Piperidine-based renin inhibitors: Upper chain optimization

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 21, 2010, Pages 6291-6296

  Corminboeuf, Olivier ^a   Bezenon, Olivier ^a   Remeň, Ľuboš ^a   Grisostomi, Corinna ^a   Richard Bildstein, Sylvia ^a   Bur, Daniel ^a   Prade, Lars ^a   Strickner, Panja ^a   Hess, Patrick ^a   Fischli, Walter ^a   Steiner, Beat ^a   Treiber, Alexander ^a  

^a ACTELION PHARMACEUTICALS LTD   (Switzerland)

Author keywords

Hypertension; Piperidine; Renin angiotensin aldosterone system; Renin inhibitor

Indexed keywords

ACT 178882; MIDAZOLAM; MK 1597; RENIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG SYNTHESIS; HUMAN; IC 50; NONHUMAN; PHARMACODYNAMICS; RAT; STRUCTURE ACTIVITY RELATION;

ANGIOTENSINOGEN; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HUMANS; INDICATORS AND REAGENTS; MODELS, MOLECULAR; PIPERIDINES; RATS; RENIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77957868394     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.087     Document Type: Article

References (11)

1. O. Corminboeuf, O. Bezenon, Ľ. Remeň, C. Grisostomi, S. Richard-Bildstein, D. Bur, L. Prade, P. Strickner, P. Hess, W. Fischli, B. Steiner, and A. Treiber Bioorg. Med. Chem. Lett. 20 2010 6286
2. B.P. Brockway, P.A. Mills, and S.H. Azar Clin. Exp. Hyper. - Theory Pract. 13 1991 885
3. C. Guiol, C. Ledoussal, and J.-M. Surgé J. Pharmcol. Toxicol. Methods 28 1992 99
4. P. Hess, M. Clozel, and J.-P. Clozel J. Appl. Physiol. 81 1996 1027
5. R. Güller, A. Binggeli, V. Breu, D. Bur, W. Fischli, G. Hirth, C. Jenny, M. Kansy, F. Montavon, M. Müller, C. Oefner, H. Stadler, E. Vieira, M. Wilhelm, W. Wostl, and H.P. Märki Bioorg. Med. Chem. Lett. 9 1999 1403
6. O. Bezenon, D. Bur, T. Weller, S. Richard-Bildstein, Ľ. Remeň, T. Sifferlen, O. Corminboeuf, C. Grisostomi, C. Boss, L. Prade, S. Delahaye, A. Treiber, P. Strickner, C. Binkert, P. Hess, B. Steiner, and W. Fischli J. Med. Chem. 52 2009 3689
7. P.C. Meltzer, P. Blundell, Y.F. Yong, Z. Chen, C. George, M.D. Gonzalez, and B.K. Madras J. Med. Chem. 43 2000 2982
8. J. Rahuel, V. Rasetti, J. Maibaum, H. Rüeger, R. Göschke, N.-C. Cohen, S. Stutz, F. Cumin, W. Fuhrer, J.M. Wood, and M.G. Grütter Chem. Biol. 7 2000 493
9. J.M. Fortunato, and B. Ganem J. Org. Chem. 41 1976 2194
10. M. Ihara, Y. Tokunaga, and K. Fukumoto J. Org. Chem. 55 1990 4497
11. V. Jurkauskas, J.P. Sadighi, and S. Buchwald Org. Lett. 5 2003 2417