Perinatal nutrient restriction reduces nephron endowment increasing renal morbidity in adulthood: A review

Early Human Development

Volumn 86, Issue SUPPL. 1, 2010, Pages 37-42

  Fanos, V ^a   Puddu, M ^a   Reali, A ^a   Atzei, A ^a   Zaffanello, M ^b  

^a Neonatal Intensive Care Unit   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN RECEPTOR; FAT; PROTEIN; RETINOID; SODIUM; VITAMIN;

ADULTHOOD; CALCIUM INTAKE; CALORIC INTAKE; CALORIC RESTRICTION; CHILD NUTRITION; FAT INTAKE; HUMAN; IRON INTAKE; KIDNEY DEVELOPMENT; MALNUTRITION; MORBIDITY; NEPHRON; NONHUMAN; NUTRITIONAL PARAMETERS; OVERNUTRITION; PERINATAL CARE; POSTNATAL CARE; POTASSIUM INTAKE; PROTEIN INTAKE; RETINOL DEFICIENCY; SHORT SURVEY; ADULT; FEMALE; FETAL MALNUTRITION; GROWTH, DEVELOPMENT AND AGING; KIDNEY DISEASE; MATERNAL NUTRITION; NEWBORN; ONSET AGE; PHYSIOLOGY; PREGNANCY; PRENATAL DEVELOPMENT; REVIEW;

ADULT; AGE OF ONSET; CALORIC RESTRICTION; FEMALE; FETAL NUTRITION DISORDERS; HUMANS; INFANT, NEWBORN; KIDNEY DISEASES; MALNUTRITION; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; MORBIDITY; NEPHRONS; PREGNANCY;

EID: 77957941286     PISSN: 03783782     EISSN: 18726232     Source Type: Journal    
DOI: 10.1016/j.earlhumdev.2010.01.007     Document Type: Short Survey

References (92)

