Reduced expression of TCR zeta is involved in the abnormal production of cytokines by peripheral T cells of patients with systemic lupus erythematosus

Journal of Biomedicine and Biotechnology

Volumn 2010, Issue , 2010, Pages

  Yoshimoto, Keiko ^a   Setoyama, Yumiko ^a   Tsuzaka, Kensei ^a,c   Abe, Tohru ^a   Takeuchi, Tsutomu ^a,b  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c TOKYO DENTAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; IONOMYCIN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ZETA CHAIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CYTOKINE RELEASE; DISEASE COURSE; FEMALE; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

ADULT; ANTIGENS, CD3; CASE-CONTROL STUDIES; CYTOKINES; FEMALE; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-2; IONOMYCIN; LUPUS ERYTHEMATOSUS, SYSTEMIC; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 77957844454     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2010/509021     Document Type: Article

References (33)

1. Boumpas D. T., Austin H. A. III, Fessler B. J., Balow J. E., Klippel J. H., Lockshin M. D., Systemic lupus erythematosus: emerging conceptspart 1: renal, neuropsychiatric, cardiovascular, pulmonary, and hematologic disease Annals of Internal Medicine 1995 122 12 940 950
2. Boumpas D. T., Fessler B. J., Austin H. A. III, Balow J. E., Klippel J. H., Lockshin M. D., Systemic lupus erythematosus: emerging conceptspart 2: dermatologic and joint disease, the antiphospholipid antibody syndrome, pregnancy and hormonal therapy, morbidity and mortality, and pathogenesis Annals of Internal Medicine 1995 123 1 42 53
3. Mills J. A., Systemic lupus erythematosus New England Journal of Medicine 1994 330 26 1871 1879
4. Al-Janadi M., Al-Balla S., Al-Dalaan A., Raziuddin S., Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis, and other rheumatic diseases Journal of Clinical Immunology 1993 13 1 58 67
5. Baechler E. C., Batliwalla F. M., Karypis G., Gaffney P. M., Ortmann W. A., Espe K. J., Shark K. B., Grande W. J., Hughes K. M., Kapur V., Gregersen P. K., Behrens T. W., Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus Proceedings of the National Academy of Sciences of the United States of America 2003 100 5 2610 2615
6. Machold K. P., Smolen J. S., Interferon- induced exacerbation of systemic lupus erythematosus Journal of Rheumatology 1990 17 6 831 832
7. Karonitsch T., Feierl E., Steiner C. W., Dalwigk K., Korb A., Binder N., Rapp A., Steiner G., Scheinecker C., Smolen J., Aringer M., Activation of the interferon- signaling pathway in systemic lupus erythematosus peripheral blood mononuclear cells Arthritis and Rheumatism 2009 60 5 1463 1471
8. Mellor-Pita S., Citores M. J., Castejon R., Yebra-Bango M., Tutor-Ureta P., Rosado S., Andreu J. L., Vargas J. A., Monocytes and T lymphocytes contribute to a predominance of interleukin 6 and interleukin 10 in systemic lupus erythematosus Cytometry Part B 2009 76 4 261 270
9. Brinkmann V., Geiger T., Alkan S., Heusser C. H., Interferon increases the frequency of interferon -producing human CD4+ T cells Journal of Experimental Medicine 1993 178 5 1655 1663
10. Cohen P. L., T- and B-cell abnormalities in systemic lupus Journal of Investigative Dermatology 1993 100 1 69S 72S
11. Chang D. M., Su W. L., Chu S. J., The expression and significance of intracellular T helper cytokines in systemic lupus erythematosus Immunological Investigations 2002 31 1 1 12
12. Sierakowski S., Kucharz E. J., Lightfoot R. W., Goodwin J. S., Impaired T-cell activation in patients with systemic lupus erythematosus Journal of Clinical Immunology 1989 9 6 469 476
13. Kawamoto M., Harigai M., Hara M., Kawaguchi Y., Tezuka K., Tanaka M., Sugiura T., Katsumata Y., Fukasawa C., Ichida H., Higami S., Kamatani N., Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus: possible involvement in excessive interferon- and anti-double-stranded DNA antibody production Arthritis Research and Therapy 2006 8 3, article no. R62
14. Linker-Israeli M., Bakke A. C., Quismorio F. P. Jr., Horwitz D. A., Correction of interleukin-2 production in patients with systemic lupus erythematosus by removal of spontaneously activated suppressor cells Journal of Clinical Investigation 1985 75 2 762 768
