A high-throughput label-free cell-based biosensor (CBB) system

Proceedings of SPIE - The International Society for Optical Engineering

Volumn 7693, Issue , 2010, Pages

  Xu, Feng ^a   Moon, SangJun ^a   Hefner, Evan ^a,b   Beyazoglu, Turker ^a   Emre, Ahmet E ^a   Manzur, Tariq ^c   Demirci, Utkan ^a,d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c NAVAL UNDERSEA WARFARE CENTER   (United States)

^d HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

Author keywords

CCD; Cell printing; Cell based biosensor; High throughput

Indexed keywords

ALIGNMENT; BIOSENSORS; CHARGE COUPLED DEVICES; DROPS; ENVIRONMENTAL TECHNOLOGY; IMAGE PROCESSING; MUSCLE;

CELL PRINTING; CELL-BASED BIOSENSOR; ENVIRONMENTAL CHANGE; ENVIRONMENTAL TEMPERATURE CHANGES; HIGH THROUGHPUT; INTEGRATED PLATFORM; MORPHOLOGICAL INFORMATION; MORPHOLOGICAL RESPONSE;

CELL IMMOBILIZATION;

EID: 77957899345     PISSN: 0277786X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.852187     Document Type: Conference Paper

References (35)

1. C. Ziegler, "Cell-based biosensors," Fresenius J Anal Chem, 366(6-7), 552-9 (2000).
2. D. A. Stenger, G. W. Gross, E. W. Keefer et al., "Detection of physiologically active compounds using cellbased biosensors," Trends Biotechnol, 19(8), 304-9 (2001).
3. S. Belkin, "Microbial whole-cell sensing systems of environmental pollutants," Curr Opin Microbiol, 6(3), 206-12 (2003).
4. P. Banerjee, D. Lenz, J. P. Robinson et al., "A novel and simple cell-based detection system with a collagenencapsulated B-lymphocyte cell line as a biosensor for rapid detection of pathogens and toxins," Lab Invest, 88(2), 196-206 (2008).
5. T. H. Rider, M. S. Petrovick, F. E. Nargi et al., "A B cell-based sensor for rapid identification of pathogens," Science, 301(5630), 213-5 (2003).
6. T. Curtis, R. M. Naal, C. Batt et al., "Development of a mast cell-based biosensor," Biosens Bioelectron, 23(7), 1024-31 (2008).
7. N. Li, A. Tourovskaia, and A. Folch, "Biology on a chip: microfabrication for studying the behavior of cultured cells," Crit Rev Biomed Eng, 31(5-6), 423-88 (2003).
8. T. J. O. S. a. J. J. Pancrazio, [Broadband Detection of Environmental Neurotoxicants], (2007).
9. F. Pampaloni, E. G. Reynaud, and E. H. K. Stelzer, "The third dimension bridges the gap between cell culture and live tissue," Nat Rev Mol Cell Biol, 8(10), 839-845 (2007).
10. P. Banerjee, and A. K. Bhunia, "Mammalian cell-based biosensors for pathogens and toxins," Trends Biotechnol, 27(3), 179-88 (2009).
11. P. Wang, G. Xu, L. Qin et al., "Cell-based biosensors and its application in biomedicine," Sensors and Actuators B: Chemical, 108(1-2), 576-584 (2005).
12. Q. Liu, H. Cai, Y. Xu et al., "Detection of heavy metal toxicity using cardiac cell-based biosensor," Biosens Bioelectron, 22(12), 3224-9 (2007).
13. T. H. Park, and M. L. Shuler, "Integration of cell culture and microfabrication technology," Biotechnol Prog, 19, 243-253 (2003).
14. S. M. O'Connor, J. D. Andreadis, and K. M. Shaffer, "Immobilization of neural cells in three-dimensional matrices for biosensor applications," Biosens Bioelectron, 14, 871-881 (2000).
15. L. Bousse, "Whole cell biosensors," Sensors and Actuators B: Chemical, 34(1-3), 270-275 (1996).
16. A. Natarajan, P. Molnar, K. Sieverdes et al., "Microelectrode array recordings of cardiac action potentials as a high throughput method to evaluate pesticide toxicity," Toxicology in Vitro, 20(3), 375-381 (2006).
