The synovial fluid adiponectin-leptin ratio predicts pain with knee osteoarthritis

Clinical Rheumatology

Volumn 29, Issue 11, 2010, Pages 1223-1228

  Gandhi, Rajiv ^a,b,e   Takahashi, Mark ^c   Smith, Holly ^a,b   Rizek, Randy ^a,b   Mahomed, Nizar N ^a,c,d  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY HEALTH NETWORK   (Canada)

^e TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

Leptin; Obesity; Osteoarthritis; Pain

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; LEPTIN;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; KNEE OSTEOARTHRITIS; KNEE PAIN; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MCGILL PAIN QUESTIONNAIRE; NONPARAMETRIC TEST; OBESITY; OUTCOME ASSESSMENT; PAIN ASSESSMENT; PREDICTOR VARIABLE; PRIORITY JOURNAL; SYNOVIAL FLUID; WESTERN ONTARIO AND MCMASTER UNIVERSITIES ARTHRITIS INDEX;

ADIPONECTIN; AGED; AGED, 80 AND OVER; ARTHROPLASTY, REPLACEMENT; FEMALE; HUMANS; KNEE JOINT; LEPTIN; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; OUTCOME ASSESSMENT (HEALTH CARE); PAIN; RISK FACTORS; SYNOVIAL FLUID;

EID: 77957697385     PISSN: 07703198     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10067-010-1429-z     Document Type: Article

References (47)

