메뉴 건너뛰기




Volumn 5, Issue 8, 2010, Pages

Environmental enrichment induces behavioral recovery and enhanced hippocampal cell proliferation in an antidepressant-resistant animal model for PTSD

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; BUTYRIC ACID; ESCITALOPRAM; IMIPRAMINE; NORADRENALIN; SEROTONIN; BIOGENIC AMINE;

EID: 77957806908     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011943     Document Type: Article
Times cited : (62)

References (56)
  • 2
    • 1342331480 scopus 로고    scopus 로고
    • Risk and resilience in posttraumatic stress disorder
    • Yehuda R (2004) Risk and resilience in posttraumatic stress disorder. J Clin Psychiatry 65 Suppl 1: 29-36.
    • (2004) J Clin Psychiatry , vol.65 , Issue.SUPPL. 1 , pp. 29-36
    • Yehuda, R.1
  • 3
    • 27944476928 scopus 로고    scopus 로고
    • Treating traumatized children: Current status and future directions
    • Cohen JA (2005) Treating traumatized children: current status and future directions. J Trauma Dissociation 6: 109-121.
    • (2005) J Trauma Dissociation , vol.6 , pp. 109-121
    • Cohen, J.A.1
  • 4
    • 33744791753 scopus 로고    scopus 로고
    • Long-term pharmacotherapy for post-traumatic stress disorder
    • Davis LL, Frazier EC, Williford RB, Newell JM (2006) Long-term pharmacotherapy for post-traumatic stress disorder. CNS Drugs 20: 465-476.
    • (2006) CNS Drugs , vol.20 , pp. 465-476
    • Davis, L.L.1    Frazier, E.C.2    Williford, R.B.3    Newell, J.M.4
  • 5
    • 67649386619 scopus 로고    scopus 로고
    • Post-traumatic stress disorder: Emerging concepts of pharmacotherapy
    • Baker DG, Nievergelt CM, Risbrough VB (2009) Post-traumatic stress disorder: emerging concepts of pharmacotherapy. Expert Opin Emerg Drugs 14: 251-272.
    • (2009) Expert Opin Emerg Drugs , vol.14 , pp. 251-272
    • Baker, D.G.1    Nievergelt, C.M.2    Risbrough, V.B.3
  • 6
    • 34548634603 scopus 로고    scopus 로고
    • The effects of aerobic exercise on childhood PTSD, anxiety, and depression
    • Newman CL, Motta RW (2007) The effects of aerobic exercise on childhood PTSD, anxiety, and depression. Int J Emerg Ment Health 9: 133-158.
    • (2007) Int J Emerg Ment Health , vol.9 , pp. 133-158
    • Newman, C.L.1    Motta, R.W.2
  • 8
    • 77957787515 scopus 로고    scopus 로고
    • Exercise parameters in the treatment of clinical depression: A systematic review of randomized controlled trials
    • Perraton LG, Kumar S, Machotka Z (2009) Exercise parameters in the treatment of clinical depression: a systematic review of randomized controlled trials. J Eval Clin Pract.
    • (2009) J Eval Clin Pract
    • Perraton, L.G.1    Kumar, S.2    Machotka, Z.3
  • 10
    • 26844483210 scopus 로고    scopus 로고
    • Leisuretime physical activity at midlife and the risk of dementia and Alzheimer's disease
    • Rovio S, Kareholt I, Helkala EL, Viitanen M, Winblad B, et al. (2005) Leisuretime physical activity at midlife and the risk of dementia and Alzheimer's disease. Lancet Neurol 4: 705-711.
    • (2005) Lancet Neurol , vol.4 , pp. 705-711
    • Rovio, S.1    Kareholt, I.2    Helkala, E.L.3    Viitanen, M.4    Winblad, B.5
  • 11
    • 33847363137 scopus 로고    scopus 로고
    • Language-enriched exercise plus socialization slows cognitive decline in Alzheimer's disease
    • Arkin S (2007) Language-enriched exercise plus socialization slows cognitive decline in Alzheimer's disease. Am J Alzheimers Dis Other Demen 22: 62-77.
