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Volumn 74, Issue 1, 2010, Pages 16-23

Purification and characterization of Yersinia enterocolitica and Yersinia pestis LcrV-cholera toxin A2/B chimeras

Author keywords

A2B chimera; Cholera toxin; Expression; Mucosal adjuvant; Trafficking; Yersinia pestis

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL VACCINE; CHOLERA TOXIN; LCRV PROTEIN, YERSINIA; PORE FORMING CYTOTOXIC PROTEIN;

EID: 77957862166     PISSN: 10465928     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pep.2010.04.021     Document Type: Article
Times cited : (8)

References (63)
  • 4
    • 0014215005 scopus 로고
    • Pneumonic plague in an untreated plague-vaccinated individual
    • R.J. Cohen, and J.L. Stockard Pneumonic plague in an untreated plague-vaccinated individual Jama 202 1967 365 366
    • (1967) Jama , vol.202 , pp. 365-366
    • Cohen, R.J.1    Stockard, J.L.2
  • 5
    • 17044450091 scopus 로고
    • Live, attenuated Yersinia pestis vaccine: Virulent in nonhuman primates, harmless to guinea pigs
    • K.F. Meyer, G. Smith, L. Foster, M. Brookman, and M. Sung Live, attenuated Yersinia pestis vaccine: virulent in nonhuman primates, harmless to guinea pigs J. Infect. Dis. 129 Suppl. 1974 S85 12
    • (1974) J. Infect. Dis. , vol.129 , Issue.SUPPL.
    • Meyer, K.F.1    Smith, G.2    Foster, L.3    Brookman, M.4    Sung, M.5
  • 6
    • 0035919586 scopus 로고    scopus 로고
    • Vaccination against bubonic and pneumonic plague
    • R.W. Titball, and E.D. Williamson Vaccination against bubonic and pneumonic plague Vaccine 19 2001 4175 4184
    • (2001) Vaccine , vol.19 , pp. 4175-4184
    • Titball, R.W.1    Williamson, E.D.2
  • 13
    • 0031750789 scopus 로고    scopus 로고
    • Protection against experimental bubonic and pneumonic plague by a recombinant capsular F1-V antigen fusion protein vaccine
    • D.G. Heath, G.W. Anderson Jr., J.M. Mauro, S.L. Welkos, G.P. Andrews, J. Adamovicz, and A.M. Friedlander Protection against experimental bubonic and pneumonic plague by a recombinant capsular F1-V antigen fusion protein vaccine Vaccine 16 1998 1131 1137
    • (1998) Vaccine , vol.16 , pp. 1131-1137
    • Heath, D.G.1    Anderson Jr., G.W.2    Mauro, J.M.3    Welkos, S.L.4    Andrews, G.P.5    Adamovicz, J.6    Friedlander, A.M.7
  • 14
    • 40549101035 scopus 로고    scopus 로고
    • Current challenges in the development of vaccines for pneumonic plague
    • S.T. Smiley Current challenges in the development of vaccines for pneumonic plague Expert. Rev. Vaccines 7 2008 209 221
    • (2008) Expert. Rev. Vaccines , vol.7 , pp. 209-221
    • Smiley, S.T.1
  • 15
    • 32544441535 scopus 로고    scopus 로고
    • Intranasal Protollin/F1-V vaccine elicits respiratory and serum antibody responses and protects mice against lethal aerosolized plague infection
    • T. Jones, J.J. Adamovicz, S.L. Cyr, C.R. Bolt, N. Bellerose, L.M. Pitt, G.H. Lowell, and D.S. Burt Intranasal Protollin/F1-V vaccine elicits respiratory and serum antibody responses and protects mice against lethal aerosolized plague infection Vaccine 24 2006 1625 1632
    • (2006) Vaccine , vol.24 , pp. 1625-1632
    • Jones, T.1    Adamovicz, J.J.2    Cyr, S.L.3    Bolt, C.R.4    Bellerose, N.5    Pitt, L.M.6    Lowell, G.H.7    Burt, D.S.8
  • 17
    • 0032748077 scopus 로고    scopus 로고
    • Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins
    • R. Rappuoli, M. Pizza, G. Douce, and G. Dougan Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins Immunol. Today 20 1999 493 500
    • (1999) Immunol. Today , vol.20 , pp. 493-500
    • Rappuoli, R.1    Pizza, M.2    Douce, G.3    Dougan, G.4
  • 18
    • 0028244301 scopus 로고
