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Volumn 56, Issue 7, 2010, Pages 1172-1180

Functional expression of a recombinant toxin - rPnTx2-6 - active in erectile function in rat

Author keywords

Erectile function; Nitric oxide; Phoneutria nigriventer; Recombinant toxin PnTx2 6

Indexed keywords

ION CHANNEL; RECOMBINANT PHONEUTRIA NIGRIVENTER TOXIN2 6; SPIDER VENOM; UNCLASSIFIED DRUG;

EID: 77957925667     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2010.04.010     Document Type: Article
Times cited : (12)

References (64)
  • 2
    • 0034849563 scopus 로고    scopus 로고
    • Pharmacology of penile erection
    • Andersson K.E. Pharmacology of penile erection. Pharmacol Ver. 2001, 53:417.
    • (2001) Pharmacol Ver. , vol.53 , pp. 417
    • Andersson, K.E.1
  • 5
    • 33646857665 scopus 로고    scopus 로고
    • Current strategies for the use of affinity tags and tag removal for the purification of recombinant proteins
    • Arnau J., Lauritzen C., Petersen G.E., Pedersen J. Current strategies for the use of affinity tags and tag removal for the purification of recombinant proteins. Protein Express. Purif. 2006, 48:1.
    • (2006) Protein Express. Purif. , vol.48 , pp. 1
    • Arnau, J.1    Lauritzen, C.2    Petersen, G.E.3    Pedersen, J.4
  • 6
    • 0035671356 scopus 로고    scopus 로고
    • Report of the American Foundation for Urologic Disease (AFUD) thought leader panel for evaluation and treatment priapism
    • Berger R., Billups K., Brock G. Report of the American Foundation for Urologic Disease (AFUD) thought leader panel for evaluation and treatment priapism. Int. J. Impot. Res. 2001, 13:S39.
    • (2001) Int. J. Impot. Res. , vol.13
    • Berger, R.1    Billups, K.2    Brock, G.3
  • 8
    • 0242541094 scopus 로고    scopus 로고
    • Endothelial dysfunction in erectile disfunction: role of the endothelium in erectile physiology and disease
    • Bivalacqua T.J., Usta M.F., Champion H.C., Kadowitz P.J., Hellstrom W.J.G. Endothelial dysfunction in erectile disfunction: role of the endothelium in erectile physiology and disease. J. Androl. 2003, 24:S17.
    • (2003) J. Androl. , vol.24
    • Bivalacqua, T.J.1    Usta, M.F.2    Champion, H.C.3    Kadowitz, P.J.4    Hellstrom, W.J.G.5
  • 9
  • 10
    • 77957892264 scopus 로고    scopus 로고
    • Structural and functional diversity in the venom of spiders of the genus Phoneutria
    • Editora UFMG, Belo Horizonte, M.E. De Lima, A.M.C. Pimenta, M.F. Martin-Eauclaire, R. Zingali, H. Rochat (Eds.)
    • Borges M.H., De Lima M.E., Stankiewicz M., Pelhate M., Cordeiro M.N., Beirão P.S. Structural and functional diversity in the venom of spiders of the genus Phoneutria. Animal Toxins: State of the Art. Perspectives in Health and Biotecnology 2009, 291-311. Editora UFMG, Belo Horizonte. M.E. De Lima, A.M.C. Pimenta, M.F. Martin-Eauclaire, R. Zingali, H. Rochat (Eds.).
    • (2009) Animal Toxins: State of the Art. Perspectives in Health and Biotecnology , pp. 291-311
    • Borges, M.H.1    De Lima, M.E.2    Stankiewicz, M.3    Pelhate, M.4    Cordeiro, M.N.5    Beirão, P.S.6
  • 13
    • 0031060411 scopus 로고    scopus 로고
    • Nitric oxide in the penis: physiology and pathology
    • Burnett A.L. Nitric oxide in the penis: physiology and pathology. J. Urol. 1997, 157:320.
    • (1997) J. Urol. , vol.157 , pp. 320
    • Burnett, A.L.1
  • 16
    • 0026705696 scopus 로고
    • The purification and amino acid sequences of four Tx2 neurotoxins from the venom of the Brazilian " armed" spider Phoneutria nigriventer (Keys.)