17. H. M. McConnell, J. C. Owicki, J. W. Parce et al., "The cytosensor microphysiometer: biological applications of silicon technology," Science, 257(5078), 1906-12 (1992).
18. J. R. Zysk, and W. R. Baumbach, "Homogeneous pharmacologic and cell-based screens provide diverse strategies in drug discovery: somatostatin antagonists as a case study," Combinatorial Chemistry High Throughput Screening, 1, 171-183 (1998).
19. C. R. Keese, and I. Giaever, "A biosensor that monitors cell morphology with electric fields," IEEE Engineering in Medicine and Biology, 13(3), 402-408 (1994).
20. C. Mao, and W. S. Kisaalita, "Characterization of 3-D collagen hydrogels for functional cell-based biosensing," Biosens Bioelectron, 19(9), 1075-88 (2004).
21. A. Tona, J. T. Woodward, P. L. Jones et al., "Thin Films of Collagen Affect Smooth Muscle Cell Morphology ?AU - Elliott, John T," Langmuir, 19(5), 1506-1514 (2002).
22. C. M. Lo, C. R. Keese, and I. Giaever, "pH changes in pulsed CO2 incubators cause periodic changes in cell morphology," Exp Cell Res, 213(2), 391-7 (1994).
23. I. Giaever, and C. R. Keese, "A morphological biosensor for mammalian cells," Nature, 366(6455), 591-2 (1993).
24. C. E. Campbell, M. M. Laane, E. Haugarvoll et al., "Monitoring viral-induced cell death using electric cellsubstrate impedance sensing," Biosens. Bioelectron., 23, 536-542 (2007).
25. W. H. van der Schalie, R. R. James, and T. P. Gargan, 2nd, "Selection of a battery of rapid toxicity sensors for drinking water evaluation," Biosens Bioelectron, 22(1), 18-27 (2006).
26. J. M. Farber, and J. I. Speirs, "Potential use of continuous cell lines to distinguish between pathogenic and nonpathogenic Listeria spp.," J Clin Microbiol, 25(8), 1463-1466 (1987).
27. B. Ekwall, F. A. Barile, A. Castano et al., "MEIC evaluation of acute systemic toxicity: Part VI. The prediction of human toxicity by rodent LD50 values and results from 61 in vitro methods," ATLA, 26, 617-658 (1998).
28. F. Xu, S. Moon, A. E. Emre et al., "Cell bioprinting as a potential high-throughput method for fabricating cellbased biosensors (CBBs)." 387-391.
29. F. Xu, S. Moon, A. E. Emre et al., "A droplet based building block approach for bladder smooth muscle cell (SMC) proliferation," Biofabrication, in press (2010).
30. S. Moon, S. K. Hasan, Y. S. Song et al., "Layer by layer three-dimensional tissue epitaxy by cell-laden hydrogel droplets," Tissue Eng Part C Methods, 16(1), 157-66 (2010).
31. S. Moon, H. O. Keles, A. Ozcan et al., "Integrating microfluidics and lensless imaging for point-of-care testing," Biosens Bioelectron, 24(11), 3208-3214 (2009).
32. J. L. Charest, M. T. Eliason, A. J. Garcia et al., "Combined microscale mechanical topography and chemical patterns on polymer cell culture substrates," Biomaterials, 27(11), 2487-94 (2006).
33. Y. C. Fung, [Biomechanics: Mechanical Properties of Living Tissues] Springer-Verlag, New York(1993).
34. H. Wolinsky, and S. Glagov, "Structural Basis for the Static Mechanical Properties of the Aortic Media," Circ Res, 14, 400-13 (1964).
35. L. D. Black, 3rd, J. D. Meyers, J. S. Weinbaum et al., "Cell-induced alignment augments twitch force in fibrin gel-based engineered myocardium via gap junction modification," Tissue Eng Part A, 15(10), 3099-108 (2009).