    • Strategies for the induction of immune responses at mucosal surfaces making use of cholera toxin B subunit as immunogen, carrier, and adjuvant
    • J. Holmgren, C. Czerkinsky, N. Lycke, and A.M. Svennerholm Strategies for the induction of immune responses at mucosal surfaces making use of cholera toxin B subunit as immunogen, carrier, and adjuvant Am. J. Trop. Med. Hyg. 50 1994 42 54
    • (1994) Am. J. Trop. Med. Hyg. , vol.50 , pp. 42-54
    • Holmgren, J.1    Czerkinsky, C.2    Lycke, N.3    Svennerholm, A.M.4
  • 19
    • 0022460378 scopus 로고
    • Strong adjuvant properties of cholera toxin on gut mucosal immune responses to orally presented antigens
    • N. Lycke, and J. Holmgren Strong adjuvant properties of cholera toxin on gut mucosal immune responses to orally presented antigens Immunology 59 1986 301 308
    • (1986) Immunology , vol.59 , pp. 301-308
    • Lycke, N.1    Holmgren, J.2
  • 22
    • 33644815406 scopus 로고    scopus 로고
    • Immunomodulation with enterotoxins for the generation of secretory immunity or tolerance. applications for oral infections
    • G. Hajishengallis, S. Arce, C.M. Gockel, T.D. Connell, and M.W. Russell Immunomodulation with enterotoxins for the generation of secretory immunity or tolerance. applications for oral infections J. Dent. Res. 84 2005 1104 1116
    • (2005) J. Dent. Res. , vol.84 , pp. 1104-1116
    • Hajishengallis, G.1    Arce, S.2    Gockel, C.M.3    Connell, T.D.4    Russell, M.W.5
  • 23
    • 34249866843 scopus 로고    scopus 로고
    • Induction of cell signaling events by the cholera toxin B subunit in antigen-presenting cells
    • A.C. Schnitzler, J.M. Burke, and L.M. Wetzler Induction of cell signaling events by the cholera toxin B subunit in antigen-presenting cells Infect. Immun. 75 2007 3150 3159
    • (2007) Infect. Immun. , vol.75 , pp. 3150-3159
    • Schnitzler, A.C.1    Burke, J.M.2    Wetzler, L.M.3
  • 24
    • 35448963924 scopus 로고    scopus 로고
    • Effect of adjuvants and route of immunizations on the immune response to recombinant plague antigens
    • S. Uddowla, L.C. Freytag, and J.D. Clements Effect of adjuvants and route of immunizations on the immune response to recombinant plague antigens Vaccine 25 2007 7984 7993
    • (2007) Vaccine , vol.25 , pp. 7984-7993
    • Uddowla, S.1    Freytag, L.C.2    Clements, J.D.3
  • 26
    • 43049157532 scopus 로고    scopus 로고
    • Cholera toxin structure, gene regulation and pathophysiological and immunological aspects
    • J. Sanchez, and J. Holmgren Cholera toxin structure, gene regulation and pathophysiological and immunological aspects Cell Mol, Life Sci, 65 2008 1347 1360
    • (2008) Cell Mol, Life Sci , vol.65 , pp. 1347-1360
    • Sanchez, J.1    Holmgren, J.2
  • 28
    • 0026489949 scopus 로고
    • Fusion proteins containing the A2 domain of cholera toxin assemble with B polypeptides of cholera toxin to form immunoreactive and functional holotoxin-like chimeras
    • M.G. Jobling, and R.K. Holmes Fusion proteins containing the A2 domain of cholera toxin assemble with B polypeptides of cholera toxin to form immunoreactive and functional holotoxin-like chimeras Infect. Immun. 60 1992 4915 4924
    • (1992) Infect. Immun. , vol.60 , pp. 4915-4924
    • Jobling, M.G.1    Holmes, R.K.2
  • 29
    • 0031280495 scopus 로고    scopus 로고
    • Construction and characterization of versatile cloning vectors for efficient delivery of native foreign proteins to the periplasm of Escherichia coli
    • M.G. Jobling, L.M. Palmer, J.L. Erbe, and R.K. Holmes Construction and characterization of versatile cloning vectors for efficient delivery of native foreign proteins to the periplasm of Escherichia coli Plasmid 38 1997 158 173
    • (1997) Plasmid , vol.38 , pp. 158-173
