Constitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPs

Journal of Experimental and Clinical Cancer Research

Volumn 29, Issue 1, 2010, Pages

  Pasche, Boris ^a   Wisinski, Kari B ^b   Sadim, Maureen ^c   Kaklamani, Virginia ^c   Pennison, Michael J ^a   Zeng, Qinghua ^a   Bellam, Naresh ^a   Zimmerman, Jacquelyn ^a   Yi, Nengjun ^d   Zhang, Kui ^d   Baron, John ^e   Stram, Daniel O ^f   Hayes, M Geoffrey ^c,g  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e DARTMOUTH MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^g NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; RNA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; MESSENGER RNA; PROTEIN SERINE THREONINE KINASE; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ADULT; AGED; ALLELE; ARTICLE; COLON ADENOCARCINOMA; COLORECTAL CARCINOMA; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; HUMAN; MALE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM CARCINOMA; SINGLE NUCLEOTIDE POLYMORPHISM; ADENOCARCINOMA; COLORECTAL TUMOR; CROSS-SECTIONAL STUDY; GENETICS; HAPLOTYPE; MIDDLE AGED; PATHOLOGY; POLYMERASE CHAIN REACTION; PROGNOSIS; WESTERN BLOTTING;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ALLELES; BLOTTING, WESTERN; COLORECTAL NEOPLASMS; CROSS-SECTIONAL STUDIES; DNA, NEOPLASM; FEMALE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, MESSENGER; RNA, NEOPLASM;

EID: 77957805183     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/1756-9966-29-57     Document Type: Article

References (19)