    • (2007) Am J Alzheimers Dis Other Demen , vol.22 , pp. 62-77
    • Arkin, S.1
  • 13
    • 33750618527 scopus 로고    scopus 로고
    • Therapeutic and protective effect of environmental enrichment against psychogenic and neurogenic stress
    • Fox C, Merali Z, Harrison C (2006) Therapeutic and protective effect of environmental enrichment against psychogenic and neurogenic stress. Behav Brain Res 175: 1-8.
    • (2006) Behav Brain Res , vol.175 , pp. 1-8
    • Fox, C.1    Merali, Z.2    Harrison, C.3
  • 14
    • 22244488109 scopus 로고    scopus 로고
    • Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat
    • Leggio MG, Mandolesi L, Federico F, Spirito F, Ricci B, et al. (2005) Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat. Behav Brain Res 163: 78-90.
    • (2005) Behav Brain Res , vol.163 , pp. 78-90
    • Leggio, M.G.1    Mandolesi, L.2    Federico, F.3    Spirito, F.4    Ricci, B.5
  • 15
    • 13444283646 scopus 로고    scopus 로고
    • New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment
    • Bruel-Jungerman E, Laroche S, Rampon C (2005) New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment. Eur J Neurosci 21: 513-521.
    • (2005) Eur J Neurosci , vol.21 , pp. 513-521
    • Bruel-Jungerman, E.1    Laroche, S.2    Rampon, C.3
  • 16
    • 40049093899 scopus 로고    scopus 로고
    • Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice
    • Duman CH, Schlesinger L, Russell DS, Duman RS (2008) Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice. Brain Res 1199: 148-158.
    • (2008) Brain Res , vol.1199 , pp. 148-158
    • Duman, C.H.1    Schlesinger, L.2    Russell, D.S.3    Duman, R.S.4
  • 17
    • 0037386918 scopus 로고    scopus 로고
    • Freewheel running prevents learned helplessness/behavioral depression: Role of dorsal raphe serotonergic neurons
    • Greenwood BN, Foley TE, Day HE, Campisi J, Hammack SH, et al. (2003) Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons. J Neurosci 23: 2889-2898.
    • (2003) J Neurosci , vol.23 , pp. 2889-2898
    • Greenwood, B.N.1    Foley, T.E.2    Day, H.E.3    Campisi, J.4    Hammack, S.H.5
  • 18
    • 34250684053 scopus 로고    scopus 로고
    • Functional recovery in rats with chronic spinal cord injuries after exposure to an enriched environment
    • Fischer FR, Peduzzi JD (2007) Functional recovery in rats with chronic spinal cord injuries after exposure to an enriched environment. J Spinal Cord Med 30: 147-155.
    • (2007) J Spinal Cord Med , vol.30 , pp. 147-155
    • Fischer, F.R.1    Peduzzi, J.D.2
  • 19
    • 55249101750 scopus 로고    scopus 로고
    • The extended hippocampal-diencephalic memory system: Enriched housing promotes recovery of the flexible use of spatial representations after anterior thalamic lesions
    • Wolff M, Loukavenko EA, Will BE, Dalrymple-Alford JC (2008) The extended hippocampal-diencephalic memory system: enriched housing promotes recovery of the flexible use of spatial representations after anterior thalamic lesions. Hippocampus 18: 996-1007.
    • (2008) Hippocampus , vol.18 , pp. 996-1007
    • Wolff, M.1    Loukavenko, E.A.2    Will, B.E.3    Dalrymple-Alford, J.C.4
  • 20
    • 33750517964 scopus 로고    scopus 로고
    • Effects of daily environmental enrichment on memory deficits and brain injury following neonatal hypoxia-ischemia in the rat
    • Pereira LO, Arteni NS, Petersen RC, da Rocha AP, Achaval M, et al. (2007) Effects of daily environmental enrichment on memory deficits and brain injury following neonatal hypoxia-ischemia in the rat. Neurobiol Learn Mem 87: 101-108.
