-
1
-
-
70449180531
-
Problem of secondary failure in the oral treatment of diabetes mellitus
-
article in German
-
Pfeiffer EF, Schoffling K, Steigerwald H, Treser G, Otto M (1957) Problem of secondary failure in the oral treatment of diabetes mellitus. Dtsch Med Wochenschr 82:1528-1531 (article in German)
-
(1957)
Dtsch Med Wochenschr
, vol.82
, pp. 1528-1531
-
-
Pfeiffer, E.F.1
Schoffling, K.2
Steigerwald, H.3
Treser, G.4
Otto, M.5
-
2
-
-
0022544897
-
Secondary failure to treatment with oral antidiabetic agents in non-insulin-dependent diabetes
-
Groop LC, Pelkonen R, Koskimies S, Bottazzo GF, Doniach D (1986) Secondary failure to treatment with oral antidiabetic agents in non-insulin-dependent diabetes. Diab Care 9:129-133
-
(1986)
Diab Care
, vol.9
, pp. 129-133
-
-
Groop, L.C.1
Pelkonen, R.2
Koskimies, S.3
Bottazzo, G.F.4
Doniach, D.5
-
3
-
-
0028817815
-
U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: A progressive disease
-
U.K. Prospective Diabetes Study Group
-
U.K. Prospective Diabetes Study Group (1995) U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. Diabetes 44:1249-1258
-
(1995)
Diabetes
, vol.44
, pp. 1249-1258
-
-
-
4
-
-
0032983666
-
Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49)
-
UK Prospective Diabetes Study (UKPDS) Group
-
Turner RC, Cull CA, Frighi V, Holman RR (1999) Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA 281:2005-2012
-
(1999)
JAMA
, vol.281
, pp. 2005-2012
-
-
Turner, R.C.1
Cull, C.A.2
Frighi, V.3
Holman, R.R.4
-
5
-
-
0037195507
-
Early disturbances in insulin secretion in the development of type 2 diabetes mellitus
-
van Haeften TW (2002) Early disturbances in insulin secretion in the development of type 2 diabetes mellitus. Mol Cell Endocrinol 197:197-204
-
(2002)
Mol Cell Endocrinol
, vol.197
, pp. 197-204
-
-
Van Haeften, T.W.1
-
6
-
-
41149141306
-
Too much of a good thing: Why it is bad to stimulate the beta cell to secrete insulin
-
Aston-Mourney K, Proietto J, Morahan G, Andrikopoulos S (2008) Too much of a good thing: why it is bad to stimulate the beta cell to secrete insulin. Diabetologia 51:540-545
-
(2008)
Diabetologia
, vol.51
, pp. 540-545
-
-
Aston-Mourney, K.1
Proietto, J.2
Morahan, G.3
Andrikopoulos, S.4
-
7
-
-
0032556969
-
Familial hyperinsulinism caused by an activating glucokinase mutation
-
Glaser B, Kesavan P, Heyman M et al (1998) Familial hyperinsulinism caused by an activating glucokinase mutation. N Engl J Med 338:226-230
-
(1998)
N Engl J Med
, vol.338
, pp. 226-230
-
-
Glaser, B.1
Kesavan, P.2
Heyman, M.3
-
8
-
-
70350741368
-
Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia
-
Osbak KK, Colclough K, Saint-Martin C et al (2009) Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia. Hum Mutat 30:1512-1526
-
(2009)
Hum Mutat
, vol.30
, pp. 1512-1526
-
-
Osbak, K.K.1
Colclough, K.2
Saint-Martin, C.3
-
9
-
-
23844470618
-
Importance of mitochondrial superoxide dismutase expression in insulin-producing cells for the toxicity of reactive oxygen species and proinflammatory cytokines
-
Lortz S, Gurgul-Convey E, Lenzen S, Tiedge M (2005) Importance of mitochondrial superoxide dismutase expression in insulin-producing cells for the toxicity of reactive oxygen species and proinflammatory cytokines. Diabetologia 48:1541-1548
-
(2005)
Diabetologia
, vol.48
, pp. 1541-1548
-
-
Lortz, S.1
Gurgul-Convey, E.2
Lenzen, S.3
Tiedge, M.4
-
10
-
-
39149104320
-
The role for endoplasmic reticulum stress in diabetes mellitus
-
Eizirik DL, Cardozo AK, Cnop M (2008) The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 29:42-61
-
(2008)
Endocr Rev
, vol.29
, pp. 42-61
-
-
Eizirik, D.L.1
Cardozo, A.K.2
Cnop, M.3
-
11
-
-
33845405222
-
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
-
