Effect of vitamin K-dependent protein precursor propeptide, vitamin K hydroquinone, and glutamate substrate binding on the structure and function of γ-glutamyl carboxylase

Journal of Biological Chemistry

Volumn 285, Issue 41, 2010, Pages 31502-31508

  Higgins Gruber, Shannon L ^b,c   Mutucumarana, Vasantha P ^a   Lin, Pen Jen ^a,d   Jorgenson, James W ^b   Stafford, Darrel W ^a   Straight, David L ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b The University of North Carolina at Chapel Hill   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d TEXAS A M COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; CARBOXYLATION; CATALYST ACTIVITY; COMPLEXATION; ELECTROCHEMICAL SENSORS; ENZYMES; KETONES; PHENOLS;

CATALYTIC ACTIVITY; ENZYME INTERACTION; GLUTAMATE SUBSTRATES; GLUTAMIC ACID RESIDUES; PRIMARY BINDING SITES; PROPEPTIDES; PROTEIN PRECURSORS; SUBSTRATE BINDING; VITAMIN K;

SUBSTRATES;

BICARBONATE; BLOOD CLOTTING FACTOR 9; GLUTAMIC ACID; HYDROQUINONE; PENTAPEPTIDE; PHENYLALANYLLEUCYLGLUTAMYGLUTAMYLLEUCINE; PROTEIN C; PROTHROMBIN; UNCLASSIFIED DRUG; VITAMIN K DEPENDENT CARBOXYLASE; FARNOQUINONE; GLUTAMYL CARBOXYLASE; LIGASE; OLIGOPEPTIDE; PROTEIN PRECURSOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXYLATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INACTIVATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN VERSUS ANIMAL COMPARISON; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN VARIANT; STRUCTURE ANALYSIS; ANIMAL; CHEMISTRY; HUMAN; METABOLISM; MOUSE; STRUCTURE ACTIVITY RELATION; TETRAODONTIFORMES;

ANIMALS; CARBON-CARBON LIGASES; HUMANS; MICE; OLIGOPEPTIDES; PROTEIN PRECURSORS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TETRAODONTIFORMES; VITAMIN K 2;

EID: 77957810981     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.143297     Document Type: Article

References (25)

1. Knobloch, J. E., and Suttie, J. W. (1987) J. Biol. Chem. 262, 15334-15337
2. Cheung, A., Engelke, J. A., Sanders, C., and Suttie, J. W. (1989) Arch. Biochem. Biophys. 274, 574-581
3. Cheung, A., Suttie, J. W., and Bernatowicz, M. (1990) Biochim. Biophys. Acta 1039, 90-93
4. Li, S., Furie, B. C., Furie, B., and Walsh, C. T. (1997) Biochemistry 36, 6384-6390
5. Ulrich, M. M., Furie, B., Jacobs, M. R., Vermeer, C., and Furie, B. C. (1988) J. Biol. Chem. 263, 9697-9702
6. Presnell, S. R., Tripathy, A., Lentz, B. R., Jin, D. Y., and Stafford, D. W. (2001) Biochemistry 40, 11723-11733
7. Lin, P. J., Straight, D. L., and Stafford, D. W. (2004) J. Biol. Chem. 279, 6560-6566
8. Bouchard, B. A., Furie, B., and Furie, B. C. (1999) Biochemistry 38, 9517-9523
9. Soute, B. A., Ulrich, M. M., Watson, A. D., Maddison, J. E., Ebberink, R. H., and Vermeer, C. (1992) Thromb. Haemost. 68, 521-525
10. Sugiura, I., Furie, B., Walsh, C. T., and Furie, B. C. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 9069-9074
11. Morris, D. P., Soute, B. A., Vermeer, C., and Stafford, D. W. (1993) J. Biol. Chem. 268, 8735-8742
12. Stanley, T. B., Jin, D. Y., Lin, P. J., and Stafford, D. W. (1999) J. Biol. Chem. 274, 16940-16944
13. Kuzmic, P. (1996) Anal. Biochem. 237, 260-273
14. Wu, S. M., Soute, B. A., Vermeer, C., and Stafford, D. W. (1990) J. Biol. Chem. 265, 13124-13129
15. Sugiura, I., Furie, B., Walsh, C. T., and Furie, B. C. (1996) J. Biol. Chem. 271, 17837-17844
16. Chu, K., Wu, S. M., Stanley, T., Stafford, D. W., and High, K. A. (1996) J. Clin. Investig. 98, 1619-1625
17. Oldenburg, J., Quenzel, E. M., Harbrecht, U., Fregin, A., Kress, W., Müller, C. R., Hertfelder, H. J., Schwaab, R., Brackmann, H. H., and Hanfland, P. (1997) Br. J. Haematol. 98, 240-244
18. Stanley, T. B., Humphries, J., High, K. A., and Stafford, D. W. (1999) Biochemistry 38, 15681-15687
19. Mutucumarana, V. P., Acher, F., Straight, D. L., Jin, D. Y., and Stafford, D. W. (2003) J. Biol. Chem. 278, 46488-46493
20. Rishavy, M. A., and Berkner, K. L. (2008) Biochemistry 47, 9836-9846
21. Hallgren, K. W., Hommema, E. L., McNally, B. A., and Berkner, K. L. (2002) Biochemistry 41, 15045-15055
22. Uotila, L. (1988) Arch. Biochem. Biophys. 264, 135-143
23. Rishavy, M. A., Hallgren, K. W., Yakubenko, A. V., Shtofman, R. L., Runge, K. W., and Berkner, K. L. (2006) Biochemistry 45, 13239-13248
24. Davis, C. H., Deerfield, D., 2nd, Wymore, T., Stafford, D. W., and Pedersen, L. G. (2007) J. Mol. Graph. Model. 26, 409-414
25. Davis, C. H., Deerfield, D., 2nd, Stafford, D. W., and Pedersen, L. G. (2007) J. Phys. Chem. 111, 7257-7261