Analysis of the Yersinia pestis V protein for the presence of linear antibody epitopes

Infection and Immunity

Volumn 66, Issue 2, 1998, Pages 521-527

  Pullen, Jeffrey K ^a,b   Anderson Jr , George W ^a   Welkos, Susan L ^a   Friedlander, Arthur M ^a  

^a Fort Detrick   (United States)

^b GLAXOSMITHKLINE BIOLOGICALS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; EPITOPE; IMMUNOGLOBULIN G ANTIBODY; KEYHOLE LIMPET HEMOCYANIN; PLAGUE VACCINE; RECOMBINANT PROTEIN; SYNTHETIC PEPTIDE; VIRULENCE FACTOR;

ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; BACTERIAL VIRULENCE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GRAM NEGATIVE BACTERIUM; IMMUNIZATION; IMMUNOGENICITY; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PLAGUE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SUBCUTANEOUS DRUG ADMINISTRATION; YERSINIA PESTIS;

EID: 0031907148     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.2.521-527.1998     Document Type: Article

References (42)

1. Anderson, G. W., Jr., S. C. Lean, E. D. Williamson, R. W. Titball, S. L. Welkos, P. L. Worsham, and A. M. Friedlander. 1996. Recombinant V antigen protects mice against pneumonic and bubonic plague caused by F1-capsule-positive and -negative strains of Yersinia pestis. Infect. Immun. 64:4580-4585.
2. Antoni, G., G. D. Maso, B. Berti, C. Soldatini, and F. Cocola, 1996. Detection of antigenic determinants in the Treponema pallidum membrane protein TmpA using overlapping synthetic peptides. J. Immunol. Methods 189:137-140.
3. Ball, D. J., G. Argentieri, R. Krause, M. Lipinski, R. L. Robison, R. E. Stoll, and G. E. Visscher. 1491. Evaluation of a microchip implant system used for animal identification in rats. Lab. Anim. Sci. 41:185-186.
4. Bergman, T., S. Hakansson, A. Forsberg, L. Norlander, A. Macellaro, A. Backman, I. Bolin, and H. Wolf-Watz. 1491. Analysis of the V antigen IcrGVH-yopBD operon of Yersinia pseudotuberculosis: evidence for a regulatory role of LcrH and LcrV. J. Bacteriol. 173:1607-1616.
5. Boersma, W. J. A., J. J. Haaijman, and E. Claassen. 1993. Use of synthetic peptide determinants for the production of antibodies, p. 1-77. In A. C. Cullo (ed.). Immunohistochemistry, vol. II. John Wiley & Sons, Inc., New York. N.Y.
6. Boudet, F., J. Theze, and M. Zouali. 1991. UV-treated polystyrene microtitre plates for use in an ELISA to measure antibodies against synthetic peptides. J. Immunol. Methods 142:73-82.
7. Brubaker, R. R. 1991. Factors promoting acute and chronic diseases caused by yersiniae. Clin. Microbiol. Rev. 4:309-324.
8. Brubaker, R. R. 1991. The V antigen of Yersiniae: an overview. Contrib. Microbiol. Immunol. 12:127-133.
9. Brubaker, R. R., A. K. Sample, D. Z. Yu, R. J. Zahorchak, P. C. Hu, and J. M. Fowler. 1987. Proteolysis of V antigen from Yersinia pestis. Microb. Pathog. 2:49-62.
10. Burrows, T. W. 1957. Virulence of Pasteuretla pestis. Nature (London) 179: 1246-1247.
11. Burrows, T. W., and G. A. Bacon. 1958. The effects of loss of different virulence determinants on the virulence and immunogenicity of strains of Pasteurella pestis. Br. J. Exp. Pathol. 39:278-291.
12. Chong, P., Y.-P. Yang, D. Persaud, M. Haer, B. Tripet, E. Tam, C. Sia, and M. Klein. 1995. Immunogenicity of synthetic peptides of Haemophilus influenzae type b outer membrane protein P1. Infect. Immun. 63:3751-3758.
13. Chong, P., Y.-P. Yang, R. Fahim, P. McVerry, C. Sia, and M. Klein. 1993. Immunogenicity of overlapping synthetic peptides covering the entire sequence of Haemophilus influenzae type B outer membrane protein P2. Infect. Immun. 61:2653-2661.
14. Chong, P., G. Zobrist, C. Sia, S. Loosmore, and M. Klein. 1992. Identification of T- and B-cell epitopes of the S2 and S3 subunits of pertussis toxin by use of synthetic peptides. Infect. Immun. 60:4640-4647.
15. Doll, J. M., P. S. Zeitz, P. Ettestad, A. L. Bucholtz, T. Davis, and K. Gage. 1994. Cat-transmitted fatal pneumonic plague in a person who traveled from Colorado to Arizona. Am. J. Trop. Med. Hyg. 51:109-114.
16. Francis, M. J., G. Z. Hastings, A. D. Syred, B. McGinn, F. Brown, and D. Rowlands. 1987. Non-responsiveness to a foot and mouth disease peptide overcome by addition of foreign helper T-cell determinants. Nature 330:168-171.
17. Gilleland, L. B., and H. E. Gilleland, Jr. 1995. Synthetic peptides representing two protective, linear B-cell epitopes of outer membrane protein of Pseudomonas aeniginosa elicit whole-cell-reactive antibodies that are functionally pseudomonad specific. Infect. Immun. 63:2347-2351.
18. Heath, D. G., G. W. Anderson, Jr., J. M. Mauro, S. L. Welkos, G. P. Andrews, and A. M. Friedlander. 1997. A recombinant capsular F1-V antigen fusion protein vaccine protects against experimental bubonic and pneumonic plague. Vaccines (Cold Spring Harbor) 97:197-200.
