Expression and sequence diversity of the complement regulating outer surface protein E in borrelia afzelii vs. borrelia garinii in patients with erythema migrans or neuroborreliosis

Microbial Pathogenesis

Volumn 49, Issue 6, 2010, Pages 363-368

  Panelius, Jaana ^a,b   Ranki, Annamari ^b   Meri, Taru ^a,c   Seppälä, Ilkka ^a,c   Meri, Seppo ^a,c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Erythema migrans; Factor H; Lyme disease; Neuroborreliosis; OspE

Indexed keywords

BACTERIUM ANTIBODY; MEMBRANE PROTEIN; OUTER SURFACE PROTEIN A; OUTER SURFACE PROTEIN E; UNCLASSIFIED DRUG;

ARTICLE; BORRELIA AFZELII; BORRELIA GARINII; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; ERYTHEMA CHRONICUM MIGRANS; HUMAN; LYME DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SERUM; SKIN BIOPSY; STRAIN IDENTIFICATION;

ANTIBODIES, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BASE SEQUENCE; BORRELIA BURGDORFERI GROUP; CEREBROSPINAL FLUID; COMPLEMENT SYSTEM PROTEINS; DNA, BACTERIAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GLOSSITIS, BENIGN MIGRATORY; HUMANS; IMMUNOGLOBULIN G; LYME NEUROBORRELIOSIS; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SERUM; SKIN;

BORRELIA; BORRELIA AFZELII; BORRELIA GARINII;

EID: 77957822387     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2010.06.006     Document Type: Article

References (32)

