in human intestinal tissue
    • Bischoff SC, Lorentz A, Schwengberg S et al. Mast cells are an important cellular source of tumour necrosis factor a in human intestinal tissue. Gut 44, 643-652 (1999).
    • (1999) Gut , vol.44 , pp. 643-652
    • Bischoff, S.C.1    Lorentz, A.2    Schwengberg, S.3
  • 50
    • 0036177948 scopus 로고    scopus 로고
    • Tumour necrosis factor a potentiates ion secretion induced by histamine in a human intestinal epithelial cell line and in mouse colon: Involvement of the phospholipase D pathway
    • Oprins JC, van der Burg C, Meijer HP et al. Tumour necrosis factor a potentiates ion secretion induced by histamine in a human intestinal epithelial cell line and in mouse colon: Involvement of the phospholipase D pathway. Gut 50, 314-321 (2002).
    • (2002) Gut , vol.50 , pp. 314-321
    • Oprins, J.C.1    Van Der Burg, C.2    Meijer, H.P.3
  • 51
    • 24744432512 scopus 로고    scopus 로고
    • Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and b-arrestins
    • Jacob C, Yang PC, Darmoul D et al. Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and b-arrestins. J. Biol. Chem. 280, 31936-31948 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 31936-31948
    • Jacob, C.1    Yang, P.C.2    Darmoul, D.3
  • 52
    • 4444377666 scopus 로고    scopus 로고
    • PAR2 activation alters colonic paracellular permeability in mice via IFN-g-dependent and -independent pathways
    • Cenac N, Chin AC, Garcia-Villar R et al. PAR2 activation alters colonic paracellular permeability in mice via IFN-g-dependent and -independent pathways. J. Physiol. 558, 913-925 (2004).
    • (2004) J. Physiol. , vol.558 , pp. 913-925
    • Cenac, N.1    Chin, A.C.2    Garcia-Villar, R.3
  • 53
    • 0031955440 scopus 로고    scopus 로고
    • The rat mucosal mast cell chymase, RMCP-II, alters epithelial cell monolayer permeability in association with altered distribution of the tight junction proteins ZO-1 and occludin
    • Scudamore CL, Jepson MA, Hirst BH et al. The rat mucosal mast cell chymase, RMCP-II, alters epithelial cell monolayer permeability in association with altered distribution of the tight junction proteins ZO-1 and occludin. Eur. J. Cell. Biol. 75, 321-330 (1998).
    • (1998) Eur. J. Cell. Biol. , vol.75 , pp. 321-330
    • Scudamore, C.L.1    Jepson, M.A.2    Hirst, B.H.3
  • 54
    • 33947418941 scopus 로고    scopus 로고
    • Chymase increases glomerular albumin permeability via protease-activated receptor-2
    • Sharma R, Prasad V, McCarthy ET et al. Chymase increases glomerular albumin permeability via protease-activated receptor-2. Mol. Cell. Biochem. 297, 161-169 (2007).
    • (2007) Mol. Cell. Biochem. , vol.297 , pp. 161-169
    • Sharma, R.1    Prasad, V.2    McCarthy, E.T.3
  • 55
    • 33947575354 scopus 로고    scopus 로고
    • The autonomic nervous system and inflammatory bowel disease
    • Taylor CT, Keely SJ. The autonomic nervous system and inflammatory bowel disease. Auton. Neurosci. 133, 104-114 (2007).
    • (2007) Auton. Neurosci. , vol.133 , pp. 104-114
    • Taylor, C.T.1    Keely, S.J.2
  • 56
    • 0034601140 scopus 로고    scopus 로고
    • Types of neurons in the enteric nervous system
    • Furness JB. Types of neurons in the enteric nervous system. J. Auton. Nerv. Syst. 81, 87-96 (2000).
    • (2000) J. Auton. Nerv. Syst. , vol.81 , pp. 87-96
    • Furness, J.B.1
  • 57
    • 23244443343 scopus 로고    scopus 로고
    • Glial cells in the gut
    • Descriptive review on the role and characteristics of enteric glial cells (EGCs
    • Ruhl A. Glial cells in the gut. Neurogastroenterol. Motil. 17, 777-790 (2005). Descriptive review on the role and characteristics of enteric glial cells (EGCs).