    • Cordeiro M.N., Diniz C.R., Valentim A.C., Von Eickstedt V.R.D., Gilroy J., Richardson M. The purification and amino acid sequences of four Tx2 neurotoxins from the venom of the Brazilian " armed" spider Phoneutria nigriventer (Keys.). FEBS 1992, 310:153.
    • (1992) FEBS , vol.310 , pp. 153
    • Cordeiro, M.N.1    Diniz, C.R.2    Valentim, A.C.3    Von Eickstedt, V.R.D.4    Gilroy, J.5    Richardson, M.6
  • 18
    • 0035239222 scopus 로고    scopus 로고
    • The cystine knot motif in toxins and implications for drug design
    • Craik D.J., Daly N.L., Waine C. The cystine knot motif in toxins and implications for drug design. Toxicon 2001, 39:43.
    • (2001) Toxicon , vol.39 , pp. 43
    • Craik, D.J.1    Daly, N.L.2    Waine, C.3
  • 20
    • 0027739665 scopus 로고
    • Mutations that allow disulphide bond formation in the cytoplasm of Escherichia coli
    • Derman A.I., Prinz W.A., Belin D., Beckwith J. Mutations that allow disulphide bond formation in the cytoplasm of Escherichia coli. Science 1993, 262:1744.
    • (1993) Science , vol.262 , pp. 1744
    • Derman, A.I.1    Prinz, W.A.2    Belin, D.3    Beckwith, J.4
  • 21
    • 0027234680 scopus 로고
    • Sequence of the DNA coding for the lethal neurotoxin Tx1 from the Brazilian " armed" spider Phoneutria nigriventer predicts the synthesis and processing of a preprotoxin
    • Diniz M.R.V., Paine M.J.I., Diniz C.R., Theakston R.D.G., Crampton J.M. Sequence of the DNA coding for the lethal neurotoxin Tx1 from the Brazilian " armed" spider Phoneutria nigriventer predicts the synthesis and processing of a preprotoxin. J. Biol. Chem. 1993, 268:15340.
    • (1993) J. Biol. Chem. , vol.268 , pp. 15340
    • Diniz, M.R.V.1    Paine, M.J.I.2    Diniz, C.R.3    Theakston, R.D.G.4    Crampton, J.M.5
  • 22
    • 33750437439 scopus 로고    scopus 로고
    • Functional expression and purification of recombinant Tx1, a sodium channel blocker neurotoxin from the venom of the Brazilian " armed" spider, Phoneutria nigriventer
    • Diniz M.R.V., Theakston R.D., Crampton J.M., Nascimento Cordeiro M., Pimenta A.M., De Lima M.E., Diniz C.R. Functional expression and purification of recombinant Tx1, a sodium channel blocker neurotoxin from the venom of the Brazilian " armed" spider, Phoneutria nigriventer. Protein Express. Purif. 2006, 50:18.
    • (2006) Protein Express. Purif. , vol.50 , pp. 18
    • Diniz, M.R.V.1    Theakston, R.D.2    Crampton, J.M.3    Nascimento Cordeiro, M.4    Pimenta, A.M.5    De Lima, M.E.6    Diniz, C.R.7
  • 23
    • 0345269175 scopus 로고    scopus 로고
    • Recent findings on natural products with erectile-dysfunction activity
    • Drewes S.E., George J., Khan F. Recent findings on natural products with erectile-dysfunction activity. Phytochemistry 2003, 62:1019.
    • (2003) Phytochemistry , vol.62 , pp. 1019
    • Drewes, S.E.1    George, J.2    Khan, F.3
  • 24
    • 0033731951 scopus 로고    scopus 로고
    • Structure and pharmacology of spider venom neurotoxins
    • Escoubas P., Diochot S., Corzo G. Structure and pharmacology of spider venom neurotoxins. Biochimie 2000, 82:893.
    • (2000) Biochimie , vol.82 , pp. 893
    • Escoubas, P.1    Diochot, S.2    Corzo, G.3
  • 25
    • 0031939209 scopus 로고    scopus 로고
    • Protein disulphide isomerase
    • Gilbert H.F. Protein disulphide isomerase. Methods Enzymol. 1998, 290:26.