    • (2007) Neurobiol Learn Mem , vol.87 , pp. 101-108
    • Pereira, L.O.1    Arteni, N.S.2    Petersen, R.C.3    da Rocha, A.P.4    Achaval, M.5
  • 21
    • 0033360314 scopus 로고    scopus 로고
    • Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
    • van Praag H, Kempermann G, Gage FH (1999) Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 2: 266-270.
    • (1999) Nat Neurosci , vol.2 , pp. 266-270
    • van Praag, H.1    Kempermann, G.2    Gage, F.H.3
  • 22
    • 0034006822 scopus 로고    scopus 로고
    • Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice
    • Rampon C, Tang YP, Goodhouse J, Shimizu E, Kyin M, et al. (2000) Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. Nat Neurosci 3: 238-244.
    • (2000) Nat Neurosci , vol.3 , pp. 238-244
    • Rampon, C.1    Tang, Y.P.2    Goodhouse, J.3    Shimizu, E.4    Kyin, M.5
  • 23
    • 3542999278 scopus 로고    scopus 로고
    • VEGF links hippocampal activity with neurogenesis, learning and memory
    • Cao L, Jiao X, Zuzga DS, Liu Y, Fong DM, et al. (2004) VEGF links hippocampal activity with neurogenesis, learning and memory. Nat Genet 36: 827-835.
    • (2004) Nat Genet , vol.36 , pp. 827-835
    • Cao, L.1    Jiao, X.2    Zuzga, D.S.3    Liu, Y.4    Fong, D.M.5
  • 25
    • 77649259349 scopus 로고    scopus 로고
    • Role of brain-derived neurotrophic factor in the aetiology of depression: Implications for pharmacological treatment
    • Castren E, Rantamaki T (2010) Role of brain-derived neurotrophic factor in the aetiology of depression: implications for pharmacological treatment. CNS Drugs 24: 1-7.
    • (2010) CNS Drugs , vol.24 , pp. 1-7
    • Castren, E.1    Rantamaki, T.2
  • 26
    • 71649100470 scopus 로고    scopus 로고
    • Synaptic adaptations of CA1 pyramidal neurons induced by a highly effective combinational antidepressant therapy
    • Marchetti C, Tafi E, Middei S, Rubinacci MA, Restivo L, et al. (2010) Synaptic adaptations of CA1 pyramidal neurons induced by a highly effective combinational antidepressant therapy. Biol Psychiatry 67: 146-154.
    • (2010) Biol Psychiatry , vol.67 , pp. 146-154
    • Marchetti, C.1    Tafi, E.2    Middei, S.3    Rubinacci, M.A.4    Restivo, L.5
  • 28
    • 33746409003 scopus 로고    scopus 로고
    • Toward an animal model of posttraumatic stress disorder
    • Siegmund A, Wotjak CT (2006) Toward an animal model of posttraumatic stress disorder. Ann N Y Acad Sci 1071: 324-334.
    • (2006) Ann N Y Acad Sci , vol.1071 , pp. 324-334
    • Siegmund, A.1    Wotjak, C.T.2
  • 29
    • 34247871449 scopus 로고    scopus 로고
    • A mouse model of posttraumatic stress disorder that distinguishes between conditioned and sensitised fear
    • Siegmund A, Wotjak CT (2007) A mouse model of posttraumatic stress disorder that distinguishes between conditioned and sensitised fear. J Psychiatr Res 41: 848-860.
    • (2007) J Psychiatr Res , vol.41 , pp. 848-860
    • Siegmund, A.1    Wotjak, C.T.2
  • 30
    • 46949107805 scopus 로고    scopus 로고
    • A modified singleprolonged stress model for post-traumatic stress disorder
    • Wang W, Liu Y, Zheng H, Wang HN, Jin X, et al. (2008) A modified singleprolonged stress model for post-traumatic stress disorder. Neurosci Lett 441: 237-241.
