The R438W polymorphism of human DNA polymerase lambda triggers cellular sensitivity to camptothecin by compromising the homologous recombination repair pathway

Carcinogenesis

Volumn 31, Issue 10, 2010, Pages 1742-1747

  Capp, Jean Pascal ^a,c   Boudsocq, François ^a,d   Bergoglio, Valérie ^a   Trouche, Didier ^b   Cazaux, Christophe ^a   Blanco, Luis ^e   Hoffmann, Jean Sébastien ^a   Canitrot, Yvan ^a,b  

^a INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^b CNRS   (France)

^c INSA   (France)

^d Université Paul Sabatier   (France)

^e CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; DNA POLYMERASE; DNA POLYMERASE LAMBDA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DNA DIRECTED DNA POLYMERASE BETA; DNA POLYMERASE BETA2;

ANIMAL CELL; ARTICLE; CHEMOSENSITIVITY; CONTROLLED STUDY; DNA DAMAGE; DNA POLYMORPHISM; ENZYME ACTIVITY; GENE FREQUENCY; GENE MUTATION; GENOMIC INSTABILITY; HOMOLOGOUS RECOMBINATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SISTER CHROMATID EXCHANGE; ANIMAL; CHO CELL LINE; CRICETULUS; DNA REPAIR; DRUG EFFECTS; GENETIC POLYMORPHISM; GENETIC RECOMBINATION; GENETICS; HAMSTER; HUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CHO CELLS; CRICETINAE; CRICETULUS; DNA POLYMERASE BETA; DNA REPAIR; HUMANS; POLYMORPHISM, GENETIC; RECOMBINATION, GENETIC; SISTER CHROMATID EXCHANGE;

EID: 77957757791     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq166     Document Type: Article

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