Adaptor protein is essential for insect cytokine signaling in hemocytes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 36, 2010, Pages 15862-15867

  Oda, Yasunori ^a   Matsumoto, Hitoshi ^a   Kurakake, Maiko ^a   Ochiai, Masanori ^b   Ohnishi, Atsushi ^c   Hayakawa, Yoichi ^a  

^a SAGA UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

Growth blocking peptide; Integrin; ITAM; SH2 SH3 domain binding; Tyrosine phosphorylation

Indexed keywords

ADAPTOR PROTEIN; ADAPTOR PROTEIN P77; BETA INTEGRIN; CYTOKINE; DOUBLE STRANDED RNA; GROWTH BLOCKING PEPTIDE; IMMUNORECEPTOR TYROSINE ACTIVATION MOTIF; INSECT PROTEIN; MEMBRANE PROTEIN; PROTEIN SH2; PROTEIN SH3; TYROSINE; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BLOOD CELL; CARBOXY TERMINAL SEQUENCE; CELL ACTIVATION; CELL SPREADING; CELL STIMULATION; CELL SUSPENSION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOPLASM; ENTEROBACTER CLOACAE; INCUBATION TIME; INSECT; LARVA; MICROCOCCUS LUTEUS; MOLECULAR WEIGHT; NONHUMAN; PATHOGENESIS; PLASMA CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN TARGETING; RNA INTERFERENCE; SERRATIA MARCESCENS; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY;

HEXAPODA; LEPIDOPTERA; MICROCOCCUS LUTEUS; MYTHIMNA SEPARATA; SERRATIA MARCESCENS;

AMINO ACID SEQUENCE; ANIMALS; CYTOKINES; HEMOCYTES; INSECT PROTEINS; INSECTS; MOLECULAR SEQUENCE DATA; SIGNAL TRANSDUCTION;

EID: 77957679470     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1003785107     Document Type: Article

References (41)

