Gender-related differences in pharmacokinetics of enantiomers of trans-tramadol and its active metabolite, trans-O-demethyltramadol, in rats

Acta Pharmacologica Sinica

Volumn 24, Issue 12, 2003, Pages 1265-1269

  Liu, Hui Chen ^a   Jin, Shu Min ^a   Wang, Yong Li ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Pharmacokinetics; Sex factors; Tramadol

Indexed keywords

DRUG METABOLITE; O NORTRAMADOL; TRAMADOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CAPILLARY ELECTROPHORESIS; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG METABOLISM; ENANTIOMER; FEMALE; MALE; NONHUMAN; RAT; SEX DIFFERENCE; STEREOCHEMISTRY;

ANIMALS; AREA UNDER CURVE; FEMALE; MALE; NARCOTICS; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS; STEREOISOMERISM; TRAMADOL;

EID: 0344667673     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Guo WY, Zhan Q, Zhao Y, Wang L. Determination of cis and trans isomers of tramadol hydrochloride by capillary zone electrophoresis. Biomed Chromatogr 1998; 12: 13-4.
2. Raffa RB, Friderichs E, Reimann W, Shink RP, Codd EE, Vanght JL, et al. Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol. J Pharmacol Exp Ther 1993; 267: 331-40.
3. Garrido MJ, Valle M, Campanero MA, Calvo R, Troconiz IF. Modeling of the in vivo antinociceptive interaction between an opioid agonist, (+)-O-demethyltramadol, and an monoamine reuptake inhibitor, (-)-demethyltramadol, in rats. J Pharmacol Exp Ther 2000; 295: 352-9.
4. Raffa RB. A novel approach to the pharmacology of analgesics. Am J Med 1996; 101: 40s-60s.
5. Liu HC, Liu TJ, Yang YY, Hou YN. Pharmacokinetics of enantiomers of trans-tramadol and its active metabolite, trans-O-demethyltramadol, in human subjects. Acta Pharmacol Sin 2001; 22: 91-6.
6. Liu HC, Wang N, Liu CS, Hu YQ, Liu JF, Hou YN. Distribution of the enantiomers of trans-tramadol and trans-O-demethyltramadol in the central nervous system of rats. Acta Pharmacol Sin 2001; 22: 871-5.
7. Liu HC, Zhang XJ, Yang YY, Wang N, Hou YN. The stereoselectivity in renal clearance of trans-tramadol and its active metabolite, trans-O-demethyltramadol. Acta Pharmacol Sin 2002; 23: 83-6.
8. Liu HC, Wang N, Yu Y, Hou YN. Stereoselectivity in trans-tramadol metabolism and trans-O-demethyltramadol formation in rat liver microsomes. Acta Pharmacol Sin 2003; 24: 85-90.
9. Fuder S, Stiegler S, Wetzelsberger N, Wieckhorst G, Lange R, Lucker PW. Effect of buffering on pharmacokinetics of ketoprofen enantiomers in man. Br J Pharmacol 1997; 44: 527-30.
10. Czerniak R. Gender-based differences in pharmacokinetics in laboratory animal models. Int J Toxicol 2001; 20: 161-3.
11. Lintz W, Erlacin S, Frankus E, Uragg H. Biotransformation of tramadol in man and animal. Arzneimittelforsch 1981; 31: 1932-43.
12. Paar WD, Poche S, Gerloff J, Dengler HJ. Polymorphic CYP2D6 mediates O-demethylation of the opioid analgesic tramadol. Eur J Clin Pharmacol 1997; 53: 235-9.
13. Meibohm B, Beierle I, Derendor H. How important are gender differences in pharmacokinetics. Clin Pharmacokinet 2002; 41: 329-42.