Cerebral amyloid angiopathy as a cause of an extensive brain hemorrhage in adult patient with Down's syndrome - A case report

Folia Neuropathologica

Volumn 48, Issue 3, 2010, Pages 206-211

  Mendel, Tadeusz ^a   Bertrand, Ewa ^a   Szpak, Grazyna M ^a   Stȩpień, Tomasz ^a   Wierzba Bobrowicz, Teresa ^a  

^a INSTITUTE OF PSYCHIATRY AND NEUROLOGY   (Poland)

Author keywords

Brain hemorrhage; Cerebral amyloid angiopathy; Down's syndrome; Spinal cord compression

Indexed keywords

AMYLOID BETA PROTEIN;

ADULT; ARTICLE; BRAIN HEMORRHAGE; CASE REPORT; CAUSE OF DEATH; DEMYELINATION; DOWN SYNDROME; FEMALE; HISTOPATHOLOGY; HUMAN; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; QUADRIPLEGIA; SPINAL CORD COMPRESSION; VASCULAR AMYLOIDOSIS;

EID: 77957663933     PISSN: 16414640     EISSN: 1509572X     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Amstrong RA. Spatial correlations between β-amyloid (Aβ) deposits and blood vessels in familial Alzheimer's disease. Folia Neuropathol 2008; 46: 241-248.
2. Attems J. Sporadic cerebral amyloid angiopathy: pathology, clini cal implications, and possible pathomechanisms. Acta Neuropathol 2005; 110: 345-359.
3. Belza MG, Urich H. Cerebral amyloid angiopathy in Down's syndrome. Clin Neuropathol 1986; 5: 257-260.
4. Bertrand E, Lewandowska E, Stȩpień T, Szpak GM, Pasennik E, Modzelewska J. Amyloid angiopathy in idiopathic Parkinson's disease. Immunohistochemical and ultrastructural study. Folia Neuropathol 2008; 46: 255-270.
5. Cabrejo L, Guyant-Maréchal L, Laquerrière A, Vercelletto M, De La Fournière F, Thomas-Antérion C, Verny C, Letournel F, Pasquier F, Vital A, Checler F, Frebourg T, Campion D, Hannequin D. Phenotype associated with APP duplication in five fami lies. Brain 2006; 129: 2966-2976.
6. Crosgrove GR, Leblanc R, Meagher-Villemure K, Ethier R. Cerebral amyloid angiopathy. Neurology 1985; 35: 625-628.
7. Day SM, Strauss DJ, Shavelle RM, Reynolds RJ. Mortality and causes of death in persons with Down syndrome in California. Dev Med Child Neurol 2005; 47: 171-176.
8. Donahue JE, Khurana JS, Adelman LS. Intracerebral hemorrhage in two patients with Down's syndrome and cerebral amyloid angiopathy. Acta Neuropathol 1998; 95: 213-216.
9. Ellis RJ, Olichney JM, Thal LJ, Mirra SS, Morris JC, Beekly D, Heyman A. Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience, part XV. Neurology 1996; 46: 1592-1596.
10. Flynn JT. Congophilic angiopathy. N Y State J Med 1990; 2: 64-68.
11. Ghiso J, Fragione B. Amyloidosis and Alzheimer's disease. Adv Drug Deliv Rev 2002; 54: 1539-1551.
12. Glenner GG, Wong CW. Alzeimer's disease and Down's syndrome: sparing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun 1984; 122: 1131-1135.
13. Head E, Lott IT. Down syndrome and beta-amyloid deposition. Curr Opin Neurol 2004; 17: 95-100.
14. Ikeda SI, Tokuda T, Yanagisawa N, Kametani F, Ohshima T, Allsop D. Variability of β-amyloid protein deposited lesions in Down's syndrome brains. Tohoku J Exp Med 1994; 174: 189-198.
15. Ishida S, Date M, Doi Y, Sato T, Sugino M, Kimura F, Hanafusa T. Recurrent cerebral embolism in a young adult with Down's syndrome. A case report. J Neurol 2004; 251: 1275-1277.
16. Kumar-Singh S. Cerebral amyloid angiopathy: pathogenetic mechanisms and link to dense amyloid plaques. Genes Brain Behavior 2008; 7 (Suppl 1): 67-82.
17. Lai F, Williams RS. A prospective study of Alzheimer disease in Down syndrome. Arch Neurol 1989; 46: 849-853.
18. Lemere CA, Blusztajn JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ. Sequence of deposition of heterogenous amyloid β-peptides and Apo E in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiol Dis 1996; 3: 16-32.
19. Lockstone HE, Harris LW, Swatton JE, Wayland MT, Holland AJ, Bahn S. Gene expression profiling in the adult Down syndrome brain. Genomics 2007; 90: 647-660.
20. López JR, Infante ER, Montero JLM, Carretero MJM. Cerebral amyloid angiopathy, recurrent intracerebral haemorrhage and Down's syndrome. Neurologia 2006; 21: 729-732.
21. McCarron MO, Nicoll JAR, Graham DI. A quartet of Down's syndrome, Alzheimer's disease, cerebral amyloid angiopathy, and cerebral haemorrhage: interacting genetic risk factor. J Neurol Neurosurg Psychiatry 1998; 65: 405-406.
22. Mehta PD, Mehta SP, Fedor B, Patrick BA, Emmerling M, Dalton AJ. Plasma amyloid β protein 1-42 levels are increased in old Down Syndrome but not in young Down Syndrome. Neurosci Lett 2003; 342: 155-158.
23. Mrak RE, Griffin WST. Trisomy 21 and the brain. J Neuropathol Exp Neurol 2004; 63: 679-685.
24. Naito KS, Sekijima Y, Ikeda S. Cerebral amyloid angiopathy-related hemorrhage in a middle-aged patient with Down's syndrome. Amyloid 2008; 15: 275-277.
25. Rensink AAM, de Waal RMW, Kremer B, Verbeek MM. Pathogenesis of cerebral amyloid angiopathy. Brain Res Rev 2003; 43: 207-223.
26. Sekijama Y, Ikeda A, Tokuda T, Satoh S, Hikada H, Hikada E, Ishikawa M, Yanagisawa M. Prevalence of dementia of Alzheimer type and apolipoprotien E phenotypes in aged patients with Down's syndrome. Eur Neurol 1998; 39: 234-237.
27. Styczyńska M, Strosznajder JB, Religa D, Chodakowska- Żebrowska M, Pfeiffer A, Gabryelewicz T, Czapski GA, Kobryś M, Karciauskas G, Barcikowska M. Association between genetic and environmental factors and the risk of Alzheimer's disease. Folia Neuropathol 2008; 46: 249-254.
28. Vinters HV. Cerebral amyloid angiopathy. A critical review. Stroke 1987; 18: 311-324.
29. Wierzba-Bobrowicz T, Lewandowska E, Schmidt-Sidor B, Gwiazda E. The comparison of microglia maturation in CNS of normal fetuses and fetuses with Down's syndrome. Folia Neuropathol 1999; 37: 227-234.
30. Wisniewski KE, Wisniewski HM, Wen GY. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann Neurol 1985; 17: 278-282.