    • (2005) Neurogastroenterol. Motil. , vol.17 , pp. 777-790
    • Ruhl, A.1
  • 58
    • 0141612894 scopus 로고    scopus 로고
    • Interactions between the enteric nervous system and the immune system: Role of neuropeptides and nutrition
    • Genton L, Kudsk KA. Interactions between the enteric nervous system and the immune system: Role of neuropeptides and nutrition. Am. J. Surg. 186, 253-258 (2003).
    • (2003) Am. J. Surg. , vol.186 , pp. 253-258
    • Genton, L.1    Kudsk, K.A.2
  • 59
    • 0032540266 scopus 로고    scopus 로고
    • Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice
    • Demonstrates for the first time that EGCs are crucial in the regulation of the epithelial barrier and identifies EGC-secreted GNSO as a crucial factor in maintaining intestinal barrier function
    • Bush TG, Savidge TC, Freeman TC et al. Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Cell 93, 189-201 (1998). Demonstrates for the first time that EGCs are crucial in the regulation of the epithelial barrier and identifies EGC-secreted GNSO as a crucial factor in maintaining intestinal barrier function.
    • (1998) Cell , vol.93 , pp. 189-201
    • Bush, T.G.1    Savidge, T.C.2    Freeman, T.C.3
  • 60
    • 34247183551 scopus 로고    scopus 로고
    • Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione
    • Savidge TC, Newman P, Pothoulakis C et al. Enteric glia regulate intestinal barrier function and inflammation via release of S- nitrosoglutathione. Gastroenterology 132, 1344-1358 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 1344-1358
    • Savidge, T.C.1    Newman, P.2    Pothoulakis, C.3
  • 61
    • 77950894917 scopus 로고    scopus 로고
    • A by-product of glutathione production in cancer cells may cause disruption in bone metabolic processes
    • Seidlitz EP, Sharma MK, Singh G. A by-product of glutathione production in cancer cells may cause disruption in bone metabolic processes. Can. J. Physiol. Pharmacol. 88, 197-203 (2010).
    • (2010) Can. J. Physiol. Pharmacol. , vol.88 , pp. 197-203
    • Seidlitz, E.P.1    Sharma, M.K.2    Singh, G.3
  • 62
    • 33646260927 scopus 로고    scopus 로고
    • Changes in enteric neurone phenotype and intestinal functions in a transgenic mouse model of enteric glia disruption
    • Aube AC, Cabarrocas J, Bauer J et al. Changes in enteric neurone phenotype and intestinal functions in a transgenic mouse model of enteric glia disruption. Gut 55, 630-637 (2006).
    • (2006) Gut , vol.55 , pp. 630-637
    • Aube, A.C.1    Cabarrocas, J.2    Bauer, J.3
  • 63
    • 33846159496 scopus 로고    scopus 로고
    • Enteric glia inhibit intestinal epithelial cell proliferation partly through a TGF-b1-dependent pathway
    • Neunlist M, Aubert P, Bonnaud S et al. Enteric glia inhibit intestinal epithelial cell proliferation partly through a TGF-b1-dependent pathway. Am. J. Physiol. Gastrointest. Liver Physiol. 292, G231-G241 (2007).
    • (2007) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.292
    • Neunlist, M.1    Aubert, P.2    Bonnaud, S.3
  • 64
    • 70849109591 scopus 로고    scopus 로고
    • Regulation of intestinal epithelial cells transcriptome by enteric glial cells: Impact on intestinal epithelial barrier functions
    • Van LL, Mahe MM, Teusan R et al. Regulation of intestinal epithelial cells transcriptome by enteric glial cells: Impact on intestinal epithelial barrier functions. BMC Genomics 10, 507 (2009).
    • (2009) BMC Genomics , vol.10 , pp. 507
    • Van, L.L.1    Mahe, M.M.2    Teusan, R.3
  • 65
    • 77951631636 scopus 로고    scopus 로고
    • Enteric glial cells protect neurons from oxidative stress in part via reduced glutathione
    • Abdo H, Derkinderen P, Gomes P et al. Enteric glial cells protect neurons from oxidative stress in part via reduced glutathione. FASEB J. 24(4), 1082-1094 (2009).
    • (2009) FASEB J. , vol.24 , Issue.4 , pp. 1082-1094
    • Abdo, H.1    Derkinderen, P.2    Gomes, P.3
  • 66
    • 58149252324 scopus 로고    scopus 로고
    • The vagus nerve as a modulator of intestinal inflammation
    • Comprehensive review on all aspects of modulation of the intestinal immune response by the vagus nerve
    • Van Der Zanden EP, Boeckxstaens GE, de Jonge WJ. The vagus nerve as a modulator of intestinal inflammation. Neurogastroenterol. Motil. 21, 6-17 (2009). Comprehensive review on all aspects of modulation of the intestinal immune response by the vagus nerve.