1. Ingelfinger J.R. Is microanatomy destiny?. N Engl J Med 2003, 348:99-100.
2. Gilbert J.S., Ford S.P., Lang A.L., Pahl L.R., Drumhiller M.C., Babcock S.A., et al. Nutrient restriction impairs nephrogenesis in a gender-specific manner in the ovine fetus. Pediatr Res 2007, 61:42-47.
3. Ingelfinger J.R. Disparities in renal endowment: causes and consequences. Adv Chronic Kidney Dis 2008, 15:107-114.
4. Hotoura E., Argyropoulou M., Papadopoulou F., Giapros V., Drougia A., Nikolopoulos P., et al. Kidney development in the first year of life in small-for-gestational-age preterm infants. Pediatr Radiol 2005, 35:991-994.
5. Puddu M., Fanos V., Podda F., Zaffanello M. The kidney from prenatal to adult life: perinatal programming and reduction of number of nephrons during development. Am J Nephrol 2009, 30:162-170.
6. Amann K., Plank C., Dötsch J. Low nephron number-a new cardiovascular risk factor in children?. Pediatr Nephrol 2004, 19:1319-1323.
7. Hoy W.E., Hughson M.D., Bertram J.F., Douglas-Denton R., Amann K. Nephron number, hypertension, renal disease, and renal failure. J Am Soc Nephrol 2005, 16:2557-2564.
8. Luyckx V.A., Brenner B.M. Low birth weight, nephron number, and kidney disease. Kidney Int Suppl 2005, S68-S77.
9. Barker D.J., Osmond C., Law C.M. The intrauterine and early postnatal origins of cardiovascular disease and chronic bronchitis. J Epidemiol Community Health 1989, 43:237-240.
10. Barker D.J., Osmond C., Simmonds S.J., Wield G.A. The relation of small head circumference and thinness at birth to death from cardiovascular disease in adult life. BMJ 1993, 306:422-426.
11. Brenner B.M., Garcia D.L., Anderson S. Glomeruli and blood pressure: less of one, more of the other?. Am J Hypertens 1988, 1:335-347.
12. Rodríguez M.M., Gómez A.H., Abitbol C.L., Chandar J.J., Duara S., Zilleruelo G.E. Histomorphometric analysis of postnatal glomerulogenesis in extremely preterm infants. Pediatr Dev Pathol 2004, 7:17-25.
13. Guignard J.P. Nephron deficit: causes and late consequences. Arch de Pediatrie 2005, 12:726-727.
14. Vikse B.E., Irgens L.M., Leivestad T., Hallan S., Iversen B.M. Low birth weight increases risk for end-stage renal disease. J Am Soc Nephrol 2008, 19:151-157.
15. Kuzawa C.W. Fetal origins of developmental plasticity: are fetal cues reliable predictors of future nutritional environments?. Am J Hum Biol 2005, 17:5-21.
16. Zeman F.J. Effects of maternal protein restriction on the kidney of the new born young of rats. J Nutr 1968, 94:111-116.
17. Merlet-Benichou C., Gilbert T., Muffat-Joly M., Lelievre-Pegorier M., Leroy B. Intrauterine growth retardation leads to a permanent nephron deficit in the rat. Pediatr Nephrol 1994, 8:175-180.
18. Woods L.L., Ingelfinger J.R., Nyengaard J.R., Rasch R. Maternal protein restriction suppresses the newborn renin-angiotensin system and programs adult hypertension in rats. Pediatr Res 2001, 49:460-467.
19. Vehaskari V.M., Aviles D.H., Manning J. Prenatal programming of adult hypertension in the rat. Kidney Int 2001, 59:238-245.
20. Jones S.E., Bilous R.W., Flyvbjerg A., Marshall S.M. Intra-uterine environment influences glomerular number and the acute renal adaptation to experimental diabetes. Diabetologia 2001, 44:721-728.
21. McMullen S., Gardner D.S., Langley-Evans S.C. Prenatal programming of angiotensin II type 2 receptor expression in the rat. Br J Nutr 2004, 91:133-140.
22. Sanders M.W., Fazzi G.E., Janssen G.M., de Leeuw P.W., Blanco C.E., De Mey J.G. Reduced uteroplacental blood flow alters renal arterial reactivity and glomerular properties in the rat offspring. Hypertension 2004, 43:1283-1289.
23. Gilbert J.S., Lang A.L., Grant A.R., Nijland M.J. Maternal nutrient restriction in sheep: hypertension and decreased nephron number in offspring at 9months of age. J Physiol 2005, 565:137-147.
24. Gopalakrishnan G.S., Gardner D.S., Dandrea J., Langley-Evans S.C., Pearce S., Kurlak L.O., et al. Influence of maternal pre-pregnancy body composition and diet during early-mid pregnancy on cardiovascular function and nephron number in juvenile sheep. Br J Nutr. 2005, 94:938-947.
