Tramadol and caffeine produce synergistic interactions on antinociception measured in a formalin model

Pharmacology Biochemistry and Behavior

Volumn 97, Issue 2, 2010, Pages 357-362

  Díaz Reval, M Irene ^a   Carrillo Munguía, Norma ^a   Martínez Casas, Maribel ^a   González Trujano, Ma Eva ^b  

^a UNIVERSIDAD DE COLIMA   (Mexico)

^b INSTITUTO NACIONAL DE PSIQUIATRÍA RAMÓN DE LA FUENTE MUÑIZ   (Mexico)

Author keywords

Antinociceptive effect; Caffeine; Formalin test; Synergism; Tramadol

Indexed keywords

CAFFEINE; FORMALDEHYDE; TRADOL; TRAMADOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG POTENTIATION; MALE; MONOTHERAPY; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT;

ANALGESICS, OPIOID; ANIMALS; CAFFEINE; CENTRAL NERVOUS SYSTEM STIMULANTS; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FORMALDEHYDE; MALE; PAIN MEASUREMENT; RATS; RATS, WISTAR; TRAMADOL;

RATTUS;

EID: 77957773393     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2010.09.004     Document Type: Article

References (40)

1. Budd K., Langford R. Tramadol revisited. Br J Anaesth 1999, 82:493-495.
2. Castañeda-Hernández G., Castillo-Méndez M.S., López-Muñoz F.J., Granados-Soto V., Flores-Murrieta F.J. Potentiation by caffeine of the analgesic effect of aspirin in the pain-induced functional impairment model in the rat. Can J Physiol Pharmacol 1994, 72:1127-1131.
3. Chen Y., Chan S.Y., Ho P.C. Isobolographic analysis of the analgesic interactions between ketamine and tramadol. J Pharm Pharmacol 2002, 54:623-631.
4. Chou T.C. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 2006, 58:621-681.
5. Chou T.C. Preclinical versus clinical drug combination studies. Leuk Lymphoma 2008, 49:2059-2080.
6. Chou T.C. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res 2010, 70:440-446.
7. Chou T.C., Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984, 22:27-55.
8. Dayer P., Desmeules J., Collart L. Pharmacologie du tramadol. Drugs 1997, 53:18-24.
9. Díaz-Reval M.I., Ventura-Martínez R., Hernández-Delgadillo G.P., Domínguez-Ramírez A.M., López-Muñoz F.J. Effect of caffeine on antinociceptive action of ketoprofen in rats. Arch Med Res 2001, 32:13-20.
10. Diener H.C., Pfaffenrath V., Pageler L., Peil H., Aicher B. The fixed combination of acetylsalicylic acid, paracetamol and caffeine is more effective than single substances and dual combination for the treatment of headache: a multicentre, randomized double-blind, single-dose, placebo controlled parallel group study. Cephalalgia 2005, 25:776-787.
11. Driessen B., Reimann W. Interaction of the central analgesic, tramadol, with the uptake and release of 5-hydroxytryptamine in the rat brain in vitro. Br J Pharmacol 1992, 105:147-151.
12. Engelhardt G., Mauz A.B., Pairet M. Role of caffeine in combined analgesic drugs from the point of view of experimental pharmacology. Arzneimittelforschung 1997, 47:917-927.
13. Fernández-Dueñas V., Sánchez S., Planas E., Poveda R. Adjuvant effect of caffeine on acetylsalicylic acid anti-nociception: prostaglandin E2 synthesis determination in carrageenan-induced peripheral inflammation in rat. Eur J Pain 2008, 12:157-163.
14. Flores-Acevedo D.M., Flores-Murrieta F.J., Castañeda-Hernández G., López-Muñoz F.J. Potentiation of the analgesic effect of tolmetin, a potent non-steroidal anti-inflammatory drug, by caffeine in the rat. Pharm Sci 1995, 1:441-444.
15. Gayawali K., Pandhi P., Sharma P.L. Determination of the optimal analgesia-potentiating dose of caffeine and a study of its effect on the pharmacokinetics of aspirin in mice. Meth Find Exp Clin Pharmacol 1991, 13:529-533.
16. Hernandez-Delgadillo G.P., Ventura R., Díaz M.I., Domínguez A.M., López-Muñoz F.J. Metamizol potentiates morphine antinociception but not constipation after chronic treatment. Eur J Pharmacol 2002, 441:177-183.
17. Lewis K.S., Han N.H. Tramadol: a new centrally acting analgesic. Am J Health-Syst Pharm 1997, 54:643-652.
