Hepatoprotective and antioxidant action of Moringa oleifera lam. againsts acetaminophen induced hepatoxicity in rats

International Journal of Pharmacology

Volumn 4, Issue 4, 2008, Pages 270-275

  Fakurazi, S ^a   Nanthini, U ^a   Hairuszah, I ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Acetaminophen; Glutathione; Hepatoprotective; Hepatotoxicity; Moringa oleifera; Paracetamol

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; GLUTATHIONE; MORINGA OLEIFERA EXTRACT; PARACETAMOL; SILYMARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; HISTOPATHOLOGY; LIVER LEVEL; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; RAT; SPRAGUE DAWLEY RAT;

EID: 60249100428     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2008.270.275     Document Type: Article

References (25)

1. Ahmed, B. M. and M.R. Khater, 2001. Evaluation of the protective potential of Ambrosia maritime extract on acetaminophen-induced liver damage. J. Ethnopharmacol., 75: 169-174.
2. Anwar, F., S. Latif, M. Ashraf and A.H. Gilani 2007. Moringa oleifera: A food plant with multiple medicinal uses. Phytother. Res., 21: 17-25.
3. Asha, V.V., S. Akhila, P.J. Wills and A. Subramoniam, 2004. Further studies on the antihepatotoxic activity of Phyllanthus maderaspatensis Linn. J. Ethnopharmacol., 92: 67-70.
4. Cáceres, A., A. Saravia, S. Rizzo, L. Zabala, E. De Leon and F. Nave, 1992. Pharmacologic properties of Moringa oleifera. 2: Screening for antispasmodic, anti-inflammatory and diuretic activity. J. Ethnopharmacol., 36: 233-237.
5. Chung, Y.H., J.A. Kim, B.C. Song Song, I.H. Koh, M.S. Lee, H.C. Eunsil, Y.S. Lee and D.J. Su, 2001. Centrilobular hepatic necrosis; Isocitrate dehydrogenase as a marker of centrilobular model of rats. J. Gastroenterol. Hepatol., 16: 328-332.
6. Costa Lotufo, L.V., M.T. Khan, A. Ather, D.V. Wilke, P.C. Jimenez, C. Pessoa, M.E. de Moraes and M.O. de Moraes, 2005. Studies of anticancer potential of plant used in Bangladeshi folk medicine. J. Ethnopharmacol., 99: 21-30.
7. Ellman, G.L., 1959. Tissue sulphydryl groups. Arch. Biochem. Biophys., 82: 70-77.
8. Faizi, S., B.S. Siddiqui, R. Saleem, S. Siddiqui, K. Aftab and A.H. Gilani, 1995. Fully acetylated carbamate and hypotensive thiocarbamate glycosides from Moringa oleifera. Phytochemistry, 38: 957-963.
9. Giordano, F.J., 2005. Oxygen, oxidative stress, hypoxia and heart failure. J. Clin. Invest., 115: 500-508.
10. Guevara, A.P., C. Vargas, H. Sakurai, Y. Fujiwara, K. Hashimoto, T. Maoka, M. Kozuka, Y. Ito, H. Tokuda and H. Nishino, 1999. Antitumour promoter from Moringa oleifera Lam. Mutat. Res., 440: 181-188.
11. Hewawasam, R.P., K.A.P.W. Jayatilaka, C. Pathirana and L.K.B. Mudduwa, 2004. Hepatoprotective effect of Epaltes divaricata extract on carbon tetrachloride induced hepatotoxicity in mice. Indian J. Med. Res., 120: 30-34.
12. Hossain, M.Z., B.A. Shibib and R. Rahman, 1992. Hypoglycemic effects of Coccinia indica inhibition of key gluconeogenic enzyme, glucose-6-Phosphatase. Indian. J. Exp. Biol., 30: 418-420.
13. Jaeschke, H., T.R. Knight J.J. Lemasters and M. Bajt, 2003. Oxidant stress precedes liver injury after acetaminophen in cultured mouse hepatocytes. Toxicol. Sci., 72: 10-10.
14. James, LP., P.R. Mayeux and J.A. Hison, 2003. Acetaminophen induced hepatotoxicity. Drug Metab. Dispos., 31: 1499-1506.
15. Kumar, G., G.S. Banu, P.V. Pappa, M. Sundararajan and M.R. Pandian, 2004. Hepatoprotective activity of Trianthema portulacastrum L. against paracetamol and thioacetamide intoxication in albino rats. J. Ethnopharmacol., 92: 37-40
16. Kumar, N.A. and L. Pari, 2003. Antioxidant action of Moringa oleifera Lam. (Drumstick) against antitubercular drugs induced lipid peroxidation in rats. J. Med. Food, 6: 255-259.
17. Kumari, P., P. Sharma, S. Srivastava and M.M. Srivastava, 2005. Arsenic removal from the aqueous system using plant biomass: A bioremedial approach. J. Ind. Microbiol. Biotechnol., 32: 521-526.
18. Lampronti, I., M.T. Khan, N. Bianchi, A. Ather, M. Borgatti, L. Vizziello, E. Fabbri and R. Gambari, 2005. Bangladeshi medicinal plant extracts exhibiting molecular interactions between nuclear factors and target DNA sequences mimicking NF-kappa B binding sites. Med. Chem., 1: 327-333.
19. Mehta, K., R. Balaraman, A.H. Amin, P.A. Bafna and O.D. Gulati, 2003. Effects of fruits of Moringa oleifera on lipid profile of normal and hypercholestrolaemic rabbits. J. Ethnopharmacol., 86: 191-195.
20. Michell, J.R., D.J. Jollow, W.Z. Potter, J.R. Gillette and B.B. Brodie, 1973. Acetaminophen induced hepatic necrosis. IV. Protective role of glutathione. J. Pharmacol. Exp. Ther., 187: 211-217.
21. Sharma, P., P. Kumari, M.M. Srivastava and S. Srivastava, 2006. Removal of cadmium from the aqueous system by shelled Moringa oleifera Lam. Seed powder. Bioresour. Technol., 97: 299-305.
22. Shyamal, S., P.O. Latha, V.J., Shine, S.R. Suja, S. Rajasekharan and T.G. Devi, 2006. Hepatoprotective effects of Pittosporum neelgherrense Wight&Arn., a popular Indian ethnomedicine. J. Ethnopharmacol., 107: 151-155.
23. Yanpallewar, S.U., S. Sen, S. Tapas, M. Kumar, S.S. Raju and S.B. Acharya, 2003. Effect of Azadirachta indica on paracetamol-induced hepatic damage in albino rats. Phytomedicine, 10: 391-396.
24. Yapar, V., A. Kart, M. Karapehlivan, O. Atakisi, R. Tuncac, S. Erginsoy and M. Citil, 2007. Hepatoprotective effect of L-carnitine against acute acetaminophen toxicity in mice. Exp. Toxicol. Pathol., 59: 121-128.
25. Yen, F.L., T.H. Wu, L.T. Lin and C.C. Lin, 2007. Hepatoprotective and antioxidant effects of Cuscuta chinensis against acetaminophen-induced hepatotoxicity in rats. J. Ethnopharmacol., 111: 123-128.