1. MF Sowers M Yosef D jamadar J Jacobson C Karvonen-gutierrez M Jaffe 2008 BMI vs. body composition and radiographically defined osteoarthritis of the knee in women: a 4-year follow-up study Osteoathr Cartil 16 3 367 372 1:STN:280:DC%2BD1c7msVWkug%3D%3D 10.1016/j.joca.2007.07.016
2. M Grotle KB Hagen B Natvig FA Dahl TK Kvien 2008 Obesity and osteoarthritis in knee, hip, and/or hand: an epidemiological study in the general population with 10 years follow-up BMC Musculoskelet Disord 9 1 132 10.1186/1471-2474-9-132 18831740
3. R Bourne S Mukhi N Zhu M Keresteci M Marin 2007 Role of obesity on the risk for total hip or knee arthroplasty Clin Orthop Relat Res 465 185 188 17906592
4. E Toussirot G Streit D Wendling 2007 The contribution of adipose tissue and adipokines to inflammation in joint diseases Curr Med Chem 14 10 1095 1100 1:CAS:528:DC%2BD2sXksVKru7k%3D 10.2174/092986707780362826 17456023
5. H Dumond N Presle B Terlain D Mainard D Loeuille P Netter P Pottie 2003 Evidence for a key role of leptin in osteoarthritis Arthritis Rheum 48 11 3118 3129 1:CAS:528:DC%2BD3sXpvVygtLo%3D 10.1002/art.11303 14613274
6. T Simopoulou KN Malizos D Iliopoulos N Stefanou L Papatheodorou M Ioannou A Tsezou 2007 Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism Osteoarthr Cartil 15 8 872 883 1:STN:280:DC%2BD2svntFygtA%3D%3D 10.1016/j.joca.2007.01.018 17350295
7. M Otero R Lago F Lago JJ Reino O Gualillo 2005 Signaling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1 Arthritis Res Ther 7 581e91 10.1186/ar1708
8. HA Waldron 1997 Association between osteoarthritis of the hand and knee in a population of skeletons from London Ann Rheum Dis 56 116 118 1:STN:280:DyaK2s3itFagug%3D%3D 10.1136/ard.56.2.116 9068284
9. DJ Hart TD Spector 1993 The relationship of obesity, fat distribution, and osteoarthritis in women in the general population: the Chingford Study J Rheumatol 20 2 331 335 1:STN:280:DyaK3s3jtlSrtQ%3D%3D 8474072
10. N Sattar G Wannamethee N Sarwar J Chernova DA Lawlor A Kelly AM Wallace J Danesh PH Whincup 2009 Leptin and coronary heart disease: prospective study and systematic review J Am Coll Cardiol 53 2 167 175 1:CAS:528: DC%2BD1MXjvFahtA%3D%3D 10.1016/j.jacc.2008.09.035 19130985
11. S Soderberg D Colquhoun A Keech J Yallop EH Barnes C Pollicino J Simes AM Tonkin P Nestel 2009 Leptin, but not adiponectin, is a predictor of recurrent cardiovascular events in men: results from the LIPID study Int J Obes (Lond) 33 1 123 130 1:STN:280:DC%2BD1M%2Fmt1KitA%3D%3D 10.1038/ijo.2008.224
12. J Liu KR Butler SF Buxbaum JH Sung BW Campbell HA Taylor 2010 Leptinemia and its association with stroke and coronary heart disease in the Jackson Heart Study Clin Endocrinol 72 1 32 37 1:CAS:528:DC%2BC3cXptlChtg%3D%3D 10.1111/j.1365-2265.2009.03627.x
13. Y Figenschau G Knutsen S Shahazcydi O Johansen B Sveinbjornson 2001 Human articular chondrocytes express functional leptin receptors Biochem Biophys Res Commun 287 190 197 1:CAS:528:DC%2BD3MXms1anu7s%3D 10.1006/bbrc.2001.5543 11549273
14. O Gualillo JR Gonzalez-Juanatey F Lago 2007 The emerging role of adipokines as mediators of cardiovascular diseases: physiological and clinical perspectives Trends Cardiovasc Med 17 277e85 10.1016/j.tcm.2007.09.005
15. R Lago R Gomez M Otero F Lago R Gallega C Dieguez JJ Gomez-Reino O Gualillo 2008 A new player in cartilage homeostatsis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes Osteoarth Cartil 16 1101 1109 1:STN:280:DC%2BD1critVKgsw%3D%3D 10.1016/j.joca.2007.12.008
16. GD Norata S Raselli L Grigore K Garlaschelli E Dozio P Magni AL Catapano 2007 Leptin:adiponectin ratio is an independent predictor of intima media thickness of the common carotid artery Stroke 38 2844 2846 1:CAS:528: DC%2BD2sXhtVKhtrrL 10.1161/STROKEAHA.107.485540 17823381
17. H Tilg AR Moschen 2006 Adipocytokines: mediators linking adipose tissue, inflammation and immunity Nat Rev Immunol 6 772 783 1:CAS:528:DC%2BD28XhtVSgurnN 10.1038/nri1937 16998510
18. A Ehling A Schaffler H Herfarth IH Tarner S Anders O Distler G Paul J Distler S Gay J Scholmerich E Neumann U Muller-Ladner 2006 The potential of adiponectin in driving arthritis J Immunol 176 7 4468 4478 1:CAS:528: DC%2BD28Xis1eqsLY%3D 16547285
19. E Galluccio P Piatti L Citterio PCG Lucotti E Setola L Cassina M Oldani I Zavaroni E Bosi A Columbo O Alfieri G Casari GM Reaven LD Monti 2008 Hyperinsulinemia and impaired leptin-adiponectin ratio associate with endothelial nitric oxide synthase polymorphisms in subjects with in-stent restenosis Am J Physiol Endocrinol Metab 294 E978 E986 1:CAS:528: DC%2BD1cXlvFCisr0%3D 10.1152/ajpendo.00003.2008 18349107
20. N Satoh M Naruse T Usui T Tagami T Suganami K Yamada H Kuzuya A Shimatsu Y Ogawa 2004 Leptin-to-Adiponectin ratio as a potential atherogenic index in obese type 2 diabetic patients Diabetes Care 27 10 2488 2490 1:CAS:528:DC%2BD2cXovFOmurw%3D 10.2337/diacare.27.10.2488 15451921
21. R Altman E Asch D Bloch G Bole D Borenstein K Brandt, et al. 1986 Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee Arthritis Rheum 29 1039 1049 1:STN:280:DyaL283psF2msQ%3D%3D 10.1002/art.1780290816 3741515