    • (2009) Neurogastroenterol. Motil. , vol.21 , pp. 6-17
    • Van Der Zanden, E.P.1    Boeckxstaens, G.E.2    De Jonge, W.J.3
  • 67
    • 26844436564 scopus 로고    scopus 로고
    • Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve
    • Luyer MD, Greve JW, Hadfoune M et al. Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. J. Exp. Med. 202, 1023-1029 (2005).
    • (2005) J. Exp. Med. , vol.202 , pp. 1023-1029
    • Luyer, M.D.1    Greve, J.W.2    Hadfoune, M.3
  • 68
    • 56149118481 scopus 로고    scopus 로고
    • Postshock intervention with high-lipid enteral nutrition reduces inflammation and tissue damage
    • de Haan JJ, Lubbers T, Hadfoune M et al. Postshock intervention with high-lipid enteral nutrition reduces inflammation and tissue damage. Ann. Surg. 248, 842-848 (2008).
    • (2008) Ann. Surg. , vol.248 , pp. 842-848
    • De Haan, J.J.1    Lubbers, T.2    Hadfoune, M.3
  • 69
    • 33749321161 scopus 로고    scopus 로고
    • The vagus nerve: A tonic inhibitory influence associated with inflammatory bowel disease in a murine model
    • Ghia JE, Blennerhassett P, Kumar-Ondiveeran H et al. The vagus nerve: A tonic inhibitory influence associated with inflammatory bowel disease in a murine model. Gastroenterology 131, 1122-1130 (2006).
    • (2006) Gastroenterology , vol.131 , pp. 1122-1130
    • Ghia, J.E.1    Blennerhassett, P.2    Kumar-Ondiveeran, H.3
  • 71
    • 68849099107 scopus 로고    scopus 로고
    • Neuroimmune mechanisms in postoperative ileus
    • Boeckxstaens GE, de Jonge WJ. Neuroimmune mechanisms in postoperative ileus. Gut 58, 1300-1311 (2009).
    • (2009) Gut , vol.58 , pp. 1300-1311
    • Boeckxstaens, G.E.1    De Jonge, W.J.2
  • 72
    • 68849103815 scopus 로고    scopus 로고
    • Vagus nerve activity augments intestinal macrophage phagocytosis via nicotinic acetylcholine receptor α4β2
    • Van Der Zanden EP, Snoek SA, Heinsbroek SE et al. Vagus nerve activity augments intestinal macrophage phagocytosis via nicotinic acetylcholine receptor α4β2. Gastroenterology 137, 1029-1039 (2009).
    • (2009) Gastroenterology , vol.137 , pp. 1029-1039
    • Van Der Zanden, E.P.1    Snoek, S.A.2    Heinsbroek, S.E.3
  • 73
    • 68249101621 scopus 로고    scopus 로고
    • Orexigenic hormone ghrelin ameliorates gut barrier dysfunction in sepsis in rats
    • Wu R, Dong W, Qiang X et al. Orexigenic hormone ghrelin ameliorates gut barrier dysfunction in sepsis in rats. Crit. Care Med. 37, 2421-2426 (2009).
    • (2009) Crit. Care Med. , vol.37 , pp. 2421-2426
    • Wu, R.1    Dong, W.2    Qiang, X.3
  • 74
    • 14744277377 scopus 로고    scopus 로고
    • Central vagal stimulation activates enteric cholinergic neurons in the stomach and VIP neurons in the duodenum in conscious rats
    • Yuan PQ, Kimura H, Million M et al. Central vagal stimulation activates enteric cholinergic neurons in the stomach and VIP neurons in the duodenum in conscious rats. Peptides 26, 653-664 (2005).
    • (2005) Peptides , vol.26 , pp. 653-664
    • Yuan, P.Q.1    Kimura, H.2    Million, M.3
  • 75
    • 0024363390 scopus 로고
    • Identification of vagal efferent fibers and putative target neurons in the enteric nervous system of the rat
    • Kirchgessner AL, Gershon MD. Identification of vagal efferent fibers and putative target neurons in the enteric nervous system of the rat. J. Comp. Neurol. 285, 38-53 (1989).
