Metamizol potentiates morphine antinociception but not constipation after chronic treatment

European Journal of Pharmacology

Volumn 441, Issue 3, 2002, Pages 177-183

  Hernández Delgadillo, Gloria P ^a   Ventura Martı́nez, Rosa ^a   Dı́az Reval, Ma Irene ^a   Domı́nguez Ramı́rez, Adriana M ^b   López Muñoz, Francisco J ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Antinociception; Chronic treatment; Constipation; Metamizol; Morphine; Synergism

Indexed keywords

DIPYRONE; MORPHINE; OPIATE RECEPTOR; ANALGESIC AGENT; NALOXONE;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONSTIPATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; DRUG SCREENING; INFLAMMATION; INTESTINE TRANSIT TIME; LONG TERM EXPOSURE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TEST MEAL; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG ADMINISTRATION; DRUG COMBINATION; PAIN ASSESSMENT; WISTAR RAT;

ANALGESICS; ANIMAL; CONSTIPATION; DIPYRONE; DRUG ADMINISTRATION SCHEDULE; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; MALE; MORPHINE; NALOXONE; PAIN MEASUREMENT; RATS; RATS, WISTAR; SUPPORT, NON-U.S. GOV'T; ANIMALS;

EID: 0037177393     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)01344-4     Document Type: Article

References (33)

1. Evidence for a peripheral mechanism of action for the potentiation of the antinociceptive effect of morphine by dipyrone
2. A possible central antinociceptive effect of dipyrone in mice
3. Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanisms of action
4. The additive analgesic efficacy of acetaminophen, 1000 mg, and codeine, 60 mg, in dental pain
5. Diversity of agents that modify opioid tolerance, physical dependence, abstinence syndrome and self-administrative behavior
6. Gastrointestinal transit following intrathecal or subcutaneous narcotic analgesics
7. Cross-tolerance between morphine- and bombesin-induced inhibition of intestinal transit in rats
8. Additive and augmentative synergism between analgesic drugs
9. Endogenous and exogenous opioids in the control of gastrointestinal motility and secretion
10. Surface of synergistic interaction between dipyrone and morphine in the PIFIR model
11. Analgesic effects of combinations containing opioid drugs with either aspirin or acetaminophen in the rat
12. A new model to assess analgesic activity: Pain-induced functional impairment in the rat (PIFIR)
13. Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction
14. Inhibition of gastrointestinal transit by morphine in rats results primarily from direct drug action on gut opioid sites
15. Diclofenac versus dipyrone in acute renal colic: A double-blind controlled trial
16. Use of intravenous patient-controlled analgesia for the documentation of synergy between tramadol and metamizol
17. Intestinal effect and analgesia: Evidence for different involvement of opioid receptor subtypes in periaqueductal gray matter
18. Supraspinal cerebral areas involved in morphine's intestinal inhibition and analgesia
19. Differential tolerance to the intestinal inhibitory effect of opiates in mice
20. Oral metamizol (1 g and 2 g) versus ibuprofen and placebo in the treatment of lower third molar surgery pain: Randomised double-blind multi-centre study
21. Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse
22. Opioid analgesics and antagonists
23. Prophylactic use of epidural mepivacaine/morphine, systemic diclofenac and metamizole reduces postoperative morphine consumption after abdominal surgery
24. Efficacy and tolerance of oral dipyrone versus oral morphine for cancer pain
25. The potentiation of analgesic activity of paracetamol plus morphine involves the serotonergic system in rat brain
26. Centrally and peripherally mediated inhibition of intestinal motility by opioids
27. Metamizol potentiates morphine effects on visceral pain and evoked c-Fos immunoreactivity in spinal cord
28. Opioid tolerance induced by metamizol (dipyrone) microinjections into the periaqueductal grey of rats
29. Naloxone partial reversal of the antinociception produced by dipyrone microinjected into the periaqueductal gray of rats. Possible involvement of medullary off- and on-cells
30. Mechanism of action of anti-inflammatory drugs
31. The analgesic activity of propoxyphene napsylate with and without aspirin
32. Tolerance to the effect of morphine on intestinal transit
33. Ethical guidelines for investigations of experimental pain in conscious animals