New synthetic routes to chain-extended selenium, sulfur, and nitrogen analogues of the naturally occurring glucosidase inhibitor salacinol and their inhibitory activities against recombinant human maltase glucoamylase

Journal of Organic Chemistry

Volumn 72, Issue 17, 2007, Pages 6562-6572

  Liu, Hui ^a   Nasi, Ravindranath ^a   Jayakanthan, Kumarasamy ^a   Sim, Lyann ^b   Heipel, Heather ^b   Rose, David R ^b   Pinto, B Mario ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACYCLIC CHAINS; CARBON ATOMS; ZWITTERIONIC GLYCOSIDASE INHIBITORS;

NITROGEN COMPOUNDS; SELENIUM; SULFUR; SYNTHESIS (CHEMICAL);

ENZYME INHIBITION;

ACETAL DERIVATIVE; ALPHA GLUCOSIDASE INHIBITOR; AMMONIUM SULFATE; AMPHOLYTE; BLINTOL; BUTANE; GALACTOSE; GHAVAMIOL; GLUCOSE; GLUCOSIDASE; IMINE; INTESTINE ENZYME; NITROGEN DERIVATIVE; OLIGOSACCHARIDE; RECOMBINANT ENZYME; SALACINOL; SELENIUM DERIVATIVE; SULFATE; SULFONIUM DERIVATIVE; SULFUR DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYST; CROSS COUPLING REACTION; DECOMPOSITION; DEPROTECTION REACTION; DRUG SYNTHESIS; ENZYME INHIBITION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTUM YIELD; RING OPENING; STEREOCHEMISTRY; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

ALPHA-GLUCOSIDASES; ENZYME INHIBITORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; NITROGEN; RECOMBINANT PROTEINS; SELENIUM; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUGAR ALCOHOLS; SULFATES; SULFUR;

EID: 34547933514     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo071045m     Document Type: Article

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