    • (1989) J. Comp. Neurol. , vol.285 , pp. 38-53
    • Kirchgessner, A.L.1    Gershon, M.D.2
  • 76
    • 0024416437 scopus 로고
    • VIP antisera inhibit the relaxatory motor responses of the feline sphincter of Oddi and gall-bladder induced by VIP or vagal nerve stimulation
    • Dahlstrand C, Theodorsson E, Dahlstrom A et al. VIP antisera inhibit the relaxatory motor responses of the feline sphincter of Oddi and gall-bladder induced by VIP or vagal nerve stimulation. Acta Physiol. Scand. 137, 375-378 (1989).
    • (1989) Acta Physiol. Scand. , vol.137 , pp. 375-378
    • Dahlstrand, C.1    Theodorsson, E.2    Dahlstrom, A.3
  • 77
    • 0142150993 scopus 로고    scopus 로고
    • Human ENS regulates the intestinal epithelial barrier permeability and a tight junction-associated protein ZO-1 via VIPergic pathways
    • Neunlist M, Toumi F, Oreschkova T et al. Human ENS regulates the intestinal epithelial barrier permeability and a tight junction-associated protein ZO-1 via VIPergic pathways. Am. J. Physiol. Gastrointest. Liver Physiol. 285, G1028-G1036 (2003).
    • (2003) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.285
    • Neunlist, M.1    Toumi, F.2    Oreschkova, T.3
  • 78
    • 49449094458 scopus 로고    scopus 로고
    • Acetylcholine beyond neurons: The non-neuronal cholinergic system in humans
    • Wessler I, Kirkpatrick CJ. Acetylcholine beyond neurons: The non-neuronal cholinergic system in humans. Br. J. Pharmacol. 154, 1558-1571 (2008).
    • (2008) Br. J. Pharmacol. , vol.154 , pp. 1558-1571
    • Wessler, I.1    Kirkpatrick, C.J.2
  • 79
    • 77950212662 scopus 로고    scopus 로고
    • Neuropeptide receptors in intestinal disease: Physiology and therapeutic potential
    • Snoek SA, Borensztajn KS, van den Wijngaard RM et al. Neuropeptide receptors in intestinal disease: Physiology and therapeutic potential. Curr. Pharm. Des. 16(9), 1091-1105 (2010).
    • (2010) Curr. Pharm. Des. , vol.16 , Issue.9 , pp. 1091-1105
    • Snoek, S.A.1    Borensztajn, K.S.2    Van Den Wijngaard, R.M.3
  • 80
    • 62949144800 scopus 로고    scopus 로고
    • Purinergic neuron-to-glia signaling in the enteric nervous system
    • Gulbransen BD, Sharkey KA. Purinergic neuron-to-glia signaling in the enteric nervous system. Gastroenterology 136, 1349-1358 (2009).
    • (2009) Gastroenterology , vol.136 , pp. 1349-1358
    • Gulbransen, B.D.1    Sharkey, K.A.2
  • 81
    • 34548125019 scopus 로고    scopus 로고
    • Critical role of stress in increased oesophageal mucosa permeability and dilated intercellular spaces
    • Farre R, De VR, Geboes K et al. Critical role of stress in increased oesophageal mucosa permeability and dilated intercellular spaces. Gut 56, 1191-1197 (2007).
    • (2007) Gut , vol.56 , pp. 1191-1197
    • Farre, R.1    De, V.R.2    Geboes, K.3
  • 82
    • 34548077178 scopus 로고    scopus 로고
    • The role of psychological stress in inflammatory bowel disease
    • Mawdsley JE, Rampton DS. The role of psychological stress in inflammatory bowel disease. Neuroimmunomodulation 13, 327-336 (2006).
    • (2006) Neuroimmunomodulation , vol.13 , pp. 327-336
    • Mawdsley, J.E.1    Rampton, D.S.2
  • 83
    • 67849089070 scopus 로고    scopus 로고
    • A role for corticotropin-releasing factor in functional gastrointestinal disorders
    • Tache Y, Kiank C, Stengel A. A role for corticotropin-releasing factor in functional gastrointestinal disorders. Curr. Gastroenterol. Rep. 11, 270-277 (2009).