    • (1998) Methods Enzymol. , vol.290 , pp. 26
    • Gilbert, H.F.1
  • 26
    • 0034130955 scopus 로고    scopus 로고
    • Central neural regulation of penile erection
    • Giuliano F., Rampin O. Central neural regulation of penile erection. Neurosci. Biobehav. Rev. 2000, 24:517.
    • (2000) Neurosci. Biobehav. Rev. , vol.24 , pp. 517
    • Giuliano, F.1    Rampin, O.2
  • 30
    • 13844271129 scopus 로고    scopus 로고
    • From gene to protein: a review of new and enabling technologies for multi-parallel protein expression
    • Hunt I. From gene to protein: a review of new and enabling technologies for multi-parallel protein expression. Protein. Express. Purif. 2005, 40:1.
    • (2005) Protein. Express. Purif. , vol.40 , pp. 1
    • Hunt, I.1
  • 31
    • 0029006074 scopus 로고
    • Measurement of glutathione redox state in cytosol and secretory pathway of cultured cells
    • Hwang C., Lodish H.F., Sinskey A.J. Measurement of glutathione redox state in cytosol and secretory pathway of cultured cells. Methods Enzymol. 1995, 251:212.
    • (1995) Methods Enzymol. , vol.251 , pp. 212
    • Hwang, C.1    Lodish, H.F.2    Sinskey, A.J.3
  • 32
    • 0025081992 scopus 로고
    • Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle
    • Ignarro L.J., Bush P.A., Buga G.M., Wood K.S., Fukuto J.M., Rajfer L. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem. Biophys. Res. Commun. 1990, 170:843.
    • (1990) Biochem. Biophys. Res. Commun. , vol.170 , pp. 843
    • Ignarro, L.J.1    Bush, P.A.2    Buga, G.M.3    Wood, K.S.4    Fukuto, J.M.5    Rajfer, L.6
  • 35
  • 37
    • 0028064457 scopus 로고
    • Pharmacological characterization of rabbit corpus cavernosum relaxation mediated by the tissue kallikrein-kinin system
    • Lopes-Martins R.A., Antunes E., Oliva M.L., Sampaio C.A., Burton J., de Nucci G. Pharmacological characterization of rabbit corpus cavernosum relaxation mediated by the tissue kallikrein-kinin system. Br. J. Pharmacol. 1994, 113:81.
    • (1994) Br. J. Pharmacol. , vol.113 , pp. 81
    • Lopes-Martins, R.A.1    Antunes, E.2    Oliva, M.L.3    Sampaio, C.A.4    Burton, J.5    de Nucci, G.6
  • 38
    • 0023751860 scopus 로고
    • Spiders in Brazil
    • Lucas S. Spiders in Brazil. Toxicon 1988, 26:759.
    • (1988) Toxicon , vol.26 , pp. 759
    • Lucas, S.1
  • 39
    • 0034660235 scopus 로고    scopus 로고
    • Erectile dysfunction
    • Lue T.F. Erectile dysfunction. New Engl. J. Med. 2000, 342:1802.
    • (2000) New Engl. J. Med. , vol.342 , pp. 1802
    • Lue, T.F.1
  • 42
    • 0028216450 scopus 로고
    • Effects of castration and androgen replacement on the hemodynamics of penile erection in the rat
    • Mills T.M., Stopper V.S., Wiedmeier V.T. Effects of castration and androgen replacement on the hemodynamics of penile erection in the rat. Biol. Reprod. 1994, 51:234-238.
    • (1994) Biol. Reprod. , vol.51 , pp. 234-238
    • Mills, T.M.1    Stopper, V.S.2    Wiedmeier, V.T.3
  • 43
    • 0031843261 scopus 로고    scopus 로고
    • Investigation of the effect of PhTx2, from the venom of the spider Phoneutria nigriventer, on the release of [3H]-acetylcholine from rat cerebrocortical synaptosomes
    • Moura J.R., Prado M.A., Gomez M.V., Kalapothakis E., Diniz C.R., Cordeiro M.N., Romano-Silva M.A. Investigation of the effect of PhTx2, from the venom of the spider Phoneutria nigriventer, on the release of [3H]-acetylcholine from rat cerebrocortical synaptosomes. Toxicon 1998, 36:1189.