    • Jobling, M.G.1    Palmer, L.M.2    Erbe, J.L.3    Holmes, R.K.4
  • 30
    • 0031908219 scopus 로고    scopus 로고
    • Mucosal immunogenicity of a holotoxin-like molecule containing the serine-rich Entamoeba histolytica protein (SREHP) fused to the A2 domain of cholera toxin
    • F. Sultan, L.L. Jin, M.G. Jobling, R.K. Holmes, and S.L. Stanley Jr. Mucosal immunogenicity of a holotoxin-like molecule containing the serine-rich Entamoeba histolytica protein (SREHP) fused to the A2 domain of cholera toxin Infect. Immun. 66 1998 462 468
    • (1998) Infect. Immun. , vol.66 , pp. 462-468
    • Sultan, F.1    Jin, L.L.2    Jobling, M.G.3    Holmes, R.K.4    Stanley Jr., S.L.5
  • 31
    • 9244255836 scopus 로고    scopus 로고
    • Use of translational fusion of the MrpH fimbrial adhesin-binding domain with the cholera toxin A2 domain, coexpressed with the cholera toxin B subunit, as an intranasal vaccine to prevent experimental urinary tract infection by Proteus mirabilis
    • X. Li, J.L. Erbe, C.V. Lockatell, D.E. Johnson, M.G. Jobling, R.K. Holmes, and H.L. Mobley Use of translational fusion of the MrpH fimbrial adhesin-binding domain with the cholera toxin A2 domain, coexpressed with the cholera toxin B subunit, as an intranasal vaccine to prevent experimental urinary tract infection by Proteus mirabilis Infect. Immun. 72 2004 7306 7310
    • (2004) Infect. Immun. , vol.72 , pp. 7306-7310
    • Li, X.1    Erbe, J.L.2    Lockatell, C.V.3    Johnson, D.E.4    Jobling, M.G.5    Holmes, R.K.6    Mobley, H.L.7
  • 32
    • 23944432459 scopus 로고    scopus 로고
    • Heteropentameric cholera toxin B subunit chimeric molecules genetically fused to a vaccine antigen induce systemic and mucosal immune responses: A potential new strategy to target recombinant vaccine antigens to mucosal immune systems
    • T. Harakuni, H. Sugawa, A. Komesu, M. Tadano, and T. Arakawa Heteropentameric cholera toxin B subunit chimeric molecules genetically fused to a vaccine antigen induce systemic and mucosal immune responses: a potential new strategy to target recombinant vaccine antigens to mucosal immune systems Infect. Immun. 73 2005 5654 5665
    • (2005) Infect. Immun. , vol.73 , pp. 5654-5665
    • Harakuni, T.1    Sugawa, H.2    Komesu, A.3    Tadano, M.4    Arakawa, T.5
  • 33
    • 28244463329 scopus 로고    scopus 로고
    • Induction and recall of immune memory by mucosal immunization with a non-toxic recombinant enterotoxin-based chimeric protein
    • C.M. Gockel, and M.W. Russell Induction and recall of immune memory by mucosal immunization with a non-toxic recombinant enterotoxin-based chimeric protein Immunology 116 2005 477 486
    • (2005) Immunology , vol.116 , pp. 477-486
    • Gockel, C.M.1    Russell, M.W.2
  • 34
    • 0029036648 scopus 로고
    • Mucosal immunization with a bacterial protein antigen genetically coupled to cholera toxin A2/B subunits
    • G. Hajishengallis, S.K. Hollingshead, T. Koga, and M.W. Russell Mucosal immunization with a bacterial protein antigen genetically coupled to cholera toxin A2/B subunits J. Immunol. 154 1995 4322 4332
    • (1995) J. Immunol. , vol.154 , pp. 4322-4332
    • Hajishengallis, G.1    Hollingshead, S.K.2    Koga, T.3    Russell, M.W.4
  • 35
    • 0035872945 scopus 로고    scopus 로고
    • In vitro assembly of novel cholera toxin-like complexes
    • S.O. Hatic 2nd, J.A. McCann, and W.D. Picking In vitro assembly of novel cholera toxin-like complexes Anal. Biochem. 292 2001 171 177
    • (2001) Anal. Biochem. , vol.292 , pp. 171-177
    • Hatic II, S.O.1    McCann, J.A.2    Picking, W.D.3
  • 36
    • 0037031855 scopus 로고    scopus 로고