    • (2009) Curr. Gastroenterol. Rep. , vol.11 , pp. 270-277
    • Tache, Y.1    Kiank, C.2    Stengel, A.3
  • 84
    • 47249141324 scopus 로고    scopus 로고
    • Pathophysiological mechanisms of stress-induced intestinal damage
    • Gareau MG, Silva MA, Perdue MH. Pathophysiological mechanisms of stress-induced intestinal damage. Curr. Mol. Med. 8, 274-281 (2008).
    • (2008) Curr. Mol. Med. , vol.8 , pp. 274-281
    • Gareau, M.G.1    Silva, M.A.2    Perdue, M.H.3
  • 85
    • 73949151843 scopus 로고    scopus 로고
    • Peripheral relays in stress-induced activation of visceral afferents in the gut
    • van den Wijngaard RM, Klooker TK, de Jonge WJ et al. Peripheral relays in stress-induced activation of visceral afferents in the gut. Auton. Neurosci. 153, 99-105 (2010).
    • (2010) Auton. Neurosci. , vol.153 , pp. 99-105
    • Van Den Wijngaard, R.M.1    Klooker, T.K.2    De Jonge, W.J.3
  • 86
    • 0036787474 scopus 로고    scopus 로고
    • Chronic stress induces mast cell-dependent bacterial adherence and initiates mucosal inflammation in rat intestine
    • Soderholm JD, Yang PC, Ceponis P et al. Chronic stress induces mast cell-dependent bacterial adherence and initiates mucosal inflammation in rat intestine. Gastroenterology 123, 1099-1108 (2002).
    • (2002) Gastroenterology , vol.123 , pp. 1099-1108
    • Soderholm, J.D.1    Yang, P.C.2    Ceponis, P.3
  • 87
    • 33646265743 scopus 로고    scopus 로고
    • The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: Mucins, antimicrobial peptides, and microbiota
    • Lievin-Le Moal, V, Servin AL. The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: Mucins, antimicrobial peptides, and microbiota. Clin. Microbiol. Rev. 19, 315-337 (2006).
    • (2006) Clin. Microbiol. Rev. , vol.19 , pp. 315-337
    • Lievin-Le Moal, V.1    Servin, A.L.2
  • 88
    • 0031776639 scopus 로고    scopus 로고
    • Colonic mucin release in response to immobilization stress is mast cell dependent
    • Castagliuolo I, Wershil BK, Karalis K et al. Colonic mucin release in response to immobilization stress is mast cell dependent. Am. J. Physiol. 274, G1094-G1100 (1998).
    • (1998) Am. J. Physiol. , vol.274
    • Castagliuolo, I.1    Wershil, B.K.2    Karalis, K.3
  • 89
    • 33645114029 scopus 로고    scopus 로고
    • Histamine, mast cells, and the enteric nervous system in the irritable bowel syndrome, enteritis, and food allergies
    • Wood JD. Histamine, mast cells, and the enteric nervous system in the irritable bowel syndrome, enteritis, and food allergies. Gut 55, 445-447 (2006).
    • (2006) Gut , vol.55 , pp. 445-447
    • Wood, J.D.1
  • 90
    • 43649100298 scopus 로고    scopus 로고
    • Bacterial flora in irritable bowel syndrome: Role in pathophysiology, implications for management
    • Quigley EM. Bacterial flora in irritable bowel syndrome: Role in pathophysiology, implications for management. J. Dig. Dis. 8, 2-7 (2007).
    • (2007) J. Dig. Dis. , vol.8 , pp. 2-7
    • Quigley, E.M.1
  • 91
    • 33644520005 scopus 로고    scopus 로고
    • Noradrenergic and cholinergic neural pathways mediate stress-induced reactivation of colitis in the rat
    • Saunders PR, Miceli P, Vallance BA et al. Noradrenergic and cholinergic neural pathways mediate stress-induced reactivation of colitis in the rat. Auton. Neurosci. 124, 56-68 (2006).
    • (2006) Auton. Neurosci. , vol.124 , pp. 56-68
    • Saunders, P.R.1    Miceli, P.2    Vallance, B.A.3
  • 92
    • 34447271491 scopus 로고    scopus 로고
    • Mucosal mast cells are pivotal elements in inflammatory bowel disease that connect the dots: Stress, intestinal hyperpermeability and inflammation
    • Farhadi A, Fields JZ, Keshavarzian A. Mucosal mast cells are pivotal elements in inflammatory bowel disease that connect the dots: Stress, intestinal hyperpermeability and inflammation. World J. Gastroenterol. 13, 3027-3030 (2007).