15. Kotzin B. L., Systemic lupus erythematosus Cell 1996 85 3 303 306
16. Pang M., Setoyama Y., Tsuzaka K., Yoshimoto K., Amano K., Abe T., Takeuchi T., Defective expression and tyrosine phosphorylation of the T cell receptor zeta chain in peripheral blood T cells from systemic lupus erythematosus patients Clinical and Experimental Immunology 2002 129 1 160 168
17. Tsuzaka K., Takeuchi T., Onoda N., Pang M., Tohru A., Mutations in T cell receptor chain mRNA of peripheral T cells from systemic lupus erythematosus patients Journal of Autoimmunity 1998 11 5 381 385
18. Berg L., Rnnelid J., Klareskog L., Bucht A., Down-regulation of the T cell receptor CD3 chain in rheumatoid arthritis (RA) and its influence on T cell responsiveness Clinical and Experimental Immunology 2000 120 1 174 182
19. Krymskaya L., Lee W.-H., Zhong L., Liu C.-P., Polarized development of memory cell-like IFN- -producing cells in the absence of TCR -chain Journal of Immunology 2005 174 3 1188 1195
20. Nambiar M. P., Krishnan S., Warke V. G., Tsokos G. C., TCR zeta-chain abnormalities in human systemic lupus erythematosus Methods in Molecular Medicine 2004 102 49 72
21. Takeuchi T., Tsuzaka K., Pang M., Amano K., Koide J., Abe T., TCR chain lacking exon 7 in two patients with systemic lupus erythematosus International Immunology 1998 10 7 911 921
22. Yoshimoto K., Takahashi Y., Ogasawara M., Setoyama Y., Suzuki K., Tsuzaka K., Abe T., Takeuchi T., Aberrant expression of BAFF in T cells of systemic lupus erythematosus, which is recapitulated by a human T cell line, Loucy International Immunology 2006 18 7 1189 1196
23. Weissman A. M., Baniyash M., Hou D., Samelson E., Burgess W. H., Klausner R. D., Molecular cloning of the zeta chain of the T cell antigen receptor Science 1988 239 4843 1018 1021
24. Frank S. J., Niklinska B. B., Orloff D. G., Mercep M., Ashwell J. D., Klausner R. D., Structural mutations of the T cell receptor chain and its role in T cell activation Science 1990 249 4965 174 177
25. Irving B. A., Weiss A., The cytoplasmic domain of the T cell receptor chain is sufficient to couple to receptor-associated signal transduction pathways Cell 1991 64 5 891 901
26. Funauchi M., Sugishima H., Minoda M., Horiuchi A., Effect of interferon- on B lymphocytes of patients with systemic lupus erythematosus Journal of Rheumatology 1991 18 3 368 372
27. Tsuzaka K., Setoyama Y., Yoshimoto K., Shiraishi K., Suzuki K., Abe T., Takeuchi T., A splice variant of the TCR mRNA lacking exon 7 leads to the down-regulation of TCR, the TCR/CD3 complex, and IL-2 production in systemic lupus erythematosus T cells Journal of Immunology 2005 174 6 3518 3525
28. Tsuzaka K., Fukuhara I., Setoyama Y., Yoshimoto K., Suzuki K., Abe T., Takeuchi T., TCR mRNA with an alternatively spliced 3′ -untranslated region detected in systemic lupus erythematosus patients leads to the down-regulation of TCR and TCR/CD3 complex Journal of Immunology 2003 171 5 2496 2503
29. Tsuzaka K., Itami Y., Kumazawa C., Suzuki M., Setoyama Y., Yoshimoto K., Suzuki K., Abe T., Takeuchi T., Conservative sequences in 3′ UTR of TCR mRNA regulate TCR in SLE T cells Biochemical and Biophysical Research Communications 2008 367 2 311 317
30. Holst J., Wang H., Eder K. D., Workman C. J., Boyd K. L., Baquet Z., Singh H., Forbes K., Chruscinski A., Smeyne R., van Oers N. S. C., Utz P. J., Vignali D. A. A., Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity Nature Immunology 2008 9 6 658 666
31. Chikuma S., Imboden J. B., Bluestone J. A., Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4 Journal of Experimental Medicine 2003 197 1 129 135
32. Lee K.-M., Chuang E., Griffin M., Khattri R., Hong D. K., Zhang W., Straus D., Samelson L. E., Thompson C. B., Bluestone J. A., Molecular basis of T cell inactivation by CTLA-4 Science 1998 282 5397 2263 2266
33. Jury E. C., Flores-Borja F., Kalsi H. S., Lazarus M., Isenberg D. A., Mauri C., Ehrenstein M. R., Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus European Journal of Immunology 2010 40 2 569 578