An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase λ

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 43, 2009, Pages 18201-18206

  Van Loon, Barbara ^a   Hübscher, Ulrich ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Base excision repair; DNA ligase I; DNA ligase III; Oxidation damage

Indexed keywords

8 HYDROXYGUANINE; CELL EXTRACT; CYCLINE; DNA DIRECTED DNA POLYMERASE DELTA; DNA GLYCOSYLASE MUTY; FLAP ENDONUCLEASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; REACTIVE OXYGEN METABOLITE;

ARTICLE; CARCINOGENESIS; DNA DAMAGE; DNA TEMPLATE; EXCISION REPAIR; GENOMIC INSTABILITY; HELA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MOLECULAR INTERACTION; OXIDATIVE STRESS; PRIORITY JOURNAL;

DNA DAMAGE; DNA GLYCOSYLASES; DNA LIGASES; DNA POLYMERASE BETA; DNA REPAIR; DNA REPLICATION; GENOMIC INSTABILITY; GUANINE; HELA CELLS; HUMANS; MUTAGENESIS; OXIDATION-REDUCTION; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN BINDING; REACTIVE OXYGEN SPECIES; SUBSTRATE SPECIFICITY;

EID: 70849113575     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0907280106     Document Type: Article

References (44)

1. Collins AR (1999) Oxidative DNA damage, antioxidants, and cancer. Bioessays 21:238-246. (Pubitemid 29172891)
2. Avkin S, Livneh Z (2002) Efficiency, specificity and DNA polymerase-dependence of translesion replication across the oxidative DNA lesion 8-oxoguanine in human cells. Mutat Res 510:81-90. (Pubitemid 35379888)
3. Greenman C, et al. (2007) Patterns of somatic mutation inhumancancer genomes. Nature 446:153-158. (Pubitemid 46398669)
4. Slupska MM, Luther WM, Chiang JH, Yang H, Miller JH (1999) Functional expression of hMYH, a human homolog of the Escherichia coli MutY protein. J Bacteriol 181:6210-6213. (Pubitemid 29459939)
5. Takao M, Zhang QM, Yonei S, Yasui A (1999) Differential subcellular localization of human MutY homolog (hMYH) and the functional activity of adenine:8-oxoguanine DNA glycosylase. Nucleic Acids Res 27:3638-3644. (Pubitemid 29435742)
6. Braithwaite EK, et al. (2005) DNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts. J Biol Chem 280:18469-18475.
7. Fortini P, et al. (1998) Different DNA polymerases are involved in the short- and long-patch base excision repair in mammalian cells. Biochemistry 37:3575-3580. (Pubitemid 28162911)
8. Stucki M, et al. (1998) Mammalian base excision repair by DNA polymerases delta and epsilon. Oncogene 17:835-843. (Pubitemid 28430206)
9. Allinson SL, Dianova II, Dianov GL (2001) DNA polymerase beta is the major dRP lyase involved in repair of oxidative base lesions in DNA by mammalian cell extracts. EMBO J 20:6919-6926.
10. Dianov GL, Prasad R, Wilson SH, Bohr VA (1999) Role of DNA polymerase beta in the excision step of long patch mammalian base excision repair. J Biol Chem 274:13741-13743. (Pubitemid 129518667)
11. Podlutsky AJ, Dianova II, Podust VN, Bohr VA, Dianov GL (2001) Human DNA polymerase beta initiates DNA synthesis during long-patch repair of reduced AP sites in DNA. EMBO J 20:1477-1482.
12. Sobol RW, et al. (1996) Requirement of mammalian DNA polymerase-beta in base-excision repair. Nature 379:183-186. (Pubitemid 26020204)
13. Sobol RW, et al. (2000) The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicity. Nature 405:807-810.
14. Ramadan K, Shevelev I, Hubscher U (2004) The DNA-polymerase-X family: Controllers of DNA quality? Nat Rev Mol Cell Biol 5:1038-1043. (Pubitemid 39611539)
15. Garcia-Diaz M, Bebenek K, Kunkel TA, Blanco L (2001) Identification of an intrinsic 5′-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: A possible role in base excision repair. J Biol Chem 276:34659-34663. (Pubitemid 37384461)
16. Lee JW, et al. (2004) Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts. J Biol Chem 279:805-811.
17. Nick McElhinny SA, et al. (2005) A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining. Mol Cell 19:357-366.
18. Maga G, et al. (2007) 8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins. Nature 447:606-608. (Pubitemid 46868042)
19. Maga G, et al. (2002) Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis. J Biol Chem 277:48434-48440. (Pubitemid 35470801)