25. Bauer R., Walter B., Bauer K., Klupsch R., Patt S., Zwiener U. Intrauterine growth restriction reduces nephron number and renal excretory function in newborn piglets. Acta Physiol Scand 2002, 176:83-90.
26. Bassan H., Trejo L.L., Kariv N., Bassan M., Berger E., Fattal A., Gozes I., Harel S. Experimental intrauterine growth retardation alters renal development. Pediatr Nephrol 2000, 15:192-195.
27. Langley-Evans S.C., Welham S.J., Jackson A.A. Fetal exposure to a maternal low protein diet impairs nephrogenesis and promotes hypertension in the rat. Life Sci 1999, 64:965-974.
28. Zimanyi M.A., Bertram J.F., Black M.J. Does a nephron deficit in rats predispose to salt-sensitive hypertension?. Kidney Blood Press Res 2004, 27:239-247.
29. Franco Mdo C., Arruda R.M., Fortes Z.B., de Oliveira S.F., Carvalho M.H., Tostes R.C., Nigro D. Severe nutritional restriction in pregnant rats aggravates hypertension, altered vascular reactivity, and renal development in spontaneously hypertensive rats offspring. J Cardiovasc Pharmacol 2002, 3:369-377.
30. Nwagwu M.O., Cook A., Langley-Evans S.C. Evidence of progressive deterioration of renal function in rats exposed to a maternal low-protein diet in utero. Br J Nutr 2000, 83:79-85.
31. Magalhães J.C., da Silveira A.B., Mota D.L., Paixão A.D. Renal function in juvenile rats subjected to prenatal malnutrition and chronic salt overload. Exp Physiol 2006, 91(3):611-619.
32. Woods L.L., Rasch R. Perinatal ANG II programs adult blood pressure, glomerular number, and renal function in rats. Am J Physiol 1998, 275(5 Pt 2):R1593-R1599.
33. Robillard J.E., Page W.V., Mathews M.S., Schutte B.C., Nuyt A.M., Segar J.L. Differential gene expression and regulation of renal angiotensin II receptor subtypes (AT1 and AT2) during fetal life in sheep. Pediatr Res 1995, 38(6):896-904.
34. Segar J.L., Bedell K., Page W.V., Mazursky J.E., Nuyt A.M., Robillard J.E. Effect of cortisol on gene expression of the renin-angiotensin system in fetal sheep. Pediatr Res 1995, 37:741-746.
35. Vehaskari V.M., Stewart T., Lafont D., Soyez C., Seth D., Manning J. Kidney angiotensin and angiotensin receptor expression in prenatally programmed hypertension. Am J Physiol Renal Physiol 2004, 287:F262-F267.
36. Chou H.C., Wang L.F., Lu K.S., Chen C.M. Effects of maternal undernutrition on renal angiotensin II and chymase in hypertensive offspring. Acta Histochem 2008, 110:497-504.
37. Brennan K.A., Olson D.M., Symonds M.E. Maternal nutrient restriction alters renal development and blood pressure regulation of the offspring. Proc Nutr Soc 2006, 65:116-124.
38. Woods L.L. Maternal nutrition and predisposition to later kidney disease. Curr Drug Targets 2007, 8(8):906-913.
39. Schreuder M.F., Nauta J. Prenatal programming of nephron number and blood pressure. Kidney Int 2007, 72(3):265-268.
40. Wlodek M.E., Westcott K., Siegel A.L., Owens J.A., Moritz K.M. Growth restriction before or after birth reduces nephron number and increases blood pressure in male rats. Kidney Int 2008, 74:187-195.
41. Vickers M.H., Breier B.H., Cutfield W.S., Hofman P.L., Gluckman P.D. Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition. Am J Physiol Endocrinol Metab 2000, 279:E83-E87.
42. Wlodek M.E., Mibus A., Tan A., Siebel A.L., Owens J.A., Moritz K.M. Normal Lactational environment restores nephron endowment and prevents hypertension after placental restriction in the rat. J Am Soc Nephrol 2007, 18:1688-1696.
43. Hinchliffe S.A., Lynch M.R., Sargent P.H., Howard C.V., van Velzen D. The effect of intrauterine growth retardation on the development of renal nephrons. Br J Obstet Gynaecol 1992, 99:296-301.
44. Kyle U.G., Pichard C. The Dutch Famine of 1944-1945: a pathophysiological model of long-term consequences of wasting disease. Curr Opin Clin Nutr Metab Care 2006, 9:388-394.
45. Painter R.C., Roseboom T.J., van Montfrans G.A., Bossuyt P.M.M., Krediet R.T., Osmond C., et al. Microalbuminuria in Adults after Prenatal Exposure to the Dutch Famine. J Am Soc Nephrol 2005, 16:189-194.
46. Stanner S.A., Yudkin J.S. Fetal programming and the Leningrad Siege study. Twin Res 2001, 4:287-292.
