Evaluation of antihepatotoxic effect of watercress extract and its fractions in rats

International Journal of Pharmacology

Volumn 6, Issue 6, 2010, Pages 896-902

  Ebadollahi Natanzi, A R ^a,b   Ghahremani, M H ^a   Monsef Esfeham, H R ^a   Minaei, M B ^c   Nazarian, H ^b   Sabzevari, O ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Agricultural Research Education and Extension Organization   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Hepatoprotection; Hepatotoxicity; Nasturtium officinale; Paracetamol; Sequential fractions

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ASPARTATE AMINOTRANSFERASE; BUTANOL; LACTATE DEHYDROGENASE; PARACETAMOL; PETROLEUM ETHER; PLANT EXTRACT; UNCLASSIFIED DRUG; WATER; WATERCRESS EXTRACT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFICACY; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; HISTOPATHOLOGY; LACTATE DEHYDROGENASE BLOOD LEVEL; LD 50; LIVER CELL DAMAGE; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; RAT; SINGLE DRUG DOSE; WATERCRESS;

EID: 77957996585     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2010.896.902     Document Type: Article

References (33)

1. Bahramikia, S. and R. Yazdanparast, 2008. Effect of hydro alcoholic extracts of Nasturtium officinale leaves on lipid profile in high fat diet rats. J. Ethnopharmacol., 115: 116-121.
2. Basu, S.K., M. Rupeshkumar and K. Kavitha, 2009. Hepatoprotective and antioxidant effect of Andrographis echioides N. against acetaminophen induced hepatotoxicity in rats. J. Biol. Sci., 9: 351-356.
3. Beumer, J.H., J.H.M. Schellens and J.H. Beynen, 2005. Hepatotoxicity and metabolism of trabectedin: a literature review. Pharmacol. Res., 51: 391-398.
4. Chen, Y.H., F.Y. Lin, P.L. Liu, Y.T. Huang and J.H. Chiu et al., 2009. Antioxidative and hepatoprotective effects of Magnolol on acetaminophen-induced liver damage in rats. Arch. Pharm. Res., 32: 221-228.
5. Dahhn, D.C., G.T. Miwa, A.Y. Lu and S.D. Nelson, 1984. N-acetyl-p-benzoquinone imine: A cytochrome P-450-mediated oxidation product of acetaminophen. Proc. Natl. Acad. Sci. USA., 81: 1327-1331.
6. Fakurazi, S., U. Nanthini and I. Hairuszah, 2008. Hepatoprotective and antioxidant action of Moringa oleifera Lam.against acetaminophen induced hepatotoxicity in rats. Int. J. Pharmacol., 4: 270-275.
7. Fakurazi, S., I. Hairuszah, J. Mohd-Lip, G. Shanthi and U. Nanthini et al., 2009. Hepatoprotective action of zerumbone against paracetamol induced hepatotoxicity. J. Med. Sci., 9: 161-164.
8. Guengrich, F.P., 2000. Metabolism of chemical carcinogen. Carcinogenesis, 21: 341-351.
9. Handa, S.S., A. Sharma and K.K. Chakraborti, 1986. Natural products and plants as liver protecting drugs. Fitoterapia, 57: 307-351.
10. Harbon, J.B., 1998. A Guide to Modern Techniques of Plant Analysis Recommended Techniques (A) Glucosinolate. 3rd Edn., Chapman and Hall, London, pp: 180-182.
11. Hayes, J.D., M.O. Kelleher and I. M. Eggleston, 2008. The cancer chemopreventive actions of phytochemicals derived from glucosinolates. Eur. J. Nutr., 47: 73-88.
12. Hinson, J., 1983. Reactive metabolites of phenacetin and acetaminophen: A review. Environ. Health Perspect, 49: 71-79.
13. Hodgson E. and H. Cunny, 2004. A Text Book of Modern Toxicology. 3rd Edn., John Wiley and Sons, USA.
14. Hofman, T., A. Kuhnert, A. Schubert, C. Gill, I.R. Rowland, B.L. Pool-Zobel and M. Glei. 2009. Modulation of detoxification enzymes by watercress: In vitro and in vivo investigations in human peripheral blood cells. Eur. J. Nutr., 48: 483-491.
