Binding of the Factor IX γ-Carboxyglutamic Acid Domain to the Vitamin K-dependent γ-Glutamyl Carboxylase Active Site Induces an Allosteric Effect That May Ensure Processive Carboxylation and Regulate the Release of Carboxylated Product

Journal of Biological Chemistry

Volumn 279, Issue 8, 2004, Pages 6560-6566

  Lin, Pen Jen ^a   Straight, David L ^a   Stafford, Darrel W ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLATION; CARBOXYLIC ACIDS; DISSOCIATION; ENZYMES; RATE CONSTANTS;

EXOSITE; PROPEPTIDES;

BIOCHEMISTRY;

4 CARBOXYGLUTAMIC ACID; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 9; GAMMA GLUTAMYL HYDROLASE; VITAMIN K GROUP;

ALLOSTERISM; ARTICLE; CARBOXYLATION AND DECARBOXYLATION; ENDOPLASMIC RETICULUM; ENZYME ACTIVE SITE; ENZYME INDUCTION; ENZYME REGULATION; ENZYME RELEASE; ENZYME SUBSTRATE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PROCESSING; STEADY STATE;

1-CARBOXYGLUTAMIC ACID; ALLOSTERIC SITE; ANISOTROPY; BINDING SITES; CARBON-CARBON LIGASES; CARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; FACTOR IX; GLUTAMIC ACID; HUMANS; KINETICS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY; TIME FACTORS; VITAMIN K;

EID: 1342325432     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M312239200     Document Type: Article

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