Minocycline recovers MTT-formazan exocytosis impaired by amyloid beta peptide

Cellular and Molecular Neurobiology

Volumn 30, Issue 7, 2010, Pages 979-984

  Kreutzmann, Peter ^a   Wolf, Gerald ^a   Kupsch, Kathleen ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Amyloid; Alzheimer's disease; Exocytosis; Minocycline; MTT assay; Neuroprotection

Indexed keywords

AMYLOID BETA PROTEIN; CHOLESTEROL; FORMAZAN; LACTATE DEHYDROGENASE; MINOCYCLINE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL VIABILITY; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME RELEASE; EXOCYTOSIS; HIPPOCAMPUS; NEUROPROTECTION; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANTI-BACTERIAL AGENTS; CELLS, CULTURED; EXOCYTOSIS; FORMAZANS; HIPPOCAMPUS; HUMANS; MINOCYCLINE; NEURONS; RATS; RATS, WISTAR; TETRAZOLIUM SALTS;

EID: 77957709215     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-010-9528-6     Document Type: Article

References (25)

1. K Abe H Saito 1998 Amyloid beta protein inhibits cellular MTT reduction not by suppression of mitochondrial succinate dehydrogenase but by acceleration of MTT formazan exocytosis in cultured rat cortical astrocytes Neurosci Res 31 295 305 1:CAS:528:DyaK1cXlsl2ks70%3D 10.1016/S0168-0102(98)00055-8 9809588 (Pubitemid 28446012)
2. D Blum A Chtarto L Tenenbaum J Brotchi M Levivier 2004 Clinical potential of minocycline for neurodegenerative disorders Neurobiol Dis 17 359 366 1:CAS:528:DC%2BD2cXhtVansbvI 10.1016/j.nbd.2004.07.012 15571972 (Pubitemid 39574870)
3. Y Choi HS Kim KY Shin EM Kim M Kim CH Park YH Jeong J Yoo JP Lee KA Chang S Kim YH Suh 2007 Minocycline attenuates neuronal cell death and improves cognitive impairment in Alzheimer's disease models Neuropsychopharmacology 32 2393 2404 1:CAS:528:DC%2BD2sXhtFOjtL%2FF 10.1038/sj.npp.1301377 17406652 (Pubitemid 47587688)
4. R Fan F Xu ML Previti J Davis AM Grande JK Robinson WE Van Nostrand 2007 Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid J Neurosci 27 3057 3063 1:CAS:528:DC%2BD2sXktlKns7Y%3D 10.1523/JNEUROSCI.4371-06.2007 17376966 (Pubitemid 46474134)
5. MF Haroon A Fatima S Scholer A Gieseler TF Horn E Kirches G Wolf P Kreutzmann 2007 Minocycline, a possible neuroprotective agent in Leber's hereditary optic neuropathy (LHON): studies of cybrid cells bearing 11778 mutation Neurobiol Dis 28 237 250 1:CAS:528:DC%2BD2sXhtlGgsr%2FF 10.1016/j.nbd.2007.07.021 17822909 (Pubitemid 350116596)
6. HS Hong I Maezawa N Yao B Xu R Diaz-Avalos S Rana DH Hua RH Cheng KS Lam LW Jin 2007 Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity Brain Res 1130 223 234 1:CAS:528:DC%2BD2sXls1aisg%3D%3D 10.1016/j.brainres.2006.10.093 17157826 (Pubitemid 46075114)
7. I Isobe M Michikawa K Yanagisawa 1999 Enhancement of MTT, a tetrazolium salt, exocytosis by amyloid beta-protein and chloroquine in cultured rat astrocytes Neurosci Lett 266 129 132 1:CAS:528:DyaK1MXjtlCqsrw%3D 10.1016/S0304-3940(99)00282-7 10353344 (Pubitemid 29227341)
8. J Jordan FJ Fernandez-Gomez M Ramos I Ikuta N Aguirre MF Galindo 2007 Minocycline and cytoprotection: shedding new light on a shadowy controversy Curr Drug Deliv 4 225 231 1:CAS:528:DC%2BD2sXmsFSiu70%3D 10.2174/156720107781023938 17627496 (Pubitemid 47025406)
9. P Kerokoski H Soininen T Pirttila 2001 Beta-amyloid (1-42) affects MTT reduction in astrocytes: implications for vesicular trafficking and cell functionality Neurochem Int 38 127 134 1:CAS:528:DC%2BD3MXotVartA%3D%3D 10.1016/S0197-0186(00)00071-1 11137881 (Pubitemid 32014382)
10. K Kupsch S Hertel P Kreutzmann G Wolf CW Wallesch D Siemen P Schonfeld 2009 Impairment of mitochondrial function by minocycline FEBS J 276 1729 1738 1:CAS:528:DC%2BD1MXjsFWgtL0%3D 10.1111/j.1742-4658.2009.06904.x 19243427
