Amyloid angiopathy in idiopathic Parkinson's disease. Immunohistochemical and ultrastructural study

Folia Neuropathologica

Volumn 46, Issue 4, 2008, Pages 255-270

  Bertrand, Ewa ^a   Lewandowska, Eliza ^a   Stepień, Tomasz ^a   Szpak, Grazyna M ^a   Pasennik, Elzbieta ^a   Modzelewska, Joanna ^a  

^a INSTITUTE OF PSYCHIATRY AND NEUROLOGY   (Poland)

Author keywords

Alzheimer's dsease type pathology; Cerebral amyloid angiopathy; Idiopathic Parkinson's disease; Immunohistochemistry; Ultrastructure

Indexed keywords

ALPHA ACTIN; ALPHA SYNUCLEIN; AMYLOID; AMYLOID BETA PROTEIN ANTIBODY; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; CD34 ANTIBODY; COLLAGEN TYPE 3; COLLAGEN TYPE 4; FIBRILLAR COLLAGEN; SMOOTH MUSCLE ACTIN; AMYLOID BETA PROTEIN;

ADOLESCENT; ADULT; AGED; ALZHEIMER DISEASE; ARTERY INTIMA PROLIFERATION; ARTICLE; AUTOPSY; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN TISSUE; IDIOPATHIC DISEASE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NEUROPATHOLOGY; PARKINSON DISEASE; PREVALENCE; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; ULTRASTRUCTURE; VASCULAR AMYLOIDOSIS; BRAIN; METABOLISM; MIDDLE AGED; PATHOLOGY; TRANSMISSION ELECTRON MICROSCOPY; VASCULARIZATION;

AGED; AGED, 80 AND OVER; AMYLOID BETA-PROTEIN; BRAIN; CEREBRAL AMYLOID ANGIOPATHY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; PARKINSON DISEASE;

