Protective effect of a herbal formula against carbontetrachloride induced hepatotoxicity

International Journal of Pharmacology

Volumn 4, Issue 4, 2008, Pages 282-286

  Prakash, O ^a   Singh, G N ^a   Singh, Raman Mohan ^a   Mathur, S C ^a   Bajpai, M ^b   Yadav, S ^b  

^a GOVERNMENT OF INDIA   (India)

^b Rajkumar Goel Institute of Technology   (India)

Author keywords

Carbontetrachloride; Hepatoprotective; Herbal formula; Serum glutamate oxaloacetate transminase; Serum glutamate pyruvate transaminase

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BACOPA MONNIERI EXTRACT; BCEZ; CARBON TETRACHLORIDE; CURCUMA LONGA EXTRACT; EMBLICA OFFICINALIS EXTRACT; GINGER EXTRACT; HERBACEOUS AGENT; SILYMARIN; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; HISTOPATHOLOGY; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN;

EID: 60249085247     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2008.282.286     Document Type: Article

References (25)

1. Achliya, G.S., S.G. Wadodkar and A.K. Dorle, 2004. Evaluation of hepatoprotective effect of Amalkadi Ghrita against carbon tetrachloride-induced hepatic damage in rats. J. Ethnopharmacol., 90: 229-232.
2. Al-Rehailya, A.J., T.S. Al-Howirinya, M.O. Al-Sohaibanib and S. Rafatullaha, 2002. Gastroproteetive effects of Amla Emblica officinalis on in vivo test models in rats. Phytomedicine, 9: 515-522.
3. Ammon, H.P.T. and. M-A. Wahl, 1991. Pharmacology of Curcuma longa. Planta Medica, 57: 1-7.
4. Bhandari, U., J.N. Sharma and R. Zafar, 1998. Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats. J. Ethnopharmacol., 61: 167-171.
5. Bhandari, U., A. Anwer Shamsher, K.K. Pillai and M.S.Y. Khan, 2003. Antihepatotoxic activity of ginger ethanol extract in rats. Phamaceut. Biol., 41: 68-71.
6. Bhattacharya, A., A. Chatterjee, S. Ghosal and S.K. Bhattacharya, 1999. Antioxidant activity of active tannoid principles of Emblica officinalis (Amla). Indian J. Experi. Biol., 37: 676-680.
7. Brautbar, N. and J. Williams, 2002. Industrial solvents and liver toxicity: Risk assessment, risk factors and mechanisms. Int. J. Hyg. Environ. Health, 205: 479-491.
8. Brent, J.A. and B.H. Rumack, 1993. Role of free radicals in toxic hepatic injury. J. Toxicol. Clin. Toxicol., 31: 173-196.
9. 4-induced liver injury and survival in rats. J. Ethnopharmacol., 56: 159-164.
10. Dutta, B.K., I. Rahman and J.K. Das, 1998. Antifungal activity of Indian plant extracts. Mycoses, 41: 535-536.
11. Jose, J.K. and R. Kuttan, 2000. Hepatoprotective activity of Emblica officinalis and chyavanaprash. J. Ethnopharmacol., 72: 135-140.
12. Lowry, O.H., N.J. Rosenbrough, A.L. Farr and R.J. Randall, 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem., 193: 265-275.
13. Maiti, K., K. Mukherjee, A. Gantait, H.N. Ahamed, B.P. Saha and P.K. Mukherjee, 2005. Enhanced therapeutic benefit of quercetin-phospholipid complex in carbon tetrachloride induced acute liver injury in rats: A comparative study. Iranian J. Pharmacol. Therapeut., 4: 84-90.
14. Mathur, R.A., A. Sharma, V.P. Dixit and M. Varma, 1996. Hypolipidaemic effect of fruit juice of Emblica officinalis in cholesterol-fed rabbits. J. Ethnopharmacol., 50: 61-68.
15. Mitra, S.K., M.V. Venkataranganna, R. Sundaram and S. Gopumadhavan, 1998. Protective effect of HD-03, a herbal formulation, against various hepatotoxic agents in rats. J. Ethnopharmacol., 63: 181-186.
16. Mitra, S.K., S.J. Seshadri, M.V. Venkantaranganna, S. Gopumaaaaaadhavan, U. Venkatesh Udapa and D.N.K. Sarma, 2000. Effect of HD-03 -a herbal formulation in galactosamine-induced hepatopathy in rats. Indian J. Physiol. Pharmacol., 44: 82-86.
17. Penna, S.C., M.V. Medeiros, F. S.C. Aimbire, H.C.C. Faria-Neto, J.A. Sertie and R.A. Lopes-Martins, 2003. Anti-inflammatory effect of the hydroalcholic extract of Zingiber officinale rhizomes on rat paw and skin edema. Phytomedicine, 10: 381-385.
18. Perianayagam, J.B., S.K. Sharma, A. Joseph and A.J. Christina, 2004. Evaluation of anti-pyretic and analgesic activity of Emblica officinalis Gaertn. J. Ethnopharmacol., 95: 83-85.
19. Rege, N.N., U.M. Thatte and S.A. Dahanukar, 1999. Adaptogenic properties of six rasayana herbs used in Aurvedic medicine. Phytother. Res., 13: 275-291.
20. Sairam, K., Ch.V. Rao, M.D. Babu, K.V. Kumar, V.K. Agrawal and R.K. Goel, 2002a. Antiulcerogenic effect of methanolic extract of Emblica officinalis: An experimental study. J. Ethnopharmacol., 82: 1-9.
21. Sairam, M., D. Neetu, B. Yogesh, B. Anju and P. Dipti et al., 2002b. Cyto-protective and immunomodulating properties of Amla ( Emblica officinalis) on lymphocytes: An in vitro study. J. Ethnopharmacol., 81: 5-10.
22. Sallie, R., J.M. Tredger and R. Williams, 1991. Drugs and the liver Part 1: Testing liver function. Biopharm. Drug Dispos., 12: 251-259.
23. Subramoniam, A., D.A. Evans, S. Rajasekharan and P. Pushpangadan, 1998. Hepatoprotective activity of Trichopus zeylanicus extracts against paracetamol induced hepatic damage in rats. Indian J. Exp. Biol., 36: 385-389.
24. Tripathi, Y.B., S. Chaurasia, E. Tripathi, A. Upadhyay and G.P. Dubey, 1996. Bacopa monniera Linn. as an antioxidant: Mechanism of action. Indian J. Exp. Biol., 34: 523-526.
25. Venkateswaran, S., L. Pari, P. Viswanathan and V.P. Menon, 1997. Protective effect of Livex, a herbal formulation against erythromycin estolate induced hepatotoxicity in rats. J. Ethnopharmacol., 57: 161-167.