Probing the active-site requirements of human intestinal N-terminal maltase glucoamylase: The effect of replacing the sulfate moiety by a methyl ether in ponkoranol, a naturally occurring α-glucosidase inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 19, 2010, Pages 5686-5689

  Eskandari, Razieh ^a   Jones, Kyra ^b   Rose, David R ^b   Pinto, B Mario ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

^b UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Glucosidase inhibitors; 3 O Methylponkoranol; Maltase glucoamylase; Sulfonium ion; Thiosugar

Indexed keywords

ALPHA GLUCOSIDASE; ALPHA GLUCOSIDASE INHIBITOR; COUNTERION; DE O SULFONATED KOTALANOL; DE O SULFONATED SALACINOL; DIMETHYL ETHER; KOTALANOL; METHYL GROUP; PONKORANOL; SALACINOL; SALAPRINOL; SODIUM BOROHYDRIDE; SULFATE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; MEDICINAL PLANT; NONHUMAN; SALACIA; SALACIA RETICULATA; STEREOISOMERISM;

ALPHA-GLUCOSIDASES; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; INTESTINES; METHYL ETHERS; PROTEIN STRUCTURE, TERTIARY; SULFATES; THIOPHENES;

SALACIA RETICULATA;

EID: 77957606215     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.020     Document Type: Article

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