    • (2008) Neurosci Lett , vol.441 , pp. 237-241
    • Wang, W.1    Liu, Y.2    Zheng, H.3    Wang, H.N.4    Jin, X.5
  • 31
    • 0026491114 scopus 로고
    • Characterization of stress-induced long-term behavioural changes in rats: Evidence in favor of anxiety
    • van Dijken HH, Mos J, van der Heyden JA, Tilders FJ (1992) Characterization of stress-induced long-term behavioural changes in rats: evidence in favor of anxiety. Physiol Behav 52: 945-951.
    • (1992) Physiol Behav , vol.52 , pp. 945-951
    • van Dijken, H.H.1    Mos, J.2    van der Heyden, J.A.3    Tilders, F.J.4
  • 33
    • 0026554138 scopus 로고
    • Inescapable footshocks induce progressive and long-lasting behavioural changes in male rats
    • Van Dijken HH, Van der Heyden JA, Mos J, Tilders FJ (1992) Inescapable footshocks induce progressive and long-lasting behavioural changes in male rats. Physiol Behav 51: 787-794.
    • (1992) Physiol Behav , vol.51 , pp. 787-794
    • van Dijken, H.H.1    van der Heyden, J.A.2    Mos, J.3    Tilders, F.J.4
  • 34
    • 0035829390 scopus 로고    scopus 로고
    • Measuring normal and pathological anxiety-like behaviour in mice: A review
    • Belzung C, Griebel G (2001) Measuring normal and pathological anxiety-like behaviour in mice: a review. Behav Brain Res 125: 141-149.
    • (2001) Behav Brain Res , vol.125 , pp. 141-149
    • Belzung, C.1    Griebel, G.2
  • 35
    • 34248523169 scopus 로고    scopus 로고
    • Recovery of learning and memory is associated with chromatin remodelling
    • Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai LH (2007) Recovery of learning and memory is associated with chromatin remodelling. Nature 447: 178-182.
    • (2007) Nature , vol.447 , pp. 178-182
    • Fischer, A.1    Sananbenesi, F.2    Wang, X.3    Dobbin, M.4    Tsai, L.H.5
  • 36
    • 1642499190 scopus 로고    scopus 로고
    • Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible
    • Heine VM, Maslam S, Zareno J, Joels M, Lucassen PJ (2004) Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible. Eur J Neurosci 19: 131-144.
    • (2004) Eur J Neurosci , vol.19 , pp. 131-144
    • Heine, V.M.1    Maslam, S.2    Zareno, J.3    Joels, M.4    Lucassen, P.J.5
  • 37
    • 33947585039 scopus 로고    scopus 로고
    • Longterm behavioral changes after cessation of chronic antidepressant treatment in olfactory bulbectomized rats
    • Breuer ME, Groenink L, Oosting RS, Westenberg HG, Olivier B (2007) Longterm behavioral changes after cessation of chronic antidepressant treatment in olfactory bulbectomized rats. Biol Psychiatry 61: 990-995.
    • (2007) Biol Psychiatry , vol.61 , pp. 990-995
    • Breuer, M.E.1    Groenink, L.2    Oosting, R.S.3    Westenberg, H.G.4    Olivier, B.5
  • 38
    • 34248530339 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: Multiple mechanisms of action
    • Kim HJ, Rowe M, Ren M, Hong JS, Chen PS, et al. (2007) Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J Pharmacol Exp Ther 321: 892-901.
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 892-901
    • Kim, H.J.1    Rowe, M.2    Ren, M.3    Hong, J.S.4    Chen, P.S.5
  • 39
    • 0030300023 scopus 로고    scopus 로고
    • 5- HT1D receptor agonist properties of novel 2-[5-[[(trifluoromethyl)sulfonyl]oxy]- indolyl]ethylamines and their use as synthetic intermediates
    • Barf TA, de Boer P, Wikstrom H, Peroutka SJ, Swensson K, et al. (1996) 5- HT1D receptor agonist properties of novel 2-[5-[[(trifluoromethyl)sulfonyl]oxy]- indolyl]ethylamines and their use as synthetic intermediates. J Med Chem 39: 4717-4726.
