Comparative study of stemness characteristics of mesenchymal cells from bone marrow of children and adults

Cytotherapy

Volumn 12, Issue 7, 2010, Pages 881-887

  Choumerianou, Despoina M ^a   Martimianaki, Georgia ^a   Stiakaki, Eftichia ^a   Kalmanti, Lida ^a   Kalmanti, Maria ^a   Dimitriou, Helen ^a  

^a UNIVERSITY HOSPITAL OF HERAKLION   (Greece)

Author keywords

adults; bone marrow; children; mesenchymal stromal cells; nanog; Oct 4; telomeres

Indexed keywords

CD146 ANTIGEN; CD34 ANTIGEN; ENDOGLIN; FAS ANTIGEN; OCTAMER TRANSCRIPTION FACTOR 4; THY 1 ANTIGEN; TRANSCRIPTION FACTOR NANOG;

ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL STRUCTURE; CELL THERAPY; CHILD; CLINICAL ARTICLE; COLONY FORMING UNIT F; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; MESENCHYME CELL; PRESCHOOL CHILD; PRIORITY JOURNAL; STROMA CELL; TELOMERE; TISSUE ENGINEERING;

EID: 77958020348     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.3109/14653249.2010.501790     Document Type: Article

References (32)

1. Prockop DJ. Marrow stromal cells as stem cells for nonhe-maopoietic tissues. Science. 1997;276:71-4.
2. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Moscka JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143-7.
3. Caplan AI, Bruder SP. Mesenchymal stem cells: building blocks for molecular medicine in the 21st century. Trends Mol Med. 2001;7:259-64.
4. D ' Ippolito G, Schiller PC, Ricordi C, Roos BA, Howard GA. Age-related osteogenic potential of mesenchymal stromal cells from human vertebral bone marrow. J Bone Miner Res. 1999;14:1115-22.
5. Zhou S, Greenberger JS, Epperly MW, Goff JP, Adler C, LeBoff MS, et al. Age related intrinsic changes in human bone marrow derived mesenchymal stem cells and their differentiation to osteoblasts. Aging Cells. 2008;7:335-43.
6. Mareschi K, Ferrero I, Rustichelli D, Aschero S, Gammaitoni L, Aglietta M, et al. Expansion of mesenchy-mal stem cells isolated from pediatric and adult donor bone marrow. J Cell Biochem. 2006;97:744-54.
7. Sethe S, Scutt A, Stolzing A. Aging of mesenchymal stem cells. Ageing Res Rev. 2006;5:91-116.
8. Stolzing A, Jones E, McGonagle D, Scutt A. Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. Mech Ageing Dev. 2008;129:163-73.
9. Vulliamy T, Marrone A, Goldman F, Dearlove A, Bessler M, Mason PJ, et al. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenital. Nature. 2001;413:432-5.
10. Vaziri H, Dragowska W, Allsopp RC, Thomas TE, Harley CB, Lansdorp PM. Evidence of mitotic clock in hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci USA. 1994;91:9857-60.
11. D'Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature. 2003;426: 194-8.
12. Liedtke S, Stephan M, Kogler G. Oct-4 expression revisited: potential pitfalls for data misinterpretation in stem cell research. Biol Chem. 2008;389:845-50.
13. Guillot PV, Gotherstrom C, Chan J, Kurata H, Fisk NM. Human first-trimester fetal MSC express pluripotency markers and grow faster and have longer telomeres than adult MSC. Stem Cells. 2007;25:646-54.
14. Zangrossi S, Marabese M, Broggini M, Giordano R, D'Erasmo M, Montelatici E, et al. Oct-4 expression in adult human differentiated cells challenges its role as a pure stem cell marker. Stem Cells. 2007;25:1675-80.
15. Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 2003;113:631-42.
