Design and optimization of new piperidines as renin inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 21, 2010, Pages 6286-6290

  Corminboeuf, Olivier ^a   Bezenon, Olivier ^a   Grisostomi, Corinna ^a   Remeň, Ľuboš ^a   Richard Bildstein, Sylvia ^a   Bur, Daniel ^a   Prade, Lars ^a   Hess, Patrick ^a   Strickner, Panja ^a   Fischli, Walter ^a   Steiner, Beat ^a   Treiber, Alexander ^a  

^a ACTELION PHARMACEUTICALS LTD   (Switzerland)

Author keywords

Hypertension; Piperidines; Renin inhibitors; Renin angiotensin aldosterone system

Indexed keywords

PIPERIDINE DERIVATIVE; RENIN; RENIN INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG EFFICACY; HYPERTENSION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TRANSGENIC RAT;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; ENZYME INHIBITORS; MODELS, MOLECULAR; PIPERIDINES; PROTEIN CONFORMATION; RATS; RENIN; STRUCTURE-ACTIVITY RELATIONSHIP; X-RAY DIFFRACTION;

RATTUS;

EID: 77957887804     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.086     Document Type: Article

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