Regulation of CD8+ regulatory T cells: Interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 49, 2008, Pages 19420-19425

  Lu, Linrong ^a   Kim, Hye Jung ^b   Werneck, Miriam B F ^b   Cantor, Harvey ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b NONE

Author keywords

Autoimmunity; CD8 treg; Suppression

Indexed keywords

CD94 ANTIGEN; HLA E ANTIGEN; NATURAL KILLER CELL RECEPTOR NKG2A; PERFORIN; PROTEOLIPID PROTEIN; T LYMPHOCYTE RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; C57BL 6 MOUSE; CD8+ T LYMPHOCYTE; CELL ACTIVITY; CONTROLLED STUDY; FEMALE; KNOCKOUT MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; REGULATORY T LYMPHOCYTE;

ADOPTIVE TRANSFER; ANIMALS; AUTOIMMUNITY; CD8-POSITIVE T-LYMPHOCYTES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENE KNOCK-IN TECHNIQUES; HISTOCOMPATIBILITY ANTIGENS CLASS I; IMMUNE TOLERANCE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY C; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY D; PERFORIN; T-LYMPHOCYTES, REGULATORY;

MUS;

EID: 58049220247     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0810383105     Document Type: Article

References (20)

1. + natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 212:8-27.
2. Noble A, Zhao Z-S, Cantor H (1998) Suppression of immune responses by CD8 cells, II: Qa-1 on activated B-cells stimulates CD8 cell suppression of Th2-dependent antibody responses. J Immunol 160:566-571.
3. Jiang H, Chess L (2004) An integrated view of suppressor T cell subsets in immunoregulation. J Clin Invest 114:1198-1208.
4. Hu D, et al. (2004) Analysis of regulatory CD8 T cells in Qa-1-deficient mice. Nat Immunol 5:516-523.
5. Vance RE, Kraft JR, Altman JD, Jensen PE, Raulet DH (1998) Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b). J Exp Med 188:1841-1848.
6. Moser JM, Gibbs J, Jensen PE, Lukacher AE (2002) CD94-NKG2A receptors regulate antiviral CD8(+) T cell responses. Nat Immunol 3:189-195.
7. + T cells by NK cells via the Qa-1-NKG2A pathway. Immunity 26:593-604.
8. Luescher IF, et al. (1995) CD8 modulation of T-cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes. Nature 373:353-356.
9. Vivier E, Anfossi N (2004) Inhibitory NK-cell receptors on T cells: Witness of the past, actors of the future. Nat Rev Immunol 4:190-198.
10. Wang R, Ramaswamy S, Hu D, Cantor H (2001) Definition of a novel binding site on CD8 cells for a conserved region of the MHC class Ib molecule Qa-1 that regulates IFN-gamma expression. Eur J Immunol 31:87-93.
11. + suppressor T cells. J Clin Invest 114:1218-1221.
12. Jiang H, Chess L (2004) An integrated model of immunoregulation mediated by regulatory T cell subsets. Adv Immunol 83:253-288.
13. Chen W, et al. (2007) Perceiving the avidity of T cell activation can be translated into peripheral T cell regulation. Proc Natl Acad Sci U S A 104:20472-20477.
14. + T cells fine-tune the myelin basic protein-reactive T cell receptor V beta repertoire during experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 100:8378-8383.
15. Lu L, Werneck MB, Cantor H (2006) The immunoregulatory effects of Qa-1. Immunol Rev 212:51-59.
16. + T cells. Proc Natl Acad Sci U S A 95:4533-4537.
17. Correale J, et al. (2000) T cell vaccination in secondary progressive multiple sclerosis. J Neuroimmunol 107:130-139.
18. + regulatory T cells in multiple sclerosis. J Neuroimmunol 195:121-134.
19. Bettelli E, et al. (2003) Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med 197:1073-1081.
20. Gorman JR, et al. (1996) The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes. Immunity 5:241-252.