    • Detoxification of cholera toxin without removal of its immunoadjuvanticity by the addition of (STa-related) peptides to the catalytic subunit. A potential new strategy to generate immunostimulants for vaccination
    • J. Sanchez, G. Wallerstrom, M. Fredriksson, J. Angstrom, and J. Holmgren Detoxification of cholera toxin without removal of its immunoadjuvanticity by the addition of (STa-related) peptides to the catalytic subunit. A potential new strategy to generate immunostimulants for vaccination J. Biol. Chem. 277 2002 33369 33377
    • (2002) J. Biol. Chem. , vol.277 , pp. 33369-33377
    • Sanchez, J.1    Wallerstrom, G.2    Fredriksson, M.3    Angstrom, J.4    Holmgren, J.5
  • 37
    • 0027102749 scopus 로고
    • Intermolecular interactions between the A and B subunits of heat-labile enterotoxin from Escherichia coli promote holotoxin assembly and stability in vivo
    • S.J. Streatfield, M. Sandkvist, T.K. Sixma, M. Bagdasarian, W.G. Hol, and T.R. Hirst Intermolecular interactions between the A and B subunits of heat-labile enterotoxin from Escherichia coli promote holotoxin assembly and stability in vivo Proc. Natl. Acad. Sci. USA 89 1992 12140 12144
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 12140-12144
    • Streatfield, S.J.1    Sandkvist, M.2    Sixma, T.K.3    Bagdasarian, M.4    Hol, W.G.5    Hirst, T.R.6
  • 38
    • 0002588630 scopus 로고
    • Coordinated assembly of multisubunit proteins: Oligomerization of bacterial enterotoxins in vivo and in vitro
    • S.J. Hardy, J. Holmgren, S. Johansson, J. Sanchez, and T.R. Hirst Coordinated assembly of multisubunit proteins: oligomerization of bacterial enterotoxins in vivo and in vitro Proc. Natl. Acad. Sci. USA 85 1988 7109 7113
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 7109-7113
    • Hardy, S.J.1    Holmgren, J.2    Johansson, S.3    Sanchez, J.4    Hirst, T.R.5
  • 39
    • 0029018327 scopus 로고
    • Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter
    • L.M. Guzman, D. Belin, M.J. Carson, and J. Beckwith Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter J. Bacteriol. 177 1995 4121 4130
    • (1995) J. Bacteriol. , vol.177 , pp. 4121-4130
    • Guzman, L.M.1    Belin, D.2    Carson, M.J.3    Beckwith, J.4
  • 40
    • 0025180566 scopus 로고
    • Recombinant fusion protein for simple detection of Escherichia coli heat-stable enterotoxin by GM1 enzyme-linked immunosorbent assay
    • J. Sanchez, J. Holmgren, and A.M. Svennerholm Recombinant fusion protein for simple detection of Escherichia coli heat-stable enterotoxin by GM1 enzyme-linked immunosorbent assay J. Clin. Microbiol. 28 1990 2175 2177
    • (1990) J. Clin. Microbiol. , vol.28 , pp. 2175-2177
    • Sanchez, J.1    Holmgren, J.2    Svennerholm, A.M.3
  • 41
    • 0033548246 scopus 로고    scopus 로고
    • Structural basis for the differential toxicity of cholera toxin and Escherichia coli heat-labile enterotoxin. Construction of hybrid toxins identifies the A2-domain as the determinant of differential toxicity
    • C. Rodighiero, A.T. Aman, M.J. Kenny, J. Moss, W.I. Lencer, and T.R. Hirst Structural basis for the differential toxicity of cholera toxin and Escherichia coli heat-labile enterotoxin. Construction of hybrid toxins identifies the A2-domain as the determinant of differential toxicity J. Biol. Chem. 274 1999 3962 3969
    • (1999) J. Biol. Chem. , vol.274 , pp. 3962-3969
    • Rodighiero, C.1    Aman, A.T.2    Kenny, M.J.3    Moss, J.4    Lencer, W.I.5    Hirst, T.R.6
  • 42
    • 19744375740 scopus 로고    scopus 로고
    • Characterization of fluorescent chimeras of cholera toxin and Escherichia coli heat-labile enterotoxins produced by use of the twin arginine translocation system