47. Sahajpal V., Ashton N. Renal function and angiotensin AT1 receptor expression in young rats following intrauterine exposure to a maternal low-protein diet. Clin Sci (Lond) 2003, 104(6):607-614.
48. Sahajpal V., Ashton N. Increased glomerular angiotensin II binding in rats exposed to a maternal low protein diet in utero. J Physiol 2005, 15;563(Pt 1):193-201.
49. McMullen S., Langley-Evans S.C. Sex-specific effects of prenatal low-protein and carbenoxolone exposure on renal angiotensin receptor expression in rats. Hypertension 2005, 46:1374-1380.
50. Harrison M., Langley-Evans S.C. Intergenerational programming of impaired nephrogenesis and hypertension in rats following maternal protein restriction during pregnancy. Br J Nutr 2008, 9:1-11.
51. Shelley P., Tarry-Adkins J., Martin-Gronert M., Poston L., Heales S., Clark J., et al. Rapid neonatal weight gain in rats results in a renal ubiquinone (CoQ) deficiency associated with premature death. Mech Ageing Dev 2007, 128:681-687.
52. Tarry-Adkins J.L., Joles J.A., Chen J.H., Martin-Gronert M.S., van der Giezen D.M., Goldschmeding R., et al. Protein restriction in lactation confers nephroprotective effects in the male rat and is associated with increased antioxidant expression. Am J Physiol Regul Integr Comp Physiol 2007, 293:R1259-R1266.
53. des Robert C., Li N., Caicedo R., Frost S., Lane R., Hauser N., Neu J. Metabolic effects of different protein intakes after short term undernutrition in artificially reared infant rats. Early Hum Dev 2009, 85:41-49.
54. Hoppe C.C., Evans R.G., Bertram J.F., Moritz K.M. Effects of dietary protein restriction on nephron number in the mouse. Am J Physiol: Regul, Integr Comp Physiol 2007, 292(5):R1768-R1774.
55. Frank J.W., Escobar J., Suryawan A., Kimball S.R., Nguyen H.V., Jefferson L.S., et al. Protein synthesis and translation initiation factor activation in neonatal pigs fed increasing levels of dietary protein. J Nutr 2005, 135:1374-1381.
56. Lucas S.R.R., Miraglia S.M., Zaladek F., Coimbra T.M. Intrauterine food restriction as a determinant of nephrosclerosis. Am J Kidney Dis 2001, 37:467-476.
57. Godfrey K., Robinson S., Barker D.J., Osmond C., Cox V. Maternal nutrition in early and late pregnancy in relation to placental and fetal growth. BMJ 1996, 312:410-414.
58. Rostand S.G. Oligonephronia, primary hypertension and renal disease: 'is the child father to the man?. Nephrol Dial Transplant 2003, 18:1434-1438.
59. Sinha A.K., Scharschmidt L.A., Neuwirth R., Holthofer H., Gibbons N., Arbeeny C.M., et al. Effects of fish oil on glomerular function in rats with diabetes mellitus. J Lipid Res 1990, 31:1219-1228.
60. Awazu M., Yared A., Swift L.L., Hoover R.L., Ichikawa I. Dietary fatty acid modulates glomerular atrial natriuretic peptide receptor. Kidney Int 1992, 42:265-271.
61. Awad A.B., Brown G.P., Fink C.S., Helinski J.D. Effect of dietary fat on glomerular lipid composition and angiotensin II receptors. Jpn J Physiol 1993, 43:775-784.
62. Armitage J.A., Lakasing L., Taylor P.D., Balachandran A.A., Jensen R.I., Dekou V., et al. Developmental programming of aortic and renal structure in offspring of rats fed fat-rich diets in pregnancy. J Physiol 2005, 565(Pt 1):171-184.
63. Bhat P.V., Manolescu D.C. Role of vitamin A in determining nephron mass and possible relationship to hypertension. J Nutr 2008, 138:1407-1410.
64. Vilar J., Gilbert T., Moreau E., Merlet-Bénichou C. Metanephros organogenesis is highly stimulated by vitamin A derivatives in organ culture. Kidney Int 1996, 49(5):1478-1487.
65. Moreau E., Vilar J., Lelièvre-Pégorier M., Merlet-Bénichou C., Gilbert T. Regulation of c-ret expression by retinoic acid in rat metanephros: implication in nephron mass control. Am J Physiol. 1998, 275(6 Pt 2):F938-F945.
66. Batourina E., Gim S., Bello N., Shy M., Clagett-Dame M., Srinivas S., et al. Vitamin A controls epithelial/mesenchymal interactions through Ret expression. Nat Genet 2001, 27:74-78.
67. Gilbert T., Merlet-Bénichou C. Retinoids and nephron mass control. Pediatr Nephrol 2000, 14:1137-1144.
68. Lelièvre-Pégorier M., Vilar J., Ferrier M.L., Moreau E., Freund N., Gilbert T., et al. Mild vitamin A deficiency leads to inborn nephron deficit in the rat. Kidney Int 1998, 54:1455-1462.