    • (1996) J Med Chem , vol.39 , pp. 4717-4726
    • Barf, T.A.1    de Boer, P.2    Wikstrom, H.3    Peroutka, S.J.4    Swensson, K.5
  • 41
    • 67650004237 scopus 로고    scopus 로고
    • Pharmacotherapy of PTSD: Premises, principles, and priorities
    • Ravindran LN, Stein MB (2009) Pharmacotherapy of PTSD: premises, principles, and priorities. Brain Res 1293: 24-39.
    • (2009) Brain Res , vol.1293 , pp. 24-39
    • Ravindran, L.N.1    Stein, M.B.2
  • 42
    • 0035413972 scopus 로고    scopus 로고
    • Lifetime events and posttraumatic stress disorder in 4 postconflict settings
    • de Jong JT, Komproe IH, Van Ommeren M, El Masri M, Araya M, et al. (2001) Lifetime events and posttraumatic stress disorder in 4 postconflict settings. JAMA 286: 555-562.
    • (2001) JAMA , vol.286 , pp. 555-562
    • de Jong, J.T.1    Komproe, I.H.2    van Ommeren, M.3    El Masri, M.4    Araya, M.5
  • 43
    • 0035191204 scopus 로고    scopus 로고
    • Environmental enrichment in BALB/c mice: Effects in classical tests of anxiety and exposure to a predatory odor
    • Roy V, Belzung C, Delarue C, Chapillon P (2001) Environmental enrichment in BALB/c mice: effects in classical tests of anxiety and exposure to a predatory odor. Physiol Behav 74: 313-320.
    • (2001) Physiol Behav , vol.74 , pp. 313-320
    • Roy, V.1    Belzung, C.2    Delarue, C.3    Chapillon, P.4
  • 44
    • 0034885169 scopus 로고    scopus 로고
    • Voluntary physical activity prevents stressinduced behavioral depression and anti-KLH antibody suppression
    • Moraska A, Fleshner M (2001) Voluntary physical activity prevents stressinduced behavioral depression and anti-KLH antibody suppression. Am J Physiol Regul Integr Comp Physiol 281: R484-489.
    • (2001) Am J Physiol Regul Integr Comp Physiol , vol.281
    • Moraska, A.1    Fleshner, M.2
  • 45
    • 60349110953 scopus 로고    scopus 로고
    • Olfactory bulbectomy induces rapid and stable changes in basal and stressinduced locomotor activity, heart rate and body temperature responses in the home cage
    • Vinkers CH, Breuer ME, Westphal KG, Korte SM, Oosting RS, et al. (2009) Olfactory bulbectomy induces rapid and stable changes in basal and stressinduced locomotor activity, heart rate and body temperature responses in the home cage. Neuroscience 159: 39-46.
    • (2009) Neuroscience , vol.159 , pp. 39-46
    • Vinkers, C.H.1    Breuer, M.E.2    Westphal, K.G.3    Korte, S.M.4    Oosting, R.S.5
  • 46
    • 78650254503 scopus 로고    scopus 로고
    • Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress
    • [Epub ahead of print]
    • Schloesser RJ, Lehmann M, Martinowich K, Manji HK, Herkenham M (2010) Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress. Mol Psychiatry [Epub ahead of print].
    • (2010) Mol Psychiatry
    • Schloesser, R.J.1    Lehmann, M.2    Martinowich, K.3    Manji, H.K.4    Herkenham, M.5
  • 47
    • 33745684603 scopus 로고    scopus 로고
    • Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment
    • Meshi D, Drew MR, Saxe M, Ansorge MS, David D, et al. (2006) Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment. Nat Neurosci 9: 729-731.
    • (2006) Nat Neurosci , vol.9 , pp. 729-731
    • Meshi, D.1    Drew, M.R.2    Saxe, M.3    Ansorge, M.S.4    David, D.5
  • 48
    • 34548395111 scopus 로고    scopus 로고
    • The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior
    • Schmidt HD, Duman RS (2007) The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behav Pharmacol 18: 391-418.
