In vitro evaluation of a targeted and sustained release system for retinoblastoma cells using doxorubicin as a model drug

Journal of Ocular Pharmacology and Therapeutics

Volumn 26, Issue 5, 2010, Pages 459-468

  Boddu, Sai H S ^a   Jwala, Jwala ^a   Chowdhury, Monica R ^a   Mitra, Ashim K ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE; DIMETHYL SULFOXIDE; DOXORUBICIN; FOLATE RECEPTOR; FOLIC ACID; MACROGOL; N,N DIMETHYLFORMAMIDE; POLYGLACTIN;

ARTICLE; CYTOTOXICITY; DRUG DELIVERY SYSTEM; ENCAPSULATION; HUMAN; HUMAN CELL; PARTICLE SIZE; RETINOBLASTOMA;

ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; CELL SURVIVAL; DELAYED-ACTION PREPARATIONS; DOXORUBICIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FOLIC ACID; GELS; HUMANS; LACTIC ACID; MICELLES; MOLECULAR TARGETED THERAPY; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID; POLYMERS; RETINOBLASTOMA; SOLVENTS;

EID: 77957963484     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.2010.0048     Document Type: Article

References (40)

1. Albert, D.M. Historic review of retinoblastoma. Ophthalmology 94:654-662, 1987.
2. Bishop, J.O., and Madson, E.C. Retinoblastoma. Review of the current status. Surv. Ophthalmol. 19:342-366, 1975.
3. Honavar, S.G., and Singh, A.D. Management of advanced retinoblastoma. Ophthalmol. Clin. North Am. 18:65-73, 2005.
4. Sanchez de Toledo, J. Retinoblastoma. Can we do more? Clin. Transl. Oncol. 10:525-526, 2008.
5. Pesin, S.R., and Shields, J.A. Seven cases of trilateral retinoblastoma. Am. J. Ophthalmol. 107:121-126, 1989.
6. Henkes, H.E., Henkes, H.E., and Oosterhuis, J.A. Tumors of the eye. Doc. Ophthalmol. 43:341-342, 1977.
7. Aerts, I., Lumbroso-Le Rouic, L., Gauthier-Villars, M., Brisse, H., Doz, F., and Desjardins, L. Retinoblastoma. Orphanet J. Rare Dis. 1:31, 2006.
8. De Potter, P. Current treatment of retinoblastoma. Curr. Opin. Ophthalmol. 13:331-336, 2002.
9. Chintagumpala, M., Chevez-Barrios, P., Paysse, E.A., Plon, S.E., and Hurwitz, R. Retinoblastoma: review of current management. Oncologist 12:1237-1246, 2007.
10. Eng, C., Li, F.P., Abramson, D.H., Ellsworth, R.M., Wong, F.L., Goldman, M.B., Seddon, J., Tarbell, N., and Boice, Jr., J.D. Mortality from second tumors among long-term survivors of retinoblastoma. J. Natl. Cancer Inst. 85:1121-1128, 1993.
11. Beck, M.N., Balmer, A., Dessing, C., Pica, A., and Munier, F. First-line chemotherapy with local treatment can prevent external-beam irradiation and enucleation in low-stage intraocular retinoblastoma. J. Clin. Oncol. 18:2881-2887, 2000.
12. Murphree, A.L., Villablanca, J.G., Deegan, W.F., 3rd, Sato, J.K., Malogolowkin, M., Fisher, A., Parker, R., Reed, E., and Gomer, C.J. Chemotherapy plus local treatment in the management of intraocular retinoblastoma. Arch. Ophthalmol. 114:1348-1356, 1996.
13. Rizzuti, A.E., Dunkel, I.J., and Abramson, D.H. The adverse events of chemotherapy for retinoblastoma: what are they? Do we know? Arch. Ophthalmol. 126:862-865, 2008.
14. Gallie, B.L., Budning, A., DeBoer, G., Thiessen, J.J., Koren, G., Verjee, Z., Ling, V., and Chan, H.S. Chemotherapy with focal therapy can cure intraocular retinoblastoma without radiotherapy. Arch. Ophthalmol. 114:1321-1328, 1996.
15. Chin, K.V., and Liu, B. Regulation of the multidrug resistance (MDR1) gene expression. In Vivo 8:835-841, 1994.
16. Kuo, M.T. Roles of multidrug resistance genes in breast cancer chemoresistance. Adv. Exp. Med. Biol. 608:23-30, 2007.
17. Chan, H.S., Canton, M.D., and Gallie, B.L. Chemosensitivity and multidrug resistance to antineoplastic drugs in retinoblastoma cell lines. Anticancer Res. 9:469-474, 1989.
18. Kartner, N., Evernden-Porelle, D., Bradley, G., and Ling, V. Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies. Nature 316:820-823, 1985. (Pubitemid 15003741)
19. Li, B., Gao, R., Zhang, H., Li, L.Q., Gao, F., and Ren, R.J. [Studies on multidrug resistance associated protein in retinoblastoma]. Zhonghua Yan Ke Za Zhi 45:314-317, 2009.
20. Janoria, K.G., Gunda, S., Boddu, S.H., and Mitra, A.K. Novel approaches to retinal drug delivery. Expert Opin. Drug Deliv. 4:371-388, 2007.