    • (2007) World J. Gastroenterol. , vol.13 , pp. 3027-3030
    • Farhadi, A.1    Fields, J.Z.2    Keshavarzian, A.3
  • 93
    • 0034750910 scopus 로고    scopus 로고
    • Reduction of colonic mucus by repeated short-term stress enhances experimental colitis in rats
    • Pfeiffer CJ, Qiu B, Lam SK. Reduction of colonic mucus by repeated short-term stress enhances experimental colitis in rats. J. Physiol. Paris 95, 81-87 (2001).
    • (2001) J. Physiol. Paris , vol.95 , pp. 81-87
    • Pfeiffer, C.J.1    Qiu, B.2    Lam, S.K.3
  • 94
    • 34247556499 scopus 로고    scopus 로고
    • The role of PPARg on restoration of colonic homeostasis after experimental stress-induced inflammation and dysfunction
    • Ponferrada A, Caso JR, Alou L et al. The role of PPARg on restoration of colonic homeostasis after experimental stress-induced inflammation and dysfunction. Gastroenterology 132, 1791 - 1803 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 1791-1803
    • Ponferrada, A.1    Caso, J.R.2    Alou, L.3
  • 95
    • 58849136276 scopus 로고    scopus 로고
    • Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: Involvement of soluble mediators
    • Piche T, Barbara G, Aubert P et al. Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: Involvement of soluble mediators. Gut 58, 196-201 (2009).
    • (2009) Gut , vol.58 , pp. 196-201
    • Piche, T.1    Barbara, G.2    Aubert, P.3
  • 96
    • 33846193703 scopus 로고    scopus 로고
    • Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome
    • Barbara G, Wang B, Stanghellini V et al. Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome. Gastroenterology 132, 26-37 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 26-37
    • Barbara, G.1    Wang, B.2    Stanghellini, V.3
  • 97
    • 46049111834 scopus 로고    scopus 로고
    • Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation
    • Alonso C, Guilarte M, Vicario M et al. Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation. Gastroenterology 135, 163-172 (2008).
    • (2008) Gastroenterology , vol.135 , pp. 163-172
    • Alonso, C.1    Guilarte, M.2    Vicario, M.3
  • 98
    • 11144310689 scopus 로고    scopus 로고
    • Acute stress-induced hypersensitivity to colonic distension depends upon increase in paracellular permeability: Role of myosin light chain kinase
    • Ait-Belgnaoui A, Bradesi S, Fioramonti J et al. Acute stress-induced hypersensitivity to colonic distension depends upon increase in paracellular permeability: Role of myosin light chain kinase. Pain 113, 141-147 (2005).
    • (2005) Pain , vol.113 , pp. 141-147
    • Ait-Belgnaoui, A.1    Bradesi, S.2    Fioramonti, J.3
  • 99
    • 67349267370 scopus 로고    scopus 로고
    • Acute stress increases colonic paracellular permeability in mice through a mast cell-independent mechanism: Involvement of pancreatic trypsin
    • Demaude J, Leveque M, Chaumaz G et al. Acute stress increases colonic paracellular permeability in mice through a mast cell-independent mechanism: Involvement of pancreatic trypsin. Life Sci. 84, 847-852 (2009).
    • (2009) Life Sci. , vol.84 , pp. 847-852
    • Demaude, J.1    Leveque, M.2    Chaumaz, G.3
  • 100
    • 0031832878 scopus 로고    scopus 로고
    • Structural abnormalities of the nervous system in Crohn's disease and ulcerative colitis
    • Geboes K, Collins S. Structural abnormalities of the nervous system in Crohn's disease and ulcerative colitis. Neurogastroenterol. Motil. 10, 189-202 (1998).
    • (1998) Neurogastroenterol. Motil. , vol.10 , pp. 189-202
    • Geboes, K.1    Collins, S.2
  • 101
    • 0037215542 scopus 로고    scopus 로고
    • Changes in chemical coding of mysenteric neurones in ulcerative colitis
    • Neunlist M, Aubert P, Toquet C et al. Changes in chemical coding of mysenteric neurones in ulcerative colitis. Gut 52, 84-90 (2003).