    • (1998) Toxicon , vol.36 , pp. 1189
    • Moura, J.R.1    Prado, M.A.2    Gomez, M.V.3    Kalapothakis, E.4    Diniz, C.R.5    Cordeiro, M.N.6    Romano-Silva, M.A.7
  • 44
    • 32244435178 scopus 로고    scopus 로고
    • ENos Function and dysfunction in the penis. Minireview
    • Musicki B., Burnett A.L. eNos Function and dysfunction in the penis. Minireview. Exp. Biol. Med. (Maywood) 2006, 231:154.
    • (2006) Exp. Biol. Med. (Maywood) , vol.231 , pp. 154
    • Musicki, B.1    Burnett, A.L.2
  • 45
    • 0028092958 scopus 로고
    • Nitric oxide synthases: roles, tolls and controls
    • Nathan C., Xie Q.W. Nitric oxide synthases: roles, tolls and controls. Cell 1994, 78:915-918.
    • (1994) Cell , vol.78 , pp. 915-918
    • Nathan, C.1    Xie, Q.W.2
  • 46
    • 84942949401 scopus 로고
    • Impotence: NIH consensus development panel on impotence
    • NIH Consensus Conference
    • NIH Consensus Conference Impotence: NIH consensus development panel on impotence. JAMA 1993, 270:83.
    • (1993) JAMA , vol.270 , pp. 83
  • 47
    • 77957922826 scopus 로고    scopus 로고
    • Thesis. Belo Horizonte: Department of Physiology and Pharmacology, Federal University of Minas Gerais.
    • Nunes K.P., 2008. Thesis. Belo Horizonte: Department of Physiology and Pharmacology, Federal University of Minas Gerais.
    • (2008)
    • Nunes, K.P.1
  • 49
    • 77957898987 scopus 로고    scopus 로고
    • Animal toxins as potential pharmacological tools for treatment of erectile dysfunction
    • Editora UFMG, Belo Horizonte, M.E. De Lima, A.M.C. Pimenta, M.F. Martin-Eauclaire, R. Zingali, H. Rochat (Eds.)
    • Nunes K.P., Cardoso F.L., Cardoso H.C., Pimenta A.M.C., De Lima M.E. Animal toxins as potential pharmacological tools for treatment of erectile dysfunction. Animal Toxins: State of the Art. Perspectives in Health and Biotechnology 2009, 313-322. Editora UFMG, Belo Horizonte. M.E. De Lima, A.M.C. Pimenta, M.F. Martin-Eauclaire, R. Zingali, H. Rochat (Eds.).
    • (2009) Animal Toxins: State of the Art. Perspectives in Health and Biotechnology , pp. 313-322
    • Nunes, K.P.1    Cardoso, F.L.2    Cardoso, H.C.3    Pimenta, A.M.C.4    De Lima, M.E.5
  • 52
    • 0026353632 scopus 로고
    • Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission
    • Rajfer J., Aronson W.J., Bush P.A., Dorey F.J., Ignarro L.J. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. New Engl. J. Med. 1992, 326:90.
    • (1992) New Engl. J. Med. , vol.326 , pp. 90
    • Rajfer, J.1    Aronson, W.J.2    Bush, P.A.3    Dorey, F.J.4    Ignarro, L.J.5
  • 53
    • 0026049291 scopus 로고
    • Isolation of neurotoxic peptides from the venom of the " armed" spider Phoneutria nigriventer
    • Rezende L., Cordeiro M.N., Oliveira E.B., Diniz C.R. Isolation of neurotoxic peptides from the venom of the " armed" spider Phoneutria nigriventer. Toxicon 1991, 29:1225.