Kahn SE, Haffner SM, Heise MA et al (2006) Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med 355:2427-2443
-
(2006)
N Engl J Med
, vol.355
, pp. 2427-2443
-
-
Kahn, S.E.1
Haffner, S.M.2
Heise, M.A.3
-
12
-
-
0035122490
-
Overstimulation and beta-cell function
-
Grill V, Bjorklund A (2001) Overstimulation and beta-cell function. Diabetes 50(Suppl 1):S122-S124
-
(2001)
Diabetes
, vol.50
, Issue.SUPPL. 1
-
-
Grill, V.1
Bjorklund, A.2
-
13
-
-
0024160877
-
Banting lecture 1988. Role of insulin resistance in human disease
-
Reaven GM (1988) Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 37:1595-1607
-
(1988)
Diabetes
, vol.37
, pp. 1595-1607
-
-
Reaven, G.M.1
-
14
-
-
33645304589
-
Insulin resistance, the insulin resistance syndrome, andcardiovasculardisease
-
Reaven GM (2005) Insulin resistance, the insulin resistance syndrome, andcardiovasculardisease. PanminervaMed47:201-210
-
(2005)
PanminervaMed
, vol.47
, pp. 201-210
-
-
Reaven, G.M.1
-
15
-
-
70349863175
-
Beta cell (dys)function in non-diabetic offspring of diabetic patients
-
Stadler M, Pacini G, Petrie J, Luger A, Anderwald C (2009) Beta cell (dys)function in non-diabetic offspring of diabetic patients. Diabetologia 52:2435-2444
-
(2009)
Diabetologia
, vol.52
, pp. 2435-2444
-
-
Stadler, M.1
Pacini, G.2
Petrie, J.3
Luger, A.4
Anderwald, C.5
-
16
-
-
54049144285
-
New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function
-
Perry JR, Frayling TM (2008) New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function. Curr Opin Clin Nutr Metab Care 11:371-377
-
(2008)
Curr Opin Clin Nutr Metab Care
, vol.11
, pp. 371-377
-
-
Perry, J.R.1
Frayling, T.M.2
-
17
-
-
33846944329
-
Metabolic syndrome: A solution in search of a problem
-
Ferrannini E (2007) Metabolic syndrome: a solution in search of a problem. J Clin Endocrinol Metab 92:396-398
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 396-398
-
-
Ferrannini, E.1
-
18
-
-
33745863033
-
Islet beta cell failure in type 2 diabetes
-
Prentki M, Nolan CJ (2006) Islet beta cell failure in type 2 diabetes. J Clin Invest 116:1802-1812
-
(2006)
J Clin Invest
, vol.116
, pp. 1802-1812
-
-
Prentki, M.1
Nolan, C.J.2
-
19
-
-
0036153256
-
Minireview: Secondary beta-cell failure in type 2 diabetes-a convergence of glucotoxicity and lipotoxicity
-
Poitout V, Robertson RP (2002) Minireview: secondary beta-cell failure in type 2 diabetes-a convergence of glucotoxicity and lipotoxicity. Endocrinology 143:339-342
-
(2002)
Endocrinology
, vol.143
, pp. 339-342
-
-
Poitout, V.1
Robertson, R.P.2
-
20
-
-
0036608545
-
Desensitization of insulin secretion
-
Rustenbeck I (2002) Desensitization of insulin secretion. Biochem Pharmacol 63:1921-1935
-
(2002)
Biochem Pharmacol
, vol.63
, pp. 1921-1935
-
-
Rustenbeck, I.1
-
21
-
-
0037219411
-
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
-
Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102-110
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
22
-
-
53549093011
-
Pancreatic beta-cell mass in European subjects with type 2 diabetes
-
Rahier J, Guiot Y, Goebbels RM, Sempoux C, Henquin JC (2008) Pancreatic beta-cell mass in European subjects with type 2 diabetes. Diabetes Obes Metab 10(Suppl 4):32-42
-
(2008)
Diabetes Obes Metab
, vol.10
, Issue.SUPPL.4
, pp. 32-42
-
-
Rahier, J.1
Guiot, Y.2
Goebbels, R.M.3
Sempoux, C.4
Henquin, J.C.5
-
23
-
-
35848963392
-
The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients
-
Marchetti P, Bugliani M, Lupi R et al (2007) The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. Diabetologia 50:2486-2494
-
(2007)
Diabetologia
, vol.50
, pp. 2486-2494
-
-
Marchetti, P.1
Bugliani, M.2
Lupi, R.3
-
24
-
-
0002096610
-
Insulin, oral hypoglycaemic agents and the pharmacology of the endocrine pancreas.