19. Hill, J., S. E. C. Leary, K. F. Griffin, E. D. Williamson, and R. W. Titball. 1996. Localisation of immunologically important regions of Yersinia pestis V antigen, abstr. B-222, p. 193. In Abstracts of the 96th General Meeting of the American Society of Microbiology 1996. American Society for Microbiology. Washington. D.C.
20. Hughes, E. E., and H. E. Gilleland, Jr. 1995. Ability of synthetic peptides representing epitopes of outer membrane protein F of Pseudomonas aeruginosa to afford protection against P. aeruginosa infection in a murine acute pneumonia model. Vaccine 13:1750-1753.
21. Langeveld, J. P. M., J. I. Casal, E. Cortes, G. van de Wetering, R. S. Boshuizen, W. M. M. Schaaper, K. Dalsgaard, and R. H. Meloen. 1994. Effective induction of neutralizing antibodies with the amino terminus of VP2 of canine parvovirus as a synthetic peptide. Vaccine 12:1473-1480.
22. Lawton, W. D., R. L. Erdman, and M. J. Surgalla. 1963. Biosynthesis and purification of V and W antigen in Pasteurella pestis. J. Immunol. 91:179-184.
23. Leary, S. E. C., E. D. Williamson, K. F. Griffin, P. Russell, S. M. Eley, and R. W. Titball. 1995. Active immunization with recombinant V antigen from Yersinia pestis protects mice against plague. Infect. Immun. 63:2854-2858.
24. Motin, V. L., Y. A. Nedialkov, and R. R. Brubaker. 1996. V antigen-polyhistidine fusion peptide: binding to LcrH and active immunity against plague. Infect. Immun. 64:4313-4318.
25. Motin, V. L., R. Nakajima, G. B. Smirnov, and R. R. Brubaker. 1994. Passive immunity to yersiniae mediated by anti-recombinant V antigen and protein A-V antigen fusion peptide. Infect. Immun. 62:4192-4201.
26. Nakajima, R., V. L. Motin, and R. R. Brubaker. 1995. Suppression of cytokines in mice by protein A-V antigen fusion peptide and restoration of synthesis by active immunization. Infect. Immun. 63:3021-3029.
27. Nakajuima, R., and R. R. Brubaker. 1993. Association between virulence of Yersinia pestis and suppression of gamma Interferon and tumor necrosis factor alpha. Infect. Immun. 61:23-31.
28. National Research Council, Institute of Laboratory Animal Resources. 1986. Guide for the care of and use of laboratory animals. U.S. Department of Health and Human Services publication (NIH) 86-23. U.S. Department of Health and Human Services, Bethesda, Md.
29. Nedialkov, Y. A., V. L. Motin, and R. R. Brubaker. 1997. Resistance to lipopolysaccharide mediated by the Yersinia pestis V antigen-polyhistidine fusion peptide: amplification of interleukin-10. Infect. Immun. 65:1196-1203.
30. 2+ response virulence genes. J. Bacteriol. 173:2649-2657.
31. Price, S. B., K. Y. Leung, S. S. Barve, and S. C. Straley. 1989. Molecular analysis of IcrGVH, the V antigen operon of Yersinia pestis. J. Bacteriol. 171:5646-5663.
32. Robinson, K., T. Bellaby, W. C. Chan, and D. Wakelin. 1995. High levels of protection induced by a 40-mer synthetic peptide vaccine against the intestinal nematode parasite Trichinella spiralis. Immunology 86:495-498.
33. Roggenkamp, A., A. M. Geiger, L. Leitritz, A. Kessler, and J. Heesemann. 1997. Passive immunity to infection with Yersinia spp. mediated by antirecombinant V antigen is dependent on polymorphism of V antigen. Infect. Immun. 65:446-451.
34. Salo, P., A. Narvanen, and M. Leinonen. 1993. Mapping of immunoreactive sites of pneumococcal pneumolysin by use of synthetic peptides. Infect. Immun. 61:2822-2826.
35. SAS Institute, Inc. 1989. SAS/STAT user's guide, version 6, 4th ed., vol. 2. SAS Institute. Inc., Cary, N.C.
36. Sato, K., R. Nakajima, F. Hara, T. Une, and Y. Osada. 1991. Preparation of monoclonal antibody to V antigen from Yersinia pestis. Contrib. Microhiol. Immunol. 12:225-229.
37. 2+ response, and virulence of Yersinia pestis. J. Bacteriol. 177:2530-2542.
38. Une, T., and R. R. Brubaker. 1984. Roles of V antigen in promoting virulence and immunity in Yersiniae. J. Immunol. 133:2226-2230.
39. Tabatabai, L. B., and G. W. Pugh, Jr. 1994. Modulation of immune responses in Balb/c mice vaccinated with Brucella abortus Cu-Zn Superoxide dismutase synthetic peptide vaccine. Vaccine 12:919-924.
40. Taubman, M. A., C. J. Holmberg, and D. J. Smith. 1995. Immunization of rats with synthetic peptide constructs from the glucan-binding or catalytic region of mutants streptococcal glucosyltransferase protects against dental caries. Infect. Immun. 63:3088-3093.
41. Wake, A., T. Maruyama, K. Akiyama, and M. Yamamoto. 1983. The role of virulence antigens (VW) in the protection of mice against Yersinia pestis infection. Curr. Microbiol. 8:73-77.
42. Williamson, E. D., S. M. Eley, K. F. Griffin, M. Green, P. Russell, S. E. C. Leary, P. C. F. Oyston, T. Easterbrook, K. M. Reddin, A. Robinson, and R. W. Titball. 1995. A new improved sub-unit vaccine for plague: the basis of protection. FEMS Immunol. Med. Microbiol. 12:223-230.