    • J.K. Tinker, J.L. Erbe, and R.K. Holmes Characterization of fluorescent chimeras of cholera toxin and Escherichia coli heat-labile enterotoxins produced by use of the twin arginine translocation system Infect. Immun. 73 2005 3627 3635
    • (2005) Infect. Immun. , vol.73 , pp. 3627-3635
    • Tinker, J.K.1    Erbe, J.L.2    Holmes, R.K.3
  • 43
    • 0030777667 scopus 로고    scopus 로고
    • Regions of Yersinia pestis v antigen that contribute to protection against plague identified by passive and active immunization
    • J. Hill, S.E. Leary, K.F. Griffin, E.D. Williamson, and R.W. Titball Regions of Yersinia pestis V antigen that contribute to protection against plague identified by passive and active immunization Infect. Immun. 65 1997 4476 4482
    • (1997) Infect. Immun. , vol.65 , pp. 4476-4482
    • Hill, J.1    Leary, S.E.2    Griffin, K.F.3    Williamson, E.D.4    Titball, R.W.5
  • 44
    • 0031907148 scopus 로고    scopus 로고
    • Analysis of the Yersinia pestis v protein for the presence of linear antibody epitopes
    • J.K. Pullen, G.W. Anderson Jr., S.L. Welkos, and A.M. Friedlander Analysis of the Yersinia pestis V protein for the presence of linear antibody epitopes Infect. Immun. 66 1998 521 527
    • (1998) Infect. Immun. , vol.66 , pp. 521-527
    • Pullen, J.K.1    Anderson Jr., G.W.2    Welkos, S.L.3    Friedlander, A.M.4
  • 47
    • 84934441945 scopus 로고    scopus 로고
    • Oral vaccination with different antigens from Yersinia pestis KIM delivered by live attenuated Salmonella typhimurium elicits a protective immune response against plague
    • C.G. Branger, J.D. Fetherston, R.D. Perry, and R. Curtiss 3rd Oral vaccination with different antigens from Yersinia pestis KIM delivered by live attenuated Salmonella typhimurium elicits a protective immune response against plague Adv. Exp. Med. Biol. 603 2007 387 399
    • (2007) Adv. Exp. Med. Biol. , vol.603 , pp. 387-399
    • Branger, C.G.1    Fetherston, J.D.2    Perry, R.D.3    Curtiss III, R.4
  • 48
    • 68349096228 scopus 로고    scopus 로고
    • Oral vaccination with LcrV from Yersinia pestis KIM delivered by live attenuated Salmonella enterica serovar Typhimurium elicits a protective immune response against challenge with Yersinia pseudotuberculosis and Yersinia enterocolitica
    • C.G. Branger, A. Torres-Escobar, W. Sun, R. Perry, J. Fetherston, K.L. Roland, and R. Curtiss 3rd Oral vaccination with LcrV from Yersinia pestis KIM delivered by live attenuated Salmonella enterica serovar Typhimurium elicits a protective immune response against challenge with Yersinia pseudotuberculosis and Yersinia enterocolitica Vaccine 27 2009 5363 5370
    • (2009) Vaccine , vol.27 , pp. 5363-5370
    • Branger, C.G.1    Torres-Escobar, A.2    Sun, W.3    Perry, R.4    Fetherston, J.5    Roland, K.L.6    Curtiss III, R.7
  • 50
    • 0031018415 scopus 로고    scopus 로고
    • Passive immunity to infection with Yersinia spp. mediated by anti-recombinant v antigen is dependent on polymorphism of v antigen
    • A. Roggenkamp, A.M. Geiger, L. Leitritz, A. Kessler, and J. Heesemann Passive immunity to infection with Yersinia spp. mediated by anti-recombinant V antigen is dependent on polymorphism of V antigen Infect. Immun. 65 1997 446 451
    • (1997) Infect. Immun. , vol.65 , pp. 446-451
    • Roggenkamp, A.1    Geiger, A.M.2    Leitritz, L.3    Kessler, A.4    Heesemann, J.5
  • 51
    • 0029741379 scopus 로고    scopus 로고
    • Imaging the intracellular trafficking and state of the AB5 quaternary structure of cholera toxin
    • P.I. Bastiaens, I.V. Majoul, P.J. Verveer, H.D. Soling, and T.M. Jovin Imaging the intracellular trafficking and state of the AB5 quaternary structure of cholera toxin Embo J. 15 1996 4246 4253
    • (1996) Embo J. , vol.15 , pp. 4246-4253