-
Hardman JG, Goodman Gilman A, Limbird LE (eds), McGraw-Hill, New York
-
Davis SN, Granner DK (1996) Insulin, oral hypoglycaemic agents and the pharmacology of the endocrine pancreas. In: Hardman JG, Goodman Gilman A, Limbird LE (eds) The pharmacological basis of therapeutics. McGraw-Hill, New York, pp 1487-1517
-
(1996)
The Pharmacological Basis of Therapeutics
, pp. 1487-1517
-
-
Davis, S.N.1
Granner, D.K.2
-
25
-
-
0014484402
-
Appraisal of the extrapancreatic actions of sulfonylureas
-
Feldman JM, Lebovitz HE (1969) Appraisal of the extrapancreatic actions of sulfonylureas. Arch Intern Med 123:314-322
-
(1969)
Arch Intern Med
, vol.123
, pp. 314-322
-
-
Feldman, J.M.1
Lebovitz, H.E.2
-
26
-
-
0024436438
-
Glyburide enhances the responsiveness of the beta-cell to glucose but does not correct the abnormal patterns of insulin secretion in noninsulin-dependent diabetes mellitus
-
Shapiro ET, van Cauter E, Tillil H et al (1989) Glyburide enhances the responsiveness of the beta-cell to glucose but does not correct the abnormal patterns of insulin secretion in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 69:571-576
-
(1989)
J Clin Endocrinol Metab
, vol.69
, pp. 571-576
-
-
Shapiro, E.T.1
Van Cauter, E.2
Tillil, H.3
-
27
-
-
0022504453
-
Regulation of energy metabolism in pancreatic islets by glucose and tolbutamide
-
Panten U, Zünkler BJ, Scheit S, Kirchhoff K, Lenzen S (1986) Regulation of energy metabolism in pancreatic islets by glucose and tolbutamide. Diabetologia 29:648-654
-
(1986)
Diabetologia
, vol.29
, pp. 648-654
-
-
Panten, U.1
Zünkler, B.J.2
Scheit, S.3
Kirchhoff, K.4
Lenzen, S.5
-
28
-
-
0031737867
-
A minimum of fuel is necessary for tolbutamide to mimic the effects of glucose on electrical activity in pancreatic beta-cells
-
Henquin JC (1998) A minimum of fuel is necessary for tolbutamide to mimic the effects of glucose on electrical activity in pancreatic beta-cells. Endocrinology 139:993-998
-
(1998)
Endocrinology
, vol.139
, pp. 993-998
-
-
Henquin, J.C.1
-
29
-
-
0028140192
-
Long-term randomized placebo-controlled double-blind therapeutic comparison of glipizide and glyburide. Glycemic control and insulin secretion during 15 months
-
Birkeland KI, Furuseth K, Melander A, Mowinckel P, Vaaler S (1994) Long-term randomized placebo-controlled double-blind therapeutic comparison of glipizide and glyburide. Glycemic control and insulin secretion during 15 months. Diab Care 17:45-49
-
(1994)
Diab Care
, vol.17
, pp. 45-49
-
-
Birkeland, K.I.1
Furuseth, K.2
Melander, A.3
Mowinckel, P.4
Vaaler, S.5
-
30
-
-
0017341229
-
Onset and reversibility of changes in secretory function and composition of isolated rat pancreatic islets following long-term administrationof high or low tolbutamide doses
-
Schauder P, Arends J, Frerichs H (1977) Onset and reversibility of changes in secretory function and composition of isolated rat pancreatic islets following long-term administrationof high or low tolbutamide doses. Metabolism 26:9-15
-
(1977)
Metabolism
, vol.26
, pp. 9-15
-
-
Schauder, P.1
Arends, J.2
Frerichs, H.3
-
31
-
-
0032509446
-
2+ concentration
-
Efanova IB, Zaitsev SV, Zhivotovsky B et al (1998) Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration. J Biol Chem 273:33501-33507
-
(1998)
J Biol Chem
, vol.273
, pp. 33501-33507
-
-
Efanova, I.B.1
Zaitsev, S.V.2
Zhivotovsky, B.3
-
32
-
-
12244287074
-
Sulfonylurea induced beta-cell apoptosis in cultured human islets
-
