Homogeneous pharmacologic and cell-based screens provide diverse strategies in drug discovery: Somatostatin antagonists as a case study

Combinatorial Chemistry and High Throughput Screening

Volumn 1, Issue 4, 1998, Pages 171-183

  Zysk, John R ^a   Baumbach, William R ^b  

^a Caliper Life Sciences   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE LIBRARY; SOMATOSTATIN;

ANIMAL; CELL CULTURE; CELL FREE SYSTEM; DRUG ANTAGONISM; DRUG SCREENING; HUMAN; METHODOLOGY; REVIEW; SPECTROFLUOROMETRY;

ANIMALS; CELL-FREE SYSTEM; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; HUMANS; PEPTIDE LIBRARY; SOMATOSTATIN; SPECTROMETRY, FLUORESCENCE;

EID: 0032241658     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Udenfriend, S.; Gerber, L.; Nelson, N., Anal. Biochem., 1987, 161, 494.
2. Alam, J.; Cook, J. Anal. Biochem., 1990, 188, 245.
3. Mellor, G.W.; Burden, M.N.; Preaudat, M; Joseph, Y.; Cooksley, S.B.; Ellis, J.H.; Banks, M.N. J. Biomol. Screening, 1998, 3, 91.
4. Guiliano, K.A.; DeBiasio, R.L.; Dunlay, R.T.; Gough, A.; Volosky, J.M.; Zock, J.; Pavlakis, G.N.; Taylor, D.L. J. Biomol. Screening, 1997, 2, 249.
5. Bertherat, J.; Berod, A.; Normand, E.; Bloch, B.; Rostene, W.; Kordon, C., Epelbaum, J. Neuroendocrinology, 1990, 52 (Suppl. 1), 119.
6. Gillies, G. Trends Pharmacol. Sci., 1997, 18, 87.
7. Reubi, J.-C.; Landolt, A.M. J. Clin. Endocrinol. Metab., 1988, 68, 844.
8. Reubi, J.-C.; Laissue, J. Trends Pharmacol. Sci., 1995, 16, 110.
9. Beal, M.F.; Mazurek, M.F.; Tran, V.; Chattha, G.; Bird, E.D.; Martin, J.B. Science, 1985, 229, 289.
10. Bissette, G.; Widerlov, E.; Walleus, H.; Karlsson, I.; Eklund, K.; Forsman, A.; Nemeroff, C.B. Arch. Gen. Psychiatry, 1986, 43, 1148.
11. Baumbach, W.R.; Carrick, T.A.; Pausch, M.H.; Bingham, B.; Carmignac, D.; Robinson, I.C.A.F.; Houghten, R.; Eppler, C.M.; Price, L.A.; Zysk, J.R. Mol. Pharm., Nov., 1998, 54 (in press).
12. th Meeting of the Endocrine Society, Minneapolis, 1997, Abstract no. OR43-5.
13. Manly, S.P. J. Biomol. Screening, 1997, 2, 197.
14. Parandoosh, Z. J. Biomol. Screening, 1997, 2, 201.
15. Pert, C.B.; Snyder, S.H.; Mol. Pharm., 1974, 10, 868.
16. Cerione, R.A.; Codina, J.; Benovic, J.L.; Lefkowitz, R.J.; Birnbaumer, L.; Caron, M.G. Biochemistry, 1984, 23, 4519.
17. Sheets, M.P.; Warrior, U.P.; Yoon, H.; Mollison, K.W.; Djuric, S.W.; Trevillyan, J.M. J. Biomol. Screening, 1998, 3, 139.
18. Brazeau, P.; Vale, W.W.; Burgus, R.; Ling, N.; Butcher, M.; Rivier, J.; Guillemin, R. Science, 1973, 179, 77.
19. Reichlin, S. N. Engl. J. Med., 1982, 309, 1495 and 1556.
20. Lewin, M.J.M. Annu. Rev. Physiol., 1992, 54, 455.
21. Epelbaum, J. In Somatostatin; C. Weil; E.E. Muller; M.O. Thomer, Eds.; Springer Verlag: New York, 1992, pp. 17-28.
22. Reisine, T.; Bell, G.I. Endocrine Rev., 1995, 16, 427.
23. Eppler, C.M.; Zysk, J.Z.; Corbett, M.J.; Shieh, H-M. J. Biol. Chem., 1992, 267, 15603.
24. Hulmes, J.D.; Corbett, M.J.; Zysk, J.R.; Bohlen, P.; Eppler, C.M. Biochem. Biophys. Res. Comm., 1992, 184, 131.
25. Baumbach, W.R.; Bingham, B.; Zysk, J.R. In Molecular Endocrinology: Genetic Analysis of Hormones and Their Receptors; G. Rumsby; S.M. Farrow, Eds; BIOS Scientific Publishers Ltd.: Oxford, 1997, pp. 157-178.