    • (2003) Gut , vol.52 , pp. 84-90
    • Neunlist, M.1    Aubert, P.2    Toquet, C.3
  • 102
    • 59649121303 scopus 로고    scopus 로고
    • Intestinal cytoskeleton degradation precedes tight junction loss following hemorrhagic shock
    • Thuijls G, de Haan JJ, Derikx JP et al. Intestinal cytoskeleton degradation precedes tight junction loss following hemorrhagic shock. Shock 31, 164-169 (2009).
    • (2009) Shock , vol.31 , pp. 164-169
    • Thuijls, G.1    De Haan, J.J.2    Derikx, J.P.3
  • 103
    • 38349105118 scopus 로고    scopus 로고
    • The potential role for xanthine oxidase inhibition in major intra-abdominal surgery
    • Mittal A, Phillips AR, Loveday B et al. The potential role for xanthine oxidase inhibition in major intra-abdominal surgery. World J. Surg. 32, 288-295 (2008).
    • (2008) World J. Surg. , vol.32 , pp. 288-295
    • Mittal, A.1    Phillips, A.R.2    Loveday, B.3
  • 104
    • 0033944499 scopus 로고    scopus 로고
    • Role of xanthine oxidase in small bowel mucosal dysfunction after surgical stress
    • Anup R, Susama P, Balasubramanian KA. Role of xanthine oxidase in small bowel mucosal dysfunction after surgical stress. Br. J. Surg. 87, 1094-1101 (2000).
    • (2000) Br. J. Surg. , vol.87 , pp. 1094-1101
    • Anup, R.1    Susama, P.2    Balasubramanian, K.A.3
  • 105
  • 106
    • 67249112674 scopus 로고    scopus 로고
    • Metabolic stress evokes decreases in epithelial barrier function
    • Lewis K, McKay DM. Metabolic stress evokes decreases in epithelial barrier function. Ann. N.Y. Acad. Sci. 1165, 327-337 (2009).
    • (2009) Ann. N.Y. Acad. Sci. , vol.1165 , pp. 327-337
    • Lewis, K.1    McKay, D.M.2
  • 107
    • 23744461829 scopus 로고    scopus 로고
    • Intraoperative splanchnic hypoperfusion, increased intestinal permeability, down-regulation of monocyte class II major histocompatibility complex expression, exaggerated acute phase response, and sepsis
    • Holland J, Carey M, Hughes N et al. Intraoperative splanchnic hypoperfusion, increased intestinal permeability, down-regulation of monocyte class II major histocompatibility complex expression, exaggerated acute phase response, and sepsis. Am. J. Surg. 190, 393-400 (2005).
    • (2005) Am. J. Surg. , vol.190 , pp. 393-400
    • Holland, J.1    Carey, M.2    Hughes, N.3
  • 108
    • 33947322314 scopus 로고    scopus 로고
    • Review article: Bacterial translocation in the critically ill - evidence and methods of prevention
    • Gatt M, Reddy BS, MacFie J. Review article: Bacterial translocation in the critically ill - evidence and methods of prevention. Aliment. Pharmacol. Ther. 25, 741-757 (2007).
    • (2007) Aliment. Pharmacol. Ther. , vol.25 , pp. 741-757
    • Gatt, M.1    Reddy, B.S.2    MacFie, J.3
  • 109
    • 30944435036 scopus 로고    scopus 로고
    • Bacterial translocation studied in 927 patients over 13 years
    • MacFie J, Reddy BS, Gatt M et al. Bacterial translocation studied in 927 patients over 13 years. Br. J. Surg. 93, 87-93 (2006).
    • (2006) Br. J. Surg. , vol.93 , pp. 87-93
    • MacFie, J.1    Reddy, B.S.2    Gatt, M.3
  • 110
    • 16444367569 scopus 로고    scopus 로고
    • Current status of bacterial translocation as a cause of surgical sepsis
    • MacFie J. Current status of bacterial translocation as a cause of surgical sepsis. Br. Med. Bull. 71, 1-11 (2004).
    • (2004) Br. Med. Bull. , vol.71 , pp. 1-11
    • MacFie, J.1
  • 111
    • 33947223688 scopus 로고    scopus 로고
    • Bacterial translocation: Overview of mechanisms and clinical impact
    • Balzan S, de Almeida QC, de CR et al. Bacterial translocation: Overview of mechanisms and clinical impact. J. Gastroenterol. Hepatol. 22, 464-471 (2007).