18. Liu H.C., Jin S.M., Wang Y.L. Gender-related differences in pharmacokinetics of enantiomers of trans-tramadol and its active metabolite, trans-O-demethyltramadol, in rats. Acta Pharmacol Sin 2003, 24:1265-1269.
19. López-Muñoz F.J., Castañeda-Hernández G., Flores-Murrieta F.J., Granados-Soto V. Effect of caffeine coadministration and nitric oxide synthesis inhibition on the antinociceptive action of ketorolac. Eur J Pharmacol 1996, 308:275-277.
20. López-Muñoz F.J., Díaz-Reval M.I., Terrón J.A., Déciga-Campos M. Analysis of the analgesic interactions between ketorolac and tramadol during arthritic nociception in rat. Eur J Pharmacol 2004, 484:157-165.
21. Malec D., Michalska E. The effect of methylxanthines on morphine analgesia in mice and rats. Pol J Physiol Pharmacol 1988, 40:223-232.
22. Malmberg A.B., Yaksh T.L. Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science 1992, 257:1276-1279.
23. Medina L.J.R., Domínguez-Ramírez A.M., Jung C.H., Bravo G., Díaz-Reval M.I., Déciga-Campos M., et al. Enhancement of antinociception by co-administration of ibuprofen and caffeine in arthritic rats. Eur J Pharmacol 2006, 544:31-38.
24. Miranda H.F., Pinardi G. Antinociception, tolerante and physical dependence comparison between morphine and tramadol. Pharmacol Biochem Behav 1998, 61:357-360.
25. Misra A.L., Pontani R.B., Vadlamani N.L. Potentiation of morphine analgesia by caffeine. Br J Pharmacol 1985, 84:789-791.
26. Nehlig A., Daval J.L., Debry G. Caffeine and central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res Rev 1992, 17:139-170.
27. Oliva P., Aurilio C., Massimo F., Grella A., Maione S., Grella E., et al. The antinociceptive effect of tramadol in the formalin test is mediated by the serotonergic component. Eur J Pharmacol 2002, 445:179-185.
28. Ortiz M.I., Castañeda-Hernández G. Examination of the interaction between peripheral lumiracoxib and opioids on the 1% formalin test in rats. Eur J Pain 2008, 12:233-240.
29. Person D.L., Kissin I., Brown P.T., Xavier A.V., Vinik H.R., Bradley E.L. Morphine-caffeine analgesic interaction in rats. Anesth Analg 1985, 64:851-856.
30. Radbruch L., Grond S., Lehmann K.A. A risk-benefit assessment of tramadol in the management of pain. Drug Saf 1996, 15:8-29.
31. Raffa R.B., Friderichs E., Reimann W., Shank R.P., Codd E.E., Vaught J.L. Opioid and non opioid components independently contribute to the mechanism of action of tramadol, an atypical opioid analgesic. J Pharmacol Exp Ther 1992, 260:275-285.
32. Raffa R.B., Friderichs E., Reimann W., Shank R.P., Codd E.E., Vaught J.L., et al. Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol. J Pharmacol Exp Ther 1993, 267:331-340.
33. Roux P.J., Coetze J.F. Tramadol today. Curr Opin Anaesthesiol 2000, 13:457-461.
34. Sawynok J., Reid A. Neurotoxin-induced lesions to central serotonegic, noradrenergic and dopaminergic systems modify caffeine-induced antinociception in the formalin test and locomotor stimulation in rats. J Pharmacol Exp Ther 1996, 277:646-653.
35. Sawynok J., Yaksh T.L. Caffeine as an analgesic adjuvant: a review of pharmacology and mechanisms of action. Pharmacol Rev 1993, 45:43-84.
36. Shargel L., Wu-Pong S., Yu A.B.C. Applied biopharmaceutics & pharmacokinetics 2005, 28-34. McGraw-Hill, New York. Fifth ed.
37. Vinegar R., Truax J.F., Selph J.L., Welch R.M., White H.L. Potentiation of the anti-inflammatory and analgesic activity of aspirin by caffeine in the rat. Proc Soc Exp Biol Med 1976, 151:556-560.
38. Wheeler-Aceto H., Cowan A. Standardization of the rat paw formalin test for the evaluation of analgesics. Psychopharmacology (Berl) 1991, 104:35-44.
39. Wu W.P., Hao J.X., Fredholm B.B., Wiesenfeld-Hallin Z., Xu X.J. Effect of acute and chronic administration of caffeine on pain-like behaviors in rats with partial sciatic nerve injury. Neurosci Lett 2006, 402:164-166.
40. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983, 16:109-110.