EID: 62249115018     PISSN: 16414640     EISSN: 1509572X     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Alonzo NC, Hyman BT, Rebeck GW, Greenberg SM. Progression of cerebral amyloid angiopathy: accumulation of amyloid-be-ta40 in affected vessels. J Neuropathol Exp Neurol 1998; 57: 353-359.
2. Attems J, Jellinger KA. Only cerebral capillary amyloid angiopathy correlates with Alzheimer pathology - a pilot study. Acta Neuropathol 2004; 107: 83-90.
3. Attems J, Lintner F, Jellinger KA. Amyloid beta peptide 1-42 highly correlates with capillary cerebral amyloid angiopathy and Alzheimer disease pathology. Acta Neuropathol 2004; 107: 283-291.
4. Attems J, Quass M, Jellinger KA, Lintner F. Topographical distribution of cerebral amyloid angiopathy and its effect on cognitive decline are influenced by Alzheimer disease pathology. J Neurol Sci 2007; 257: 49-55.
5. Bertrand E, Lechowicz W, Lewandowska E, Szpak GM, Dymecki J, Kosno-Kruszewska E, Wierzba-Bobrowicz T. Degenerative axonal changes In the hippocampus and amygdala in Parkinson's disease. Folia Neuropathol 2003; 41: 197-207.
6. Bertrand E, Lewandowska E, Mendel T, Stepień T, Szpak GM, Wierzba-Bobrowicz. Severe cerebral amyloid angiopathy in dementia with Lewy bodies. Immuhistochemical and ultrastuctural study. Folia Neuropathol 2008, in press.
7. Braak H, Braak E. Neuropathological staging of Alzheimer related changes. Acta Neuropathol (Berl) 1991; 82: 239-259.
8. Cadavid D, Mena H, Koeller K, Frommelt RA. Cerebral beta amyloid angiopathy is a risk factor for cerebral ischemic infarction. A case control study in human brain biopsies. J Neuropathol Exp Neurol 2000; 59: 768-773.
9. Davis DG, Schmitt FA, Wekstein DR, Markesbery WR. Alzheimer neuropathologic alterations in aged cognitively normal subjects. J Neuropathol Exp Neurol 1999; 58: 376-388.
10. Farkas E, De Jong GI, de Vos RA, Jansen Steur EN, Luiten PG. Pathological features of cerebral cortical capillaries are doubled in Alzheimer's disease and Parkinson's disease. Acta Neuropathol 2000; 100: 395-402.
11. Frackowiak J, Potempska A, Levine H, Haske T, Dickson D, Mazur-Kolecka B. Extracellular deposits of A beta produced in cultures of Alzheimer disease brain vascular smooth muscle cells. J Neuropathol Exp Neurol 2005; 64: 82-90.
12. Galvin JE, Pollack J, Morris JC. Clinical phenotype of Parkinson disease dementia. Neurology 2006; 67: 1605-1611.
13. Harding AJ, Krill JJ, Halliday G. Practical measures to simplify the Braak tangle staging method for routine pathological screening. Acta Neuropathol 2000; 99: 199-208.
14. Harding AJ, Halliday GM. Simplified neuropathological diagnosis of dementia with Lewy bodies. Neuropathol Appl Neurobiol 1998; 24: 195-201.
15. Herzig MC, Van Nostrand WE, Jucker M. Mechanism of cerebral β-amyloid angiopathy: murine and cellular models. Brain Pathol 2006; 16: 40-54.
16. Jellinger KA. Alzheimer disease and cerebrovascular pathology: an update. J Neural Transm 2002; 109: 813-836.
17. Jellinger KA. The morphological basis of mental dysfunction in Parkinson's disease. J Neurol Sci 2006; 248: 167-172.
18. Jellinger KA, Attems J. Prevalence and pathogenic role of cerebrovascular lesions in Alzheimer disease. J Neurol Sci 2005; 229-230: 37-41.
19. Jellinger KA, Attems J. Cerebral amyloid angiopathy in Lewy body disease. J Neural Transm 2008; 115: 473-482.
20. Jellinger KA, Mitter-Ferstl E. The impact of cerebrovascular lesions in Alzheimer disease. A comparative autopsy study. J Neurol 2003; 250: 1050-1055.
21. Jimenez-Huette A, Alfonso P, Soto C, Albar JP, Rábano A, Ghiso J, Frangione B, Méndez E. Antibodies directed to the carboxyl terminus of amyloid β-peptide recognize sequence epitopes and distincts in Alzheimer's disease brain. Alzheimer's Reports 1998; 1: 41-48.
22. Mastaglia FL, Johnsen RD, Byrnes ML, Kakulas BA. Prevalence of amyloid-beta deposition in the cerebral cortex in Parkinson's disease. Mov Disord 2003; 18: 81-86.
23. McGowan E, Pickford F, Kim J, Onstead L, Eriksen J, Yu C, Skipper L, Murphy MP, Beard J, Das P, Jansen K, Delucia M, Lin WL, Dolios G, Wang R, Eckman CB, Dickson DW, Hutton M, Hardy J, Golde T. Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron 2005; 47: 191-199.
24. McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, Salmon DP, Lowe J, Mirra SS, Byrne EJ, Lennox G, Quinn NP, Edwardson JA, Ince PG, Bergeron C, Burns A, Miller BL, Lovestone S, Collerton D, Jansen EN, Ballard C, de Vos RA, Wilcock GK, Jellinger KA, Perry RH. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB). Report of the consortium on DLB International Workshop. Neurology 1996; 47: 1113-1124.
25. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991; 41: 479-486.
26. Morel F, Wildi E. Contribution à la connaissance des différentes alterations cerebrales des grande áge. Schweiz Arch Neurol Psychiat 1957; 174-223.
27. Nicoll JA, Yamada M, Frackowiak J, Mazur-Kolecka B, Weller RO. Cerebral amyloid angiopoathy playes a direct role in the pathogenesis of Alzheimer's disease Pro-CAA position statement. Neurobiol Aging 2004; 25: 589-597.
28. Olichney JM, Hansen LA, Hofstetter CR, Grundman M, Katzman R, Thal LJ. Cerebral infarction in Alzheimer's disease is associated with severe amyloid angiopathy and hypertension. Arch Neurol 1995; 52: 702-708.
29. Pfeifer LA, White LR, Ross GW, Petrovitch H, Launer LJ. Cerebral amyloid angiopathy and cognitive function: the HAAS autopsy study. Neurology 2002; 58: 1629-1634.
30. Preston SD, Steart PV, Wilkinson A, Nicoll JA, Weller RO. Capillary and arterial amyloid angiopathy in Alzheimer's disease: defining the perivascular route for the elimination of amyloid beta from the human brain. Neuropathol Appl Neurobiol 2003; 29: 106-117.
31. Revesz T, Holton JL, Lashley T, Plant G, Rostagno A, Ghiso J, Frangione B. Sporadic and familial cerebreal amyloid angiopathies. Brain Pathol 2002; 12: 343-357.
32. Ritter MA, Droste DW, Hegedüs K, Szepesi R, Nabavi DG, Csiba L, Ringelstein EB. Role of cerebral amyloid angiopathy in intracerebral hemorrhage in hypertensive patients. Neurology 2005; 64: 1233-1237.
33. Roher AE, Lowenson JD, Clarke S, Woods AS, Cotter RJ, Gowing E, Ball MJ. beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. Proc Natl Acad Sci U S A 1993; 90: 10836-10840.
34. Roher AE, Kuo YM, Esh C, Knebel C, Weiss N, Kalback W, Luehrs DC, Childress JL, Beach TG, Weller RO, Kokjohu TA. Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's disease. Mol Med 2003; 9: 112-122.
35. Scholz W. Studien zur pathologie der hirngefässe II. Die drusige entartung der hirnarterien und-capillaren. (Eine form seniler gerfässerkrankung). Z Gesamte Neurol Psychiatr 1938; 162: 694-715.
36. Smith EE, Gurol ME, Eng JA, Engel CR, Nguyen TN, Rosand J, Greenberg SM. White matter lesions, cognition, and recurrent hemorrhage in lobar intracerebral hemorrhage. Neurology 2004; 63: 1606-1612.
37. Szpak GM, Lewandowska E, Wierzba-Bobrowicz T, Bertrand E, Pasennik E, Mendel T, Stepieñ T, Leszczyńska A, Rafałowska J. Small cerebral vessel disease in familial amyloid and nonamyloid angiopathies: Fad-PS-1 (P117L) mutation and Cadasil immunohistochemical and ultrastructural studies. Folia Neuropathol 2007; 45: 192-204.
38. Thal DR, Capetillo-Zarate E, Larionov S, Staufenbiel M, Zurbruegg S, Beckmann N. Capillary cerebral amyloid angiopathy is associated with vessel occlusion and cerebral blood flow disturbances. Neurobiol Aging 2008 (in press).
39. Thal DR, Dhebremedhin E, Orantes M, Wiestler OD. Small vessel lesions related to cerebral amyloid angiopathy (CAA) and arteriosclerosis/ lipohialinosis (AS/LH) are assiociated with Alzheimer disease. Brain Pathol 2003; 13 (Suppl 1): S7-S8.
40. Thal DR, Ghebremedhin E, Rüb U, Yamaguchi H, Del Tredici K, Braak H. Two types of sporadic cerebral amyloid angiopathy. J Neuropathol Exp Neurol 2002; 61: 282-293.
41. Vinters HV. Cerebral amyloid angiopathy: a microvascular link between parenchymal and vascular dementia? Ann Neurol 2001; 49: 691-693.
42. Weller RO, Massey A, Kuo YM, Roher AE. Cerebral amyloid angiopathy: accumulation of A beta in interstitial fluid drainage pathways in Alzheimer's disease. Ann N Y Acad Sci 2000; 903: 110-117.
43. Weller RO, Subash M, Preston SD, Mazanti I, Carare RO. Perivascular drainage of amyloid-β peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. Symposium: clearance of Aβ from the brain in Alzheimer's disease. Brain Pathology 2008; 18: 253-266.
44. Wisniewski HM, Wegiel J. Beta-amyloid formation by myocytes of leptomeningeal vessels. Acta Neuropathol 1994; 87: 233-241.
45. Xu D, Yang C, Wang L. Cerebral amyloid angiopathy in aged chinese: a clinico-neuropathological study. Acta Neuropathol 2003; 106: 89-91.
46. Zekry D, Duyckaerts C, Belmin J, Geoffre C, Moulias R, Hauw JJ. Cerebral amyloid angiopathy in the elderly: vessel walls changes and relationship with dementia. Acta Neuropathol 2003; 106: 367-373.