1. Fingerle V., Schulte-Spechtel U., Ruzic-Sabljic E., Leonhard S., Hofmann H., Weber K., et al. Epidemiological aspects and molecular characterization of Borrelia burgdorferi s.l. from southern Germany with special respect to the new species Borrelia spielmanii sp. nov. Int J Med Microbiol 2008, 298:279-290.
2. Ruzic-Sabljic E., Zore A., Strle F. Characterization of Borrelia burgdorferi sensu lato isolates by pulsed-field gel electrophoresis after M1uI restriction of genomic DNA. Res Microbiol 2008, 159:441-448.
3. Zipfel P.F., Jokiranta T.S., Hellwage J., Koistinen V., Meri S. The factor H protein family. Immunopharmacology 1999, 42:53-60.
4. Alitalo A., Meri T., Rämö L., Jokiranta T.S., Heikkilä T., Seppälä I.J.T., et al. Complement evasion by Borrelia burgdorferi: serum-resistant strains promote C3b inactivation. Infect Immun 2001, 69:3685-3691.
5. Hellwage J., Meri T., Heikkilä T., Alitalo A., Panelius J., Lahdenne P., et al. The complement regulator factor H binds to the surface protein OspE of Borrelia burgdorferi. J Biol Chem 2001, 276:8427-8435.
6. Kraiczy P., Skerka C., Kirschfink M., Zipfel P.F., Brade V. Mechanism of complement resistance of pathogenic Borrelia burgdorferi isolates. Int Immunopharmacol 2001, 1:393-401.
7. Kenedy M.R., Vuppala S.R., Siegel C., Kraiczy P., Akins D.R. CspA-mediated binding of human factor H inhibits complement deposition and confers serum resistance in Borrelia burgdorferi. Infect Immun 2009, 77:2773-2782.
8. Alitalo A., Meri T., Lankinen H., Seppälä I., Lahdenne P., Hefty P.S., et al. Complement inhibitor factor H binding to Lyme disease spirochetes is mediated by inducible expression of multiple plasmid-encoded outer surface protein E paralogs. J Immunol 2002, 169:3847-3853.
9. Stevenson B., El-Hage N., Hines M.A., Miller J.C., Babb K. Differential binding of host complement inhibitor factor H by Borrelia burgdorferi Erp surface proteins: a possible mechanism underlying the expansive host range of Lyme disease spirochetes. Infect Immun 2002, 70:491-497.
10. Alitalo A., Meri T., Cheng T., Lankinen H., Cheng Z.-Z., Jokiranta T.S., et al. Lysine-dependent multipoint binding of the Borrelia burgdorferi virulence factor outer surface protein E to the C terminus of factor H. J Immunol 2004, 172:6195-6201.
11. Brooks C.S., Vuppala S.R., Jett A.M., Alitalo A., Meri S., Akins R.A. Complement regulator-acquiring surface protein 1 imparts resistance to human serum in Borrelia burgdorferi. J Immunol 2005, 175:3299-3308.
12. Coleman A.S., Yang X., Kumar M., Zhang X., Promnares K., Shroder D., et al. Borrelia burgdorferi complement regulator-acquiring surface protein 2 does not contribute to complement resistance or host infectivity. PLoS ONE (Electronic Resource) 2008, 3(8):3010.
13. Kraiczy P., Hellwage J., Skerka C., Kirschfink M., Brade V., Zipfel P.F., et al. Immune evasion of Borrelia burgdorferi: mapping of a complement inhibitor factor H-binding site of BbCRASP-3, a novel member of the Erp protein family. Eur J Immunol 2003, 33:697-707.
14. Miller J.C., Stevenson B. Borrelia burgdorferi erp genes are expressed at different levels within tissues of chronically infected mammalian hosts. Int J Med Microbiol 2006, 296(S1):185-194.
15. Lam T.T., Nguyen T.-P.K., Montgomery R.R., Kantor F.S., Fikrig E., Flavell R.A. Outer surface proteins E and F of Borrelia burgdorferi, the agent of Lyme disease. Infect Immun 1994, 62:290-298.
16. Stevenson B., Schwan T.G., Rosa P.A. Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi. Infect Immun 1995, 63:4535-4539.
17. McDowell J.V., Wolfgang J., Tran E., Metts M.S., Hamilton D., Marconi R.T. Comprehensive analysis of the factor H binding capabilities of Borrelia species associated with Lyme disease: delineation of two distinct classes of factor H binding proteins. Infect Immun 2003, 71:3597-3602.
18. Alitalo A., Meri T., Comstedt P., Jeffery L., Tornberg J., Strandin T., et al. Expression of complement factor H binding immunoevasion proteins in Borrelia garinii isolated from patients with neuroborreliosis. Eur J Immunol 2005, 35:3043-3053.
19. Panelius J., Meri T., Seppälä I., Eholuoto M., Alitalo A., Meri S. Outer surface protein E antibody response and its effect on complement factor H binding to OspE in Lyme borreliosis. Microbes Infect 2008, 10:135-142.
20. Van Dam A.P., Oei A., Jaspars R., Fijen C., Wilske L., Spanjaard L., et al. Complement-mediated serum sensitivity among spirochetes that cause Lyme disease. Infect Immun 1997, 65:1228-1236.
21. Marconi R.T., Hohenberger S., Jauris-Heipke S., Schulte-Spechtel U., LaVoie C.P., Rössler D., et al. Genetic analysis of Borrelia garinii OspE serotype 4 strains associated with neuroborreliosis: evidence for extensive genetic homogeneity. J Clin Microbiol 1999, 37:3965-3970.
22. Ornstein K., Berglund J., Nilsson I., Norrby R., Bergström S. Characterization of Lyme borreliosis isolates from patients with erythema migrans and neuroborreliosis in southern Sweden. J Clin Microbiol 2001, 39:1294-1298.
23. Gylfe Å Olsen B., Strasevicius D., Marti Ras N., Weihe P., Noppa L., Östberg Y., et al. Isolation of Lyme disease Borrelia from puffins (Fratercula arctica) and seabird ticks (Ixodes uriae) on the Faeroe Islands. J Clin Microbiol 1999, 37:890-896.
24. Lahdenne P., Panelius J., Saxen H., Heikkilä T., Sillanpää H., Peltomaa M., et al. Improved serodiagnosis of erythema migrans using novel recombinant borrelial BBK32 antigens. J Med Microbiol 2003, 52:563-567.
25. Carlsson S.-A., Granlund H., Jansson C., Nyman D., Wahlberg P. Characteristics of erythema migrans in Borrelia afzelii and Borrelia garinii infections. Scand J Infect Dis 2003, 35:31-33.
26. Kraiczy P., Hellwage J., Skerka C., Becker H., Kirschfink M., Simon M.M., et al. Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins. J Biol Chem 2004, 279:2421-2429.
27. Wilske B., Busch U., Fingerle V., Jauris-Heipke S., Preac-Mursic V., Rossler D., et al. Immunological molecular variability of OspA and OspC. Implications for Borrelia vaccine development. Infection 1996, 24:208-212.
28. Marconi R.T., Sung S.Y., Hughes C.A., Carlyon J.A. Molecular and evolutionary analyses of a variable series of genes in Borrelia burgdorferi that are related to ospE and ospF, constitute a gene family, and share a common upstream homology box. J Bacteriol 1996, 178:5615-5626.
29. Kraiczy P., Seling A., Brissette C.A., Rossmann E., Hunfeld K.-P., Bykowski T., et al. Borrelia burgdorferi complement regulator-acquiring surface protein 2 (CspZ) as a serological marker of human Lyme disease. Clin Vaccine Immunol 2008, 15:484-491.
30. Ranki A., Aavik E., Peterson P., Schauman K., Nurmilaakso P. Successful amplification of DNA specific for Finnish Borrelia burgdorferi isolates in erythema chronicum migrans but not in circumscribed scleroderma lesions. J Invest Dermatol 1994, 102:339-345.
31. Junttila J., Peltomaa M., Soini H., Marjamäki M., Viljanen M.K. Prevalence of Borrelia burgdorferi in Ixodes ricinus ticks in urban recreational areas of Helsinki. J Clin Microbiol 1999, 37:1361-1365.
32. Seppälä I.J.T., Kroneld R., Schauman K., Forsen K.-O., Lassenius R. Diagnosis of Lyme borreliosis: non-specific serological reactions with Borrelia burgdorferi sonicate antigen caused by IgG2 antibodies. J Med Microbiol 1994, 40:293-302.