SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 19, 2010, Pages 5763-5766

Identification of a sub-micromolar, non-peptide inhibitor of β-secretase with low neural cytotoxicity through in silico screening

(4) Xu, Weijun a Chen, Gang a Zhu, Weiliang b Zuo, Zhili c

a SINGAPORE POLYTECHNIC (Singapore)

b SHANGHAI INSTITUTE OF MATERIA MEDICA (China)

c CURTIN UNIVERSITY (Australia)

Author keywords

BACE 1; Bioassay; FRET; Virtual screening

Indexed keywords

BETA SECRETASE; BETA SECRETASE INHIBITOR;

ARTICLE; BLOOD BRAIN BARRIER; COMPUTER MODEL; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; FLUORESCENCE RESONANCE ENERGY TRANSFER; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; NEUROBLASTOMA CELL; PHARMACOPHORE; PHYSICAL CHEMISTRY;

AMYLOID PRECURSOR PROTEIN SECRETASES; BINDING SITES; BLOOD-BRAIN BARRIER; CELL LINE, TUMOR; COMPUTER SIMULATION; ENZYME INHIBITORS; HUMANS; HYDRAZONES; PROTEIN STRUCTURE, TERTIARY; PYRAZOLES;

EID: 77957591555 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.07.140 Document Type: Article

Times cited : (22)

References (17)

1
- 34548510854
- E.W. Baxter, K.A. Conway, L. Kennis, F. Bischoff, M.H. Mercken, H.L. Winter, C.H. Reynolds, B.A. Tounge, C. Luo, M.K. Scott, Y. Huang, M. Braeken, S.M. Pieters, D.J. Berthelot, S. Masure, W.D. Bruinzeel, A.D. Jordan, M.H. Parker, R.E. Boyd, J. Qu, R.S. Alexander, D.E. Brenneman, and A.B. Reitz J. Med. Chem. 50 2007 4261
- (2007) J. Med. Chem. , vol.50 , pp. 4261
- Baxter, E.W.¹ Conway, K.A.² Kennis, L.³ Bischoff, F.⁴ Mercken, M.H.⁵ Winter, H.L.⁶ Reynolds, C.H.⁷ Tounge, B.A.⁸ Luo, C.⁹ Scott, M.K.¹⁰ Huang, Y.¹¹ Braeken, M.¹² Pieters, S.M.¹³ Berthelot, D.J.¹⁴ Masure, S.¹⁵ Bruinzeel, W.D.¹⁶ Jordan, A.D.¹⁷ Parker, M.H.¹⁸ Boyd, R.E.¹⁹ Qu, J.²⁰ more..

2
- 33745893779
- C. Mount, and C. Downton Nat. Med. 12 2006 780
- (2006) Nat. Med. , vol.12 , pp. 780
- Mount, C.¹ Downton, C.²

3
- 34247876141
- I. Melnikova Nat. Rev. 6 2007 341
- (2007) Nat. Rev. , vol.6 , pp. 341
- Melnikova, I.¹

4
- 0030779677
- M.P. Mattson Physiol. Rev. 77 1997 1081
- (1997) Physiol. Rev. , vol.77 , pp. 1081
- Mattson, M.P.¹

5
- 0035477333
- J. Walter, C. Kaether, H. Steiner, and C. Haass Curr. Opin. Neurobiol. 11 2001 585
- (2001) Curr. Opin. Neurobiol. , vol.11 , pp. 585
- Walter, J.¹ Kaether, C.² Steiner, H.³ Haass, C.⁴

6
- 0035112647
- H. Cai, Y. Wang, D. McCarthy, H. Wen, D.R. Borchelt, D.L. Price, and P.C. Wong Nat. Neurosci. 4 2001 233
- (2001) Nat. Neurosci. , vol.4 , pp. 233
- Cai, H.¹ Wang, Y.² McCarthy, D.³ Wen, H.⁴ Borchelt, D.R.⁵ Price, D.L.⁶ Wong, P.C.⁷

7
- 0035289779
- C.A. Lipinski, F. Lombardo, B.W. Dominy, and P.J. Feeney Adv. Drug Delivery Rev. 46 2001 3
- (2001) Adv. Drug Delivery Rev. , vol.46 , pp. 3
- Lipinski, C.A.¹ Lombardo, F.² Dominy, B.W.³ Feeney, P.J.⁴

8
- 10644249886
- S.J. Stachel, C.A. Coburn, T.G. Steele, K.G. Jones, E.F. Loutzenhiser, A.R. Gregro, H.A. Rajapakse, M.T. Lai, M.C. Crouthamel, M. Xu, K. Tugusheva, J.E. Lineberger, B.L. Pietrak, A.S. Espeseth, X.P. Shi, E. Chen-Dodson, M.K. Holloway, S. Munshi, A.J. Simon, L. Kuo, and J.P. Vacca J. Med. Chem. 47 2004 6447
- (2004) J. Med. Chem. , vol.47 , pp. 6447
- Stachel, S.J.¹ Coburn, C.A.² Steele, T.G.³ Jones, K.G.⁴ Loutzenhiser, E.F.⁵ Gregro, A.R.⁶ Rajapakse, H.A.⁷ Lai, M.T.⁸ Crouthamel, M.C.⁹ Xu, M.¹⁰ Tugusheva, K.¹¹ Lineberger, J.E.¹² Pietrak, B.L.¹³ Espeseth, A.S.¹⁴ Shi, X.P.¹⁵ Chen-Dodson, E.¹⁶ Holloway, M.K.¹⁷ Munshi, S.¹⁸ Simon, A.J.¹⁹ Kuo, L.²⁰ Vacca, J.P.²¹ more..

