Restoration of dysregulated CC chemokine signaling for monocyte/macrophage chemotaxis in head and neck squamous cell carcinoma patients by neem leaf glycoprotein maximizes tumor cell cytotoxicity

Cellular and Molecular Immunology

Volumn 7, Issue 5, 2010, Pages 396-408

  Chakraborty, Krishnendu ^a   Bose, Anamika ^a   Chakraborty, Tathagata ^a   Sarkar, Koustav ^a   Goswami, Shyamal ^a   Pal, Smarajit ^a   Baral, Rathindranath ^a  

^a CHITTARANJAN NATIONAL CANCER INSTITUTE   (India)

Author keywords

CCR5; chemokine; head and neck squamous cell carcinoma; monocytes; neem leaf glycoprotein

Indexed keywords

AZADIRACHTA INDICA GLYCOPROTEIN; B7 ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR5; HLA ANTIGEN; IMMUNOMODULATING AGENT; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE P38; RANTES; UNCLASSIFIED DRUG; BETA CHEMOKINE; GLYCOPROTEIN; VEGETABLE PROTEIN;

ANTIGEN PRESENTATION; ARTICLE; AZADIRACHTA INDICA; CELL FUNCTION; CHEMOTAXIS; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG MECHANISM; DRUG SCREENING; EFFECTOR CELL; FEMALE; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE DYSREGULATION; MALE; MIGRATION INHIBITION; MONOCYTE MACROPHAGE PRECURSOR CELL; MOUTH CANCER; PLANT LEAF; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SQUAMOUS CELL CARCINOMA; TUMOR CELL DESTRUCTION; CHEMISTRY; CYTOLOGY; CYTOTOXICITY; DRUG EFFECT; GENETICS; HEAD AND NECK TUMOR; IMMUNOLOGY; MACROPHAGE; METABOLISM; MONOCYTE; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE;

AZADIRACHTA INDICA;

AZADIRACHTA; CARCINOMA, SQUAMOUS CELL; CHEMOKINES, CC; CHEMOTAXIS; CYTOTOXICITY, IMMUNOLOGIC; GLYCOPROTEINS; HEAD AND NECK NEOPLASMS; HUMANS; MACROPHAGES; MONOCYTES; PLANT LEAVES; PLANT PROTEINS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 77957653090     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2010.29     Document Type: Article

References (28)