16. Provan D, Stasi R, Newland AC, Blanchette VS, Bolton-Maggs P, Bussel JB, et al. International consensus report on the investigation and management of primary immune throm-bocytopenia. Blood. 2010;115:168-86.
17. Dinauer MC, Newburger PE. The phagocyte system and disorders of Granulopoiesis and Granulocyte function. In: Orkin SH, Fisher DE, Look AT, Lux SE IV, Ginsburg D, Nathan DG. Nathan and Oski' s Hematology of Infancy and Childhood. 7th ed Philadelphia: Saunders/Elsevier; 2009. p. 1147-52.
18. Dimitriou H, Linardakis E, Martimianaki G, Stiakaki E, Perdikogianni CH, Charbord P, et al. Properties and potential of bone marrow mesenchymal stromal cells from children with hematologic diseases. Cytotherapy. 2008;10:125-33.
19. Dimitriou H, Perdikogianni C, Martimianaki G, Choume-rianou DM, Pelagiadis J, Kalmanti M. Are mesenchymal stromal cells from children resistant to apoptosis? Cell Prolif. 2009;42:276-83.
20. Pelagiadis I, Dimitriou H, Kalmanti M. Biologic characteristics of mesenchymal stromal cells and their clinical applications in pediatric patients. J Pediatr Hematol Oncol. 2008; 30:301-9.
21. Granero-Molto F, Weis JA, Longobardi L, Spagnoli A. Role of mesenchymal stem cells in regenerative medicine: application to bone and cartilage repair. Expert Opin Biol Ther. 2008;8:255-68.
22. Ozawa K, Sato K, Oh I, Ozaki K, Uchibori R, Obara Y, et al. Cell and gene therapy using mesenchymal stem cells (MSCs). J Autoimmun. 2008;30:121-7.
23. Yen BL, Chien CC, Chen YC, Chen JT, Huang JS, Lee FK, et al. Placenta-derived multipotent cells differentiate into neu-ronal and glial cells in vitro. Tissue Eng A. 2008;14:9-17.
24. Tsai MS, Lee JL, Chang YJ, Hwang SM. Isolation of human multipotent mesenchymal stem cells from second-trimester amniotic fl uid using a novel two-stage culture protocol. Hum Reprod. 2004;19:1450-6.
25. IN ' t Anker PS, Noort WA, Scherjon SA, Kleijburg-van der Keur C, Kruisselbrink AB, van Bezooijen RL, et al. Mesenchymal stem cells in human second-trimester bone marrow, liver lung, and spleen exhibit a similar immunophe-notype but a heterogeneous multilineage differentiation potential. Hematologica. 2003;88:845-52.
26. De la Fuente J, O ' Donoghue K, Kumar S, Chan J, Fisk NM, Roberts IA. Ontogeny-related changes in integrin expression and cytokine production by fetal mesenchymal stem cells (MSC). Blood. 2002;v 100:526a.
27. Perdikogianni C, Dimitriou H, Stiakaki E, Martimianaki G, Kalmanti M. Could cord blood be a source of mesenchymal stromal cells for clinical use? Cytotherapy. 2008;10:452-9.
28. Banfi A, Bianchi G, Notaro R, Luzzatto L, Cancedda R, Quarto R. Replicative aging and gene expression in long term cultures of human marrow stromal cells. Tissue Eng. 2002;8: 901-10.
29. Humphrey RK, Beattie GM, Lopez AD, Bucay N, King CC, Firpo MT, et al. Maintenance of pluripotency in human embryonic stem cells is STAT3 independent. Stem Cells. 2004;22:522-30.
30. Pain D, Chirn G, Strassel C, Kemp DM. Multiple retropseu-dogenes from pluripotent cell-specific gene expression indicates a potential signature for novel gene identification. J Biol Chem. 2005;280:6265-8.
31. Choumerianou DM, Dimitriou H, Perdikogianni C, Mar-timianaki G, Riminucci M, Kalmanti M. Study of oncogenic transformation in ex vivo expanded mesenchymal cells from bone marrow of children. Cell Prolif. 2008;41:909-22.
32. Baxter MA, Wynn RF, Jowitt SN, Wraith JE, Fairbairn LJ, Bellantuono I. Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion. Stem Cells. 2004;22:675-82.