Maedler K, Carr RD, Bosco D, Zuellig RA, Berney T, Donath MY (2005) Sulfonylurea induced beta-cell apoptosis in cultured human islets. J Clin Endocrinol Metab 90:501-506
-
(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 501-506
-
-
Maedler, K.1
Carr, R.D.2
Bosco, D.3
Zuellig, R.A.4
Berney, T.5
Donath, M.Y.6
-
33
-
-
55949116427
-
Chronic antidiabetic sulfonylureas in vivo: Reversible effects on mouse pancreatic beta-cells
-
Remedi MS, Nichols CG (2008) Chronic antidiabetic sulfonylureas in vivo: reversible effects on mouse pancreatic beta-cells. PLoS Med 5:e206
-
(2008)
PLoS Med
, vol.5
-
-
Remedi, M.S.1
Nichols, C.G.2
-
35
-
-
0013844346
-
Studies in obese-hyperglycemic mice
-
Hellman B (1965) Studies in obese-hyperglycemic mice. Ann NY Acad Sci 131:541-558
-
(1965)
Ann NY Acad Sci
, vol.131
, pp. 541-558
-
-
Hellman, B.1
-
36
-
-
33846609221
-
Twelve weeks' treatment with diazoxide without insulin supplementation in type 2 diabetes is feasible but does not improve insulin secretion
-
Radtke M, Kollind M, Qvigstad E, Grill V (2007) Twelve weeks' treatment with diazoxide without insulin supplementation in type 2 diabetes is feasible but does not improve insulin secretion. Diabet Med 24:172-177
-
(2007)
Diabet Med
, vol.24
, pp. 172-177
-
-
Radtke, M.1
Kollind, M.2
Qvigstad, E.3
Grill, V.4
-
37
-
-
70350331457
-
Beneficial effects of K-ATP channel openers in diabetes: An update on mechanisms and clinical experiences
-
Grill V, Radtke M, Qvigstad E, Kollind M, Bjorklund A (2009) Beneficial effects of K-ATP channel openers in diabetes: an update on mechanisms and clinical experiences. Diabetes Obes Metab 11(Suppl 4):143-148
-
(2009)
Diabetes Obes Metab
, vol.11
, Issue.SUPPL.4
, pp. 143-148
-
-
Grill, V.1
Radtke, M.2
Qvigstad, E.3
Kollind, M.4
Bjorklund, A.5
-
39
-
-
0027391607
-
Preserved incretin activity of glucagonlike peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
-
Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W (1993) Preserved incretin activity of glucagonlike peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 91:301-307
-
(1993)
J Clin Invest
, vol.91
, pp. 301-307
-
-
Nauck, M.A.1
Heimesaat, M.M.2
Orskov, C.3
Holst, J.J.4
Ebert, R.5
Creutzfeldt, W.6
-
40
-
-
33847617011
-
Mechanisms of action of glucagonlike peptide 1 in the pancreas
-
Doyle ME, Egan JM (2007) Mechanisms of action of glucagonlike peptide 1 in the pancreas. Pharmacol Ther 113:546-593
-
(2007)
Pharmacol Ther
, vol.113
, pp. 546-593
-
-
Doyle, M.E.1
Egan, J.M.2
-
41
-
-
67349139275
-
Assessing the potential of glucokinase activators in diabetes therapy
-
Matschinsky FM (2009) Assessing the potential of glucokinase activators in diabetes therapy. Nat Rev Drug Discov 8:399-416
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 399-416
-
-
Matschinsky, F.M.1
-
42
-
-
14644396894
-
Discovery and action of glucokinase activators
-
Matschinsky FM, Magnuson MA (eds), Karger, Basel
-
Grimsby J, Matschinsky FM, Grippo JF (2004) Discovery and action of glucokinase activators. In: Matschinsky FM, Magnuson MA (eds) Glucokinase and glycemic disease: from basics to novel therapeutics. Karger, Basel, pp 360-378
-
(2004)
Glucokinase and Glycemic Disease: From Basics to Novel Therapeutics
, pp. 360-378
-
-
Grimsby, J.1
Matschinsky, F.M.2
Grippo, J.F.3
-
43
-
-
0034850648
-
Imidazoline binding sites in the endocrine pancreas: Can they fulfil their potential as targets for the development of new insulin secretagogues?
