Development and application of a biorelevant dissolution method using USP apparatus 4 in early phase formulation development

Molecular Pharmaceutics

Volumn 7, Issue 5, 2010, Pages 1466-1477

  Fang, Jiang B ^a   Robertson, Vivian K ^a   Rawat, Archana ^a,b   Flick, Tawnya ^a,c   Tang, Zhe J ^a,d   Cauchon, Nina S ^a,e   McElvain, James S ^a  

^a AMGEN INC   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^e ALLERGAN PLC   (United States)

Author keywords

Biorelevant; dissolution; flow through cell; food effect; formulation development; formulation rank order; in vivo drug release; rate profile; USP apparatus 4

Indexed keywords

CARBAMAZEPINE; DANAZOL; IBUPROFEN; KETOCONAZOLE; LANSOPRAZOLE; NAPROXEN; RALOXIFENE; TROGLITAZONE; WARFARIN;

APPARATUS; ARTICLE; DISSOLUTION; DRUG BIOAVAILABILITY; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; FOOD DRUG INTERACTION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; SPECTROPHOTOMETER; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMALS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DOSAGE FORMS; FOOD-DRUG INTERACTIONS; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; PHARMACOKINETICS; SOLUBILITY;

EID: 77957744143     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp100125b     Document Type: Article

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