11. Y Liu D Schubert 1997 Cytotoxic amyloid peptides inhibit cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction by enhancing MTT formazan exocytosis J Neurochem 69 2285 2293 1:CAS:528: DyaK2sXntlKmu7c%3D 10.1046/j.1471-4159.1997.69062285.x 9375659
12. Y Liu D Schubert 1998 Steroid hormones block amyloid fibril-induced 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) formazan exocytosis: relationship to neurotoxicity J Neurochem 71 2322 2329 1:CAS:528:DyaK1cXns1eitrc%3D 10.1046/j.1471-4159.1998.71062322.x 9832130
13. Y Liu DA Peterson H Kimura D Schubert 1997 Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction J Neurochem 69 581 593 1:CAS:528:DyaK2sXkvFGktb0%3D 10.1046/j.1471-4159.1997. 69020581.x 9231715
14. Y Liu DA Peterson D Schubert 1998 Amyloid beta peptide alters intracellular vesicle trafficking and cholesterol homeostasis Proc Natl Acad Sci USA 95 13266 13271 1:CAS:528:DyaK1cXntFWrsL4%3D 10.1073/pnas.95.22.13266 9789077 (Pubitemid 28509560)
15. WJ Lukiw M Pappolla RP Pelaez NG Bazan 2005 Alzheimer's disease-a dysfunction in cholesterol and lipid metabolism Cell Mol Neurobiol 25 475 483 1:CAS:528:DC%2BD2MXnslyrtbk%3D 10.1007/s10571-005-4010-6 16075376 (Pubitemid 41186260)
16. R Mansson S Morota MJ Hansson I Sonoda Y Yasuda M Shimazu A Sugiura S Yanagi H Miura H Uchino E Elmer 2010 Minocycline sensitizes rodent and human liver mitochondria to the permeability transition: implications for toxicity in liver transplantation Hepatology 51 347 348 20034033 (author reply 349-350)
17. M Nikodemova J Lee Z Fabry ID Duncan 2010 Minocycline attenuates experimental autoimmune encephalomyelitis in rats by reducing T cell infiltration into the spinal cord J Neuroimmunol 219 33 37 1:CAS:528: DC%2BC3cXitVOit7k%3D 10.1016/j.jneuroim.2009.11.009 20089316
18. JK Ryu S Franciosi P Sattayaprasert SU Kim JG McLarnon 2004 Minocycline inhibits neuronal death and glial activation induced by beta-amyloid peptide in rat hippocampus Glia 48 85 90 10.1002/glia.20051 15326618 (Pubitemid 39390851)
19. TJ Seabrook L Jiang M Maier CA Lemere 2006 Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice Glia 53 776 782 10.1002/glia.20338 16534778
20. MS Shearman CI Ragan LL Iversen 1994 Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid- mediated cell death Proc Natl Acad Sci USA 91 1470 1474 1:CAS:528: DyaK2cXhvVykurs%3D 10.1073/pnas.91.4.1470 8108433
21. MS Shearman SR Hawtin VJ Tailor 1995 The intracellular component of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction is specifically inhibited by beta-amyloid peptides J Neurochem 65 218 227 1:CAS:528:DyaK2MXmsVCjtLk%3D 10.1046/j.1471-4159.1995.65010218.x 7790863
22. T Suzuki Y Araki T Yamamoto T Nakaya 2006 Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis J Biochem 139 949 955 1:CAS:528:DC%2BD28Xotlygu7w%3D 10.1093/jb/mvj121 16788045 (Pubitemid 44196871)
23. X Wang S Zhu M Drozda W Zhang IG Stavrovskaya E Cattaneo RJ Ferrante BS Kristal RM Friedlander 2003 Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease Proc Natl Acad Sci USA 100 10483 10487 1:CAS:528:DC%2BD3sXntFynsLw%3D 10.1073/pnas.1832501100 12930891 (Pubitemid 37071904)
24. ZY Zhang Z Zhang U Fauser HJ Schluesener 2009 Improved outcome of EAN, an animal model of GBS, through amelioration of peripheral and central inflammation by minocycline J Cell Mol Med 13 341 351 1:CAS:528: DC%2BD1MXktFKnsb0%3D 10.1111/j.1582-4934.2008.00333.x 18400050
25. S Zhu IG Stavrovskaya M Drozda BY Kim V Ona M Li S Sarang AS Liu DM Hartley DC Wu S Gullans RJ Ferrante S Przedborski BS Kristal RM Friedlander 2002 Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice Nature 417 74 78 1:CAS:528:DC%2BD38XjsFOgtbg%3D 10.1038/417074a 11986668 (Pubitemid 34498818)