15. Jaeschke, H., G.J. Gores, A.I. Cederbaum, J.A. Hinson, P. Dominique and J.J. Lemasters, 2002. Mechanisms of hepatotoxicity. Toxicol. Sci., 65: 166-176.
16. Kanter, M.Z., 2006. Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning. Am. J. Health Syst. Pharm., 63: 1821-1827.
17. Kessler F.K., M. Kessler, D. Auyeung and J. Ritter, 2002. Glucurorinidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyl transferases. Drug Metabial. Dispos, 30: 324-330.
18. Kew, M.C., 2000. Serum aminotransferase concentration as evidence of hepatocellular damage. Lancet, 355: 591-592.
19. Kitteringham, N.R., C. Lambert, J.L. Maggs and J. Colbert, 1988. A comparative study of the formation of chemically reactive drug metabolites by human liver microsomes. Br. J. Clin. Pharmacol., 26: 13-21.
20. Konsue, N. and C. Ioannidis, 2010. Modulation of carcinogen-metabolising cytochromes P450 inhuman liver by the chemopreventive phytochemical phenethyl isothiocyanate, a constituent of cruciferous vegetables. Toxicology, 268: 184-190.
21. Lhoste E.F., K. Glouxk, I. De Wazier, S. Garrido and S. Lorry et al., 2004. The activities of several detoxification enzymes are deferentially induced by juices of garden cress and mustard in human Hep G2 cells. Chem. Biol. Interact, 150: 211-219.
22. Moling, O., E. Cairon, G. Rimenti, F. Rizzi, R. Pristira and P. Mian, 2006. Sever hepatotoxicity after therapeutic doses of acetaminophen. Clin. Ther., 28: 755-760.
23. OCED, 2001. The OECD Guideline for Testing of Chemical. The Organization of Economic Co-Operation Development, Paris, pp: 1-14.
24. Ozen, T., 2009. Investigation of antioxidant properties of Nasturtium officinale (watercress) leaf extracts. Acta Pol. Pharm., 66: 187-193.
25. Prakash, O., G.N. Singh, R.M. Singh, S.C. Mathur, M. Bajpai and S. Yadav, 2008. Protective effect of a herbal formula against carbontetrachloride induced hepatotoxicity. Int. J. Pharmacol., 4: 282-286.
26. Reen, R.K, M. Karan, K. Singh, V. Karan, R.K. John and J. Singh, 2001. Screening of various Swertia species extracts in primary monolayer cultures of rat hepatocytes against carbon tetrachloride and paracetamol-induced toxicity. J. Ethnopharmacol., 75: 239-247.
27. Smith, J. A., I.D. Hme, P. Beck and P. A. Routledge, 1986. Paracetamol toxicity: Is enzyme induction important? Hum. Toxicol, 5: 383-385.
28. Steinbrecher, A., K. Nimptsch, A. Husing, S. Rohrmann and J. Linseisen, 2009. Dietary glucosinolate intake and risk of prostate cancer in the EPIC-Heidelberg cohort study. Int. J. Cancer, 125: 2179-2186.
29. Vermeulen, N.P.E., J.G.M. Bessems and R. van de Streat, 1992. Molecular aspects of paracetamol induced hepatotoxicity and its mechanism based prevention. Drug Metab. Rev., 24: 367-407.
30. Walhg, M.A., S. Kingston, R. Stack and E. Jeffery, 1998. Induction of rat pancreatic glutathione s-transferase and quinone reductase activities by a mixture of glucosinolate breakdown derivatives found in Brussels sprouts. Food Chem. Toxicol., 36: 365-373.
31. William, R.T., 1971. Detoxification Mechanisms. John Willey, New York, USA.
32. Yemitan, O.K. and M.C. Izegbu, 2006. Protective effects of Zingiber officinale (Zingiberaceae) against carbon tetrachloride and acetaminophen-induced hepatotoxicity in rats. Phytother. Res., 20: 997-1002.
33. Zhang, Q., Z. Melnikov and D.E. Feierman, 2004. Characterization of the acetaminophen-induced degradation of cytochrome p450-3A4 and the proteolytic pathway. Basic Clin. Pharmacol. Toxicol., 94: 191-200.