    • (2007) Behav Pharmacol , vol.18 , pp. 391-418
    • Schmidt, H.D.1    Duman, R.S.2
  • 49
    • 77953094107 scopus 로고    scopus 로고
    • Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice
    • [Epub ahead of print]
    • Marlatt MW, Lucassen PJ, van Praag H (2010) Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice. Brain Res [Epub ahead of print].
    • (2010) Brain Res
    • Marlatt, M.W.1    Lucassen, P.J.2    van Praag, H.3
  • 50
    • 57449116962 scopus 로고    scopus 로고
    • Impaired dendritic development and synaptic formation of postnatal-born dentate gyrus granular neurons in the absence of brain-derived neurotrophic factor signaling
    • Gao X, Smith GM, Chen J (2009) Impaired dendritic development and synaptic formation of postnatal-born dentate gyrus granular neurons in the absence of brain-derived neurotrophic factor signaling. Exp Neurol 215: 178-190.
    • (2009) Exp Neurol , vol.215 , pp. 178-190
    • Gao, X.1    Smith, G.M.2    Chen, J.3
  • 51
    • 38149116890 scopus 로고    scopus 로고
    • Distinct effect of neurotrophins delivered simultaneously by an adenoviral vector on neurite outgrowth of neural precursor cells from different regions of the brain
    • Yoo M, Joung I, Han AM, Yoon HH, Kwon YK (2007) Distinct effect of neurotrophins delivered simultaneously by an adenoviral vector on neurite outgrowth of neural precursor cells from different regions of the brain. J Microbiol Biotechnol 17: 2033-2041.
    • (2007) J Microbiol Biotechnol , vol.17 , pp. 2033-2041
    • Yoo, M.1    Joung, I.2    Han, A.M.3    Yoon, H.H.4    Kwon, Y.K.5
  • 52
    • 33645357786 scopus 로고    scopus 로고
    • Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
    • Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, et al. (2006) Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci 9: 519-525.
    • (2006) Nat Neurosci , vol.9 , pp. 519-525
    • Tsankova, N.M.1    Berton, O.2    Renthal, W.3    Kumar, A.4    Neve, R.L.5
  • 53
    • 36248989584 scopus 로고    scopus 로고
    • Structural and functional plasticity of the human brain in posttraumatic stress disorder
    • Bremner JD, Elzinga B, Schmahl C, Vermetten E (2008) Structural and functional plasticity of the human brain in posttraumatic stress disorder. Prog Brain Res 167: 171-186.
    • (2008) Prog Brain Res , vol.167 , pp. 171-186
    • Bremner, J.D.1    Elzinga, B.2    Schmahl, C.3    Vermetten, E.4
  • 54
    • 34748854338 scopus 로고    scopus 로고
    • Response variation following trauma: A translational neuroscience approach to understanding PTSD
    • Yehuda R, LeDoux J (2007) Response variation following trauma: a translational neuroscience approach to understanding PTSD. Neuron 56: 19-32.
    • (2007) Neuron , vol.56 , pp. 19-32
    • Yehuda, R.1    Ledoux, J.2
  • 55
    • 65049083672 scopus 로고    scopus 로고
    • Systemic propranolol acts centrally to reduce conditioned fear in rats without impairing extinction
    • Rodriguez-Romaguera J, Sotres-Bayon F, Mueller D, Quirk GJ (2009) Systemic propranolol acts centrally to reduce conditioned fear in rats without impairing extinction. Biol Psychiatry 65: 887-892.
    • (2009) Biol Psychiatry , vol.65 , pp. 887-892
    • Rodriguez-Romaguera, J.1    Sotres-Bayon, F.2    Mueller, D.3    Quirk, G.J.4
  • 56
    • 0034589070 scopus 로고    scopus 로고
    • Stress impairs prefrontal cortical function in rats and monkeys: Role of dopamine D1 and norepinephrine alpha-1 receptor mechanisms
    • Arnsten AF (2000) Stress impairs prefrontal cortical function in rats and monkeys: role of dopamine D1 and norepinephrine alpha-1 receptor mechanisms. Prog Brain Res 126: 183-192.
    • (2000) Prog Brain Res , vol.126 , pp. 183-192
    • Arnsten, A.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.