    • (2007) J. Gastroenterol. Hepatol. , vol.22 , pp. 464-471
    • Balzan, S.1    De Almeida, Q.C.2    De, C.R.3
  • 112
    • 76349106672 scopus 로고    scopus 로고
    • Nonhemopoietic cell TLR4 signaling is critical in causing early lipopolysaccharide-induced ileus
    • Buchholz BM, Chanthaphavong RS, Bauer AJ. Nonhemopoietic cell TLR4 signaling is critical in causing early lipopolysaccharide-induced ileus. J. Immunol. 183, 6744-6753 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 6744-6753
    • Buchholz, B.M.1    Chanthaphavong, R.S.2    Bauer, A.J.3
  • 113
    • 58149120941 scopus 로고    scopus 로고
    • New insight in loss of gut barrier during major non-abdominal surgery
    • Derikx JP, van Waardenburg DA, Thuijls G et al. New insight in loss of gut barrier during major non-abdominal surgery. PLoS One 3, e3954 (2008).
    • (2008) PLoS One , vol.3
    • Derikx, J.P.1    Van Waardenburg, D.A.2    Thuijls, G.3
  • 114
    • 51449112151 scopus 로고    scopus 로고
    • Neuroimmunology of the gut: Physiology, pathology, and pharmacology
    • Ben-Horin S, Chowers Y. Neuroimmunology of the gut: Physiology, pathology, and pharmacology. Curr. Opin. Pharmacol. 8, 490-495 (2008).
    • (2008) Curr. Opin. Pharmacol. , vol.8 , pp. 490-495
    • Ben-Horin, S.1    Chowers, Y.2
  • 115
    • 70349731677 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide ameliorates intestinal barrier disruption associated with Citrobacter rodentium-induced colitis
    • Conlin VS, Wu X, Nguyen C et al. Vasoactive intestinal peptide ameliorates intestinal barrier disruption associated with Citrobacter rodentium-induced colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 297(4). 6735-6750 (2009).
    • (2009) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.297 , Issue.4 , pp. 6735-6750
    • Conlin, V.S.1    Wu, X.2    Nguyen, C.3
  • 116
    • 4344601458 scopus 로고    scopus 로고
    • Pretreatment with high-fat enteral nutrition reduces endotoxin and tumor necrosis factor - A and preserves gut barrier function early after hemorrhagic shock
    • Luyer MD, Buurman WA, Hadfoune M et al. Pretreatment with high-fat enteral nutrition reduces endotoxin and tumor necrosis factor-a and preserves gut barrier function early after hemorrhagic shock. Shock 21, 65-71 (2004).
    • (2004) Shock , vol.21 , pp. 65-71
    • Luyer, M.D.1    Buurman, W.A.2    Hadfoune, M.3
  • 117
    • 77951687995 scopus 로고    scopus 로고
    • Selective α7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis
    • Snoek SA, Verstege MI, van Der Zanden EP et al. Selective α7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis. Br. J. Pharmacol. 160, 322-333 (2010).
    • (2010) Br. J. Pharmacol. , vol.160 , pp. 322-333
    • Snoek, S.A.1    Verstege, M.I.2    Van Der Zanden, E.P.3
  • 118
    • 0034222072 scopus 로고    scopus 로고
    • An investigation into the effect and mechanisms of action of nicotine in inflammatory bowel disease
    • Sykes AP, Brampton C, Klee S et al. An investigation into the effect and mechanisms of action of nicotine in inflammatory bowel disease. Inflamm. Res. 49, 311-319 (2000).
    • (2000) Inflamm. Res. , vol.49 , pp. 311-319
    • Sykes, A.P.1    Brampton, C.2    Klee, S.3
  • 120
    • 33644835379 scopus 로고    scopus 로고
    • Sympathetic overactivity in active ulcerative colitis: Effects of clonidine
    • Demonstrates for the first time that EGCs are crucial in the regulation of the epithelial barrier and identifies EGC-secreted GNSO as a crucial factor in maintaining intestinal barrier function
    • Furlan R, Ardizzone S, Palazzolo L et al. Sympathetic overactivity in active ulcerative colitis: Effects of clonidine. Am. J. Physiol. Regul. Integr. Comp. Physiol. 290, R224-R232 (2006). Demonstrates for the first time that EGCs are crucial in the regulation of the epithelial barrier and identifies EGC-secreted GNSO as a crucial factor in maintaining intestinal barrier function.
    • (2006) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.290
    • Furlan, R.1    Ardizzone, S.2    Palazzolo, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.