1. An update on the genetics of colorectal cancer. Z Kemp, C Thirlwell, O Sieber, A Silver, I Tomlinson, Human Molecular Genetics 2004 13 177 R185 10.1093/hmg/ddh247 15358723 (Pubitemid 39359901)
2. Genetic predisposition to colorectal cancer. A de la Chapelle, Nat Rev Cancer 2004 4 769 780 10.1038/nrc1453 15510158 (Pubitemid 39331149)
3. Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. RS Houlston, E Webb, P Broderick, AM Pittman, MC Di Bernardo, S Lubbe, et al. Nat Genet 2008 40 1426 1435 10.1038/ng.262 19011631
4. A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. P Broderick, L Carvajal-Carmona, AM Pittman, E Webb, K Howarth, A Rowan, et al. Nat Genet 2007 39 1315 1317 10.1038/ng.2007.18 17934461 (Pubitemid 350034998)
5. New insights into the aetiology of colorectal cancer from genome-wide association studies. A Tenesa, MG Dunlop, Nat Rev Genet 2009 10 353 358 10.1038/nrg2574 19434079
6. Type I transforming growth factor beta receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract. B Pasche, Y Luo, PH Rao, SD Nimer, E Dmitrovsky, P Caron, L Luzzatto, K Offit, C Cordon-Cardo, B Renault, JM Satagopan, VV Murty, Cancer Res 1998 58 2727 2732 9661882 (Pubitemid 28311899)
7. T beta R-I(6A) is a candidate tumor susceptibility allele. B Pasche, P Kolachana, K Nafa, J Satagopan, YG Chen, RS Lo, D Brener, D Yang, L Kirstein, C Oddoux, H Ostrer, P Vineis, L Varesco, S Jhanwar, L Luzzatto, J Massagué K Offit, Cancer Res 1999 59 5678 5682 10582683
8. Somatic Acquisition and Signaling of TGFBR1*6A in Cancer. B Pasche, TJ Knobloch, Y Bian, J Liu, S Phukan, D Rosman, V Kaklamani, L Baddi, FS Siddiqui, W Frankel, TW Prior, DE Schuller, A Agrawal, J Lang, ME Dolan, EE Vokes, WS Lane, CC Huang, T Caldes, A Di Cristofano, H Hampel, I Nilsson, G von Heijne, R Fodde, VV Murty, A de la Chapelle, CM Weghorst, JAMA: The Journal of the American Medical Association 2005 294 1634 1646 10.1001/jama.294.13.1634 16204663 (Pubitemid 41407356)
9. Is TGFBR1*6A Really Associated With Increased Risk of Cancer? HT Zhang, J Zhao, SY Zheng, XF Chen, J Clin Oncol 2005 23 7743 7744 10.1200/JCO.2005.02.9108 16234535 (Pubitemid 46291840)
10. TGFBR1*6A and Cancer: A Meta-Analysis of 12 Case-Control Studies. B Pasche, VG Kaklamani, N Hou, T Young, A Rademaker, P Peterlongo, N Ellis, K Offit, T Caldes, M Reiss, T Zheng, J Clin Oncol 2004 22 756 758 10.1200/JCO.2004.99.271 14966109
11. Lack of an Association between the TGFBR1*6A Variant and Colorectal Cancer Risk. y Skoglund, B Song, J Dalen, S Dedorson, D Edler, F Hjern, J Holm, C Lenander, U Lindforss, N Lundqvist, H Olivecrona, L Olsson, L Påhlman, J Rutegård, K Smedh, A Törnqvist, RS Houlston, A Lindblom, Clinical Cancer Research 2007 13 3748 3752 10.1158/1078-0432.CCR-06-2865 17575241 (Pubitemid 46955140)
12. Tgfbr1 Haploinsufficiency Is a Potent Modifier of Colorectal Cancer Development. Q Zeng, S Phukan, Y Xu, M Sadim, DS Rosman, M Pennison, J Liao, GY Yang, CC Huang, L Valle, A Di Cristofano, A de la Chapelle, B Pasche, Cancer Res 2009 69 678 686 10.1158/0008-5472.CAN-08-3980 19147584
13. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. S Markowitz, J Wang, L Myeroff, R Parsons, L Sun, J Lutterbaugh, RS Fan, E Zborowska, KW Kinzler, B Vogelstein, Science 1995 268 1336 1338 10.1126/science.7761852 7761852
14. Germline allele-specific expression of TGFBR1 confers an increased risk of colorectal cancer. L Valle, T Serena-Acedo, S Liyanarachchi, H Hampel, I Comeras, Z Li, Q Zeng, HT Zhang, MJ Pennison, M Sadim, B Pasche, SM Tanner, A de la Chapelle, Science 2008 321 1361 1365 10.1126/science.1159397 18703712
15. Infrequent Detection of Germline Allele-Specific expression of TGFBR1 in Lymphoblasts and Tissues of Colon Cancer Patients. K Guda, L Natale, J Lutterbaugh, GL Wiesner, S Lewis, SM Tanner, J Tomsic, L Valle, A de la Chapelle, RC Elston, J Willis, SD Markowitz, Cancer Res 2009 69 4959 4961 10.1158/0008-5472.CAN-09-0225 19509225
16. Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk. VG Kaklamani, KB Wisinski, M Sadim, C Gulden, A Do, K Offit, JA Baron, H Ahsan, C Mantzoros, B Pasche, JAMA 2008 300 1523 1531 10.1001/jama.300.13.1523 18827209
17. Somatic acquisition of TGFBR1*6A by epithelial and stromal cells during head and neck and colon cancer development. Y Bian, TJ Knobloch, M Sadim, V Kaklamani, A Raji, GY Yang, CM Weghorst, B Pasche, Human Molecular Genetics 2007 16 3128 3135 10.1093/hmg/ddm274 17890272 (Pubitemid 350138980)
18. Genomic Alterations in Tumor Stroma. C Eng, G Leone, MS Orloff, MC Ostrowski, Cancer Res 2009 69 6759 6764 10.1158/0008-5472.CAN-09-0985 19706759
19. TGF-{beta} Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia. NA Bhowmick, A Chytil, D Plieth, AE Gorska, N Dumont, S Shappell, MK Washington, EG Neilson, HL Moses, Science 2004 303 848 851 10.1126/science.1090922 14764882 (Pubitemid 38174665)