1. Ferrandon D, Imler J-L, Hetru C, Hoffmann JA (2007) The Drosophila systemic immune response: Sensing and signalling during bacterial and fungal infections. Nat Rev Immunol 7:862-874.
2. Kocks C, et al. (2005) Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila. Cell 123:335-346.
3. Brennan CA, Delaney JR, Schneider DS, Anderson KV (2007) Psidin is required in Drosophila blood cells for both phagocytic degradation and immune activation of the fat body. Curr Biol 17:67-72.
4. Kurucz E, et al. (2007) Nimrod, a putative phagocytosis receptor with EGF repeats in Drosophila plasmatocytes. Curr Biol 17:649-654.
5. Basset A, et al. (2000) The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response. Proc Natl Acad Sci USA 97:3376-3381. (Pubitemid 30183310)
6. Foley E, O'Farrell PH (2003) Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila. Genes Dev 17:115-125.
7. Hultmark D, Borge-Renberg K (2007) Drosophila immunity: Is antigen processing the first step? Curr Biol 17:R22-R24.
8. Lavine MD, Strand MR (2002) Insect hemocytes and their role in cellular immune responses. Insect Biochem Mol Biol 32:1295-1309.
9. Ribeiro C, Brehélin M (2006) Insect haemocytes: What type of cell is that? J Insect Physiol 52:417-429.
10. Baggiolini M, Dewald B, Moser B (1997) Human chemokines: An update. Annu Rev Immunol 15:675-705.
11. Nakatogawa S, et al. (2009) A novel peptide mediates aggregation and migration of hemocytes from an insect. Curr Biol 19:779-785.
12. Hayakawa Y (1990) Juvenile hormone esterase activity repressive factor in the plasma of parasitized insect larvae. J Biol Chem 265:10813-10816. (Pubitemid 120001054)
13. Hayakawa Y (1991) Structure of a growth-blocking peptide present in parasitized insect hemolymph. J Biol Chem 266:7982-7984.
14. Skinner WS, et al. (1991) Isolation and identification of paralytic peptides from hemolymph of the lepidopteran insects Manduca sexta, Spodoptera exigua, and Heliothis virescens. J Biol Chem 266:12873-12877.
15. Clark KD, Pech LL, Strand MR (1997) Isolation and identification of a plasmatocyte-spreading peptide from the hemolymph of the lepidopteran insect Pseudoplusia includens. J Biol Chem 272:23440-23447.
16. Strand MR, Hayakawa Y, Clark KD (2000) Plasmatocyte spreading peptide (PSP1) and growth-blocking peptide (GBP) are multifunctional homologs. J Insect Physiol 46:817-824.
17. Hayakawa Y (1995) Growth-blocking peptide: An insect biogenic peptide that prevents the onset of metamorphosis. J Insect Physiol 41:1-6.
18. Kamimura M, et al. (2001) Molecular cloning of silkworm paralytic peptide and its developmental regulation. Biochem Biophys Res Commun 286:67-73.
19. Wang Y, Jiang H, Kanost MR (1999) Biological activity of Manduca sexta paralytic and plasmatocyte spreading peptide and primary structure of its hemolymph precursor. Insect Biochem Mol Biol 29:1075-1086.
20. Underhill DM, Goodridge HS (2007) The many faces of ITAMs. Trends Immunol 28:66-73.
21. Ivashkiv LB (2009) Cross-regulation of signaling by ITAM-associated receptors. Nat Immunol 10:340-347.
22. Ohnishi A, et al. (1995) Growth-blocking peptide titer during larval development of parasitized and cold-stressed armyworm. Insect Biochem Mol Biol 25:1121-1127.
23. Aizawa T, et al. (2001) Structure and activity of the insect cytokine growth-blocking peptide: Essential regions for mitogenic and hemocyte-stimulating activities are separate. J Biol Chem 276:31813-31818.
24. Pech LL, Strand MR (1995) Encapsulation of foreign targets by hemocytes of the moth Pseudoplusia includens (Lepidoptera: Noctuidae) involves an RGD-dependent cell adhesion mechanism. J Insect Physiol 41:481-488.
25. Levin DM, et al. (2005) A hemocyte-specific integrin required for hemocytic encapsulation in the tobacco hornworm, Manduca sexta. Insect Biochem Mol Biol 35:369-380.
26. Moita LF, Vriend G, Mahairaki V, Louis C, Kafatos FC (2006) Integrins of Anopheles gambiae and a putative role of a new beta integrin, BINT2, in phagocytosis of E. coli.. Insect Biochem Mol Biol 36:282-290.
27. Mamali I, et al. (2009) A β integrin subunit regulates bacterial phagocytosis in medfly haemocytes. Dev Comp Immunol 33:858-866.
28. Schlaepfer DD, Hauck CR, Sieg DJ (1999) Signaling through focal adhesion kinase. Prog Biophys Mol Biol 71:435-478.
29. Mócsai A, et al. (2006) Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol 7:1326-1333. (Pubitemid 46111254)
30. Abtahian F, et al. (2006) Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells. Mol Cell Biol 26:6936-6949.
31. Zou W, et al. (2007) Syk, c-Src, the αvβ3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol 176:877-888.
32. Buday L, Wunderlich L, Tamás P (2002) The Nck family of adapter proteins: Regulators of actin cytoskeleton. Cell Signal 14:723-731.
33. Shcherbata HR, et al. (2007) Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy. EMBO J 26:481-493.
34. Chen M, She H, Kim A, Woodley DT, Li W (2000) Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb. Mol Cell Biol 20:7867-7880.
35. Hayakawa Y, Ohnishi A (1998) Cell growth activity of growth-blocking peptide. Biochem Biophys Res Commun 250:194-1995.
36. Ohnishi A, Oda Y, Hayakawa Y (2001) Characterization of receptors of insect cytokine, growth-blocking peptide, in human keratinocyte and insect Sf9 cells. J Biol Chem 276:37974-37979.
37. Aizawa T, et al. (1999) Solution structure of an insect growth factor, growth-blocking peptide. J Biol Chem 274:1887-1890.
38. Hayakawa Y, Ohnishi A, Yamanaka A, Izumi S, Tomino S (1995) Molecular cloning and characterization of cDNA for insect biogenic peptide, growth-blocking peptide. FEBS Lett 376:185-189.
39. Matsumoto Y, Oda Y, Uryu M, Hayakawa Y (2003) Insect cytokine growth-blocking peptide triggers a termination system of cellular immunity by inducing its binding protein. J Biol Chem 278:38579-38585.
40. Clark KD, et al. (2001) Alanine-scanning mutagenesis of plasmatocyte spreading peptide identifies critical residues for biological activity. J Biol Chem 276:18491-18496.
41. Ninomiya Y, Kurakake M, Oda Y, Tsuzuki S, Hayakawa Y (2008) Insect cytokine growth-blocking peptide signaling cascades regulate two separate groups of target genes. FEBS J 275:894-902. (Pubitemid 351230205)