-
Morgan NG, Chan SL (2001) Imidazoline binding sites in the endocrine pancreas: can they fulfil their potential as targets for the development of new insulin secretagogues? Curr Pharm Des 7:1413-1431
-
(2001)
Curr Pharm des
, vol.7
, pp. 1413-1431
-
-
Morgan, N.G.1
Chan, S.L.2
-
44
-
-
0030611227
-
Phentolamine block of KATP channels is mediated by Kir6.2
-
Proks P, Ashcroft FM (1997) Phentolamine block of KATP channels is mediated by Kir6.2. Proc Natl Acad Sci USA 94:11716-11720
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 11716-11720
-
-
Proks, P.1
Ashcroft, F.M.2
-
46
-
-
73349130452
-
+channel-blocking imidazolines
-
Hatlapatka K, Wienbergen A, Kuhne C, Jörns A, Willenborg M, Rustenbeck I (2009) Selective enhancement of nutrient-induced insulin secretion by ATP-sensitive K +channel-blocking imidazolines. J Pharmacol Exp Ther 331:1033-1041
-
(2009)
J Pharmacol Exp Ther
, vol.331
, pp. 1033-1041
-
-
Hatlapatka, K.1
Wienbergen, A.2
Kuhne, C.3
Jörns, A.4
Willenborg, M.5
Rustenbeck, I.6
-
47
-
-
14744275353
-
Interleukin (IL)-1beta toxicity to islet beta cells: Efaroxan exerts a complete protection
-
Papaccio G, Graziano A, Valiante S, D'Aquino R, Travali S, Nicoletti F (2005) Interleukin (IL)-1beta toxicity to islet beta cells: efaroxan exerts a complete protection. J Cell Physiol 203:94-102
-
(2005)
J Cell Physiol
, vol.203
, pp. 94-102
-
-
Papaccio, G.1
Graziano, A.2
Valiante, S.3
D'Aquino, R.4
Travali, S.5
Nicoletti, F.6
-
48
-
-
64749088645
-
Impact of different bariatric surgical procedures on insulin action and beta-cell function in type 2 diabetes
-
Ferrannini E, Mingrone G (2009) Impact of different bariatric surgical procedures on insulin action and beta-cell function in type 2 diabetes. Diab Care 32:514-520
-
(2009)
Diab Care
, vol.32
, pp. 514-520
-
-
Ferrannini, E.1
Mingrone, G.2
-
49
-
-
45149131667
-
Effects of intensive glucose lowering in type 2 diabetes
-
Gerstein HC, Miller ME, Byington RP et al (2008) Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 358:2545-2559
-
(2008)
N Engl J Med
, vol.358
, pp. 2545-2559
-
-
Gerstein, H.C.1
Miller, M.E.2
Byington, R.P.3
-
50
-
-
53749096863
-
10-year follow-up of intensive glucose control in type 2 diabetes
-
Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA (2008) 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 359:1577-1589
-
(2008)
N Engl J Med
, vol.359
, pp. 1577-1589
-
-
Holman, R.R.1
Paul, S.K.2
Bethel, M.A.3
Matthews, D.R.4
Neil, H.A.5
|