69. Makrakis J., Zimanyi M.A., Black M.J. Retinoic acid enhances nephron endowment in rats exposed to maternal protein restriction. Pediatr Nephrol 2007, 22:1861-1867.
70. Goodyer P., Kurpad A., Rekha S., Muthayya S., Dwarkanath P., Iyengar A., et al. Effects of maternal vitamin A status on kidney development: a pilot study. Pediatr Nephrol 2007, 22:209-214.
71. McGarvey S.T., Zinner S.H., Willett W.C., Rosner B. Maternal prenatal dietary potassium, calcium, magnesium, and infant blood pressure. Hypertension 1991, 17:218-224.
72. Belizán J.M., Villar J., Bergel E., del Pino A., Di Fulvio S., Galliano S.V., et al. Long-term effect of calcium supplementation during pregnancy on the blood pressure of offspring: follow-up of a randomised controlled trial. BMJ 1997, 315(7103):281-285.
73. Crocker J.F.S. Human embryonic kidneys in organ culture: abnormalities of development induced by decreased potassium. Science 1973, 181:1178-1179.
74. Lisle S.J., Lewis R.M., Petry C.J., Ozanne S.E., Hales C.N., Forhead A.J. Effect of maternal iron restriction during pregnancy on renal morphology in the adult rat offspring. Br J Nutr 2003, 90:33-39.
75. Boubred F., Buffat C., Feuerstein J.M., Daniel L., Tsimaratos M., Oliver C., et al. Effects of early postnatal hypernutrition on nephron number and long-term renal function and structure in rats. Am J Physiol Renal Physiol 2007, 293:F1944-F1949.
76. Cleal J.K., Poore K.R., Newman J.P., Noakes D.E., Hanson M.A., Green L.R. The effect of maternal undernutrition in early gestation on gestation length and fetal and postnatal growth in sheep. Pediatr Res 2007, 62:422-427.
77. Hoy W.E., Hughson M.D., Singh G.R., Douglas-Denton R., Bertram J.F. Reduced nephron number and glomerulomegaly in Australian Aborigines: A group at high risk for renal disease and hypertension. Kidney Int 2006, 70:104-110.
78. Keller G., Zimmer G., Mall G., Ritz E., Amann K. Nephron number in patients with primary hypertension. N Engl J Med 2003, 348(2):101-108.
79. Ortiz L.A., Quan A., Zarzar F., Weinberg A., Baum M. Prenatal dexamethasone programs hypertension and renal injury in the rat. Hypertension 2003, 41(2):328-334.
80. Woods L.L. Neonatal uninephrectomy causes hypertension in adult rats. Am J Physiol 1999, 276:R974-R978.
81. Ingelfinger J.R., Schnaper H.W. Renal endowment: developmental origins of adult disease. J Am Soc Nephrol 2005, 16:2533-2536.
82. Moritz K.M., Singh R.R., Probyn M.E., Denton K.M. Developmental programming of a reduced nephron endowment: more than just a baby's birth weight. Am J Physiol Renal Physiol 2009, 296:F1-F9.
83. Hoy W., Vanbuynder P., Mathews J.D., Pugsley D.J., Wang Z. Renal disease and the environment: lessons from Aboriginal Australia. Nephrology 2008, 6:19-24.
84. Godfrey K.M., Barker D.J. Fetal nutrition and adult disease. Am J Clin Nutr 2000, 71(5 Suppl):1344S-1352S.
85. Bagby S.P. Maternal nutrition, low nephron number, and hypertension in later life: pathways of nutritional programming. J Nutr 2007, 137:1066-1072.
86. Vikse B.E., Irgens L.M., Leivestad T., Hallan S., Iversen B.M. Low birth weight increases risk for end-stage renal disease. J Am Soc Nephrol 2008, 19:151-157.
87. Hershkovitz D., Burbea Z., Skorecki K., Brenner B.M. Fetal Programming of Adult Kidney Disease: Cellular and Molecular Mechanisms. Clin J Am Soc Nephrol 2007, 2:334-342.
88. Koleganova N., Piecha G., Ritz E. Prenatal causes of kidney disease. Blood Purif 2009, 27:48-52.
89. Ali el T.M., Abdelraheem M.B., Mohamed R.M., Hassan E.G., Watson A.R. Chronic renal failure in Sudanese children: aetiology and outcomes. Pediatr Nephrol 2009, 24:349-353.
90. Lucas A., Fewtrell M.S., Davies P.S., Bishop N.J., Clough H., Cole T.J. Breastfeeding and catch-up growth in infants born small for gestational age. Acta Paediatr 1997, 86:564-569.
91. Hughson M., Farris A.B., Douglas Denton R., Hoy V.E., Bertram G.F. Glomerular number and size in autopsy kidneys: the relationship to birth weight. Kidney Int 2003, 63:2113-2122.
92. Schreuder M., Delemarre-van de Waal H., van Wijk A. Consequences of intrauterine Growth Restriction for the Kidney. Kidney Blood Press Res 2006, 29:108-125.