1. Gough MJ, Alan A, Melcher M, Atique A, Marka RC, David S et al. Macrophages orchestrate the immune response to tumor cell death. Cancer Res 2001; 61: 7240-7247. (Pubitemid 32946521)
2. Croci DO, Zacarías Fluck MF, Rico MJ, Matar P, Rabinovich GA, Scharovsky OG et al. Dynamic cross-talk between tumor and immune cells in orchestrating the immunosuppressive network at the tumor microenvironment. Cancer Immunol Immunother 2007; 56: 1687-1700. (Pubitemid 47313090)
3. Moser B, Loetscher P. Lymphocyte traffic control by chemokines. Nat Immunol 2001; 2: 123-128. (Pubitemid 33707929)
4. Baggiolini M. Chemokines and leukocyte traffic. Nature 1998; 392: 565-568. (Pubitemid 28207705)
5. Goldberg-Bittman I, Neumark E, Sagi-Assif O, Azenshtein E, Meshel T, Witz IP et al. The expression of chemokine receptor CXCR3 and its ligand CXCL10, in human breast adenocarcinoma cell lines. Immunol Lett 2004; 92: 171-178. (Pubitemid 38470065)
6. Feferman T, Maiti PK, Berrih-Aknin S, Bismuth J, Bidault J, Fuchs S et al. Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis. J Immunol 2005; 174: 5324-5331. (Pubitemid 40598086)
7. Chakraborty K, Bose A, Pal S, Sarkar K, Goswami S, Chattopadhyay U et al. Neem leaf glycoprotein restores the impaired chemotactic activity of peripheral blood mononuclear cells from head and neck squamous cell carcinoma patients by maintaining CXCR3/CXCL10 balance. Int Immunopharmacol 2008; 8: 330-340.
8. Bose A, Chakraborty T, Chakraborty K, Pal S, Baral R. Dysregulation in immune functions is reflected in tumor cell cytotoxicity by peripheral blood mononuclear cells from head and neck squamous cell carcinoma patients. Cancer Immunity 2008; 8: 10.
9. Bose A, Baral RN. NK cellular cytotoxicity of tumor cells initiated by neem leaf preparation is associated with CD40-CD40L mediated endogenous production of interleukin-12. Human Immunol 2007; 68: 823-831. (Pubitemid 47599717)
10. Bose A, Chakraborty K, Sarkar K, Chakraborty T, Goswami S, Pal S et al. Neem leaf glycoprotein induces perforin mediated tumor cell killing by T and NK cells through differential regulation of IFNgamma signaling. J Immunother 2009; 32: 42-53.
11. Samson M, Labbe O, Mollereau C, Vassart G, Parmentier M. Molecular cloning and functional expression of a new human CC chemokine receptor gene. Biochemistry 1996; 35: 3362-3367. (Pubitemid 26092558)
12. Bleul CC, Wu L, Hoxie JA, Springer TA, Mackay CR. The HIV coreceptor CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc Natl Acad Sci USA 1997; 94: 1925-1930. (Pubitemid 27113938)
13. Durig J, de Wynter EA, Kasper C, Cross MA, Chang J. Expression of macrophage inflammatory protein-1 receptor in human CD34(+) hematopoietic cells and their modulation by tumor necrosis factor-alpha and interferon-gamma. Blood 1998; 92: 3073-3081. (Pubitemid 28492312)
14. Wu L, Paxton WA, Kassam N, Ruffing N, Rottman JB, Sullivan N. CCR5 levels and expression pattern correlate with infectability by macrophage-topic HIV-1 in vitro. J Exp Med 1997; 185: 1681-1691. (Pubitemid 27203264)
15. Zaitseva M, Blauvelt A, Lee S, Lapham CK, Klaus-Kovtun V, Mostowski H. Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implications for HIV primary infection. Nature Med 1997; 3: 1369-1375. (Pubitemid 28011037)
16. Qin S, Rottman JB, Myers P, Kassam N, Weinblatt M, Loetscher M. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J Clin Invest 1998; 101: 746-754. (Pubitemid 28096070)
17. Sarkar K, Bose A, Chakraborty K, Haque E, Ghosh D, Goswami S et al. Neem leaf glycoprotein helps to generate carcinoembryonic antigen specific anti-tumor immune responses utilizing macrophage-mediated antigen presentation. Vaccine 2008; 26: 4352-4362.
18. Baral RN, Chattopadhyay U. Neem (Azadirachta indica) leaf mediated immune activation causes prophylactic growth inhibition of murine Ehrlich carcinoma and B16 melanoma. Int Immunopharmacol 2004; 4: 355-366. (Pubitemid 38375969)
19. Baral RN, Sarkar K, Mandal-Ghosh I, Bose A. Relevance of neem leaf glycoprotein as a new vaccine adjuvant for cancer immunotherapy. In: Gupta VK (ed.) Researches in Bioactive Natural Products. Houston, , TX: Studium Press LLC, in press
20. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-275.
21. Chakraborty K, Bose A, Pal S, Chattopadhyay U, Baral R. Interferon alpha2b restores the impaired chemotactic activity of peripheral blood mononuclear cells from head and neck squamous cell carcinoma patients by modulation CXC receptor ligand interaction. J Interferon Cytokine Res 2008; 28: 487-499.
22. Scaldaferri F, Sans M, Vetrano S, Correale AV, Pagano N, Rando G et al. The role of MAPKin governing lymphocyte adhesion to and migration across the microvasculature in inflammatory bowel disease. Eur J Immunol 2009; 39: 290-300.
23. Bose A, Chakraborty K, Sarkar K, Goswami S, Haque E, Chakraborty T et al. Neem leaf glycoprotein directs T-bet associated type 1 immune commitment. Hum Immunol 2009; 70: 6-15.
24. Lang S, Lauffer L, Clausen C, Löhr I, Schmitt B, Hö lzel D et al. Impaired monocyte function in cancer patients: restoration with a cyclooxygenase-2 inhibitor. FASEB J 2003; 2: 286-288.
25. Chuang JY, Yang WH, Chen HT. CCL5/CCR5 axis promotes the motility of human oral cancer cells. J Cell Physiol 2009; 220: 418-426.
26. Bose A, Haque E, Baral RN. Neem leaf preparation induces apoptosis of tumor cells by releasing cytotoxic cytokines from human peripheral blood mononuclear cells. Phytother Res 2007; 21: 914-920. (Pubitemid 47582763)
27. Montecucco F, Steffens S, Burger F, Da Costa A, Bianchi G, Bertolotto M et al. Tumor necrosis factor-alpha (TNF-alpha) induces integrin CD11b/CD18 (Mac-1) upregulation and migration to the CC chemokine CCL3 (MIP-1alpha) on human neutrophils through defined signalling pathways. Cell Signal 2008; 20: 557-568.
28. Lee HM, Kim HJ, Won KJ, Choia WS, Parka SH, Songb H et al. Soluble form of vascular cell adhesion molecule 1 induces migration and proliferation of vascular smooth muscle cells. J Vasc Res 2008; 45: 259-268. (Pubitemid 351543150)