22. BS Linn MW Linn L Gurel 1968 Cumulative illness rating scale J Am Geriatr Soc 16 622 626 1:STN:280:DyaF1c3gtFCqtg%3D%3D 5646906
23. MD Miller CF Paradis PR Houck S Mazumdar JA Stack AH Rifai B Mulsant CF Reynolds 3rd 1992 Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale Psychiatry Res 41 237 248 1:STN:280:DyaK383nvFCntw%3D%3D 10.1016/0165-1781(92) 90005-N 1594710
24. N Bellamy WW Buchanan CH Goldsmith J Campbell LW Stitt 1998 Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes following total hip or knee arthroplasty in osteoarthritis J Rheumatol 15 1833 1840
25. R Melzack 1987 The Short-Form McGill Pain Questionnaire Pain 30 191 197 1:STN:280:DyaL1c%2FktVSmtQ%3D%3D 10.1016/0304-3959(87)91074-8 3670870
26. P Creamer M Lethbridge-Cejku MC Hockberg 1999 Determinants of pain severity in knee osteoarthritis: effect of demographic and psychosocial variables using 3 pain measures J Rheumatol 26 8 1785 1792 1:STN:280: DyaK1MznvVartQ%3D%3D 10451078
27. LJ Hardie DV Rayner S Holmes P Trayhurn 1996 Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA Biochem Biophys Res Commun 223 660 665 1:CAS:528:DyaK28XjvFCruro%3D 10.1006/bbrc.1996.0951 8687452
28. MK Sinha JP Ohannesian ML Heiman A Kriauciunas TW Stephens S Magosin C Marco JF Caro 1996 Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects J Clin Invest 97 5 1344 1347 1:CAS:528:DyaK28XhvVWhurk%3D 10.1172/JCI118551 8636448
29. Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Lawrence Erlbaum, Hillsdale
30. Harrell FE (2001) Chapter 4.4 Overfitting and limits on number of predictors. In: Multivariable modeling strategies, 2nd edn. Springer, New York
31. T Simopoulou KN Malizos D Iliopoulos N Stefanou L Papatheodorou M Ioannou A Tsezou 2007 Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism Osteoarth Cartil 15 8 872 883 1:STN:280:DC%2BD2svntFygtA%3D%3D 10.1016/j.joca.2007.01.018
32. S Kumagai H Kishimoto M Suwa B Zou H Sasaki 2005 The leptin to adiponectin ratio is a good biomarker for the prevalence of metabolic syndrome, dependent on visceral fat accumulation and endurance fitness in obese patients with diabetes mellitus Metab Syndr Relat Disord 3 2 85 94 1:CAS:528: DC%2BD2MXntVCjsLo%3D 10.1089/met.2005.3.85 18370715
33. M Matsubara S Maruoka S Katayose 2003 Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women Eur J Endocrinol 148 3 343 350 1:CAS:528:DC%2BD3sXis1amtLo%3D 10.1530/eje.0.1480343 12611616
34. M Otero JJ Gomez Reino O Gualillo 2003 Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-γ in human chondrocytes and ATDC5 chondrogenic cells Arthritis Rheum 48 2 404 409 1:CAS:528:DC%2BD3sXhslKkt78%3D 10.1002/art.10811 12571850
35. M Otero R Lago F Lago JJ Reino O Gualillo 2005 Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1 Arth Res & Therapy 7 3 R581 R591 10.1186/ar1708
36. MB Goldring F Berenbaum 2004 The regulation of chondrocyte function by proinflammatory mediators: prostaglandins and nitric oxide Clin Orthop Relat Res 427 S37e46
37. KM Tong DC Shieh CP Chen CY Tzeng SP Wang KC Huang YC Chiu YC Fong CH Tang 2008 Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts Cell Signal 20 8 1478 1488 1:CAS:528:DC%2BD1cXnsFKkurY%3D 10.1016/j.cellsig. 2008.04.003 18501560
38. D Ilipoulos KN Malizos A Tsezou 2007 Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention Ann Rheum Dis 66 1616 1621 10.1136/ard.2007.069377
39. K Vuolteenaho A Koskinen M Kukkonen R Nieminen U Paivarinta T Moilanen E Moilanen 2009 Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production Mediat Inflamm 2009 345838
40. TH Chen L Chen MS Hsieh CP Chang DT Chou SH Tsai 2006 Evidence for a protective role for adiponectin in osteoarthritis Biochim Biophys Acta 1762 8 711 718 1:CAS:528:DC%2BD28XptVGmtbo%3D 16891099
41. T Sturmer H Brenner W Koenig KP Gunther 2004 Severity and extent of osteoarthritis and low grade systemic inflammation as assessed by high sensitivity C Reactive protein Ann Rheum Dis 63 200 205 1:STN:280: DC%2BD2c%2Fit1OlsQ%3D%3D 10.1136/ard.2003.007674 14722211
42. AD Pearle CR Scanzello S George LA Mandl EF DiCarlo M Peterson TP Sculco MK Crow 2007 Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis Osteoarth Cartil 15 516 523 1:STN:280:DC%2BD2s3ntVKgsg%3D%3D 10.1016/j.joca.2006.10.010
43. GA Hawker L Stewart MR French J Cibere JM Jordan L March M Suarez-Almazor R Gooberman-Hill 2008 Understanding the pain experience in hip and knee osteoarthritis-an OARSI/OMERACT initiative Osteoarth Cartil 16 415 422 1:STN:280:DC%2BD1czitFGgug%3D%3D 10.1016/j.joca.2007.12.017
44. DT Felson 2005 The sources of pain in knee osteoarthritis Curr Opin Rheumatol 17 624 628 10.1097/01.bor.0000172800.49120.97 16093843
45. BL Kidd 2006 Osteoarthritis and joint pain Pain 123 6 9 10.1016/j.pain.2006.04.009 16714085
46. EA Spencer PN Appleby GK Davey TJ Key 2004 Accuracy of self-reported waist and hip measurements in 4492 EPIC-Oxford participants Public Health Nutr 7 6 723 727 10.1079/PHN2004600 15369609
47. C Bolton-Smith M Woodward H Tunstall-Pedoe C Morrison 2000 Accuracy of the estimated prevalence of obesity from self-reported height and weight in an adult Scottish population J Epidemiol Community Health 54 2 143 148 1:STN:280:DC%2BD3c7otVKgug%3D%3D 10.1136/jech.54.2.143 10715748