Design of more potent squalene synthase inhibitors with multiple activities

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 21, 2010, Pages 7402-7412

  Kourounakis, Angeliki P ^a   Matralis, Alexios N ^a   Nikitakis, Anastasios ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

Aromatic tetrahydro 1,4 oxazines; Autodock; Docking; Drug design; LDL cholesterol; Lipid peroxidation; Lipoxygenase; Molecular modeling; Squalene synthase; Squalene synthase inhibitors; Synthesis; Total cholesterol; Triglycerides

Indexed keywords

MORPHOLINE DERIVATIVE; SQUALENE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; DYSLIPIDEMIA; ENZYME INHIBITION; INFLAMMATION; MALE; MOLECULAR DOCKING; NONHUMAN; PAW EDEMA; RAT; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; HUMANS; HYPOLIPIDEMIC AGENTS; LIPOXYGENASE; LIPOXYGENASE INHIBITORS; MORPHOLINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77957973723     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.09.008     Document Type: Article

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