20. Picher AJ, Blanco L (2007) Human DNA polymerase lambda is a proficient extender of primer ends paired to 7, 8-dihydro-8-oxoguanine. DNA Repair (Amst) 6:1749-1756.
21. Maga G, et al. (2008) Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair. Proc Natl Acad Sci USA 105:20689-20694.
22. Kong X, et al. (2009) Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cells. Nucleic Acids Res 37:e68.
23. Parsons JL, Dianov GL (2004) Monitoring base excision repair proteins on damaged DNA using human cell extracts. Biochem Soc Trans 32:962-963. (Pubitemid 39655516)
24. Moldovan GL, Pfander B, Jentsch S (2007) PCNA, the maestro of the replication fork. Cell 129:665-679.
25. Maga G, Hubscher U (2003) Proliferating cell nuclear antigen (PCNA): A dancer with many partners. J Cell Sci 116:3051-3060. (Pubitemid 37038954)
26. Parker A, et al. (2001) Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair. J Biol Chem 276:5547-5555. (Pubitemid 37385700)
27. Fortini P, et al. (2003) 8-Oxoguanine DNA damage: At the crossroad of alternative repair pathways. Mutat Res 531:127-139. (Pubitemid 37456727)
28. Parlanti E, Fortini P, Macpherson P, Laval J, Dogliotti E (2002) Base excision repair of adenine/8-oxoguanine mispairs by an aphidicolin-sensitive DNA polymerase in human cell extracts. Oncogene 21:5204-5212. (Pubitemid 34948132)
29. Hashimoto K, Tominaga Y, Nakabeppu Y, Moriya M (2004) Futile short-patch DNA base excision repair of adenine:8-oxoguanine mispair. Nucleic Acids Res 32:5928-5934. (Pubitemid 39619174)
30. Braithwaite EK, et al. (2005) DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair. J Biol Chem 280:31641-31647.
31. Hirano S, et al. (2003) Mutator phenotype of MUTYH-null mouse embryonic stem cells. J Biol Chem 278:38121-38124. (Pubitemid 37221699)
32. Dianova II, Bohr VA, Dianov GL (2001) Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair. Biochemistry 40:12639-12644.
33. Warbrick E, Lane DP, Glover DM, Cox LS (1997) Homologous regions of Fen1 and p21Cip1 compete for binding to the same site on PCNA: A potential mechanism to co-ordinate DNA replication and repair. Oncogene 14:2313-2321. (Pubitemid 27260723)
34. Li X, Li J, Harrington J, Lieber MR, Burgers PM (1995) Lagging strand DNA synthesis at the eukaryotic replication fork involves binding and stimulation of FEN-1 by proliferating cell nuclear antigen. J Biol Chem 270:22109-22112.
35. Jonsson ZO, Hindges R, Hubscher U (1998) Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen. EMBO J 17:2412-2425. (Pubitemid 28171925)
36. Levin DS, Bai W, Yao N, O'Donnell M, Tomkinson AE (1997) An interaction between DNA ligase I and proliferating cell nuclear antigen: Implications for Okazaki fragment synthesis and joining. Proc Natl Acad Sci USA 94:12863-12868. (Pubitemid 27518442)
37. Fan J, Otterlei M, Wong HK, Tomkinson AE, Wilson DM, 3rd (2004) XRCC1 co-localizes and physically interacts with PCNA. Nucleic Acids Res 32:2193-2201.
38. Manley JL, Fire A, Samuels M, Sharp PA (1983) In vitro transcription: Whole-cell extract. Methods Enzymol 101:568-582.
39. Podust VN, Chang LS, Ott R, Dianov GL, Fanning E (2002) Reconstitution of human DNA polymerase delta using recombinant baculoviruses: The p12 subunit potentiates DNA polymerizing activity of the four-subunit enzyme. J Biol Chem 277:3894-3901. (Pubitemid 34968641)
40. van Loon B, Ferarri E, Hubscher U (2009) in DNA Replication, Methods and Protocols, eds Vengrova S, Dalgaard JZ (Humana Press - Springer, New York), pp 345-359.
41. Ramadan K, et al. (2003) Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: Implications for novel functions. J Mol Biol 328:63-72. (Pubitemid 36390280)
42. Stucki M, Jonsson ZO, Hubscher U (2001) In eukaryotic flap endonuclease 1, the C terminus is essential for substrate binding. J Biol Chem 276:7843-7849. (Pubitemid 37385578)
43. Saparbaev M, et al. (2002) 1, N(2)-ethenoguanine, a mutagenic DNA adduct, is a primary substrate of Escherichia coli mismatch-specific uracil-DNA glycosylase and human alkylpurine-DNA-N-glycosylase. J Biol Chem 277:26987-26993. (Pubitemid 34951710)
44. Toueille M, et al. (2004) The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation utilization efficiency: Implications for DNA repair. Nucleic Acids Res 32:3316-3324. (Pubitemid 39117448)