9
- 33947636525
- M. Congreve, D. Aharony, J. Albert, O. Callaghan, J. Campbell, R.A. Carr, G. Chessari, S. Cowan, P.D. Edwards, M. Frederickson, R. McMenamin, C.W. Murray, S. Patel, and N. Wallis J. Med. Chem. 50 2007 1124
- (2007) J. Med. Chem. , vol.50 , pp. 1124
- Congreve, M.¹ Aharony, D.² Albert, J.³ Callaghan, O.⁴ Campbell, J.⁵ Carr, R.A.⁶ Chessari, G.⁷ Cowan, S.⁸ Edwards, P.D.⁹ Frederickson, M.¹⁰ McMenamin, R.¹¹ Murray, C.W.¹² Patel, S.¹³ Wallis, N.¹⁴

10
- 54549115053
- J.C. Barrow, S.R. Stauffer, K.E. Rittle, P.L. Ngo, Z. Yang, H.G. Selnick, S.L. Graham, S. Munshi, G.B. McGaughey, M.K. Holloway, A.J. Simon, E.A. Price, S. Sankaranarayanan, D. Colussi, K. Tugusheva, M.T. Lai, A.S. Espeseth, M. Xu, Q. Huang, A. Wolfe, B. Pietrak, P. Zuck, D.A. Levorse, D. Hazuda, and J.P. Vacca J. Med. Chem. 51 2008 6259
- (2008) J. Med. Chem. , vol.51 , pp. 6259
- Barrow, J.C.¹ Stauffer, S.R.² Rittle, K.E.³ Ngo, P.L.⁴ Yang, Z.⁵ Selnick, H.G.⁶ Graham, S.L.⁷ Munshi, S.⁸ McGaughey, G.B.⁹ Holloway, M.K.¹⁰ Simon, A.J.¹¹ Price, E.A.¹² Sankaranarayanan, S.¹³ Colussi, D.¹⁴ Tugusheva, K.¹⁵ Lai, M.T.¹⁶ Espeseth, A.S.¹⁷ Xu, M.¹⁸ Huang, Q.¹⁹ Wolfe, A.²⁰ more..

11
- 70350050829
- M.S. Malamas, J. Erdei, I. Gunawan, K. Barnes, M. Johnson, Y. Hui, J. Turner, Y. Hu, E. Wagner, K. Fan, A. Olland, J. Bard, and A.J. Robichaud J. Med. Chem. 52 2009 6314
- (2009) J. Med. Chem. , vol.52 , pp. 6314
- Malamas, M.S.¹ Erdei, J.² Gunawan, I.³ Barnes, K.⁴ Johnson, M.⁵ Hui, Y.⁶ Turner, J.⁷ Hu, Y.⁸ Wagner, E.⁹ Fan, K.¹⁰ Olland, A.¹¹ Bard, J.¹² Robichaud, A.J.¹³

12
- 33846261909
- I. Hussain, J. Hawkins, D. Harrison, C. Hille, G. Wayne, L. Cutler, T. Buck, D. Walter, E. Demont, C. Howes, A. Naylor, P. Jeffrey, M.I. Gonzalez, C. Dingwall, A. Michel, S. Redshaw, and J.B. Davis J. Neurochem. 100 2007 802
- (2007) J. Neurochem. , vol.100 , pp. 802
- Hussain, I.¹ Hawkins, J.² Harrison, D.³ Hille, C.⁴ Wayne, G.⁵ Cutler, L.⁶ Buck, T.⁷ Walter, D.⁸ Demont, E.⁹ Howes, C.¹⁰ Naylor, A.¹¹ Jeffrey, P.¹² Gonzalez, M.I.¹³ Dingwall, C.¹⁴ Michel, A.¹⁵ Redshaw, S.¹⁶ Davis, J.B.¹⁷

13
- 67651047153
- W.H. Huang, R. Sheng, and Y.Z. Hu Curr. Med. Chem. 16 2009 1806
- (2009) Curr. Med. Chem. , vol.16 , pp. 1806
- Huang, W.H.¹ Sheng, R.² Hu, Y.Z.³

14
- 60449110304
- R. Machauer, S. Veenstra, J.M. Rondeau, M. Tintelnot-Blomley, C. Betschart, U. Neumann, and P. Paganetti Bioorg. Med. Chem. Lett. 19 2009 1361
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 1361
- MacHauer, R.¹ Veenstra, S.² Rondeau, J.M.³ Tintelnot-Blomley, M.⁴ Betschart, C.⁵ Neumann, U.⁶ Paganetti, P.⁷

15
- 65749100210
- W. Xu, G. Chen, O.W. Liew, Z. Zuo, H. Jiang, and W. Zhu Bioorg. Med. Chem. Lett. 19 2009 3188
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 3188
- Xu, W.¹ Chen, G.² Liew, O.W.³ Zuo, Z.⁴ Jiang, H.⁵ Zhu, W.⁶

16
- 0031959341
- W.M. Pardridge J. Neurochem. 70 1998 1781
- (1998) J. Neurochem. , vol.70 , pp. 1781
- Pardridge, W.M.¹

17
- 0021061819
- T. Mosmann J. Immunol. Methods 65 1983 55
- (1983) J. Immunol. Methods , vol.65 , pp. 55
- Mosmann, T.¹

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.