    • Bastiaens, P.I.1    Majoul, I.V.2    Verveer, P.J.3    Soling, H.D.4    Jovin, T.M.5
  • 52
    • 0029898287 scopus 로고    scopus 로고
    • Transport of an external Lys-Asp-Glu-Leu (KDEL) protein from the plasma membrane to the endoplasmic reticulum: Studies with cholera toxin in Vero cells
    • I.V. Majoul, P.I. Bastiaens, and H.D. Soling Transport of an external Lys-Asp-Glu-Leu (KDEL) protein from the plasma membrane to the endoplasmic reticulum: studies with cholera toxin in Vero cells J. Cell Biol. 133 1996 777 789
    • (1996) J. Cell Biol. , vol.133 , pp. 777-789
    • Majoul, I.V.1    Bastiaens, P.I.2    Soling, H.D.3
  • 53
    • 85046915477 scopus 로고    scopus 로고
    • Plague vaccines and the molecular basis of immunity against Yersinia pestis
    • L.E. Quenee, and O. Schneewind Plague vaccines and the molecular basis of immunity against Yersinia pestis Hum. Vaccine 5 2009
    • (2009) Hum. Vaccine , vol.5
    • Quenee, L.E.1    Schneewind, O.2
  • 55
    • 0037076418 scopus 로고    scopus 로고
    • Identification of a protein secretory pathway for the secretion of heat-labile enterotoxin by an enterotoxigenic strain of Escherichia coli
    • M. Tauschek, R.J. Gorrell, R.A. Strugnell, and R.M. Robins-Browne Identification of a protein secretory pathway for the secretion of heat-labile enterotoxin by an enterotoxigenic strain of Escherichia coli Proc. Natl. Acad. Sci. USA 99 2002 7066 7071
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 7066-7071
    • Tauschek, M.1    Gorrell, R.J.2    Strugnell, R.A.3    Robins-Browne, R.M.4
  • 56
    • 0036266675 scopus 로고    scopus 로고
    • Enhanced delivery of exogenous peptides into the class i antigen processing and presentation pathway
    • L. De Haan, A.R. Hearn, A.J. Rivett, and T.R. Hirst Enhanced delivery of exogenous peptides into the class I antigen processing and presentation pathway Infect. Immun. 70 2002 3249 3258
    • (2002) Infect. Immun. , vol.70 , pp. 3249-3258
    • De Haan, L.1    Hearn, A.R.2    Rivett, A.J.3    Hirst, T.R.4
  • 58
    • 0037378940 scopus 로고    scopus 로고
    • Cholera toxin and its B subunit promote dendritic cell vaccination with different influences on Th1 and Th2 development
    • K. Eriksson, M. Fredriksson, I. Nordstrom, and J. Holmgren Cholera toxin and its B subunit promote dendritic cell vaccination with different influences on Th1 and Th2 development Infect. Immun. 71 2003 1740 1747
    • (2003) Infect. Immun. , vol.71 , pp. 1740-1747
    • Eriksson, K.1    Fredriksson, M.2    Nordstrom, I.3    Holmgren, J.4
  • 59
    • 33646541417 scopus 로고    scopus 로고
    • Adjuvants modulating mucosal immune responses or directing systemic responses towards the mucosa
    • E. Cox, F. Verdonck, D. Vanrompay, and B. Goddeeris Adjuvants modulating mucosal immune responses or directing systemic responses towards the mucosa Vet. Res. 37 2006 511 539
    • (2006) Vet. Res. , vol.37 , pp. 511-539
    • Cox, E.1    Verdonck, F.2    Vanrompay, D.3    Goddeeris, B.4
  • 60
    • 17644371966 scopus 로고    scopus 로고
    • Mucosal immunity and vaccines
    • J. Holmgren, and C. Czerkinsky Mucosal immunity and vaccines Nat. Med. 11 2005 S45 53
    • (2005) Nat. Med. , vol.11
    • Holmgren, J.1    Czerkinsky, C.2
  • 61
    • 0038325751 scopus 로고    scopus 로고
    • Mucosal immunisation and adjuvants: A brief overview of recent advances and challenges
    • J. Holmgren, C. Czerkinsky, K. Eriksson, and A. Mharandi Mucosal immunisation and adjuvants: a brief overview of recent advances and challenges Vaccine 21 Suppl. 2 2003 S89 95
    • (2003) Vaccine , vol.21 , Issue.SUPPL. 2
    • Holmgren, J.1    Czerkinsky, C.2    Eriksson, K.3    Mharandi, A.4


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