    • (1991) Toxicon , vol.29 , pp. 1225
    • Rezende, L.1    Cordeiro, M.N.2    Oliveira, E.B.3    Diniz, C.R.4
  • 56
    • 0027495523 scopus 로고
    • Rat cortical synaptosomes have more than one mechanism for calcium entry linked to rapid glutamate release: Studies using the Phoneutria nigriventer toxin PhTx2 and potassium depolarization
    • Romano-Silva M.A., Ribeiro A.M., Ribeiro-Santos R., Gomez M.V., Diniz C.R., Cordeiro M.N., Brammer M.J. Rat cortical synaptosomes have more than one mechanism for calcium entry linked to rapid glutamate release: Studies using the Phoneutria nigriventer toxin PhTx2 and potassium depolarization. Biochem. J. 1993, 269:313.
    • (1993) Biochem. J. , vol.269 , pp. 313
    • Romano-Silva, M.A.1    Ribeiro, A.M.2    Ribeiro-Santos, R.3    Gomez, M.V.4    Diniz, C.R.5    Cordeiro, M.N.6    Brammer, M.J.7
  • 57
    • 0013983110 scopus 로고
    • Pharmacology of the polypeptides from the venom of the spider Phoneutria fera
    • Schenberg S., Lima F.A. Pharmacology of the polypeptides from the venom of the spider Phoneutria fera. Mem. Inst. Butantan 1966, 33:627.
    • (1966) Mem. Inst. Butantan , vol.33 , pp. 627
    • Schenberg, S.1    Lima, F.A.2
  • 58
    • 0035238926 scopus 로고    scopus 로고
    • The role of nitric oxide on the relaxations of rabbit corpus cavernosum induced by Androctonus australis and Buthotus judaicus scorpion venoms
    • Teixeira C.E., Teixeira S.A., Antunes E., De Nucci G. The role of nitric oxide on the relaxations of rabbit corpus cavernosum induced by Androctonus australis and Buthotus judaicus scorpion venoms. Toxicon 2001, 39:633.
    • (2001) Toxicon , vol.39 , pp. 633
    • Teixeira, C.E.1    Teixeira, S.A.2    Antunes, E.3    De Nucci, G.4
  • 59
    • 0037365796 scopus 로고    scopus 로고
    • Sequence and structure-activity relationship of a scorpion venom toxin with nitrergic activity in rabbit corpus cavernosum
    • Teixeira C.E., Ifa D.R., Corso G., Santagada V., Caliendo G., Antunes E., De Nucci G. Sequence and structure-activity relationship of a scorpion venom toxin with nitrergic activity in rabbit corpus cavernosum. FASEB J. 2003, 17:485.
    • (2003) FASEB J. , vol.17 , pp. 485
    • Teixeira, C.E.1    Ifa, D.R.2    Corso, G.3    Santagada, V.4    Caliendo, G.5    Antunes, E.6    De Nucci, G.7
  • 62
    • 77957894003 scopus 로고
    • Modo de ação da peçonha de armadeira (Phoneutria nigriventer) na aurícula isolada de cobaia. In: Reunião Anual da Federação das Sociedades de Biologia Experimental 2.
    • Vital Brazil, O., Bernado Leite, G., Fontana, M.D., 1987. Modo de ação da peçonha de armadeira (Phoneutria nigriventer) na aurícula isolada de cobaia. In: Reunião Anual da Federação das Sociedades de Biologia Experimental 2.
    • (1987)
    • Vital Brazil, O.1    Bernado Leite, G.2    Fontana, M.D.3
  • 63
    • 19444373996 scopus 로고    scopus 로고
    • Making the most of affinity tags
    • Wang D.S. Making the most of affinity tags. Trends. Biotechnol. 2005, 23:316.
    • (2005) Trends. Biotechnol. , vol.23 , pp. 316
    • Wang, D.S.1
  • 64
    • 3042831054 scopus 로고    scopus 로고
    • Blockade of neuronal nitric oxide synthase abolishes the toxic effects of Tx2-5, a lethal Phoneutria nigriventer spider toxin
    • Yonamine C.M., Troncone L.R.P., Camillo M.A.P. Blockade of neuronal nitric oxide synthase abolishes the toxic effects of Tx2-5, a lethal Phoneutria nigriventer spider toxin. Toxicon 2004, 44:169.
    • (2004) Toxicon , vol.44 , pp. 169
    • Yonamine, C.M.1    Troncone, L.R.P.2    Camillo, M.A.P.3


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