21. Phylactos,A.C., andUnger, W.G. Biochemical changes induced by intravitreally-injected doxorubicin in the iris-ciliary body and lens of the rabbit eye. Doc. Ophthalmol. 95:145-155, 1998.
22. Weitman, S.D., Lark, R.H., Coney, L.R., Fort, D.W., Frasca, V., Zurawski, Jr., V.R., and Kamen, B.A. Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues. Cancer Res. 52:3396-3401, 1992.
23. Shiokawa, T., Hattori, Y., Kawano, K., Ohguchi, Y., Kawakami, H., Toma, K., and Maitani, Y. Effect of polyethylene glycol linker chain length of folate-linked microemulsions loading aclacinomycin A on targeting ability and antitumor effect in vitro and in vivo. Clin. Cancer Res. 11:2018-2025, 2005.
24. Yoo, H.S., and Park, T.G. Folate receptor targeted biodegradable polymeric doxorubicin micelles. J. Control. Release 96:273-283, 2004.
25. Zhao, H., and Yung, L.Y. Selectivity of folate conjugated polymer micelles against different tumor cells. Int. J. Pharm. 349:256-268, 2008.
26. Park, E.K., Kim, S.Y., Lee, S.B., and Lee, Y.M. Folateconjugated methoxy poly(ethylene glycol)/poly(epsiloncaprolactone) amphiphilic block copolymeric micelles for tumor-targeted drug delivery. J. Control. Release 109:158-168, 2005.
27. Yoo, H.S., and Park, T.G. Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA-PEG block copolymer. J. Control. Release 70:63-70, 2001.
28. Kansara, V., Paturi, D., Luo, S., Gaudana, R., and Mitra, A.K. Folic acid transport via high affinity carrier-mediated system in human retinoblastoma cells. Int. J. Pharm. 355:210-219, 2008.
29. Duvvuri, S., Janoria, K.G., and Mitra, A.K. Development of a novel formulation containing poly(d,l-lactide-coglycolide) microspheres dispersed in PLGA-PEG-PLGA gelfor sustained delivery of ganciclovir. J. Control. Release 108: 282-293, 2005.
30. Duvvuri, S., Janoria, K.G., Pal, D., and Mitra, A.K. Controlled delivery of ganciclovir to the retina with drug-loaded poly(d,l-lactide-co-glycolide) (PLGA) microspheres dispersed in PLGA-PEG-PLGA gel: a novel intravitreal delivery system for the treatment of cytomegalovirus retinitis. J. Ocul. Pharmacol. Ther. 23:264-274, 2007.
31. Aukunuru, J.V., Sunkara, G., Bandi, N., Thoreson, W.B., and Kompella, U.B. Expression of multidrug resistanceassociated protein (MRP) in human retinal pigment epithelial cells and its interaction with BAPSG, a novel aldose reductase inhibitor. Pharm. Res. 18:565-572, 2001.
32. Treupel, L., Poupon, M.F., Couvreur, P., and Puisieux, F. [Vectorisation of doxorubicin in nanospheres and reversion of pleiotropic resistance of tumor cells]. C. R. Acad. Sci. III 313:171-174, 1991.
33. Gaudana, R., Jwala, J., Boddu, S.H., and Mitra, A.K. Recent perspectives in ocular drug delivery. Pharm. Res. 26:1197-1216, 2009.
34. Jones, M., and Leroux, J. Polymeric micelles-a new generation of colloidal drug carriers. Eur. J. Pharm. Biopharm. 48:101-111, 1999.
35. Bae, Y.H., and Yin, H. Stability issues of polymeric micelles. J. Control. Release 131:2-4, 2008.
36. Chen, H., Kim, S., He, W., Wang, H., Low, P.S., Park, K., and Cheng, J.X. Fast release of lipophilic agents from circulating PEG-PDLLA micelles revealed by in vivo forster resonance energy transfer imaging. Langmuir 24:5213-5217, 2008.
37. Jeon, H.J., Jeong, Y.I., Jang, M.K., Park, Y.H., and Nah, J.W. Effect of solvent on the preparation of surfactant-free poly(dl-lactide-co-glycolide) nanoparticles and norfloxacin release characteristics. Int. J. Pharm. 207:99-108, 2000.
38. Liu, S.Q., Tong, Y.W., and Yang, Y.Y. Incorporation and in vitro release of doxorubicin in thermally sensitive micelles made from poly(N- isopropylacrylamide-co-N,N-dimethylacrylamide)- b-poly(d,l-lactide-co-glycolide) with varying compositions. Biomaterials 26:5064-5074, 2005.
39. Qiao, M., Chen, D., Ma, X., and Liu, Y. Injectable biodegradable temperature-responsive PLGA-PEG-PLGA copolymers: synthesis and effect of copolymer composition on the drug release from the copolymer-based hydrogels. Int. J. Pharm. 294:103-112, 2005.
40. Huang, W., Prasad, P.D., Kekuda, R., Leibach, F.H., and Ganapathy, V. Characterization of N5-methyltetrahydrofolate uptake in cultured human retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 38:1578-1587, 1997.