The transnasal delivery of 5-fluorouracil to the rat brain is enhanced by acetazolamide (the inhibitor of the secretion of cerebrospinal fluid)

International Journal of Pharmaceutics

Volumn 377, Issue 1-2, 2009, Pages 85-91

  Shingaki, Tomotaka ^a   Hidalgo, Ismael J ^a   Furubayashi, Tomoyuki ^b   Katsumi, Hidemasa ^c   Sakane, Toshiyasu ^c   Yamamoto, Akira ^c   Yamashita, Shinji ^d  

^a Absorption Systems   (United States)

^b SHUJITSU UNIVERSITY   (Japan)

^c KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^d SETSUNAN UNIVERSITY   (Japan)

Author keywords

5 Fluorouracil; Acetazolamide; Brain delivery; Brain uptake clearance; Cerebrospinal fluid; Nasal absorption

Indexed keywords

ACETAZOLAMIDE; FLUOROURACIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG POTENTIATION; DRUG TRANSPORT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETAZOLAMIDE; ADMINISTRATION, INTRANASAL; ANIMALS; BRAIN; CEREBROSPINAL FLUID; DRUG INTERACTIONS; FLUOROURACIL; INFUSIONS, INTRAVENOUS; MALE; RATS; RATS, WISTAR;

EID: 67649656108     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.05.009     Document Type: Article

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