26. Price, L.A.; Kajkowski, E.M.; Hadcock, J.R.; Ozenberger, B.A.; Pausch, M.H. Mol. Cell. Biol., 1995, 15, 6188.
27. Bass, R.T.; Buckwalter, B.L.; Patel, B.P.; Pausch, M.H.; Price, L.A.; Strnad, J.; Hadcock, J.R. Mol. Pharmacology, 1996, 50, 709.
28. Houghten, R.A.; Appel, J.R.; Blondelle, S.E.; Cuervo, J.H.; Dooley, C.T.; Pinilla, C. BioTechniques, 1992, 13, 412.
29. Dooley, C.T.; Chung, N.N.; Wilkes, B.C.; Schiller, P.W.; Bidlack, J.M.; Pasternak, G.W.; Houghten, R.A. Science, 1994, 266, 2019.
30. Appell, K.C.; Chung, T.D.Y.; Solly, K.J.; Chelsky, D. J. Biomol. Screening, 1998, 3, 19.
31. Eichler, J.; Houghten, R.A. Biochem., 1993, 32, 11035.
32. Zysk, J.R.; Johnson, B.; Ozenberger, B.A.; Bingham, B.; Gorski, J. Endocrinology, 1995, 136, 1323.
33. Chien, C.; Bartel, P.; Sternglanz, R.; Fields, S. Proc. Natl. Acad. Sci. USA, 1991, 88, 9578.
34. Oldenburg, K.R.; Zhang J.-H.; Chen, T.; Maffia III, A.; Blom, K.F.; Combs, A.P.; Chung, T.D.Y. J. Biomolecular Screening, 1998, 3, 55.
35. Unger, E. C.; McCreery, T.P.,; Sweitzer, R.H. Investigative Radiology, 1997, 32, 723.
36. Bosworth, N.; Towers, P. Nature, 1989, 341, 167.
37. Fehrentz, J.A.; Chomier, B.; Bignon, E.; Venaud, S. Chermann, J.C.; Nisato, D. Biochem. Biophys. Res. Comm., 1992, 188, 865.
38. Mayo, K.E. Mol. Endocrinology, 1992, 6, 1734.
39. Lin, C.; Lin, S.-C.; Chang, C.-P.; Rosenfeld, M.G. Nature, 1992, 350, 765.
40. Gaylinn, B.D.; Harrison, J.K.; Zysk, J.R.; Lyons, C.E.; Lynch, K.R.; Thorner, M.O. Mol. Endocrinol., 1993, 7, 77.
41. Gaylinn, B.D.; Lyons, C.E.; Zysk, J.R.; Clarke, I.J.; Thorner, M.O. Endocrinology, 1994, 135, 950.
42. Carrick, T.A.; Bingham, C.; Eppler, C.M.; Baumbach, W.R.; Zysk, J.R. Endocrinology, 1995, 136, 4701.
43. Gorman, C.; Skinner, R.H.; Skelly, J.V.; Neidle, S.; Lowe, P.N. J. Biol. Chem., 1996, 271, 6713.
44. Watson, J.; Selkirk, J.V.; Brown, A.M. J. Biomol. Screening, 1998, 3, 101.
45. Cubitt, A.B.; Heim, R.; Adams, S.R.; Boyd, A.E.; Gross, L.A.; Tsien, R.Y. TiBS, 1995, 20, 448.
46. Selvin, P.R. Methods in Enzymol., 1995, 246, 300.
47. Mahajan, N.P.; Linder, K.; Berry, G.; Gordon, G.W.; Heim, R.; Herman, B. Nature Biotechnol., 1998, 16, 547.
48. Holzwarth, A.R. Methods in Enzymol., 1995, 246, 334.
49. Gaarde, W.A.; Hunter, T.; Brady, H.; Murray, B.W.; Goldman, M.E. J. Biomol. Screening, 1997, 2, 213.
50. Jolley, M.E. J. Biomol. Screening, 1996, 1, 33.
51. Levine, L.M.; Michener, M.L.; Toth, M.V.; Holverda, B.C. Anal. Biochem., 1997, 247, 83.
52. Bolger, R.; Wiese, T.E.; Ervin, K.; Nestich, S.; Checovich, W. Enviromental Health Perspectives, 1998, 106 (in press).
53. Rogers, M.V. Drug Discovery Today, 1997, 2, 156.
54. Gurney, A.M. In Receptor-Effector Coupling, A Practical Approach, E.C. Hulme, Ed.; IRL Press: Oxford, 1990, pp. 117-154.
55. Tsien, R.Y.; Rink, T.J.; Poenie, M. Cell Calcium, 1985, 6, 145.
56. George, S.E.; Bungay, P.J.; Naylor, L.H. J. Biomol. Screen., 1997, 2, 235.
57. Sadeghi, H.; Lumanglas, A.L.; Baumbach, W.R.; Wang, B.S. J. Endocrinology, 1993, 139, 495.
58. Karlsson, R.; Stahlberg, R., Anal Biochem., 1995, 223, 274.
59. Persidis, A. Nature Biotechnol., 1998, 16, 100.